Clinical trials: Digestive Discomfort
Gut Health, Microbiome
A Clinical Trial to Evaluate the Effects of a Fibre Supplement on Microbiome and Gut Health
This study will evaluate the effects of the Artah Essential Fibre+ supplement on the microbiome and gut health over an 8-week period.
- Conditions
- Gut Health, Microbiome, Bloating, Indigestion
- Trial name
- NCT07781488
- Testing
- Essential Fibre+
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Artah Nutrition Limited
Digestive Discomfort
A1 Beta-casein-free Milk in Milk-intolerant Participants
This was a single-site, double-blind, randomised, controlled, crossover study, which aimed to compare the effects of conventional cow's milk (CON, containing both A1- and A2-types of beta-casein) versus milk free of A1-type…
- Trial name
- NCT06763185
- Testing
- Dietary Supplement: conventional cow's milk consumption, and then A1PF milk consumption, Dietary Supplement: A1PF milk consumption, and then conventional cow's milk consumption
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- a2 Milk Company Ltd.
Gastrointestinal Symptoms
Effect of Bifidobacterium Lactis HN019 on Colonic Transit Time and Digestive Symptoms
The purpose of this study was to investigate the dose response effect of Bifidobacterium lactis HN019 supplementation on colonic transit time and gastrointestinal symptoms.
- Trial name
- NCT01171014
- Testing
- Bifidobacterium lactis HN019
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Fonterra Research Centre
Gastrointestinal Discomfort, Gastrointestinal Side Effects of GLP-1 Receptor Agonist Use
A Study to Evaluate the Effects of a Supplement on Gut Comfort in GLP-1 Receptor Agonist Users
This is a randomized, triple-blind, placebo-controlled, virtual clinical trial evaluating the effects of the Oxxynea® botanical supplement on gut comfort in adults who use GLP-1 receptor agonists (GLP-1 RAs).
- Conditions
- Gastrointestinal Discomfort, Gastrointestinal Side Effects of GLP-1 Receptor Agonist Use, Nausea, Abdominal Pain
- Trial name
- NCT07898189
- Testing
- Oxxynea® Supplement
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- AB Mauri (UK) Limited,
Chest Pain, Gastroesophageal Reflux
Chest Pain Pilot Study
The purpose of this study is to compare the efficacy of Nexium® with placebo in relief of acid related pain or discomfort in the chest.
- Trial name
- NCT00251901
- Testing
- Esomeprazole
- Where
- 80 sites in Canada, Denmark and 4 more
- Volunteers
- 600 people
- Sponsor
- AstraZeneca
Healthy Subjects
Evaluation of the the Efficacy of a Digestive Health Supplement in Healthy Subjects
The objective of this study is to evaluate the efficacy of a digestive health supplement via waist circumference measurements, daily bowel habit and symptom logs, and self-perception questionnaires (SPQ) over 4 weeks.
- Trial name
- NCT06680219
- Testing
- Active comparator
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Pharmanex
Gut Health
Effectiveness of a Butyrate Formulation and Butyrate + Polyphenol Formulation on Gut Health, Permeability and Associated Symptoms
The purpose of this study is the assess the effectiveness and safety of a Butyrate formulation and a Butyrate + Polyphenol formulation on gut health, permeability and associated symptoms
- Trial name
- NCT06419231
- Testing
- Butyrate Formulation, Butyrate + Polyphenol Formulation
- Where
- United States
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- Supplement Formulators, Inc.
Healthy Volunteers
Investigation of Benegut® on Immediate GI Discomfort Relief Caused by Acute Overfeeding in Healthy Subjects
To determine the relief of GI discomfort after overfeeding with a high caloric meal.
- Trial name
- NCT05603416
- Testing
- Perilla frutescens extract
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Vital Solutions GmbH
Bloating, Digestive Discomfort
A Clinical Trial to Examine the Effects of Gut Health Supplements to Improve Gut and Digestive Health and Function
This is a double-blind, randomized, placebo-controlled trial evaluating the efficacy of JSHealth's Debloat \& Detox supplement, used alone or in combination with their Probiotics supplement, on gut and digestive health and…
- Conditions
- Bloating, Digestive Discomfort, Irritable Bowel Syndrome (IBS), Flatulence
- Trial name
- NCT07902882
- Testing
- Intervention
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- JS Health & Vitamins
Moderate Gastrointestinal Discomfort
Investigating the Effectiveness of 2 Different Doses of BIOHM FX Probiotic Blend in Improving Digestive Symptoms
The rationale for this study is to observe the effect of two different doses of a consumer-grade probiotic product called FX Probiotic Blend on digestive symptoms in individuals with moderate gastrointestinal discomfort.
- Trial name
- NCT06782945
- Testing
- BIOHM FX Probiotic Blend
- Where
- United States
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Biohm Technologies
Irritable Bowel Syndrome
A Study To Investigate The Effect Of PD-217,014 On Abdominal Pain/Discomfort In Patients With IBS.
