Clinical trials: Digestive Diseases
Digestive System Disease
Improvement of Lower Digestive Endoscopy Without Anesthesia : Evaluation of the Virtual Reality Mask
90% of colonoscopies are performed with general anesthesia (GA). GA carries risks and requires a prior anesthesia consultation, a dedicated team and technical platform on the day of the examination.
- Trial name
- REVENDO (NCT06414239)
- Testing
- Use of a VR mask, Standard of care
- Volunteers
- 240 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Ovarian Neoplasms, Ovarian Diseases
89Zr-MMOT PET Imaging in Pancreatic and Ovarian Cancer Patients
The purpose of this multicenter imaging sub study is to evaluate the biodistribution and organ pharmacokinetics of 89Zr-MMOT0530A in patients with unresectable pancreatic or platinum-resistant ovarian cancer.
- Conditions
- Ovarian Neoplasms, Ovarian Diseases, Adnexal Diseases, Pancreatic Neoplasms
- Trial name
- MMOT (NCT01832116)
- Testing
- 89Zr-MMOT0530A
- Where
- 2 sites in Netherlands
- Volunteers
- 11 people
- Sponsor
- University Medical Center Groningen
Gastro-Intestinal Disorder
A Study to Compare and Evaluate the Safety, Pharmacokinetics and Pharmacodynamics of UI059 and UIC202201
A randomized, open-label, multiple-dose crossover phase 1 clinical trial to compare and evaluate the safety, pharmacokinetics and pharmacodynamics characteristics after oral administration of UI059 and UIC202201 in healthy adult…
- Trial name
- NCT06393881
- Testing
- UI059, UIC202201
- Where
- South Korea
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Korea United Pharm. Inc.
Pancreatic Neoplasm, Digestive System Neoplasm
OSPREY is a Post-market, Global, Multicentre, Observational, Prospective Registry.
The OSPREY Patient Registry has been developed to collect and assess the performance and safety of the OncoSil™ device when used within the approved indication of unresectable, locally advanced pancreatic cancer, in combination…
- Conditions
- Pancreatic Neoplasm, Digestive System Neoplasm, Neoplasms by Site, Neoplasms
- Trial name
- OSPREY (NCT04493632)
- Where
- 9 sites in Spain, United Kingdom
- Volunteers
- 500 people
- Sponsor
- OncoSil Medical Limited
Colorectal Cancer
Phase I/II Study of KRN330 Plus Irinotecan in Patients With Metastatic Colorectal Cancer
The primary objective of the Phase II portion of this study is to assess the efficacy of KRN330 in combination with irinotecan after first-line or adjuvant FOLFOX (5-fluorouracil, leucovorin, and oxaliplatin)/CapOx (capecitabine…
- Trial name
- NCT00838578
- Testing
- KRN330, Irinotecan
- Where
- 12 sites in United States
- Volunteers
- 65 people
- Sponsor
- Kyowa Kirin Co., Ltd.
Ulcerative Colitis, Digestive System Diseases
Study of a Monoclonal Antibody KHK4083 in Moderate Ulcerative Colitis
The purpose of this study is to determine the safety and tolerability of administration of multiple ascending doses of KHK4083 and to select the highest dose tolerated by subjects with moderately active Ulcerative Colitis (UC)…
- Conditions
- Ulcerative Colitis, Digestive System Diseases, Colitis, Ulcerative, Colitis
- Trial name
- NCT02647866
- Testing
- KHK4083
- Where
- 23 sites in United States, Czechia and 5 more
- Volunteers
- 66 people
- Sponsor
- Kyowa Kirin, Inc.
Hepatic Disease, Surgery-Complications
Prolonged Hypercoagulability Following Major Liver Resection for Malignancy
This clinical trial will investigate the ability of thromboelastrogrpahy (TEG®) to detect hypercoagulability after liver surgery and will examine the effect of extended thromboprophylaxis (medical treatment to prevent the…
- Conditions
- Hepatic Disease, Surgery-Complications, Hypercoagulability, Thrombosis
- Trial name
- PRIORITY (NCT06153394)
- Testing
- Redesca (enoxaparin sodium for injection), Fragmin (dalteparin)
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Western University, Canada
Esophageal Neoplasms, Head and Neck Neoplasms
Evaluate the Efficacy of Adding Intraluminal Brachytherapy After CCRT for Local-regional Thoracic Esophageal Cancer.
The purpose of this study is to observe the safety and effectiveness of the add-on of intraluminal brachytherapy with BRAXX esophageal brachytherapy applicator after definitive CCRT in patients with thoracic esophageal cancer.
- Conditions
- Esophageal Neoplasms, Head and Neck Neoplasms, Gastrointestinal Neoplasms, Digestive System Diseases
- Trial name
- NCT06365866
- Testing
- "BRAXX" Esophageal Brachytherapy Applicator., Add-on of intraluminal brachytherapy
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Gastro-Intestinal Disorder
Protein and Exercise-Induced Gastrointestinal Symptoms
Recommendations for carbohydrate intakes in the pre-exercise meal for endurance athletes are available; however, are lacking protein.
- Trial name
- NCT05855174
- Testing
- Whey protein
- Where
- Canada
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Mount Royal University
Digestive System Disease, Polyp of Colon
Deep Learning in Classifying Bowel Obstruction Radiographs
Background: Accurate labeling of obstruction site on upright abdominal radiograph is a challenging task. The lack of ground truth leads to poor performance on supervised learning models.
