Clinical trials: Digestive Diseases
Dysphagia
Post Critical Illness Dysphagia in the Intensive Care Unit
The aims of the study are to determine: 1) the prevalence of ICU acquired dysphagia, 2) identify risk factors for ICU Acquired dysphagia, and 3) consequences of ICU acquired dysphagia including: ICU mortality, hospital mortality…
- Trial name
- DysphagiaICU (NCT04349462)
- Testing
- VideoFlurosocopy Swallow Study, Water Sip Test
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Rectal Neoplasms
Choice of the Optimal Treatment Strategies for Mid-low REctal Cancer
The purpose of this study is to compare the efficacy, prognosis, health economics of different treatment modalities of mid-low rectal cancer in different centers in China, and to conduct cost utility analysis (CUA) on the…
- Trial name
- COMREC (NCT05871762)
- Testing
- Registry study, no specific intervention
- Where
- China
- Volunteers
- 3,705 people
- Sponsor
- Peking Union Medical College Hospital
Malignant Tumor of Liver, Randomized Controlled Trial
Application of ICG@HSA Complexes in Fluorescence Image-Guided Laparoscopic Anatomical Liver Resection
This study is a single-center, prospective, randomized controlled trial that aims to compare the efficacy and safety of a new indocyanine green (ICG) administration protocol with the current guideline-recommended protocol for…
- Trial name
- NCT06219096
- Testing
- NIF image-guided laparoscopic anatomical liver resection with the novel ICG@HSA administration, NIF image-guided laparoscopic anatomical liver resection with the guideline-recommended ICG administration
- Where
- China
- Volunteers
- 100 people
- Sponsor
- West China Hospital
Hepatitis C
Low-Dose Peginterferon and Ribavirin to Treat Chronic Hepatitis C in Patients Infected With HCV Genotype 2 or 3
This study will examine the effectiveness of low-dose peginterferon and ribavirin therapy for certain patients with chronic hepatitis C-a liver disease that, in some patients, can progress to cirrhosis of the liver, liver cancer…
- Trial name
- NCT00056862
- Testing
- Peginterferon alfa-2a, Ribavirin
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Carcinoma, Pancreatic Ductal, Colorectal Neoplasms
A Study to Learn About the Study Medicine PF-07934040 When Given Alone or With Other Anti-cancer Therapies in People With Advanced Solid Tumors That Have a Genetic Mutation.
The purpose of this study is to learn about the safety and effects of the study medicine alone or when given together with other anti-cancer therapies. This study also aims to find the best dose.
- Conditions
- Carcinoma, Pancreatic Ductal, Colorectal Neoplasms, Carcinoma, Non-Small-Cell Lung
- Trial name
- NCT06447662
- Testing
- PF-07934040, Gemcitabine, Nab-paclitaxel
- Where
- 27 sites in United States, Puerto Rico
- Volunteers
- 64 people
- Sponsor
- Pfizer
Colorectal Neoplasms
Endoscopic Submucosal Dissection Versus Laparoscopic Resection for Early Colorectal Neoplasms
This is a prospective randomized trial that aimed to compare the short-term clinical outcomes and systemic inflammatory/cytokine responses of endoscopic submucosal dissection versus laparoscopic resection for early colorectal…
- Trial name
- NCT01112046
- Testing
- Endoscopic submucosal dissection, Laparoscopic resection
- Where
- China
- Volunteers
- 124 people
- Sponsor
- Chinese University of Hong Kong
Hemorrhoids, Pregnancy
The Safety of Proctofoam-HC in the Third Trimester of Pregnancy
The purpose of this study is to evaluate the fetal safety of topical application of Proctofoam-HC®, an antihemorrhoidal, in the third trimester of pregnancy.
- Trial name
- NCT00405288
- Testing
- Proctofoam-HC®
- Where
- 2 sites in Canada
- Volunteers
- 408 people
- Sponsor
- The Hospital for Sick Children
Ulcerative Colitis
A Long Term Safety Study of Infliximab (Remicade) in in Ulcerative Colitis Patients
The purpose of this study is to evaluate long-term safety information of infliximab in patients who have participated in infliximab clinical studies in ulcerative colitis.
- Trial name
- NCT00207688
- Testing
- Infliximab 5 mg/kg, Infliximab 10 mg/kg
- Where
- 102 sites in United States, Argentina and 13 more
- Volunteers
- 505 people
- Sponsor
- Janssen Research & Development, LLC
KRAS G12C Mutant Solid Tumors, Carcinoma, Non-Small-Cell Lung
Study of JDQ443 in Patients With Advanced Solid Tumors Harboring the KRAS G12C Mutation
This is a phase Ib/II open label study. The escalation part will characterize the safety and tolerability of JDQ443 single agent and JDQ443 in combination with the other study treatments (TNO155 and tislelizumab) in advanced…
- Conditions
- KRAS G12C Mutant Solid Tumors, Carcinoma, Non-Small-Cell Lung, Carcinoma, Colorectal, Cancer of Lung
- Trial name
- KontRASt-01 (NCT04699188)
- Testing
- JDQ443, TNO155, tislelizumab
- Where
- 38 sites in United States, Australia and 14 more
- Volunteers
- 344 people
- Sponsor
- Novartis Pharmaceuticals
Crohn Disease (CD), Ulcerative Colitis (UC)
Education Intervention on Vaccination Adherence Among Inflammatory Bowel Disease (IBD) Patients
A retrospective chart review and a six-month prospective outcome analysis aimed to evaluate the efficacy of a vaccination education intervention and vaccination adherence among IBD patients at Weill-Cornell Medical Center.
