Clinical trials: Diffuse Parenchymal Lung Diseases
Sarcoidosis, Pulmonary, Sarcoidosis Lung
Tofacitinib Hypothesis-generating, Pilot Study for Corticosteroid-Dependent Sarcoidosis
This is a pilot study to determine whether further research is warranted to assess whether tofacitinib is an effective steroid sparing treatment for pulmonary sarcoidosis.
- Conditions
- Sarcoidosis, Pulmonary, Sarcoidosis Lung, Sarcoidosis
- Trial name
- NCT03793439
- Testing
- Tofacitinib 5mg Oral Tablet [Xeljanz] 16 week trial, Spirometry, RNA Sequencing
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Oregon Health and Science University
Idiopathic Pulmonary Fibrosis
A Study of Nalbuphine (Extended Release) ER in Idiopathic Pulmonary Fibrosis (IPF) for Treatment of Cough
To evaluate the safety and tolerability of nalbuphine ER tablets in the study population and to evaluate the effect of NAL ER tablets on the mean daytime cough frequency (coughs per hour) at Day 22 (dose 162 mg BID) as compared…
- Trial name
- CANAL (NCT04030026)
- Testing
- NAL ER
- Where
- 11 sites in United Kingdom
- Volunteers
- 42 people
- Sponsor
- Trevi Therapeutics
State Key Laboratory of Respiratory Disease
Respiratory Muscle Function and Neural Respiratory Drive in Interstitial Lung Disease
The purpose of this study is to assess the Respiratory Muscle Function and Neural Respiratory Drive in Interstitial Lung Disease patients.
- Trial name
- NCT02877121
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Zhang Jianheng
Scleroderma, Systemic, Fibrosis; Skin
Western Sweden Systemic Sclerosis Project
The main aim of the project is to identify key-factors involved in the development and progression of Systemic Sclerosis (SSc), a chronic invalidating rheumatic disease characterized by high mortality and insufficient treatment…
- Conditions
- Scleroderma, Systemic, Fibrosis; Skin, Fibrosis Lung, Interstitial Lung Disease Due to Systemic Disease
- Trial name
- WESST (NCT07345052)
- Testing
- No Intervention: Observational Cohort
- Where
- Sweden
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Sahlgrenska University Hospital
Sarcoidosis, Pulmonary
Endobronchial Ultrasound Strain Elastography in Sarcoidosis
Strain elastography (SE) is an imaging method used for the measurement of relative tissue elasticity through qualitative (color pattern) or semi-quantitative methods (strain ratio or strain histogram).
- Trial name
- NCT04895111
- Testing
- Endobronchial ultrasound strain elastography
- Where
- Italy
- Volunteers
- 701 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Primary Sjogren's Syndrome, Interstitial Lung Disease
Clinical Study of Jianfei Kangfu Cao in the Treatment of pSS-ILD
This study will evaluate the safety and efficacy of Jianfei Kangfu Cao in the treatment of primary Sjogren's syndrome associated interstitial lung disease.
- Trial name
- NCT04544722
- Testing
- Jianfei Kangfu Cao, lung rehabilitation training
- Where
- China
- Volunteers
- 138 people
- Sponsor
- Shanghai University of Traditional Chinese Medicine
Idiopathic Pulmonary Fibrosis
Safety and Efficacy of Pirfenidone in Patients With Idiopathic Pulmonary Fibrosis
The purposes of this study are to assess the efficacy of treatment with pirfenidone 2403 milligrams per day compared with placebo in patients with idiopathic pulmonary fibrosis (IPF)and to assess the safety of treatment with…
- Trial name
- NCT00287729
- Testing
- Pirfenidone
- Where
- United States
- Volunteers
- 344 people
- Sponsor
- Genentech, Inc.
Fibrosing Interstitial Lung Disease
A Study to Find Out How Nerandomilast is Tolerated, Handled by the Body, and if it Helps Children and Adolescents With Interstitial Lung Disease (FIBRONEER-chILD)
This study is open to children and adolescents aged 2 to 17 years with interstitial lung disease (ILD). Nerandomilast has just been approved in some countries to help adults with a lung condition called idiopathic pulmonary…
- Trial name
- NCT07366034
- Testing
- Nerandomilast
- Where
- 47 sites in United States, Argentina and 20 more
- Volunteers
- 35 people
- Sponsor
- Boehringer Ingelheim
Pulmonary Langerhans Cell Histiocytosis
Assessment of Safety of Air Travel in Patients With Pulmonary Langerhans Cell Histiocytosis
The aim of this study is to conduct survey-based assessments for the safety of air travel in patients with pulmonary Langerhans cell histiocytosis (PLCH).
- Trial name
- NCT03052101
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- University of Cincinnati
Acute Exacerbation, Idiopathic Pulmonary Fibrosis
Early Detection of Acute Exacerbation in Patients With Idiopathic Lung Fibrosis - a Pilot Study
Idiopathic pulmonary fibrosis (IPF) is a chronic disease, leading to poor lung function with a median survival of 2-3 years. Acute exacerbation of idiopathic IPF is a complication associated with a mortality rate > 50%.
