Clinical trials: Digestive Neoplasms
Prostate Cancer, Optic Nerve Sheath Diameter
Effect Of Trendelenburg Position And Pneumoperitoneum On Optic Nerve Sheath Diameter In Robot-Assisted Prostatectomy
This prospective study aims to evaluate the effect of steep Trendelenburg position and pneumoperitoneum on optic nerve sheath diameter in patients undergoing robot-assisted laparoscopic radical prostatectomy and open radical…
- Conditions
- Prostate Cancer, Optic Nerve Sheath Diameter, Robot-Assisted Radical Prostatectomy, Steep Trendelenburg Position With Penumoperitoneum in Robot Assisted Laparoscopic Prostatectomy
- Trial name
- ONSD-RALP (NCT07491198)
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Ege University
Gastric Cancer, Pancreatic Ductal Adenocarcinoma
A Phase 1 Study of LCAR-C182A Cells in the Treatment of Advanced Gastric Cancer and Pancreatic Ductal Adenocarcinoma
This is an open label, single center, single arm phase 1 study to evaluate the safety , tolerability, pharmacokinetics and efficacy and immunogenicity of LCAR-C182A cells targeting Claudin18.2 in the treatment of patients with…
- Trial name
- NCT03890198
- Testing
- LCAR-C182A cells
- Where
- China
- Volunteers
- 2 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Hepatocellular Carcinoma
Radiofrequency Ablation Plus Radiotherapy for Small Hepatocellular Carcinoma
Radiofrequency ablation (RFA) and hepatic resection are main treatments for early stage hepatocellular carcinoma. Many randomized controlled trials found these two treatments have similar short term overall survival.
- Trial name
- NCT03988998
- Testing
- Radiofrequency ablation with radiotherapy, Radiofrequency ablation alone
- Volunteers
- 100 people
- Sponsor
- Guangxi Medical University
Esophageal Neoplasms
A Trial of CMNa Combined With Definitive Concurrent Chemoradiotherapy for Locally Advanced ESCC
This is a perspective, multicenter,randomized controlled trial to evaluate the efficacy and safety of treatment with CMNa combined with concurrent chemoradiotherapy in patients with locally advanced squamous cell esophageal…
- Trial name
- NCT02721563
- Testing
- Sodium Glycididazole
- Where
- 10 sites in China
- Volunteers
- 77 people
- Sponsor
- Shandong Cancer Hospital and Institute
Solid Tumors, Pancreatic Cancer
CTS2190 Phase I /II Clinical Study in Patients
This is a first in human study in patients with advanced or metastatic solid tumors. The first part of the study is an open-label, dose escalation and the second part is an open label dose expansion in specific tumor types.
- Conditions
- Solid Tumors, Pancreatic Cancer, Non-small Cell Lung Cancer, Triple-negative Breast Cancer
- Trial name
- NCT06224387
- Testing
- CTS2190 capsules
- Where
- 2 sites in China
- Volunteers
- 224 people
- Sponsor
- CytosinLab Therapeutics Co., Ltd.
Colorectal Neoplasms
The Study of CIK Plus S-1 and Bevacizumab as Maintenance Treatment for Patients With Advanced Colorectal Cancer
The purpose of this study is to evaluate the safety and efficacy of cytokine-induced killer cell (CIK) plus S-1 and Bevacizumab vs S-1 and Bevacizumab as Maintenance Treatment for patients with advanced colorectal cancer.
- Trial name
- NCT02487992
- Testing
- Cytokine-Induced Killer Cells
- Volunteers
- 1,200 people
- Sponsor
- The First People's Hospital of Changzhou
Anal Cancer
The Prevent Anal Cancer Self-Swab Study
The purpose of this research study is to find ways to screen for anal cancer among gay, bisexual, and other men who have sex with men (MSM) and transgender persons.
- Trial name
- NCT03489707
- Testing
- Home-based human papillomavirus (HPV) DNA screening, Clinic-based human papillomavirus (HPV) DNA screening
- Where
- United States
- Volunteers
- 253 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Pancreas Neoplasms, Lymphatic Metastasis
Comparing of Modified Wet Suction Technique and Dry Suction Technique for EUS-FNA of Solid Occupying Lesions
The purpose of this study is to compare the diagnosis accuracy of modified wet suction technique and 5ml dry suction technique on solid occupying lesions.
- Conditions
- Pancreas Neoplasms, Lymphatic Metastasis, Neoplasm Metastases, Unknown Primary Neoplasm Metastasis
- Trial name
- NCT02789371
- Testing
- the first pass is made with 5ml suction technique, the first pass is made with modified wet suction technique
- Where
- China
- Volunteers
- 296 people
- Sponsor
- Bin Cheng
Peritoneal Carcinomatosis, Peritoneal Metastases
CAR-T Intraperitoneal Infusions for CEA-Expressing Adenocarcinoma Peritoneal Metastases or Malignant Ascites (IPC)
This is an open-label, dose-escalation, phase I trial of the safety and efficacy of anti-CEA intraperitoneal CAR-T infusions for treatment in patients with CEA-expressing adenocarcinoma peritoneal metastases or malignant ascites.
- Conditions
- Peritoneal Carcinomatosis, Peritoneal Metastases, Colorectal Cancer, Gastric Cancer
- Trial name
- NCT03682744
- Testing
- anti-CEA CAR-T cells
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Sorrento Therapeutics, Inc.
