Clinical trials: Digestive Diseases
Colorectal Cancer, RAS and BRAF Wild-type
Anlotinib Hydrochloride Capsules Combined With CAPEOX in RAS and BRAF Wild-type mCRC Patients
This is an Open, Single Arm, Exploratory and Phase II Clinical Trial of Anlotinib Hydrochloride Capsules Combined With CAPEOX in RAS and BRAF wild-type patients with Metastatic Colorectal Carcinoma(CRC) as 1st Therapy.
- Conditions
- Colorectal Cancer, RAS and BRAF Wild-type, Colorectal Neoplasms, Intestinal Neoplasms
- Trial name
- ALTER-C-002 (NCT04080843)
- Testing
- Anlotinib Hydrochloride, Capecitabine, Oxaliplatin
- Where
- 2 sites in China
- Volunteers
- 30 people
- Sponsor
- Zhejiang University
Inflammatory Bowel Diseases, Crohn Disease
Real Life Remote Monitoring of Mild, Moderate and Severe Infectious Complications in IBD by Patient Reported Assessment
Inflammatory bowel disease (IBD) is a chronic relapsing immune mediated inflammatory disease (IMID) of the gastrointestinal tract. Like all IMIDs (e.g.
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis, IBD
- Trial name
- NCT04151420
- Testing
- Remote monitoring tool (infections questionnaire) validation
- Where
- 2 sites in Netherlands
- Volunteers
- 584 people
- Sponsor
- Maastricht University Medical Center
Digestive Tract Diseases, Liver Diseases
Tongue Image Database and Diagnostic Model for Digestive Tract Disease Diagnosis
The tongue images of patients with gastrointestinal diseases and healthy people will be collected and the tongue image database will be established.
- Conditions
- Digestive Tract Diseases, Liver Diseases, Colorectal Disease, Gastric Diseases
- Trial name
- NCT05182983
- Testing
- Tongue images，coating on the tongue and clinical data
- Where
- China
- Volunteers
- 10,690 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Wenzhou Medical University
Liver Diseases, Digestive System Diseases
A Phase 1, Multicenter, Open-Label Study to Evaluate the Effect of Mild or Moderate Hepatic Impairment on the Multiple-Dose Pharmacokinetics of Ozanimod
This is a Phase 1, multicenter, nonrandomized, open-label, parallel-group study in participants with mild or moderate hepatic impairment, and in participants with normal hepatic function.
- Trial name
- NCT04639115
- Testing
- Ozanimod
- Where
- 3 sites in United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Celgene
Digestive System Disease
SROI Project on the Surgical Waiting List Management System
The waiting lists for surgery and diagnostic tests registered in the health management area of Campo de Gibraltar West are very high, and this is compounded by the lack of resources that prevent them from being managed…
- Trial name
- NCT05064163
- Where
- Spain
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- University of Malaga
Irritable Bowel Syndrome, Colonic Diseases, Functional
The Prevalence and Risk Factors of Irritable Bowel Syndrome Among Adults
This is a multicenter cross-sectional study on the prevalence of Irritable Bowel Syndrome and the risk factors associated with it. The Rome IV criteria is used for diagnosing IBS.
- Trial name
- NCT05340400
- Testing
- ROME IV Criteria
- Where
- 2 sites in Syria
- Volunteers
- 5,500 people
- Sponsor
- University of Aleppo
Exocrine Pancreatic Insufficiency, Pancreatic Diseases
Special Investigation of LipaCreon on Long-term Use in Patients With Pancreatic Exocrine Insufficiency
This study aims at collecting the information related to the safety and effectiveness in the pancreatic exocrine insufficiency patients receiving the treatment with LipaCreon for a long term in order to evaluate the effective and…
- Conditions
- Exocrine Pancreatic Insufficiency, Pancreatic Diseases, Digestive System Diseases
- Trial name
- NCT01427725
- Testing
- Lipacreon
- Where
- 189 sites in Japan
- Volunteers
- 579 people
- Sponsor
- Mylan Inc.
Cystic Fibrosis, Exocrine Pancreatic Insufficiency
Special Investigation (All Cases) of LipaCreon in Patients With Pancreatic Exocrine Insufficiency Due to Cystic Fibrosis
This study aims at collecting the information related to the safety and effectiveness in the pancreatic exocrine insufficiency patients due to cystic fibrosis receiving the treatment with LipaCreon in order to evaluate the…
- Conditions
- Cystic Fibrosis, Exocrine Pancreatic Insufficiency, Pancreatic Diseases, Digestive System Diseases
- Trial name
- NCT01427712
- Testing
- Pancrelipase
- Where
- 21 sites in Japan
- Volunteers
- 24 people
- Sponsor
- Mylan Inc.
