Clinical trials: Diffuse Parenchymal Lung Diseases
Idiopathic Pulmonary Fibrosis
Oral Ifetroban in Patients With Idiopathic Pulmonary Fibrosis (IPF)
Ifetroban prevents and treats lung fibrosis due to multiple causes (bleomycin, genetic, radiation). The safety and efficacy of oral ifetroban will be assessed in patients with IPF.
- Trial name
- NCT05571059
- Testing
- Ifetroban Sodium
- Where
- 20 sites in United States
- Volunteers
- 128 people
- Sponsor
- Cumberland Pharmaceuticals
Idiopathic Pulmonary Fibrosis
Single and Multiple Dose Safety, Tolerability, PK and Food Effect Study of HEC585 in Healthy Male and Female Subjects
The Safety, Tolerability Pharmacokinetic and Food Effect Study of HEC585 in Healthy Male and Female Subjects
- Trial name
- NCT04512170
- Testing
- HEC585
- Where
- China
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Sunshine Lake Pharma Co., Ltd.
Systemic Wegener's Granulomatosis
WEGENT - Comparison of Methotrexate or Azathioprine as Maintenance Therapy for ANCA-Associated Vasculitides
Remission of ANCA-associated vasculitis can be obtained in approximately 80% of the patients with a combination of corticosteroids and cyclophosphamide. However, relapses are frequent.
- Trial name
- NCT00349674
- Testing
- Azathioprine: 2 mg/kg/day, methotrexate 0.3 mg/kg/week, to a maximum and optimal dose of 25 mg/week
- Where
- France
- Volunteers
- 126 people
- Sponsor
- Hospices Civils de Lyon
Pulmonary Fibrosis, Hypertension, Pulmonary
Sildenafil Trial of Exercise Performance in Idiopathic Pulmonary Fibrosis
Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease that affects an individual's ability to breathe. This study will evaluate the effectiveness of sildenafil, a medication that increases blood flow to the lungs, at…
- Trial name
- STEP-IPF (NCT00517933)
- Testing
- Sildenafil Citrate
- Where
- 13 sites in United States
- Volunteers
- 180 people
- Sponsor
- Duke University
Covid19, Sars-CoV-2 Infection
Post Acute Sequelae of COVID-19
COVID-19, a novel coronavirus, has caused widespread mortality and morbidity since it emerged in 2019. There is ongoing research and growing literature describing severe acute respiratory syndrome (SARS-COV-2).
- Conditions
- Covid19, Sars-CoV-2 Infection, Dyspnea Caused by 2019-nCoV, COVID-19 Acute Respiratory Distress Syndrome
- Trial name
- PASC (NCT04964115)
- Testing
- Cohort study
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Vanderbilt University Medical Center
Sarcoidosis, Precapillary Pulmonary Hypertension
Inhaled Treprostinil in Sarcoidosis Patients With Pulmonary Hypertension
This study aims to evaluate the efficacy and safety of inhaled treprostinil in subjects with sarcoidosis-associated interstitial lung disease and pulmonary hypertension.
- Conditions
- Sarcoidosis, Precapillary Pulmonary Hypertension, Interstitial Lung Disease
- Trial name
- SAPPHIRE (NCT03814317)
- Testing
- Inhaled Treprostinil
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Florida
Lung Diseases, Interstitial, Lung Cancer
The Prevalence of Lung Cancer in Patients With Interstitial Lung Disease
The investigators will evaluate the prevalence of lung cancer associated with interstitial lung disease (ILD) and idiopathic pulmonary fibrosis (IPF) utilizing the Korean Health Insurance Review and Assessment Service (HIRA)…
- Trial name
- NCT02501668
- Volunteers
- 1,375,842 people
- Sponsor
- Keimyung University Dongsan Medical Center
Silicosis
Using Silica 12CH to Mitigate the Effects and Symptoms of Silicosis in Brazil
This clinical study aims to address a research and clinical treatment gap related to individuals with symptoms of Silicosis resulting from quartzite mining work.
- Trial name
- HOHM (NCT06011785)
- Testing
- Silica 12CH
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- HOHM Foundation
Idiopathic Pulmonary Fibrosis, Gastroesophageal Reflux
Treatment of IPF With Laparoscopic Anti-Reflux Surgery
This study will test the hypothesis that treatment with laparoscopic anti-reflux surgery in subjects with idiopathic pulmonary fibrosis (IPF) and abnormal gastroesophageal reflux (GER) will slow the decline of forced vital…
- Trial name
- WRAP-IPF (NCT01982968)
- Testing
- Surgery
- Where
- 5 sites in United States
- Volunteers
- 58 people
- Sponsor
- University of California, San Francisco
Interstitial Lung Disease (ILD), Suspected Interstitial Lung Disease
Optimizing the Diagnostic Journey in Interstitial Lung Disease: The OPTIMIZE-ILD-1 Trial
The OPTIMIZE-ILD-1 trial is a prospective, randomized, open-label clinical trial designed to evaluate the impact of a coordinated diagnostic pathway on patients with suspected interstitial lung disease (ILD).
