Clinical trials: Digestive Diseases
Pancreatic Cancer
Clinical Study of LY011 in the Treatment of Advanced Pancreatic Cancer
CLDN 18.2 chimeric antigen receptor T cells Clinical research plan for the treatment of recurrent or refractory pancreatic cancer.
- Trial name
- NCT04966143
- Testing
- LY011
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shanghai Longyao Biotechnology Inc., Ltd.
Solitary Pulmonary Nodules, Multiple Pulmonary Nodules
Extracolonic Findings on Computed Tomography (CT) Colonography
The ACRIN 7151 trial will use medical records abstraction data from participants with extracolonic findings (ECFs) reported from the ACRIN 6664 National CT Colonography Trial to: 1) measure incidence of diagnostic imaging…
- Conditions
- Solitary Pulmonary Nodules, Multiple Pulmonary Nodules, Renal Neoplasms, Adrenal Gland Neoplasms
- Trial name
- ACRIN7151 (NCT01465425)
- Volunteers
- 520 people
- Sponsor
- American College of Radiology Imaging Network
Dysphagia
Study: C-Collar and Dysphagia
The purpose of this study is to characterize oral-pharyngeal swallow function with the guidance of videofluoroscopy under two conditions, with and without cervical bracing, in patients determined to have dysphagia.
- Trial name
- NCT03349125
- Testing
- Collar On, Collar Off
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Wisconsin, Madison
Inflammatory Bowel Disease 11
Steroid-induced Mood Changes in Patients With Inflammatory Bowel Disease
Steroid is commonly used to treat autoimmune disorders such as rheumatoid arthritis, lupus, and inflammatory bowel disease (Crohn's Disease and Ulcerative Colitis).
- Trial name
- NCT01981889
- Testing
- Prednisone
- Where
- Canada
- Volunteers
- 53 people
- Sponsor
- University of British Columbia
Metastatic Colorectal Cancer
Nordic 8 - A Phase II Trial
Nordic randomized phase II trial which evaluates whether biweekly cetuximab with alternating FOLFIRI and mFOLFOX6 is more effective than biweekly cetuximab with continuously FOLFIRI in patients with potential resectable KRAS…
- Trial name
- NCT01867697
- Testing
- Cetuximab, Irinotecan, Oxaliplatin
- Where
- 12 sites in Denmark, Norway and 1 more
- Volunteers
- 173 people
- Sponsor
- Per Pfeiffer
Locally Advanced Rectal Cancer
Chemoradiation With Enadenotucirev as a Radiosensitiser in Locally Advanced Rectal Cancer
The use of chemoradiotherapy (CRT), in combination with surgery is the standard of care in the treatment of locally advanced rectal cancer. However some patients don't respond well to radiation.
- Trial name
- CEDAR (NCT03916510)
- Testing
- Enadenotucirev, Capecitabine, Radiotherapy
- Where
- 4 sites in United Kingdom
- Volunteers
- 12 people
- Sponsor
- University of Oxford
Inflammatory Bowel Diseases, Crohn Disease
Identification of Predictive Biomarkers for Response to Biologic Therapies and Tofacitinib in Inflammatory Bowel Disease
Prospective, multicentre trial which the biologic treatment will be initiated by clinical indication. The treatment selection anti-TNFα (infliximab, adalimumab or golimumab), vedolizumab, ustekinumab and tofacitinib will be made…
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis
- Trial name
- BioIBD (NCT03885713)
- Testing
- Infliximab or adalimumab or golimumab or vedolizumab or ustekinumab or tofacitinib
- Where
- 21 sites in Spain
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Fundación de Investigación Biomédica - Hospital Universitario de La Princesa
Cholecystitis, Acute
PT-GBD to EUS-GBD Conversion Versus Standard Management in High-Risk Acute Cholecystitis Patients
Acute cholecystitis in high-risk surgical patients is commonly managed with percutaneous trans-hepatic gallbladder drainage (PT-GBD).
- Trial name
- EPIC-GBD (NCT07575360)
- Testing
- EUS-GUIDED INTERNALIZATION OF PERCUTANEOUS CHOLECYSTOSTOMY (EPIC-GBD), Standard cholecystostomy (PT-GBD) management
- Where
- Italy
- Volunteers
- 484 people
- Sponsor
- University of Bologna
Liver Diseases
Liver Diseases: Extracellular Vesicles as Biomarkers
Worldwide, cirrhosis is responsible for 2 million deaths per year. Hepatocellular carcinoma (HCC) accounts for 800,000 of these deaths and is the 3rd leading cause of cancer related death.
