Clinical trials: Digestive Neoplasms
Metastatic Colorectal Cancer
Combined AlloStim+Anti-PD-L1 in 4L MSS Metastatic Colorectal Cancer
Experimental immunotherapy in chemotherapy-refractory and immunotherapy-refractory metastatic colorectal cancer patients that have progressed, or are intolerant to, Longsurf (TAS-102) +/- Avastin (bevacizumab) or Stivarga…
- Trial name
- COMUNITY (NCT06557278)
- Testing
- AlloStim, Bavencio
- Where
- 3 sites in United States
- Sponsor
- Mirror Biologics, Inc.
Metastatic Colorectal Cancer
Impact of Early and Active Nutritional and Dietary Management grade3 or More Toxicities Induced by Chemotherapy and Targeted Therapies Administered to Patients as First Intention for Non Surgical Metastatic Colorectal Cancer
Description of active nutritional support: Early and active nutritional support is mainly concerned with maintaining protein and energy intake levels despite chemotherapy.
- Trial name
- CHIMIODIET (NCT01143285)
- Testing
- Early and active nutritional support.
- Where
- 8 sites in France
- Volunteers
- 180 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Gastric Cancer
Apatinib Combined With Paclitaxol as Second Line Therapy for Advanced Gastric Cancer.
This multicenter, randomized, double-blind study will evaluate the efficacy and safety of apatinib combined with paclitaxol versus placebo combined with paclitaxol in advanced gastric cancer or gastroesophageal junction carcinoma…
- Trial name
- NCT03144843
- Testing
- Apatinib
- Where
- 2 sites in China
- Volunteers
- 110 people
- Sponsor
- Sun Yat-sen University
Barrett Esophagus, Barretts Esophagus With Dysplasia
Seattle Biopsy Protocol Versus Wide-Area Transepithelial Sampling in Patients With Barrett's Esophagus Undergoing Surveillance
The purpose of this research study is to learn about the best approach to sample patients with known or suspected Barrett's esophagus (BE) by comparing the standard Seattle biopsy protocol to sampling using wide area…
- Conditions
- Barrett Esophagus, Barretts Esophagus With Dysplasia, Esophageal Adenocarcinoma
- Trial name
- SWAT-BE (NCT05530343)
- Testing
- Seattle protocol, WATS3D brushings
- Where
- 14 sites in United States
- Volunteers
- 2,298 people
- Sponsor
- University of Colorado, Denver
Biliary Tract Cancer
A Study of TQB2102 for Injection in the Treatment of HER2-positive Biliary Tract Cancer
To evaluate the efficacy and safety TQB2102 for injection in the treatment of patients with Her2-positive biliary tract cancer.
- Trial name
- NCT06431490
- Testing
- TQB2102 for injection
- Where
- 43 sites in China
- Volunteers
- 102 people
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Nanjing Shunxin Pharmaceutical Co., Ltd.
Colorectal Neoplasms Malignant
The COLON Study: Colorectal Cancer Cohort
The main aim of this observational, prospective cohort study is to assess associations of diet and other lifestyle factors with colorectal cancer recurrence, survival and quality of life.
- Trial name
- COLON (NCT03191110)
- Testing
- No intervention: observational study
- Where
- 11 sites in Netherlands
- Volunteers
- 2,000 people
- Sponsor
- Wageningen University
Adenocarcinoma of the Gastroesophageal Junction, Cervical Cancer
Study of Physical and Psychosocial Rehabilitation Needs of Patients After Diagnosis and Treatment of Upper Gastrointestinal Cancer or Gynecological Cancer
RATIONALE: Gathering information from patients who have undergone treatment for upper gastrointestinal cancer or gynecological cancer may help doctors learn more about patients' physical and psychosocial rehabilitation needs and…
- Conditions
- Adenocarcinoma of the Gastroesophageal Junction, Cervical Cancer, Endometrial Cancer, Esophageal Cancer
- Trial name
- NCT01216813
- Testing
- informational intervention, assessment of therapy complications, psychosocial assessment and care
- Where
- United Kingdom
- Volunteers
- 33 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Liver Cancer, Hepatectomy
Effects of Different Anesthetic Techniques on Intraoperative and Postoperative Pain Levels and Cognitive Function in Patients Undergoing Hepatectomy for Liver Cancer
To evaluate the effects of general anesthesia (GA) versus combined general and epidural anesthesia (GEA) on postoperative pain, cognitive dysfunction (POCD), hospital stay, and recovery quality in liver cancer patients undergoing…
- Conditions
- Liver Cancer, Hepatectomy, Anesthesia Techniques, Postoperative Pain
- Trial name
- NCT07097220
- Testing
- General Anesthesia (GA) group, General-Epidural Anesthesia (GEA) group
- Where
- China
- Volunteers
- 106 people
- Sponsor
- Sir Run Run Shaw Hospital, Qingchun Campus, Zhejiang University School of Medicine,
Neoplasms, Lymphomas
Belinostat for Solid Tumors and Lymphomas in Patients With Varying Degrees of Hepatic Dysfunction
Background: Belinostat is an experimental cancer treatment drug that works by helping to turn on genes that limit cell growth and survival of cancer cells. These genes are often switched off in tumors.