- Conditions
- Acute Exacerbation, Idiopathic Pulmonary Fibrosis, Home Spirometry
- Trial name
- NCT03979430
- Testing
- Home spirometry
- Where
- 4 sites in Germany
- Volunteers
- 47 people
- Sponsor
- Heidelberg University
Idiopathic Pulmonary Fibrosis (IPF)
A Phase 2 Study of HB0056 in Patients With Idiopathic Pulmonary Fibrosis
This trial is a 58 week randomized, double-blind, placebo-controlled, parallel-group, multicenter trial in which the efficacy, safety, and pharmacokinetics of HB0056, either on top of stable IPF therapy or as monotherapy, are…
- Trial name
- NCT07909655
- Testing
- HB0056
- Where
- 2 sites in China
- Volunteers
- 75 people
- Sponsor
- Shanghai Huaota Biopharmaceutical Co., Ltd.
Pulmonary Fibrosis
Telomeres Length in Israeli Fibrotic ILD Patients
Individuals with fibrotic interstitial lung diseases (FILD) will be recruited after providing informed consent. in addition to routine data as usually collected in the clinic, blood samples will be taken for measurement of…
- Trial name
- NCT06885515
- Testing
- leukocyte telomere length (LTL) will be measured using the Telomere Restriction Fragment (TRF) Analysis method
- Where
- 2 sites in Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Barzilai Medical Center
Idiopathic Pulmonary Fibrosis
Rehabilitation of Idiopathic Pulmonary Fibrosis (IPF) Patients
The incidence and prevalence of IPF increase exponentially with age, and IPF occurs more often in older males. Cigarette smoking and environmental dust exposures are known risk factors for developing IPF.
- Trial name
- NCT01118221
- Testing
- pulmonary rehabilitation
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- US Department of Veterans Affairs
COVID-19, Pulmonary Fibrosis
Comparison of Pulmonary Telerehabilitation and Physical Activity Recommendations in Patients With Post Covid Fibrosis
Rehabilitation plays a very important role in the management of patients with COVID-19, focusing on respiratory and motor functions, and therefore the importance of establishing treatment strategies to ensure optimal recovery of…
- Trial name
- NCT05299333
- Testing
- Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Istanbul University - Cerrahpasa
Radiation Pneumonitis
The Efficacy of Babaodan Capsules in Preventing Radiation Pneumonia
Radiation pneumonitis (RP) is a common complication of radiotherapy for thoracic tumors, and the incidence rate of grade 2 or above RP is 20% -40%; The use of antibiotics after secondary bacterial infection due to radiation…
- Trial name
- NCT06079931
- Testing
- Babaodan Capsule
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Fifth Affiliated Hospital, Sun Yat-Sen University
Idiopathic Pulmonary Fibrosis
All-Case Surveillance of Ofev in Patients With IPF in Japan
This is a non-interventional study based on new data collection to gather real-world information (i.e., data under routine medical practice) on safety and effectiveness of the Ofev® Capsules treatment.
- Trial name
- NCT02607722
- Testing
- Nintedanib
- Where
- Japan
- Volunteers
- 10,117 people
- Sponsor
- Boehringer Ingelheim
Interstitial Lung Disease in Patients With Rheumatoid Arthritis
CXCL10 As a Biomarker Of ILD in Patients WithRA
Rheumatoid arthritis is a chronic inflammatory disease that affects the joints, causing symmetric pain, stiffness, swelling, and limited motion and function of multiple joints, its fibro inflammatory manifestations may develop in…
- Trial name
- NCT04356066
- Testing
- serum cxcl10 by ELISA
- Volunteers
- 80 people
- Sponsor
- Assiut University
Pulmonary Fibrosis
Assessment of Peripheral Endothelial Function in Idiopathic Pulmonary Fibrosis
The aim of the study is to assess the peripheral endothelial function in adult patients with idiopathic pulmonary fibrosis (IPF) and the relationship between the peripheral endothelial function and the severity of the IPF.
- Trial name
- Endoth-FPI (NCT02594059)
- Testing
- endothelial function
- Where
- 2 sites in France
- Volunteers
- 43 people
- Sponsor
- Hopital Foch
Idiopathic Pulmonary Fibrosis
IPF Italian Observational Study (FIBRONET) in Idiopathic Pulmonary Fibrosis
The purpose of the present study is to evaluate the characteristics, management and clinical course of patients with IPF as treated under real-world in Italian Pulmonary Centres, in terms of symptoms, lung function and exercise…
- Trial name
- NCT02803580
- Where
- 18 sites in Italy
- Volunteers
- 209 people
- Sponsor
- Boehringer Ingelheim
Neuroendocrine Cell Hyperplasia of Infancy
Efficacy of Methylprednisolone Pulses in Neuroendocrine Celles Hyperplasia of Infancy : An Early Phase Study
Childhood interstitial lung diseases (chILD) are a heterogeneous group of rare and severe disorders with an estimated prevalence of 1/100,000.
- Trial name
- CORTICONEHI (NCT06471556)
- Testing
- IV Methylprednisolone pulses
- Where
- France
- Volunteers
- 18 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
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