Clinical trials: Digestive Disease
GastroIntestinal Bleeding
Validation of CAGIB Score for In-hospital Mortality of Cirrhotic Patients With Acute Gastrointestinal Bleeding
Acute gastrointestinal bleeding is potentially lethal in liver cirrhosis. Accurate assessment of prognosis is critical in a timely fashion.
- Trial name
- NCT04662918
- Where
- 23 sites in United States, Brazil and 6 more
- Volunteers
- 3,000 people
- Sponsor
- Xingshun Qi
Biliary Atresia, Kasai Portoenterostomy Status
Clinical Study About the Role of COX-2 Inhibitor in Liver Cirrhosis With Biliary Atresia
In this clinical study, meloxicam will be used to the patients who are older than 2 years and underwent Kasai portoenterostomy to treat their biliary atresia before.
- Trial name
- NCT02298218
- Testing
- Meloxicam
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Cancer, Breast, Cancer, Lung
A Study of Bi-Ligand-Drug Conjugate CBP-1019 in Patients With Advanced Solid Tumors
The primary objective of this phase I study is to evaluate the safety and potential efficacy and to determine the recommended phase 2 dose (RP2D) of CBP-1019, a bi-specific ligand conjugated drugs in patients with advanced solid…
- Conditions
- Cancer, Breast, Cancer, Lung, Cancer of Pancreas, Cancer of Esophagus
- Trial name
- NCT05830097
- Testing
- CBP-1019
- Where
- 5 sites in United States, China
- Volunteers
- 260 people
- Sponsor
- Coherent Biopharma (Hefei) Co., Ltd.
Metastatic Colorectal Cancer, Drug Therapy
Efficacy and Safety of Trifluridine/Tipiracil Combined With Fufuquitinib for Third-line Treatment of mCRC
To evaluate the efficacy and safety of trifluridine/tipiracil combined with fufuquitinib versus trifluridine/tipiracil and fufuquitinib in patients with unresectable metastatic colorectal cancer.
- Trial name
- NCT06485713
- Testing
- trifluridine/tipiracil combined with fufuquitinib, fufuquitinib, Trifluridine/tipiracil
- Where
- China
- Volunteers
- 200 people
- Sponsor
- First Affiliated Hospital of Wenzhou Medical University
Colorectal Cancer Screening, Fecal Immunochemical Test
Head to Head Trial of Mailed Cologuard to Mailed FIT
The objective of this study is to measure the comparative effectiveness of mailed outreach of two stool based tests, multi-target stool DNA (Cologuard) and the fecal immunochemical test (FIT) in screening eligible adults ages…
- Conditions
- Colorectal Cancer Screening, Fecal Immunochemical Test, Multi-target Stool DNA, Colorectal Cancer (CRC)
- Trial name
- NCT06931860
- Testing
- Cologuard, Fecal Immunochemical Test
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- University of California, San Diego
Primary Esophageal Carcinoma
Angiogenic Factor Expression During Fractionated Irradiation
The main question of this study is if and when VEGF (vascular endothelial growth factor) expression in the tumor is upregulated during chemoradiation and if bevacizumab inhibits subsequent vessel growth in the tumor.
- Trial name
- NCT02072720
- Testing
- Bevacizumab
- Where
- 3 sites in Netherlands
- Volunteers
- 40 people
- Sponsor
- Amsterdam UMC, location VUmc
Diabetes Mellitus, Type 2, Metabolic Associated Fatty Liver Disease
Correlation Between Serum Nociceptin and Sympathetic Nerve Activity in Diabetic Patients With MAFLD
This observational study aims to investigate the relationship between serum nociceptin levels and sympathetic nervous system activity in patients with both type 2 diabetes mellitus (T2DM) and metabolic associated fatty liver…
- Trial name
- NCT07663682
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Second Hospital of Shanxi Medical University
Hepatitis C
Testing and Treating Hepatitis C in Community Pharmacies
Hepatitis C Virus, (HCV), infection is a major health concern in the UK with up to 0.7% of the population infected. At best, 25% of those infected will clear the infection spontaneously, though for those who develop a chronic…
- Trial name
- SuperDOT-C (NCT02706223)
- Testing
- Pharmacist Led, Nurse led
- Where
- 3 sites in United Kingdom
- Volunteers
- 356 people
- Sponsor
- University of Dundee
Ulcerative Colitis
A Study to Learn About the Safety, Effects and Pharmacokinetics of Study Medication (PF-07054894) for the Treatment of Ulcerative Colitis
This is a study to learn if the experimental medicine (called PF-07054894) is safe, effective, and how it is processed in adult people with ulcers in the colon.
- Trial name
- NCT05549323
- Testing
- PF-07054894
- Where
- 17 sites in United States, Germany and 1 more
- Volunteers
- 44 people
- Sponsor
- Pfizer
Head and Neck Cancer, Mucositis
Magic Mouthwash Plus Sucralfate Versus Benzydamine Hydrochloride for the Treatment of Radiation-induced Mucositis
Radiation treatment is very effective for treating cancers of the head and neck, however, during the course of treatment, it is common for patients to experience soreness of their mouth and throat due to the radiation.
