Clinical trials: Diffuse Parenchymal Lung Diseases
Histiocytosis, Langerhans-cell
Reduced Intensity Hematopoietic Cell Transplantation for Patients With Resistant Langerhans Cell Histiocytosis
RATIONALE: Giving a monoclonal antibody, such as alemtuzumab, and chemotherapy drugs, such as fludarabine and melphalan, before a donor stem cell transplant helps stop the patient's immune system from rejecting the donor's stem…
- Trial name
- NCT00618540
- Testing
- alemtuzumab, fludarabine phosphate, melphalan
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Silicosis
Comprehensive Risk Assessment of People With Silicosis: A Population-based Study
Objectives: This study aims to explore the risk profiles among people with silicosis in Hong Kong underpinned by the Pittsburgh Mind-Body Center model.
- Trial name
- NCT02794701
- Testing
- People with silicosis
- Where
- China
- Volunteers
- 390 people
- Sponsor
- Chinese University of Hong Kong
Idiopathic Pulmonary Fibrosis (IPF), Idiopathic Pulmonary Fibrosis
PET Study of PIPE-791 in Healthy Volunteers and Volunteers With PrMS and IPF
This is a study of PIPE-791, an investigational study drug to treat progressive multiple sclerosis (MS) and idiopathic pulmonary fibrosis (IPF).
- Conditions
- Idiopathic Pulmonary Fibrosis (IPF), Idiopathic Pulmonary Fibrosis, Multiple Sclerosis, Multiple Sclerosis, MS
- Trial name
- NCT06683612
- Testing
- PIPE-791
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Contineum Therapeutics
Interstitial Lung Disease
Impact of Lung Boost Device on Ventilatory Functions and Fatigue in Patients With Interstitial Lung Diseases
The purpose of this study will be to determine the effect of lung boost exercise on ventilatory functions, fatigue, and physical function capacity in Interstitial lung disease patients.
- Trial name
- NCT06991153
- Testing
- Lung Boost Device Training, Traditional physical therapy program, Medical Treatment
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Interstitial Lung Disease
The Effects of Glucocorticoids on Glucose Metabolism in Patients With Interstitial Lung Disease
This study is aimed at exploring the effects of glucocorticoids on glucose metabolism in patients with interstitial lung disease.
- Trial name
- NCT02824757
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Peking Union Medical College Hospital
Idiopathic Pulmonary Fibrosis
Nutritional Assessment in Idiopathic Pulmonary Fibrosis
In recent years nutritional status assumed increasing importance in the evaluation of chronic respiratory diseases, considering that their clinical course is often characterized by a progressive loss of weight and reduction of…
- Trial name
- NUTRIPF (NCT03770845)
- Where
- 9 sites in Italy
- Volunteers
- 100 people
- Sponsor
- San Gerardo Hospital
Lung Diseases, Interstitial
Interstitial Lung Disease (ILD). Diagnostic Yield of Surgical Lung Biopsy Versus Cryobiopsy in the Same Surgical Stage.
In patients with interstitial lung disease (ILD) with inconsistent clinical and radiological features, establishing a reliable diagnosis of ILD requires a surgical lung biopsy Transbronchial cryobiopsy is a minimally invasive…
- Trial name
- NCT03596528
- Testing
- Lung biopsy
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Hospital Clinic of Barcelona
Idiopathic Pulmonary Fibrosis
Cohort of IPF Patients Experiencing an Exacerbation
Extension of the PFBIO cohort which includes patients with newly diagnosed idiopathic pulmonary fibrosis (IPF) for longitudinal follow-up for up to 5 years.
- Trial name
- NCT04442711
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- University Hospital, Gentofte, Copenhagen
Interstitial Lung Disease, Pulmonary Fibrosis
P4O2 ILD Extension
The goal of this observational study is to identify early biomarkers that can predict the development of progressive pulmonary fibrosis (PPF) in participants with interstitial lung diseases (ILDs).
- Conditions
- Interstitial Lung Disease, Pulmonary Fibrosis, Interstitial Lung Fibrosis, IPF
- Trial name
- P4O2-ILD (NCT06644144)
- Testing
- No Interventions
- Where
- Netherlands
- Volunteers
- 450 people
- Sponsor
- Amsterdam UMC, location VUmc
Aplastic Anemia
Danazol for Genetic Bone Marrow and Lung Disorders
Background: Some people have bone marrow and lung disorders that are caused by genetic problems. These problems often involve damage to the ends of the chromosomes that pass down genes. One of these disorders is aplastic anemia.
- Trial name
- NCT01441037
- Testing
- Danazol
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Pneumoconiosis Coal, Asbestosis
The Nintedanib in Progressive Pneumoconiosis Study (NiPPS): a Collaborative NSW Treatment Trial
Prospective clinical pilot study for subjects diagnosed with Occupational Progressive Pneumoconiosis. Subjects will be treated with Nintedanib 150mg twice daily for 3 years.