- Trial name
- NCT01273155
- Testing
- Belinostat
- Where
- 7 sites in United States
- Volunteers
- 72 people
- Sponsor
- National Cancer Institute (NCI)
Gastric Cancer Stage III
Adjuvant Chemotherapy in Combination With Camrelizumab for Stage III Gastric Cancer (FOCUS-02)
This study is a prospective, single arm, multi-center phase II clinical trial. The primary study objective is to evaluate the safety of tegafur gimeracil oteracil potassium capsule plus oxaliplatin and Camrelizumab as adjuvant…
- Trial name
- NCT04515615
- Testing
- Camrelizumab, Oxaliplatin, Tegafur gimeracil oteracil potassium capsule
- Where
- 4 sites in China
- Volunteers
- 52 people
- Sponsor
- Yu jiren
Cancer (Solid Tumors), Vomiting
Steroid Sparing Regimen With Olanzapine and Palonosetron for Emetic Prevention for High Dose Cisplatin
A phase II study evaluating dexamethasone sparing regimen with olanzapine and palonosetron for patients receiving high dose cisplatin to prevent chemotherapy induced nausea and vomiting
- Conditions
- Cancer (Solid Tumors), Vomiting, Cisplatin, Olanzapine
- Trial name
- NCT07699276
- Testing
- dexamethasone sparing
- Where
- Thailand
- Volunteers
- 95 people
- Sponsor
- Mahidol University
Hepatocellular Carcinoma
Open-label Multicenter Phase 1 Study of TBI 302 as Second-Line Therapy in Patients With Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. TBI 302 is being developed for the treatment of inoperable HCC by intravenous infusion.
- Trial name
- NCT03908840
- Testing
- TBI 302
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Evolve Biologics
Hepatocellular Carcinoma
RFA Combined With Oxaliplatin + 5-FluoroUracil/LeucoVorin (5-FU/LV) (FOLFOX4) for Recurrent HCC
Hepatocellular carcinoma (HCC) is the fifth most common cancer in the world. Partial hepatectomy and liver transplantation are considered to be standard curative therapies for HCC.
- Trial name
- NCT02426450
- Testing
- RFA, Oxaliplatin, 5-Fluorouracil/Leucovorin
- Where
- China
- Volunteers
- 28 people
- Sponsor
- Sun Yat-sen University
Colorectal Cancer, Diverticulitis Colon
Seal-G MIST (Minimally Invasive Sealant/Spray Technology) System Safety Study [SEALAR Study]
The purpose of this study is to evaluate safety of Seal-G MIST System in reinforcing colorectal anastomosis, in subjects undergoing colorectal surgery.
- Trial name
- SEALAR (NCT03448874)
- Testing
- Seal-G MIST System
- Sponsor
- Sealantis Ltd.
Malignant Neoplasm of Stomach
Radical Gastrectomy and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Locally Advanced Gastric Cancer
The efficacy of HIPEC in prevention of local recurrence, distant metastasis or peritoneal metastasis in locally advanced gastric cancer is not definite.
- Trial name
- NCT02528110
- Testing
- Hyperthermic intraperitoneal chemotherapy (HIPEC), D2 radical gastrectomy, SOX postoperative chemotherapy
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Wuhan University
Breast Cancer, Colon Cancer
Physician Use of Non-English Language Skills in Cancer Care
The purpose of this study is to test a method for analyzing interactions between patients and doctors, the Roter Interaction Analysis System (RIAS).
- Conditions
- Breast Cancer, Colon Cancer, Lung Cancer
- Trial name
- NCT02726360
- Testing
- survey, Audio record
- Where
- 5 sites in United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Colorectal Neoplasms
Using Multimodal Prehabilitation to Improve Outcomes for Frail Patients Undergoing Resection of Colorectal Cancer
The purpose of this study is to determine if a program of physical activity, nutritional supplements and relaxation techniques is effective at decreasing post operative complications in frail colorectal cancer patients undergoing…
- Trial name
- NCT02502760
- Testing
- Physical Exercise Program, Whey Protein Isolate Powder, Relaxation Techniques
- Where
- 2 sites in Canada
- Volunteers
- 120 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Colorectal Cancer
Acupressure on Postoperative Ileus in Patients With Colorectal Cancer Surgery
The goal of this clinical trial is to learn about acupressure in patients with colorectal cancer surgery. The main questions it aims to answer are: whether acupressure can improve the motility of vagus nerve in patients after…
- Trial name
- NCT06118060
- Testing
- Acupressure
- Volunteers
- 104 people
- Sponsor
- Qilu Hospital of Shandong University
Pancreatic Cancer
Gemcitabine or Gemcitabine and Cisplatin in the Treatment of Advanced Pancreatic Cancer
The purpose of this study is to evaluate the impact of the addition of cisplatin to gemcitabine in the treatment of patients with inoperable advanced pancreatic cancer.
- Trial name
- GIP-1 (NCT00813696)
- Testing
- gemcitabine, cisplatin
- Where
- 45 sites in Italy
- Volunteers
- 400 people
- Sponsor
- Istituti Tumori Giovanni Paolo II
Pancreatic Cancer
IN10018+ Standard Chemotherapy (+KN046) in Subjects With Advanced Pancreatic Cancer
This study is a multicenter, open-label, single-arm, phase Ib/II clinical study comprising two phases: dose confirmation phase and dose expansion phase.
- Trial name
- NCT05827796
- Testing
- IN10018, Albumin-Bound Paclitaxel, Gemcitabine
- Where
- China
- Volunteers
- 70 people
- Sponsor
- InxMed (Shanghai) Co., Ltd.
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