- Trial name
- NCT00814359
- Testing
- Combination of Magic Mouthwash Plus Sucralfate, 0.15% Benzydamine HCl
- Where
- Canada
- Volunteers
- 67 people
- Sponsor
- Juravinski Cancer Centre Foundation
Ulcerative Colitis
Vedolizumab Monotherapy Vs Combination Therapy With Tacrolimus in UC
The aim of this study is to assess if a combination therapy of tacrolimus and vedolizumab is superior to vedolizumab monotherapy for induction of remission in moderate to severe UC, and its effect on long and short-term outcomes…
- Trial name
- COVET (NCT02954159)
- Testing
- Tacrolimus, Vedolizumab
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Medical College of Wisconsin
Rumination Disorder
A Pilot Study of Cognitive-Behavioral Therapy for Rumination Disorder (CBT-RD)
The primary aim of this study is to pilot cognitive behavioral therapy (CBT-RD) for 10 individuals ages 10 and older who have rumination disorder
- Trial name
- NCT03062696
- Testing
- CBT-RD
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Massachusetts General Hospital
Acute Respiratory Tract Infections, Diarrhea
Home Based Child Care to Reduce Mortality and Malnutrition in Tribal Children of Melghat, India: CRCT
Melghat is poorly developed tribal area in India with very high child mortality \& malnutrition prevalence (grossly inadequate medical facilities). Important health problems.
- Conditions
- Acute Respiratory Tract Infections, Diarrhea, Malaria, Neonatal Sepsis
- Trial name
- HBCC (NCT02473796)
- Testing
- Home based child care
- Where
- India
- Volunteers
- 7,594 people
- Sponsor
- MAHAN Trust
Gastroparesis
Limited Access Protocol for the Use of Oral Cisapride
Due to the lack of other drugs to treat gastroparesis Janssen and FDA approved the compassionate use of cisapride to treat patients who had no other effective therapy.
- Trial name
- NCT02524496
- Volunteers
- 3 people
- Sponsor
- Yale University
Crohn's Disease
Impact of Exclusive Enteral Nutrition Therapy on Sperm Quality of Patients With Crohn's Disease
The purpose of this study is to investigate the impact of enteral nutrition therapy on sperm quality of patients with crohn's disease.
- Trial name
- NCT02233062
- Testing
- Exclusive Enteral Nutrition Therapy
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Jinling Hospital, China
Acute Appendicitis, Appendicitis (Diagnosis)
Laparoscopic vs Open Appendectomy in Obese Patients
Acute appendicitis is one of the most common surgical emergencies globally. While surgical removal of the appendix (appendectomy) is the definitive treatment, the optimal surgical approach-laparoscopic versus open-remains widely…
- Conditions
- Acute Appendicitis, Appendicitis (Diagnosis), Obesity
- Trial name
- NCT07822503
- Testing
- Open Appendectomy, Laparoscopic Appendectomy
- Volunteers
- 166 people
- Sponsor
- University of Health Sciences Lahore
Growth, Tolerance
Human Milk Oligosaccharides (HMOs) Post-market Study on Infants (NEHMO)
Human milk oligosaccharides (HMOs) represent the third largest solid component of breast milk. Technology advancements made it possible to supplement infant formulas with HMOs (2'FL, LNnT).
- Conditions
- Growth, Tolerance, Adverse Event, Disorder of Intestine
- Trial name
- NeHMO DACH (NCT05150288)
- Testing
- HMO-supplemented infant formula
- Where
- 17 sites in Austria, Germany and 1 more
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Inflammatory Bowel Disease, Crohn's Disease
ENhanced Recovery in CHildren Undergoing Surgery
The institution of perioperative Enhanced Recovery Protocols (ERPs) has been found to decrease hospital length of stay, in-hospital costs, and complications among adult surgical populations but data in pediatric populations are…
- Conditions
- Inflammatory Bowel Disease, Crohn's Disease, Ulcerative Colitis
- Trial name
- ENRICH-US (NCT04060303)
- Testing
- Perioperative surgical care
- Where
- United States
- Volunteers
- 597 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Opioid-induced Constipation
A Study of Naldemedine (S-297995) for the Treatment of Opioid-Induced Constipation in Adults With Non-Malignant Chronic Pain Receiving Opioid Therapy
The purpose of this study is to determine efficacy and safety of naldemedine for the treatment of opioid-induced constipation in adults with non-malignant chronic pain receiving opioid therapy for ≥ 3 months.
- Trial name
- NCT01443403
- Testing
- Naldemedine
- Where
- 49 sites in United States
- Volunteers
- 244 people
- Sponsor
- Shionogi
Colon Cancer, Adenoma
Chemoprevention With Folic Acid
Colorectal neoplasia is the second most common cancer in the United States and other Western countries with about 140,000 newly diagnosed cases per year in the United States with a mortality rate of about 40%.
- Conditions
- Colon Cancer, Adenoma, Colonic Polyps
- Trial name
- NCT00018551
- Testing
- Folic Acid
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
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