- Trial name
- LIVER-TRACK (NCT07185360)
- Testing
- blood sampling for volunteers, blood sampling for diabetics patients with F3/F4 fibrosis, blood sampling for patients with liver disease
- Where
- France
- Volunteers
- 845 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Liver Diseases, Hepatic Encephalopathy
Effects of Branched-Chain Amino Acids on Muscle Ammonia Metabolism in Patients With Cirrhosis and Healthy Subjects
The purpose of this study is to determine whether Branched chain Amino Acids enhances the uptake of ammonia in muscle tissue.
- Conditions
- Liver Diseases, Hepatic Encephalopathy, Hepatic Insufficiency
- Trial name
- NCT00931060
- Testing
- Branched chain amino acids
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Pancreatic Carcinoma
Use Of Indocyanine Green In Pancreas Surgery
This study evaluates the use of indocyanine green to predict postoperative pancreatic leaks in patients undergoing transection of the pancreas.
- Trial name
- NCT06084013
- Testing
- Non-Interventional Study
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- OHSU Knight Cancer Institute
Cancer Colon
Clinical and Biological Database in Colon Cancer and Colic Tumors
Developement of a clinical and biological database in colon cancer and colic tumors in order to better understand tumor invasion and metastatic scattering processes.
- Trial name
- BCBCOLON (NCT03976960)
- Testing
- Biological collection
- Where
- 2 sites in France
- Volunteers
- 600 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Esophageal Reflux, Barrett Esophagus
Histology Post-Endoscopic Eradication Therapy (EET)
This study is looking at a cohort of patients who have undergone treatment for Barrett's Esophagus (BE) and who have experienced complete eradication of the disease.
- Trial name
- NCT03375060
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Northwestern University
Adenomatous Polyposis Coli
A Study of JNJ-64251330 in Participants With Familial Adenomatous Polyposis
The purpose of this study is to determine the effect of JNJ-64251330 in participants with Familial Adenomatous Polyposis (FAP) on colorectal polyp burden (sum of the polyp diameters).
- Trial name
- NCT05014360
- Testing
- JNJ-64251330
- Where
- 16 sites in United States, France and 5 more
- Volunteers
- 42 people
- Sponsor
- Janssen Research & Development, LLC
Spontaneous Bacterial Peritonitis
Clinical, Inflammatory, and Economic Impact of Dextran 70 in Treating Spontaneous Bacterial Peritonitis
The core of the proposal is a prospective, randomized, double-blinded, controlled study which will compare the efficacy of dextran 70 versus human albumin in the treatment of cirrhotic patients with spontaneous bacterial…
- Trial name
- NCT00570960
- Testing
- Dextran 70, human albumin
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Virginia
Esophagus SCC
Neoadjuvant Immunotherapy to ESCC
Currently, surgery after neoadjuvant chemoradiotherapy is the standard treatment for patients with locally advanced esophageal cancer, but the recurrence rate is high and the 5-year survival rate is low.
- Trial name
- NCT04625543
- Testing
- Sintilimab Injection plus Paclitaxel and Cisplatin, Paclitaxel and Cisplatin
- Where
- China
- Sponsor
- Qilu Hospital of Shandong University
Ulcerative Colitis
Wireless Capsule Endoscopy in Ulcerative Colitis
Based on the inaccuracies of the current classification scheme for inflammatory bowel disease (IBD), the failure of surgical pouches and the findings of retrospective observational trials to date, we hypothesize that a…
- Trial name
- NCT00145808
- Testing
- Given® Diagnostic System
- Where
- United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Primary Biliary Cholangitis
A Trial of 18-22mg/kg/d Ursodeoxycholic in Refractory Primary Biliary Cholangitis
This study evaluates the effect of 18-22mg/kg/d Ursodeoxycholic in refractory Primary Biliary Cholangitis
- Trial name
- NCT03345589
- Testing
- 18-22mg/kg/d Ursodeoxycholic, 13-15mg/kg/d Ursodeoxycholic
- Where
- China
- Volunteers
- 40 people
- Sponsor
- West China Hospital
Ulcerative Colitis, Crohn's Disease
Long Term Safety of Vedolizumab (MLN0002) in Patients With Ulcerative Colitis and Crohn's Disease
This was an open-label study to provide an opportunity for participants with Ulcerative Colitis (UC) who previously completed Study C13002 (NCT01177228), and for treatment-naïve participants with UC or Crohn's Disease (CD) to…
- Trial name
- NCT00619489
- Testing
- vedolizumab
- Where
- Canada
- Volunteers
- 72 people
- Sponsor
- Millennium Pharmaceuticals, Inc.
Eosinophilic Esophagitis
San Raffaele EoE Biobank
Eosinophilic Esophagitis (EoE) is a immuno-mediated disease, characterised by a Th-2 food-antigen driven chronic inflammatory response of the esophagus.
- Trial name
- EoEBiobank (NCT05896891)
- Testing
- esophagogastroduodenoscopy (EGD), buccal swab, blood withdrawal
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- IRCCS San Raffaele
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