- Conditions
- Pneumoconiosis Coal, Asbestosis, Silicosis
- Trial name
- NiPPs (NCT04161014)
- Testing
- Nintedanib 150 MG [Ofev]
- Where
- Australia
- Volunteers
- 100 people
- Sponsor
- Holdsworth House Medical Practice
Pulmonary Hypertension, Interstitial Lung Disease
Aerobic Exercise in Patients With Pulmonary Hypertension
This study will determine if a rehabilitation exercise program can help people with pulmonary hypertension (PH) increase their physical activity.
- Trial name
- NCT00678821
- Testing
- Aerobic exercise
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Adult Pulmonary Langerhans Cell Histiocytosis
Prospective Evaluation of Adult Pulmonary Langerhans Cell Histiocytosis
Study objectives: To estimate the incidence of pulmonary deterioration in adult pulmonary Langerhans cell histiocytosis To assess the impact of tobacco discontinuation Study Design Multicentric prospective cohort study Main…
- Trial name
- LCHA1 (NCT01225601)
- Testing
- Tabacco discontinuation
- Where
- France
- Volunteers
- 62 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Lung Neoplasm, Lung Diseases, Interstitial
Respiratory Endoscopy: Diagnostic Yield, Technical Factors and Complications
Background: Respiratory endoscopy comprises flexible bronchoscopy and medical thoracoscopy. The diagnostic yield, technical factors and complications for all patient sub-populations is still not clearly defined.
- Conditions
- Lung Neoplasm, Lung Diseases, Interstitial, Respiratory Tract Infections, Pleural Effusions
- Trial name
- NCT01374542
- Testing
- Respiratory endoscopy
- Where
- Singapore
- Volunteers
- 4,000 people
- Sponsor
- Singapore General Hospital
Idiopathic Pulmonary Fibrosis
Assess the Safety, Tolerability and Pharmacokinetics of AZD5055 Following Single and Multiple Ascending Doses in Healthy Participants
This is a phase I, First-in-Human study in healthy participants, performed at a single study center, consisting of 2 parts: Part 1 is a single ascending dose (SAD) study and Part 2 is a multiple ascending dose (MAD) study.
- Trial name
- NCT05134727
- Testing
- AZD5055
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Interstitial Lung Disease
Genentech Validation Tool for Pulmonary Fibrosis
Radiology is an important component of the multidisciplinary team. The primary goal of this project will be to create a tool using findings on chest computed tomography (CT) for nearly 300 patients with the most common types of…
- Trial name
- NCT04676594
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Columbia University
Idiopathic Pulmonary Fibrosis
Microaspiration in Pulmonary Fibrosis
Hypothesis 1: Microaspiration, as diagnosed by bronchoalveolar lavage (BAL) pepsin, is common in patients with IPF. Hypothesis 2a: Baseline clinical variables and co-morbid conditions are risk factors for microaspiration in…
- Trial name
- ROMI (NCT01150591)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, San Francisco
Pulmonary Hypertension
Dose Determination Safety and Activity Study of Inhaled NX1011 to Treat Pulmonary Arterial Hypertension
The purpose of this study is to determine the safety and maximum tolerated dose of inhaled NX1011 for the treatment of pulmonary arterial hypertension (PAH).
- Trial name
- NCT00323024
- Testing
- NX1011
- Where
- 6 sites in United States
- Volunteers
- 72 people
- Sponsor
- NITROX, LLC
Interstitial Lung Disease
Comparison of Transbronchial, Cryoprobe, and VATS Biopsy for the Diagnosis of Interstitial Lung Disease
The objective of this study is to compare the sample size, architectural preservation and diagnostic yield of bronchoscopic cryo-probe transbronchial lung biopsy (C-TBBx) in comparison to bronchoscopic standard transbronchial…
- Trial name
- NCT02075762
- Testing
- Transbronchial biopsy, Cryoprobe biopsy, VATS biopsy
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Johns Hopkins University
Idiopathic Pulmonary Fibrosis, Lung; Disease, Interstitial, With Fibrosis
A Study to Evaluate Safety, Tolerability and Pharmacokinetics of RSN0402 in Healthy Volunteers
This is a phase 1, randomized, First in Human (FIH), double-blinded, placebo-controlled study to assess the safety, tolerability, and PK of RSN0402 in healthy volunteers.
- Trial name
- NCT06482190
- Testing
- RSN0402 Part 1, RSN0402 Part 2
- Where
- 3 sites in Australia
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Shenzhen Resproly Biopharmaceutical Co., Ltd
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