Clinical trials: Digestive Disease
Esophagus Cancer
Evaluation of Full-field Coherence Tomography for ex Vivo Staging and Assessment of Superficial Esophageal Squamous Carcinoma: a Pilot Study
New tools are needed to 1) diagnose and 2) stage early esophageal squamous cell carcinoma (SCC) in order to improve outcomes of this frequent and lethal cancer.
- Trial name
- OESOCiTy (NCT03467529)
- Testing
- Non interventional study
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Nantes University Hospital
Cancer Screening Tests
Helping Patients and Providers Make Better Decisions About Colorectal Cancer Screening
Precision prevention holds great promise for colorectal cancer (CRC) screening but has not been adequately explored. A patient's chance of having an advanced colorectal neoplasm (ACN), i.e.
- Trial name
- NCT04683731
- Testing
- Decision aid without personalized message, Decision aid with personalized message, Provider notification without personalized message
- Where
- 2 sites in United States
- Volunteers
- 1,111 people
- Sponsor
- Indiana University
Breast Neoplasm, Colorectal Neoplasm
Decision Aid Website in Helping to Make Decisions About Fertility in Participants With Cancer
This trial studies how well a decision aid website works in helping to make decisions about fertility in participants with cancer.
- Conditions
- Breast Neoplasm, Colorectal Neoplasm, Female Reproductive System Neoplasm, Health Care Provider
- Trial name
- NCT03141437
- Testing
- Best Practice, Educational Intervention, Internet-Based Intervention
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- M.D. Anderson Cancer Center
Hepatocellular Carcinoma
STA-9090 in Patients With Advanced Hepatocellular Cancer
STA-9090 works by inhibiting the function of a protein in tumor cells called Hsp90. Hsp90 is thought to play a role in tumor growth. By interfering with this protein's function, STA-9090 may help kill tumor cells.
- Trial name
- NCT01665937
- Testing
- STA-9090
- Where
- 3 sites in United States
- Volunteers
- 16 people
- Sponsor
- Massachusetts General Hospital
Colorectal Cancer
SCRT Followed by Camrelizumab Combined With Fluzoparib and Chemotherapy as Neoadjuvant Therapy for LARC
To explore the safety and efficacy of neoadjuvant therapy for locally advanced rectal cancer with short course radiotherapy followed by camrelizumab combined with fluzoparib and chemotherapy
- Trial name
- NCT06516445
- Testing
- SCRT, Camrelizumab, Fluzoparib
- Where
- China
- Volunteers
- 33 people
- Sponsor
- Huazhong University of Science and Technology
Hepatitis, Autoimmune
CHLOROQUINE FOR MAINTENANCE REMISSION OF AUTOIMMUNE HEPATITIS
Autoimmune hepatitis is an autoimmune chronic liver disease whose treatment includes the use of immunosuppressive drugs, particularly azathioprine, and corticosteroids. When properly treated, patients have a good survival.
- Trial name
- NCT01980745
- Testing
- Chloroquine diphosphate 250mg
- Where
- Brazil
- Volunteers
- 61 people
- Sponsor
- University of Sao Paulo General Hospital
Hepatocellular Carcinoma
ZG005 Plus Bevacizumab vs Sintilimab Plus Bevacizumab as First-Line Therapy for Advanced Hepatocellular
The purpose of the study is to evaluate the efficacy of ZG005 combined with bevacizumab compared with sintilimab combined with bevacizumab in the first-line treatment of participants with advanced HCC
- Trial name
- NCT07813572
- Testing
- ZG005 for Injection, Bevacizumab ( Avastin), Sintilimab
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Suzhou Zelgen Biopharmaceuticals Co.,Ltd
Hepatitis C, Hepatocellular Carcinoma
Long-term Follow-up of HALT-C Sustained Virological Responders
The Hepatitis C Antiviral Long-term Treatment against Cirrhosis (HALT-C) trial is a multicenter clinical trial conducted to assess the effects of long-term antiviral drug therapy on the progression of liver disease in patients…
- Conditions
- Hepatitis C, Hepatocellular Carcinoma, Ascites, Variceal Hemorrhage
- Trial name
- NCT00825877
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Gastroesophageal Reflux Disease, Hiatal Hernia
Foreshortened Esophagus and Its Surgical Therapy
Background The existence, diagnosis and treatment of short esophagus is one of the controversies of the past which has recently re-emerged The missed diagnosis of short esophagus and the consequent inadequacy of treatment is one…
- Trial name
- GERDSurgery (NCT00507377)
- Where
- 8 sites in Italy
- Volunteers
- 180 people
- Sponsor
- University of Bologna
Barrett Esophagus
Endoscopic Biopsy Techniques in Barrett's Esophagus Patients
Barrett's esophagus (BE) is a premalignant condition of the distal esophagus, predisposing to dysplasia and esophageal adenocarcinoma.
