Clinical trials: Digestive Diseases
Rhabdomyosarcoma, Malignant Peripheral Nerve Sheath Tumors
Trial of Dasatinib in Advanced Sarcomas
This study will examine the response rate and the 6-month progression-free survival rates of subjects with advanced sarcoma treated with dasatinib.
- Conditions
- Rhabdomyosarcoma, Malignant Peripheral Nerve Sheath Tumors, Chondrosarcoma, Sarcoma, Ewing's
- Trial name
- NCT00464620
- Testing
- Dasatinib
- Where
- 20 sites in United States
- Volunteers
- 366 people
- Sponsor
- Sarcoma Alliance for Research through Collaboration
Carcinoma, Hepatocellular, Survival Rate
Resection Versus Transcatheter Arterial Chemoembolization for Hepatocellular Carcinoma With Solitary Huge Tumor
This clinical trial aims to compare hepatectomy with Transarterial Chemoembolization (TACE) for Hepatic Cellular Cancer With Solitary Huge Tumor (≥5cm).
- Trial name
- NCT03191123
- Testing
- hepatic resection, TACE
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Huazhong University of Science and Technology
Colorectal Cancer
Shared Decision-making and Colorectal Cancer Screening
Conduct a feasibility pilot RCT of a newly developed colorectal cancer screening (CRC) decision aid (DA) including 66 LHL adults 76-85 years recruited from community health centers.
- Trial name
- NCT04748380
- Testing
- CRC decision aid pamphlet, Home Safety Pamphlet
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Abramson Cancer Center at Penn Medicine
Anal Fistula
Evaluation of the Recovery Rate and Postoperative Incontinence of Surgical Fistulas in a Cohort of a Reference Centre
Fistula is a pathology that can be complex and lead to treatment difficulties for the proctologist. The proctologist's objective is to treat the infection (anal fistula and abscess) with the minimum impact on anal continence.
- Trial name
- PROFIL (NCT03865823)
- Testing
- pus sample
- Where
- France
- Volunteers
- 600 people
- Sponsor
- Groupe Hospitalier Diaconesses Croix Saint-Simon
Overweight/Obesity, Metabolic Dysfunction-associated Steatotic Liver Disease/Steatohepatitis (MASLD/MASH)
A Single-Dose Pharmacokinetic Study of HRS-4729 Injection in Healthy Participants and Patients With Renal Impairment
This study aims to evaluate the pharmacokinetic effects of a single dose of HRS-4729 injection in participants with mild, moderate, and severe renal impairment, with 8 participants enrolled in each renal impairment group and 8…
- Conditions
- Overweight/Obesity, Metabolic Dysfunction-associated Steatotic Liver Disease/Steatohepatitis (MASLD/MASH), Type 2 Diabetes Mellitus
- Trial name
- NCT07807059
- Testing
- HRS-4729
- Where
- China
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Fujian Shengdi Pharmaceutical Co., Ltd.
Gastroesophageal Reflux Disease (GERD)
Phase 3/Safety & Efficacy of Esomeprazole in Infants
The purpose of this study is to look at the improvement of a once a day dose of esomeprazole for reducing the signs and symptoms of infants with gastroesophageal reflux disease (GERD).
- Trial name
- NCT00468559
- Testing
- Open Label Run In Esomeprazole, Double Blind Esomeprazole
- Where
- 25 sites in United States, France and 2 more
- Volunteers
- 98 people
- Sponsor
- AstraZeneca
Colorectal Cancer
Study of TAS-102 Plus Radiation Therapy for the Treatment of the Liver in Patients With Hepatic Metastases From Colorectal Cancer
This research study is studying a drug in combination with radiation therapy as a possible treatment for hepatic metastases from colorectal cancer.
- Trial name
- NCT03223779
- Testing
- TAS-102, Photon SBRT
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Massachusetts General Hospital
HBV Infection, Chronic Hepatitis B
Population-wide Research for HBV-related Liver Diseases in Maoming City
Hepatitis B virus (HBV) infection is a major public health problem and chronic HBV infection affects about 296 million people worldwide and is the leading etiology of cirrhosis and hepatocellular carcinoma globally.
- Conditions
- HBV Infection, Chronic Hepatitis B, Cirrhosis, HCC
- Trial name
- PreMAO (NCT06184347)
- Testing
- Rapid tests for HBsAg
- Volunteers
- 3,700,000 people, healthy volunteers welcome
- Sponsor
- Nanfang Hospital, Southern Medical University
Gastroesophageal Reflux Disease (GERD)
Safety and Efficacy the Medigus SRS Endoscopic Stapling System in Gastroesophageal Reflux Disease (GERD)
The study is designed to test the safety and efficacy of the Medigus SRS endoscopic stapling system for the treatment of GERD. The system allows the operator to staple the stomach to the esophagus,in order to restore the…
- Trial name
- NCT00734747
- Testing
- Medigus SRS endoscopic stapling system
- Where
- 6 sites in United States, Austria and 3 more
- Volunteers
- 72 people
- Sponsor
- Aviel Roy-Shapira, M.D.
Crohn's Disease, Ulcerative Colitis
Safety of Accelerated Infliximab Infusions in Patients With Inflammatory Bowel Disease (IBD)
This study aims to test the hypothesis that the accelerated infusion of infliximab is not inferior to the conventional 2 hour infusion with respect to the frequency of infusion reaction.
