Clinical trials: Digestive Disease
Intestinal Malabsorption
Efficacy and Safety of ELGN-2112 on Intestinal Malabsorption in Preterm Infants
The study will evaluate the effect of ELGN-2112 on intestinal malabsorption in preterm infants.
- Trial name
- NCT05670951
- Testing
- ELGN-2112
- Where
- Israel
- Volunteers
- 360 people
- Sponsor
- Elgan Pharma Ltd.
COVID, Pneumonia
Bacteriotherapy in the Treatment of COVID-19
In light of its high morbidity and mortality, COronaVIrus Disease 19 (COVID-19) pandemic spread is considered an unprecedented global health challenge.
- Conditions
- COVID, Pneumonia, Diarrhea
- Trial name
- BACT-ovid (NCT04368351)
- Testing
- SivoMixx (200 billion), Azithromycin, hydroxychloroquine
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- University of Roma La Sapienza
Polycystic Ovarian Syndrome, Obesity
Post-Prandial Liver Glucose Metabolism in PCOS
The Investigators will measure if hepatic metabolism is upregulated in obese girls with PCOS and hepatic steatosis (HS), compared to PCOS without HS and obese controls without HS.
- Conditions
- Polycystic Ovarian Syndrome, Obesity, Hepatic Steatosis
- Trial name
- PLUM (NCT03041129)
- Testing
- oral glucose tolerance test, MRI of liver
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Appendicitis, Chronic Post-Procedural Pain
Pain and Discomfort After Appendectomy in Children
Appendectomy is the most common surgical procedure. Chronic abdominal pain is an uncommon complication following appendectomy. It is observed that pediatric patients who have undergone abdominal surgical procedure complained of…
- Trial name
- NCT03791229
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Sakarya University
Steatotic Liver Disease, Metabolic Dysfunction-Associated Steatotic Liver Disease
Risk Factors and Prediction Model for Liver-Related Outcomes in Elderly Patients With Steatotic Liver Disease
This is a single-center, retrospective cohort study based on data from the Nanjing Elderly Steatotic Liver Disease Cohort. The study aims to investigate risk factors for liver-related adverse outcomes (including significant…
- Trial name
- NCT07537829
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Crohn Disease, Drug Monitoring
TDM Guided Early Optimization of ADAL in Crohn's Disease
To investigate the influence of early therapeutic drug monitoring and dose optimization on disease outcome in Crohn's patients treated with Adalimumab.
- Conditions
- Crohn Disease, Drug Monitoring, Inflammatory Bowel Diseases
- Trial name
- NCT03261102
- Testing
- Adalimumab
- Where
- 6 sites in Canada
- Volunteers
- 200 people
- Sponsor
- waqqas.afif
Hepatitis C
A Study to Assess the Anti-viral Activity, Safety, Tolerability and Pharmacokinetics of TMC435350 in Participants Infected With Hepatitis C-Virus (HCV)
The purpose of this study is to assess anti-viral activity (inhibition of viral growth) of TMC435350 in genotype 2,3,4,5 and 6 hepatitis C virus infected participants who have never received treatment for their hepatitis C…
- Trial name
- NCT00812331
- Testing
- TMC435
- Where
- 10 sites in Belgium, Germany and 1 more
- Volunteers
- 37 people
- Sponsor
- Tibotec Pharmaceuticals, Ireland
Intestinal Diseases, Helminthiasis
Efficacy of Albendazole to Treat Intestinal Helminths and Its Effect on Gut Microflora
Albendazole is a main anti-helminth, however there is a lack of data regarding its efficacy in the school children population. The aim of this study is to evaluate the efficacy of the albendazole one versus two and three doses…
- Trial name
- NCT01192802
- Testing
- albendazole
- Where
- Gabon
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Albert Schweitzer Hospital
Breast Carcinoma, Head and Neck Cancer
Fluorescence for Sentinel Lymph Node Identification in Cancer Surgery
This is a single-center prospective clinical trial to evaluate non-inferiority of indocyanine green guided sentinel lymph node biopsy compared with the gold standard Technecium99 guided sentinel lymph node biopsy in patients with…
- Conditions
- Breast Carcinoma, Head and Neck Cancer, Melanoma (Skin), Squamous Cell Carcinoma, Skin
- Trial name
- GASVERT (NCT02997553)
- Testing
- Indocyanine green, Technetium99, Optonuclear probe
- Where
- France
- Volunteers
- 744 people
- Sponsor
- Institut de Cancérologie de Lorraine
Cystic Fibrosis
ENHANCE- Establishing Natural History in an Advanced New CF Care Era
Measured outcomes for people with CF have improved dramatically over the last 20 years, even prior to the widespread introduction of cystic fibrosis transmembrane conductance regulator (CTFR) modulator treatments.
- Trial name
- NCT05986045
- Testing
- Quality of Life
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Royal College of Surgeons, Ireland
Primary Biliary Cirrhosis
Mesenchymal Stem Cell Transplantation for Refractory Primary Biliary Cholangitis
Ursodeoxycholic acid is the mainstay treatment medicine for primary biliary cholangitis(PBC). About 1/3 of the patients do not respond to UDCA, which is defined as refractory PBC.