- Trial name
- BITE (NCT05578677)
- Testing
- Biopsy technique
- Where
- 2 sites in Netherlands
- Volunteers
- 120 people
- Sponsor
- St. Antonius Hospital
Colorectal Cancer
Association of Colorectal Cancer With Nutrition, Diet, Obesity, Diabetes Mellitus, and Genetic Alterations in Taiwan
We will explore the genetic (including APC, k-ras, p53, MSI, etc.) and environmental (including family history, life style, diet, nutritional status, DM, serum IGF-I, IGFBP-3, etc.) risk factors of colorectal tumorigenesis.
- Trial name
- NCT00172757
- Where
- Taiwan
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Peri-Implantitis
Peri-implantitis in HIV-positive Patients With Different Dental Prosthesis
Dental implants are widely used in human immunodeficiency virus (HIV)-positive patients, but the interaction between immune status and success of implant therapy, especially in such patients, is not clear.
- Trial name
- PERIHIV (NCT04983212)
- Testing
- periodontal control
- Where
- Italy
- Volunteers
- 85 people
- Sponsor
- Università Vita-Salute San Raffaele
Adenocarcinoma of the Pancreas, Recurrent Pancreatic Cancer
Dasatinib in Treating Patients With Metastatic Pancreatic Cancer
Dasatinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. This phase II trial is studying how well dasatinib works in treating patients with metastatic pancreatic cancer.
- Conditions
- Adenocarcinoma of the Pancreas, Recurrent Pancreatic Cancer, Stage IV Pancreatic Cancer
- Trial name
- NCT00474812
- Testing
- dasatinib, laboratory biomarker analysis, physiologic testing
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- National Cancer Institute (NCI)
Short Bowel Syndrome
Measurement of Body Composition by Air Displacement Plethysmography in Pediatric Intestinal Failure Patients
This study will determine if air-displacement plethysmography (ADP) provides accurate measurement of body composition (percent body fat and fat-free mass) in pediatric patients with intestinal failure, as compared to body…
- Trial name
- NCT02561819
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Christopher Duggan
Gastric Cancer, Gastroesophageal Junction Adenocarcinoma
A Study to Evaluate Safety, Tolerability, and Efficacy Profile of Rivoceranib With Paclitaxel in Advanced Gastric or Gastroesophageal Junction Cancer
This is an open-label, single-center, single-arm, dose escalation and dose expansion Phase I/IIa study designed to determine the recommended Phase 2 dose (RP2D) and the safety and tolerability profile along with preliminary signs…
- Trial name
- NCT03707028
- Testing
- Rivoceranib, Paclitaxel
- Where
- South Korea
- Volunteers
- 12 people
- Sponsor
- Elevar Therapeutics
Colorectal Cancer, Colorectal Carcinoma
The Problem of Colorectal Anastomosis Safety
This is a prospective cohort pilot study. The investigators are planning to develop an original, standardized colorectal anastomosis inspection method, which will systemically inspect the anastomosis vascularity using the…
- Conditions
- Colorectal Cancer, Colorectal Carcinoma, Colorectal Neoplasms, Colorectal Adenocarcinoma
- Trial name
- ANSCRS (NCT03958500)
- Testing
- Indocyanine green fluorescent angiography intraluminally and intraperitoneally
- Where
- 2 sites in Lithuania
- Volunteers
- 60 people
- Sponsor
- Vilnius University
Eating Disorder NOS
ASSESSMENT OF ORAL HEALTH AND ORAL HEALTH-RELATED QUALITY OF LIFE IN PATIENTS AGED 12-18 YEARS WITH EATING DISORDERS
Although numerous instruments are available to assess oral health-related quality of life (OHRQoL) in adults, there is a paucity of studies evaluating the impact of oral health on quality of life in children and adolescents.
- Trial name
- NCT07896707
- Testing
- general oral health interventions and scales
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Postoperative Pain, Postoperative Nausea and Vomiting (PONV)
Transauricular Vagus Nerve Stimulation Frequencies for Postoperative Pain
The goal of this clinical trial is to learn whether different frequencies of transauricular vagus nerve stimulation (tVNS) can reduce postoperative pain and opioid consumption in adults undergoing abdominal or urologic surgery.
- Conditions
- Postoperative Pain, Postoperative Nausea and Vomiting (PONV), Opioid Consumption, Postoperative
- Trial name
- TVNS-PAIN (NCT07633444)
- Testing
- Transauricular Vagus Nerve Stimulation (tVNS)
- Where
- Brazil
- Volunteers
- 174 people
- Sponsor
- Federal University of Bahia
Hepatitis B, Chronic, Acute-On-Chronic Liver Failure
Combination of DPMAS and Low Volume PE for Patients With HBV Related ACLF
This study is to investigate investigate the safety and efficacy of Double plasma molecular adsorption system with sequential low-dose plasma exchange in treating hepatitis B virus-related acute-on-chronic liver failure.
- Trial name
- NCT04597164
- Testing
- Artificial liver support system
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Oral Mucositis (Ulcerative)
Randomized Trial of Curcumin to Reduce Mucositis in Autologous Transplant Setting
Mucositis is a very common complication in bone marrow transplant setting. It is a result of injury to the gut caused by high dose chemotherapy.
- Trial name
- NCT04896164
- Testing
- Curcumin Lozenges
- Where
- India
- Volunteers
- 190 people
- Sponsor
- Tata Memorial Centre
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