- Conditions
- Digestive System Disease, Polyp of Colon, Bowel Disease
- Trial name
- NCT06321614
- Where
- China
- Volunteers
- 4,500 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Colon Cancer
ASPIRIN Trial Belgium
The purpose of this study is to determine whether acetylsalicylic acid is effective on the recurrence and survival of colon cancer patients.
- Trial name
- ASPIRIN (NCT03464305)
- Testing
- acetylsalicylic acid
- Where
- 29 sites in Belgium
- Volunteers
- 148 people
- Sponsor
- University Hospital, Antwerp
Hepatopathy
Efficacy and Safety of Herombopag in Patients With Thrombocytopenia Before Hepatectomy
This is a single center, randomized, controlled study, to evaluate the efficacy and safety of Herombopag in patients with Thrombocytopenia before hepatectomy.
- Trial name
- NCT05442632
- Testing
- Hetrombopag
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Fudan University
Cystic Fibrosis
Saline Hypertonic in Preschoolers + CT
The purpose of this study is to assess whether inhalation of 7% hypertonic saline (HS) twice daily for 48 weeks reduces structural lung disease as assessed by computed tomography (CT) in comparison with inhalation of 0.9%…
- Trial name
- SHIP-CT (NCT02950883)
- Testing
- Active Treatment Group 7% Hypertonic Saline, Control Group 0.9% Isotonic Saline
- Where
- 25 sites in United States, Australia and 7 more
- Volunteers
- 116 people
- Sponsor
- University of Washington, the Collaborative Health Studies Coordinating Center
Digestive System Disease
A Clinical Study to Assess the Effect of a Supplement on Digestive Health, Overall Well-being, and Participant Experience.
The study aims to evaluate the effectiveness of a dietary supplement (greens powder), on improving digestive health, quality of life, energy levels, and satiety over a 14-day period.
- Trial name
- NCT06283732
- Testing
- Greens powder
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Amway Corp
Respiration Disorders, Respiratory Disease
The Gut-Lung Axis and Respiratory Illness in Children
The goal of this single-centre observational study conducted at the Royal Hospital for Children in Glasgow, Scotland, is to employ a multi-omics approach to investigate the "gut-lung axis" in health and disease.
- Conditions
- Respiration Disorders, Respiratory Disease, Asthma in Children, Wheezing
- Trial name
- NCT06271213
- Testing
- observational only - no interventions as part of study
- Where
- United Kingdom
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- NHS Greater Glasgow and Clyde
Wasting, Undernutrition
Improvement of Nutrition Status, Digestive Conditions, and Upper Respiratory Infections by Using Oral Nutritional Supplementation on Children in Vietnam
Evaluating the efficiency of using the nutrient production toward nutrition status (anthropometric index, the prevalence of wasting), digestive disorders, anorexia, and upper respiratory infections in children aged 24 - 71 months.
- Conditions
- Wasting, Undernutrition, Malnourished, Malnutrition
- Trial name
- NCT05570045
- Testing
- Colos Gain
- Where
- Vietnam
- Volunteers
- 600 people
- Sponsor
- Tu Nguyen Song
Stomach Neoplasm, Gastrointestinal Neoplasms
Evaluation of Ocoxin®-Viusid® in Advanced Stomach Cancer and Gastric Esophagogastric Junction
Our main objective is to evaluate the effect of Ocoxin-Viusid on the quality of life of patients with advanced stomach cancer and esophagogastric junction.
- Conditions
- Stomach Neoplasm, Gastrointestinal Neoplasms, Digestive System Neoplasm, Esophageal Neoplasms
- Trial name
- NCT03549494
- Testing
- Ocoxin-Viusid®
- Where
- Cuba
- Volunteers
- 45 people
- Sponsor
- Catalysis SL
Colorectal Neoplasm, Intestinal Neoplasms
Evaluation of Ocoxin®-Viusid® in Metastatic Colorectal Adenocarcinoma
The research product, registered as a nutritional supplement (Ocoxin®, oral solution), manufactured by Laboratorios Catalysis S. L., comes in the form of single-dose vials of 30 ml.
- Conditions
- Colorectal Neoplasm, Intestinal Neoplasms, Gastrointestinal Neoplasms, Digestive System Neoplasm
- Trial name
- NCT03559543
- Testing
- Ocoxin-Viusid
- Where
- Cuba
- Volunteers
- 40 people
- Sponsor
- Catalysis SL
Gastrointestinal Disease
Application of Multimodal Endoscopic Functional Imaging Technology in the Diagnosis of Common Gastrointestinal Diseases
We plan the study to explore the application of endoscopic laser speckle imaging and multispectral blood oxygen imaging to observe gastrointestinal lesions, as well as the differences in the morphology, density and functional…
- Trial name
- Endo-mmfi (NCT06236594)
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Beijing 302 Hospital
Infectious Disease, Neoplasms
AnovaOS Network Powered Patient Registry
The objective of this study is the development, implementation and management of a registry of patient data that captures clinically meaningful, real-world, data on the diagnosis, nature, course of infection, treatment(s) and…
- Conditions
- Infectious Disease, Neoplasms, Diseases of the Blood and Blood-Forming Organs and Certain Disorders Involving the Immune Mechanism (D50-D89), Endocrine, Nutritional and Metabolic Diseases (E00-E89)
- Trial name
- NCT05013944
- Where
- United States
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Anova Enterprises, Inc