- Conditions
- Crohn Disease (CD), Ulcerative Colitis (UC), Indeterminate Colitis
- Trial name
- NCT04672161
- Testing
- Vaccine Education
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Weill Medical College of Cornell University
Hepatocellular Carcinoma (HCC), Intrahepatic Cholangiocellular Carcinoma
Application of Super-Resolution Ultrasound (SRUS) in Liver Tumor
The macroscopic vascular supply of liver tumors varies considerably according to histological subtype, lesion size, and disease stage.
- Conditions
- Hepatocellular Carcinoma (HCC), Intrahepatic Cholangiocellular Carcinoma, Hepatic Hemangioma, Focal Nodular Hyperplasia
- Trial name
- SRUS (NCT07707661)
- Testing
- Perform super-resolution ultrasound imaging on the study population
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Eastern Hepatobiliary Surgery Hospital
Pancreatic Neoplasm
A Clinical Trial Evaluating the Effect of Pharmacological Ascorbate on Radiation Therapy for Pancreatic Cancer Patients
Radiation therapy improves cancer cure rates by killing cancer cells but it also contributes to long-term side effects in cancer survivors by unintentionally damaging normal organs such as the intestine.
- Trial name
- XACT-PANC-2 (NCT03541486)
- Testing
- Ascorbate, Gemcitabine, radiation therapy
- Where
- United States
- Sponsor
- Joseph J. Cullen, MD, FACS
Lung Cancers, Liver Cancer
AI-Assisted Non-Contrast CT for Multi-Cancer Screening
Cancer poses a major public health challenge in China. Early detection can improve treatment outcomes and survival rates. In this study, we will conduct a large-scale, prospective, multi-center cohort study to evaluate the…
- Conditions
- Lung Cancers, Liver Cancer, Gastric Cancers, Colorectal, Cancer
- Trial name
- NCT06632886
- Testing
- AI-Assisted Non-Contrast CT for Multi-Cancer Screening
- Where
- China
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- Guo ShiWei
Cholestasis, Intrahepatic Cholestasis of Pregnancy
Investigation of the Pruritogens of Liver-related Diseases
This study hopes investigate the itch-inducing ability of different potential pruritogen candidates of cholestasis pruritus, especially the intrahepatic cholestasis of pregnancy (ICP).
- Trial name
- NCT06364969
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Peking University
Pancreatitis, Chronic Pancreatitis
Varenicline for Smoking Cessation in Pancreatitis
This study will look at how safe and how effective varenicline, a commonly used medication for smoking cessation, is in helping patients with pancreatitis stop smoking cigarettes.
- Conditions
- Pancreatitis, Chronic Pancreatitis, Acute Pancreatitis (AP), Recurrent Acute Pancreatitis
- Trial name
- NCT07874841
- Testing
- Varenicline (VAR)
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Mayo Clinic
Colorectal Cancer Stage II and III
Fuzheng Yiliu-1010
Real world study was used to evaluate the therapeutic effect of Fuzheng anti-tumor therapy on colorectal cancer patients in stage II and III after surgery and standard chemotherapy, and the prediction model of dominant population…
- Trial name
- NCT04459754
- Testing
- Fuzheng Yiliu Formulation
- Where
- China
- Volunteers
- 189 people
- Sponsor
- Guangdong Provincial Hospital of Traditional Chinese Medicine
Anemia, Iron-Deficiency, Colorectal Cancer
Efficacy of Preoperative Intravenous Iron in Anaemic Colorectal Cancer Surgical Patients
Iron deficiency anaemia is a common condition among colorectal surgical patient. Untreated anaemia would lead to increase in blood transfusion, surgical complications and mortality.
- Trial name
- NCT03565354
- Testing
- iron isomaltoside(Monofer®)
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- Prince of Wales Hospital, Shatin, Hong Kong
Breast Cancer, Colon Cancer
Copper Cu 64 Anti-CEA Monoclonal Antibody M5A PET in Diagnosing Patients With CEA Positive Cancer
This pilot clinical trial studies copper Cu 64 anti-carcinoembryonic antigen (CEA) monoclonal antibody M5A positron emission tomography (PET) in diagnosing patients with CEA positive cancer.
- Conditions
- Breast Cancer, Colon Cancer, Extrahepatic Bile Duct Cancer, Gallbladder Cancer
- Trial name
- NCT02293954
- Testing
- radionuclide imaging, positron emission tomography, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- City of Hope Medical Center
Primary Sclerosing Cholangitis, Liver Transplant, Complications
Pharmacologic Approaches to Preventing Primary Sclerosing Cholangitis Recurrence After Liver Transplantation
This study aims to determine the efficacy of 36 months once-daily fenofibrate in preventing clinically-detectable recurrence of primary sclerosing cholangitis after liver transplantation, compared with a historical control cohort…
- Conditions
- Primary Sclerosing Cholangitis, Liver Transplant, Complications, PSC, Biliary Strictures
- Trial name
- NCT06905054
- Testing
- Fenofibrate (drug), Blood draw for the laboratory assessment, MRI using a hepatobiliary phase contrast agent (Gd-EOB-DPTA)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Mayo Clinic
Liver Diseases, Liver Cancer
Liver Regeneration
The liver is the only visceral organ with a tremendous capacity to regenerate. We don't yet understand how normal liver regeneration occurs (on a molecular level) or how to distinguish between normal and "abnormal"/neoplastic…
- Trial name
- NCT03396705
- Testing
- Liver Biopsy
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- University Health Network, Toronto
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.