- Trial name
- NCT01346826
- Testing
- Standard 2 hours-infusion, Accelerated 1 hour-infusion, Accelerated 30 minutes-infusion
- Where
- South Korea
- Volunteers
- 145 people
- Sponsor
- Asan Medical Center
Eating Disorders, Suicide Risk
Cognitive-Behavioral and Digital Therapy for Suicide Risk in Eating Disorders
The purpose of this study is to determine if adding a digital intervention to standard cognitive-behavioral therapy (CBT) is more effective in preventing suicide risk and reducing eating disorder symptoms.
- Trial name
- NCT07417826
- Testing
- Cognitive Behavioural Therapy (CBT), Cognitive Behavioural Therapy (CBT) + Digital Therapy (DT)
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- Universitat Autonoma de Barcelona
Digestive System Cancer
Association Between Body Composition and Digestive System Cancer Survival
Investigators intend to utilize clinical data from the Department of Oncology at Jiangsu Provincial People's Hospital to analyze changes in body composition in digestive system tumor patients before and after receiving anti-tumor…
- Trial name
- NCT06054685
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
To Predict Early Post-hepatectomy Mortality for HCC
Calculator Predicts Early Mortality Post Hepatocellular Carcinoma Resection
Using the multicenter data, we developed and validated an individualized online calculator to predict early mortality after liver resection for hepatocellular carcinoma.
- Trial name
- NCT06621485
- Where
- China
- Volunteers
- 4,966 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Necrotizing Pancreatitis
ABTHERA ADVANCE™ Use Without Wittman Patch
The objective of this study is to evaluate the use of the ABTHERA ADVANCE for patients requiring open abdomen due to necrotizing pancreatitis.
- Trial name
- NCT04986943
- Testing
- Using ABTHERA Advance without a Wittmann Patch
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Wake Forest University Health Sciences
Esophageal Carcinoma
Comparable Study of Different Radiation Dose in Esophageal Carcinoma
Radiation therapy plus concurrent chemotherapy is now the standard therapy for patients with localized carcinoma of the esophagus selected for nonsurgical treatment.
- Trial name
- NCT01937208
- Testing
- intensity modulated radiation therapy in both arms, concurrent chemotherapy with radiation
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Zhejiang Cancer Hospital
Gastrointestinal Stromal Tumors, Small-cell Lung Cancer
A Study of the c-Kit Specific Antibody-Drug Conjugate NN3201 for Advanced and/or Metastatic Solid Tumors Known to Express c-Kit
This open-label clinical trial will evaluate the safety and tolerability of NN3201 in subjects with advanced and/or metastatic solid tumors known to express c-Kit.
- Conditions
- Gastrointestinal Stromal Tumors, Small-cell Lung Cancer, Adenoid Cystic Carcinoma, Uveal Melanoma
- Trial name
- NCT06805825
- Testing
- NN3201
- Where
- 5 sites in United States
- Volunteers
- 67 people
- Sponsor
- Novelty Nobility, Inc.
Cholangiocarcinoma, Biliary Stenosis
Contribution of the EyeMAX™ 11Fr (Micro-Tech) Digital Single-Operator Cholangioscope With a Wide Working Channel
Background and aims Digital single-operator cholangioscopy (DSOC) enhances biliary stricture diagnosis, but the collection of quality samples can be difficult due to the small diameter of the working channel.
- Conditions
- Cholangiocarcinoma, Biliary Stenosis, Bile Duct Stones, Bile Duct Stenosis
- Trial name
- EyeMAX-CREGG (NCT06933576)
- Testing
- DSOC EyeMAX 11Fr
- Where
- 5 sites in France
- Volunteers
- 28 people
- Sponsor
- Clinique Paris-Bercy
Inflammatory Bowel Diseases, Colon Cancer
Pre-Habilitation Exercise Intervention
The purpose of this study is to see whether exercise can improve the health and well-being of patients scheduled to undergo surgery for a bowel related condition.
- Conditions
- Inflammatory Bowel Diseases, Colon Cancer, Rectal Cancer, Diverticular Disease
- Trial name
- NCT02849717
- Testing
- Exercise for Cancer Patients
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- University of Rochester
Gall Stone, Gallbladder Inflammation
Benchmarks in Elective Laparoscopic Cholecystectomy
The aim of this observational cohort study is to define peri- and postoperative reference values for elective laparoscopic cholecystectomy, using the achievable benchmarks of care methodology (ABC™).
- Conditions
- Gall Stone, Gallbladder Inflammation, Gall Bladder Pain, Gallstone
- Trial name
- NCT06692517
- Testing
- Laparoscopic cholecystectomy
- Volunteers
- 60,000 people
- Sponsor
- Region Östergötland
Lymph Node Metastases, Colorectal Cancer
Ex Vivo Intraarterial Methylene Blue Injection Improve Nodal Staging Accuracy in Colorectal Cancer
Nodal staging holds both important prognostic and predictive value at colorectal cancer. Regional lymph nodes are located close to the primary tumor in the mesocolon / mesorectum.
- Trial name
- MB (NCT04842968)
- Testing
- Methylene blue injection
- Where
- Hungary
- Volunteers
- 200 people
- Sponsor
- St. Borbala Hospital
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