Neoplasms, Neoplasms, Glandular and Epithelial
Cardiac Safety Study of Entinostat in Men and Women With Advanced Solid Tumors
The purpose of this study is to evaluate the effect of entinostat on heart rate and other electrocardiogram (ECG) parameters. This study will also evaluate the safety and tolerability of entinostat, as well as pharmacokinetic and…
- Conditions
- Neoplasms, Neoplasms, Glandular and Epithelial, Neoplasms by Histologic Type, Bronchial Neoplasms
- Trial name
- NCT02897778
- Testing
- Entinostat
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Syndax Pharmaceuticals
Hepatobiliary Diseases
The Function of PET Molecular Imaging Targeting Fibroblast Activation Protein in the Hepatobiliary Malignancies
Patients with high clinical suspicion of hepatobiliary malignancies should undergo PET/CT examination with two imaging agents, 68Ga-FAPI (fibroblast activation protein inhibitor) and 18F-FDG within one week, and collect tumor…
- Trial name
- NCT05264688
- Testing
- 68Ga-FAPI-04 imaging agent
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Zhongnan Hospital
Hepatitis C, Hepatitis
Strategies for Hepatitis C Testing and Treatment in Aboriginal Communities That Lead to Elimination
A community-based "test and treat" intervention integrating point-of-care HCV RNA testing, non-invasive liver disease assessment and linkage to care will lead to a reduction in HCV prevalence among people attending Aboriginal…
- Conditions
- Hepatitis C, Hepatitis, Liver Diseases, Hepatitis, Viral, Human
- Trial name
- SCALE-C (NCT03776760)
- Testing
- Fingerstick GeneXpert HCV RNA quantitative assay, sofosbuvir/velpatesvir, glecaprevir/pibrentasvir
- Where
- 4 sites in Australia
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Kirby Institute
Colorectal Neoplasms, Intestinal Neoplasms
Palliative Primary Tumor Resection in Minimally Symptomatic Patients With Colorectal Cancer and Synchronous Unresectable Metastases
Currently, the question remains whether palliative primary tumor resection could improve overall survival of minimally symptomatic patients with colorectal cancer and synchronous unresectable metastases.
- Conditions
- Colorectal Neoplasms, Intestinal Neoplasms, Gastrointestinal Neoplasms, Digestive System Neoplasms
- Trial name
- NCT05322486
- Testing
- surgery of the primary tumour, chemotherapy
- Where
- Russia
- Volunteers
- 200 people
- Sponsor
- State Scientific Centre of Coloproctology, Russian Federation
Hepatic and Hepatobiliary Disorders
Indocyanine Green Clearance Test in Liver Transplantation (LivInG)
The gap between patients awaiting and those undergoing liver transplantation (LT) continues to grow. Marginal organs carry higher risk of failure after LT however they are increasingly used to fill such gap.
- Trial name
- LivInG (NCT05228587)
- Testing
- Indocyanine green
- Where
- Italy
- Volunteers
- 162 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Gastrointestinal Diseases
Evaluation of People With Gastrointestinal Disease
Background: Gastrointestinal diseases and disorders affect the throat, stomach, and intestines. There are many different kinds of these diseases. Clinical trials are being developed to study new ways to treat them.
- Trial name
- NCT01639924
- Where
- United States
- Volunteers
- 2,761 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Disease of Lower Digestive Tract, Nurse-Patient Relations
Design and Clinical Application of Colonoscopy Position Identification Sheet
Before colonoscopy, the nursing staff need to educate the patient with posture coordination.However, it is difficult for some patients to understand the placement of the correct body position, which takes too much time to conduct…
- Trial name
- NCT05239481
- Testing
- colonoscopy position identification sheet, Traditional disposable cleaning sheet
- Volunteers
- 1,100 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Lymphoma, Digestive System Diseases
Development of an Evaluation Method of Elderly Condition in Patient Receiving Chemotherapy Treatment
Incidence of cancer in 75+ years old is 16,500 new cases per year, more than fifty percent of people with cancerThey are very few therapeutic trials dedicated.
- Conditions
- Lymphoma, Digestive System Diseases, Ovarian Diseases, Pulmonary Disease
- Trial name
- PHRC2003 (NCT00210249)
- Where
- 18 sites in France
- Volunteers
- 364 people
- Sponsor
- Institut Bergonié
Infant Conditions, Colic, Infantile
Efficacy of a Craniosacral Therapy Protocol in the Treatment of Infant Colic
This is a randomised controlled trial that aims to determine the effectiveness of craniosacral therapy for the treatment of infantile colic.
- Conditions
- Infant Conditions, Colic, Infantile, Gastro-Intestinal Disorder
- Trial name
- NCT03675763
- Testing
- Manual treatment
- Volunteers
- 58 people
- Sponsor
- Universidad Católica San Antonio de Murcia
Digestive System Disease, Diagnoses Disease
A Novel Portable Upper Gastrointestinal Endoscopy System
The application of conventional endoscopy in remote and outdoor areas lacking facilities remains challenges. Thus, the investigators developed a novel portable upper gastrointestinal endoscopy system that has the same functions…
- Trial name
- NCT05211258
- Testing
- a novel portable upper gastrointestinal endoscopy system
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Neoplasms, Neoplasms, Glandular and Epithelial
Continuation Study of Entinostat in Combination With Pembrolizumab in Patients With Advanced Solid Tumors
The objectives of this study are to explore different dosing levels and schedules of entinostat in combination with pembrolizumab in patients with advanced solid tumors, in terms of safety, tolerability, pharmacokinetics (PK)…
- Conditions
- Neoplasms, Neoplasms, Glandular and Epithelial, Neoplasms by Histologic Type, Bronchial Neoplasms
- Trial name
- NCT02909452
- Testing
- Entinostat, Pembrolizumab
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Syndax Pharmaceuticals
Celiac Disease, Gluten Sensitivity
Effects of Home Gluten Immunogenic Peptide Testing on Children With Celiac Disease
This study aims to investigate how knowledge of gluten immunogenic peptide (GIP) levels in stool and urine affects subsequent adherence to a gluten-free diet.
- Conditions
- Celiac Disease, Gluten Sensitivity, Gluten Enteropathy, Gastrointestinal Disease
- Trial name
- NCT03462979
- Testing
- Immunochromatographic lateral flow test
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Boston Children's Hospital