The purpose of this study is to determine the effectiveness of PD-217,014 in the treatment of abdominal pain/discomfort associated with irritable bowel disease.
- Trial name
- NCT00139672
- Testing
- PD-217,014
- Volunteers
- 330 people
- Sponsor
- Pfizer
Gastrointestinal Symptoms, Bloating
A Clinical Trial to Evaluate the Effects of Super Liver Liquid Drops on Gut Health, Digestive Comfort, and Daily Energy Levels
This is a decentralized (fully virtual), single-group, open-label, prospective clinical trial evaluating the effects of Super Liver Liquid Drops, a liquid botanical dietary supplement, on gut health, digestive comfort, energy…
- Conditions
- Gastrointestinal Symptoms, Bloating, Digestive Discomfort, Low Energy Levels
- Trial name
- NCT07742657
- Testing
- Super Liver
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- SuperBonsai Inc.
Constipation, Gastrointestinal Discomfort
Clinical Evaluation of the Effects of EpiCor on Digestive Comfort
Previous in vitro studies suggest that EpiCor is well fermented in the colon and has prebiotic potential. The repeated long-term administration of low doses of EpiCor in the Simulator of the Human Intestinal Microbial Ecosystem…
- Trial name
- NCT03051399
- Testing
- EpiCor
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- ProDigest
Constipation
Effects of Cultura Yoghurt in Relation to Transit Time and Digestive Discomfort in Healthy Women and Men
The aim of this study is to determine the effect of cultura yoghurt on transit time and digestive discomfort during 2 weeks of treatment in comparison to placebo in healthy women and men.
- Trial name
- NCT01102036
- Testing
- Cultura L casei F19, acidophilus La5 , B lactis Bb 12, Yoghurt without probiotics
- Where
- Sweden
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Good Food Practice, Sweden
Abdominal Pain
Study to Evaluate the Efficacy and Safety of Hyoscine Butylbromide Tablets for the Treatment of Occasional or Recurrent Episodes of Gastric or Intestinal Spasm-like Pain or Discomfort
In contrast with Hyoscine Butylbromide Capsule 10mg, Study is to evaluate the efficacy and safety of Hyoscine Butylbromide tablets 10 mg (20mg, 3 times daily, orally) over a period of 3 days for the treatment of occasional or…
- Trial name
- NCT02242305
- Testing
- Hyoscine Butylbromide - Tablet, Hyoscine Butylbromide - Capsule
- Volunteers
- 302 people
- Sponsor
- Boehringer Ingelheim
Gastrointestinal Disorders
To Assess the Effect of Collagen on Gastrointestinal Discomfort in Healthy Adults With Gastrointestinal Symptoms.
This study will enroll healthy adults with perceived gastrointestinal symptoms to evaluate the effect of collagen peptides compared to placebo.
- Trial name
- NCT06937801
- Testing
- Collagen Peptide
- Where
- Canada
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Rousselot BVBA
Gastrointestinal Discomfort, Bloating
Multi-strain Probiotic Supplement for Digestive Comfort and Well-being in Healthy Women
This study looks at whether a daily probiotic supplement can help improve mild-to-moderate stomach and digestive symptoms, such as gas and bloating, in women who also experience symptoms commonly associated with hormonal…
- Trial name
- NCT07831317
- Testing
- Active: Multi-strain probiotic dietary supplement
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Daily Nouri
Bad Breath, Tooth Sensitivity
A Clinical Trial to Evaluate the Effects of Larineco Remineralizing Gum on Oral Health, Breath Freshness, Tooth Sensitivity, and Gum Comfort
This is a single-group, open-label, decentralized (virtual) clinical trial evaluating the effects of Larineco Remineralizing Gum on self-reported oral health outcomes in 40 generally healthy adults aged 18-57 years who experience…
- Trial name
- NCT07692581
- Testing
- Larineco Remineralizing Gum
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Larine C Corporation
Irritable Bowel Syndrome
Pain Relief In Irritable Bowel Syndrome
The purpose of this study is to determine whether Proklama is effective in significative reduction of pain, other symptoms IBS's related, and improves quality of life concerning IBS disease.
- Trial name
- PRITON (NCT02573844)
- Testing
- Proklama
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Geophyt S.r.l.s.
Dyspepsia
The Safety and Efficacy of Dexloxiglumide for the Relief of Symptoms of Functional Dyspepsia.
"Functional dyspepsia" has been defined loosely as "pain or discomfort centered in the upper abdomen." The symptoms can also include fullness, early satiety, bloating, belching, nausea, retching and vomiting.
- Trial name
- NCT00303264
- Testing
- dexloxiglumide, Nexium (esomeprazole)
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Forest Laboratories