- Conditions
- Interstitial Lung Disease (ILD), Suspected Interstitial Lung Disease, Fibrotic Interstitial Lung Disease, Idiopathic Pulmonary Fibrosis (IPF)
- Trial name
- OPTIMIZE-ILD-1 (NCT07482917)
- Testing
- Standard ILD Diagnostic Pathway, Optimized ILD Diagnostic Circuit
- Where
- Spain
- Volunteers
- 92 people
- Sponsor
- Hospital de Granollers
Cerebral Amyloid Angiopathy, Siderosis
Cerebellar Superficial Siderosis in Cerebral Amyloid Angiopathy
Cerebellar superficial siderosis (SS) has been recently reported to be present in about 10% of both hereditary (n=50) and sporadic (n=46) cerebral amyloid angiopathy (CAA) patients on 3T MRI using susceptibility-weighted imaging…
- Trial name
- CSS (NCT05394636)
- Testing
- None, pure observational study
- Where
- France
- Volunteers
- 111 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Idiopathic Pulmonary Fibrosis
23andMe IPF Research Study
The long term goal of this study is to increase genetic understanding of IPF to enable the development of an effective drug for IPF that can improve the lives of those living with the condition.
- Trial name
- IPF (NCT05028894)
- Testing
- No intervention
- Where
- United States
- Volunteers
- 690 people
- Sponsor
- 23andMe, Inc.
Interstitial Lung Disease
Specialist Dietetic Intervention in Malnourished Patients with Fibrotic ILD: a Randomised Controlled Pilot Trial
Malnutrition occurs when the body receives too few nutrients, resulting in health problems such as weight loss. The consequences of malnutrition are worrying as they include lung failure, infection, and pressure ulcers.
- Trial name
- DT-ILD (NCT06016959)
- Testing
- Dietetic intervention
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Idiopathic Pulmonary Fibrosis
Study Evaluation Rentosertib (INS018_055) Administered Orally in Patients With Idiopathic Pulmonary Fibrosis (IPF)
This is a multicenter, randomized, double-blind, placebo-controlled, parallel-group study to evaluate the efficacy and safety of Rentosertib (INS018_055) administered orally in Patients with Idiopathic Pulmonary Fibrosis.
- Trial name
- NCT07687459
- Testing
- INS018_055 tablets
- Where
- 47 sites in China
- Volunteers
- 320 people
- Sponsor
- InSilico Medicine Hong Kong Limited
Idiopathic Pulmonary Fibrosis (IPF)
A Phase 3 Study of Efficacy and Safety of AK3280 in Patients With Idiopathic Pulmonary Fibrosis
This is a phase 3 clinical study conducted in China. The primary objective is to compare the efficacy and safety of AK3280 400 mg versus placebo and active control (pirfenidone) in IPF patients.
- Trial name
- NCT07719023
- Testing
- AK3280, Pirfenidone
- Where
- China
- Volunteers
- 263 people
- Sponsor
- Shanghai Ark Biopharmaceutical Co., Ltd.
Emphysema, Chronic Obstructive Pulmonary Disease (COPD)
Phase 2 Study of Ex-vivo Perfusion and Ventilation of Lungs to Assess Transplant Suitability
The purpose of this research study is to perfect the technique of EVLP and learn about the safety of transplanting lungs that have been ventilated (attached to a breathing machine or ventilator to deliver oxygen) and perfused…
- Conditions
- Emphysema, Chronic Obstructive Pulmonary Disease (COPD), Cystic Fibrosis, Pulmonary Fibrosis
- Trial name
- NCT01241942
- Testing
- Steen Solution™, Conventional Lung Transplant
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of North Carolina, Chapel Hill
Lung Diseases, Interstitial
A Study to Evaluate Long-term Safety of Nintedanib in Children and Adolescents With Interstitial Lung Disease (InPedILD®-ON)
This study is open to children and adolescents with interstitial lung disease (ILD) that causes lung fibrosis. This is a study for people who took part in a previous study called InPedILD (study 1199-0337) and for people who are…
- Trial name
- NCT05285982
- Testing
- Nintedanib (Ofev®)
- Where
- 28 sites in United States, Argentina and 15 more
- Volunteers
- 54 people
- Sponsor
- Boehringer Ingelheim
Idiopathic Pulmonary Fibrosis, Interstitial Lung Disease
Race, Ethnicity, and Diffuse Parenchymal Lung Disease
The purpose of this study is to identify factors that contribute to higher mortality rates among blacks and Hispanics with diffuse parenchymal lung disease.
- Conditions
- Idiopathic Pulmonary Fibrosis, Interstitial Lung Disease, Diffuse Parenchymal Lung Disease
- Trial name
- NCT00453713
- Where
- United States
- Volunteers
- 565 people
- Sponsor
- Columbia University
Lung Cancer, Interstitial Lung Disease
Reducing Respiratory Symptoms of Pulmonary Irradiation in Interstitial Lung Disease
In this double-blind phase II randomized controlled trial, patients with lung cancer or ≤2 oligometastatic pulmonary lesions and a concomitant diagnosis of ILD who are planned for radical Radiation Therapy (RT) will be randomized…
- Trial name
- RESPIRE-ILD (NCT05986318)
- Testing
- N-Acetyl cysteine, Dexamethasone Oral, Radiation Therapy
- Where
- 4 sites in Canada
- Volunteers
- 98 people
- Sponsor
- David Palma
Lung Diseases, Respiratory Distress Syndrome, Newborn
Epidemiology of Surfactant Protein-B Deficiency
The purpose of this study is to test the hypothesis that excess, rare, functionally disruptive single nucleotide polymorphisms (SNPs) characterize genes (e.g., the surfactant protein-B gene)(SFTPB) and gene networks (e.g., the…
- Conditions
- Lung Diseases, Respiratory Distress Syndrome, Newborn, Pulmonary Surfactant, Lung Diseases, Interstitial
- Trial name
- NCT00014859
- Where
- United States
- Volunteers
- 5,176 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
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