- Trial name
- NCT03668145
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Cystic Fibrosis, Pseudomonas Aeruginosa
Nasal Inhalation of Tobramycin in Patients With Cystic Fibrosis and Pseudomonas Aeruginosa Colonization
The purpose of this study is to determine whether the nasal inhalation of Gernebcin® is effective to decrease the Pseudomonas aeruginosa bacterial count in the nasal lavage fluid.
- Trial name
- NCT00774072
- Testing
- Tobramycin (Gernebcin®)
- Where
- 2 sites in Germany
- Volunteers
- 9 people
- Sponsor
- University of Jena
Liver Transplant With Clinically Significant Portal Hypertension
Evaluation of Efficacy and Safety of Somatostatin Used as Inflow Modulator in Liver Transplantation.
This study is a 5 day, single-center, randomized, double blind, placebo-controlled study to evaluate the efficacy and safety of Somatostatin used as inflow modulator in liver transplantation.
- Trial name
- NCT01290172
- Testing
- Administration of Somatostatin
- Where
- Belgium
- Volunteers
- 33 people
- Sponsor
- University Hospital, Ghent
Cirrhosis, Cirrhosis Due to Hepatitis B
Abbreviated Magnetic Resonance Imaging vs Ultrasound Surveillance for Liver Cancer dETection in People at High Risk of Developing Liver Cancer
Aim: To use magnetic resonance imaging (MRI) scans without contrast to help improve diagnosis of liver cancer in people who are at increased risk of developing liver cancer.
- Conditions
- Cirrhosis, Cirrhosis Due to Hepatitis B, Cirrhosis and Chronic Liver Disease, Cirrhosis Due to Hepatitis C
- Trial name
- AMULET (NCT06658782)
- Testing
- non contrast enhanced MRI
- Where
- 2 sites in United Kingdom
- Volunteers
- 300 people
- Sponsor
- University of Oxford
HCC, Liver Cancer
A Study to Assess the Effect of Y-90 Therapy on Non-target/Background Liver
The primary question of interest is quantifying the relationship between Y-90 liver therapy and liver damage. Little is known on this subject.
- Trial name
- NCT02966223
- Testing
- MRI and HIDA scan
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Indiana University
Hepatocellular Carcinoma
Yttrium-90 Radioembolization With Glass Microspheres (TheraSphere) for Patients With Hepatocellular Carcinoma
This is a prospective pilot study that will document the clinical experience of 30 patients with unresectable hepatocellular carcinoma undergoing liver-directed therapy with Yttrium-90 glass microspheres (TheraSphere®).
- Trial name
- NCT01290523
- Testing
- Selective internal radiation therapy of the liver with Yttrium-90 glass microspheres (TheraSphere)
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of California, San Francisco
Hepatitis B
Safety and Immunogenicity Following Recombinant Hepatitis B (Bio Farma) Vaccine in Adults & Children
This trial is an experimental, randomized, double blind, prospective intervention study Approximately 100 subjects will be enrolled in this trial, divided into 2 arms, as follow: For adult (18-40 years old)
- Trial name
- NCT04188223
- Testing
- Recombinant Hepatitis B (Bio Farma) Vaccine, Recombinant Hepatitis B (Bio Farma) Vaccine®
- Where
- Indonesia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- PT Bio Farma
Carcinoma, Hepatocellular, Alcoholic Cirrhosis
Indocyanine Green and Portal Pressure in Viral and Alcoholic Cirrhotic Patients With Hepatocarcinoma
The aim of the investigators' study is to elucidate the relationship between a functional liver test (e.g., ICG) and the PREOPERATIVE value of portal hypertension in the patients with impaired liver function from alcoholic and…
- Conditions
- Carcinoma, Hepatocellular, Alcoholic Cirrhosis, Viral Cirrhosis, Postoperative Hepatic Failure
- Trial name
- NCT00827723
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- University of Lausanne Hospitals
Rumination Disorder
A Pilot Study of Cognitive-Behavioral Therapy for Rumination Disorder (CBT-RD)
The primary aim of this study is to pilot cognitive behavioral therapy (CBT-RD) for 10 individuals ages 10 and older who have rumination disorder
- Trial name
- NCT03062696
- Testing
- CBT-RD
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Massachusetts General Hospital
Melanoma, Breast Carcinoma
A Study of XmAb®20717 in Subjects With Selected Advanced Solid Tumors
This is a Phase 1, multiple dose, ascending dose escalation study to define a MTD/RD and regimen of XmAb20717, to describe safety and tolerability, to assess PK and immunogenicity, and to preliminarily assess anti-tumor activity…
- Conditions
- Melanoma, Breast Carcinoma, Hepatocellular Carcinoma, Urothelial Carcinoma
- Trial name
- DUET-2 (NCT03517488)
- Testing
- XmAb20717
- Where
- 17 sites in United States
- Volunteers
- 150 people
- Sponsor
- Xencor, Inc.
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