Digestive Cancer, Gynecologic Cancer
Development of Clinical and Biological Database
The BCB is a tool: for research in analytical and public health epidemiology, biological research and for the development of data useful for clinical research and therapeutic trials; to help scientists understand and explain…
- Conditions
- Digestive Cancer, Gynecologic Cancer, Breast Cancer, Sarcoma
- Trial name
- BCBInstitut (NCT03449264)
- Testing
- biological collection
- Where
- France
- Volunteers
- 4,000 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Colorectal Cancer
A Single Center Evaluation of AI Enabled SureForm Robotic Stapler (SureformTM) Compared to Conventional Stapler for Colorectal Cancer Procedures
Robotic-assisted surgeries are especially valuable for colorectal pathologies because they offer better vision and control for surgical manipulation given the narrow operative region within the pelvis .Some of the iatrogenic risk…
- Trial name
- NCT07371832
- Testing
- AI-enabled SureForm™ Robotic Stapler, Conventional Laparoscopic Stapler
- Where
- India
- Volunteers
- 200 people
- Sponsor
- Asian Institute of Gastroenterology, India
Gastric Cancer, Esophagogastric Junction Disorder
Savolitinib for Treating Gastric Cancer and Esophagogastric Junction Adenocarcinoma Patients
Treating Gastric Cancer and Esophagogastric junction adenocarcinoma Patients with MET gene amplifications with Savolitinib
- Trial name
- NCT04923932
- Testing
- Savolitinib
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Hutchison Medipharma Limited
Early Gastric Cancer
Multicenter Phase III Trial of Laparoscopic Sentinel Node Biopsy
Laparoscopic sentinel lymph node biopsy and stomach preserving surgery in early gastric cancer is less invasive method which can increase quality of life.
- Trial name
- NCT01804998
- Testing
- Laparoscopic Sentinel Node Biopsy, Laparoscopy Assisted Gastrectomy
- Where
- 7 sites in South Korea
- Volunteers
- 580 people
- Sponsor
- National Cancer Center, Korea
Hepatocellular Carcinoma
Efficacy and Safety of Intratumoral Injection of Recombinant Human Adenovirus Type 5 Combined With Tislelizumab and Lenvatinib in the Treatment of Advanced Hepatocellular Carcinoma
This prospective, single-arm study was aimed to evaluate the efficacy of recombinant human adenovirus type 5 injection combined with tislelizumab and lenvatinib in the treatment of advanced hepatocellular carcinoma.
- Trial name
- NCT06253598
- Testing
- Recombinant Human Adenovirus Type 5, Lenvatinib, Tislelizumab
- Volunteers
- 30 people
- Sponsor
- The First Affiliated Hospital of Bengbu Medical University
Gastric Cancer
Randomized Phase II Trial Evaluating DFS in The Absence of an Adjuvant Component of Perioperative Chemotherapy in Patients With Gastric Cancer
This single-center, open-label, randomized phase II trial (JAGC-1) will evaluate whether adjuvant chemotherapy can be safely omitted in patients with stage IB-III gastric cancer (cT2-4a and/or N+) who have achieved a pathological…
- Trial name
- JAGC1 (NCT06942663)
- Testing
- Surveillance, Adjuvant Chemotherapy
- Volunteers
- 228 people
- Sponsor
- Nizhny Novgorod Regional Clinical Oncology Center
Colon Cancer
Effect of Perioperative Intravenous Infusion of Lidocaine on the Postoperative Course and the Immune Response in Patients Undergoing Surgery for Colon Cancer - the PILDI Study
There are very few data in the literature on changes in inflammatory markers when lidocaine is administered perioperatively in patients with colorectal cancer.
- Trial name
- PILDI (NCT06923787)
- Testing
- Lidocaine
- Where
- 2 sites in Slovenia
- Volunteers
- 100 people
- Sponsor
- Institute of Oncology Ljubljana
Ovary Cancer, Cervix Cancer
Tisotumab Vedotin (HuMax®-TF-ADC) Safety Study in Patients With Solid Tumors
The purpose of the trial is to establish the tolerability of tisotumab vedotin (HuMax-TF-ADC) dosed three times every four weeks (3q4wk) in a mixed population of patients with specified solid tumors.
- Conditions
- Ovary Cancer, Cervix Cancer, Endometrium Cancer, Bladder Cancer
- Trial name
- NCT02552121
- Testing
- Tisotumab vedotin (HuMax-TF-ADC)
- Where
- 16 sites in United States, Belgium and 3 more
- Volunteers
- 33 people
- Sponsor
- Seagen Inc.
Locally Advanced Rectal Cancer
Development of a Genome-based Platform for Personalized Treatment in Locally Advanced Rectal Cancer Patients
This study is aimed to develop a genome-based platform to predict patients who can achieve pathologic complete response after neoadjuvant treatment in locally advanced rectal cancer.
- Trial name
- NCT04738214
- Testing
- Neoadjuvant CCRT+operation +/- adjuvant treatment
- Where
- South Korea
- Volunteers
- 39 people
- Sponsor
- Yonsei University
Oral Mucositis
A Study to Evaluate the Efficacy of MuGard for the Amelioration of Oral Mucositis in Head and Neck Cancer Patients
This study is a randomized, double-blind, sham-controlled, two-arm study conducted in subjects receiving chemoradiation therapy for the treatment of head and neck cancer to assess the efficacy of MuGard.
- Trial name
- MuGard (NCT01283906)
- Testing
- MuGard, Control Rinse
- Where
- 18 sites in United States
- Volunteers
- 120 people
- Sponsor
- Access Pharmaceuticals, Inc.
Pancreatic Cancer, Pancreatic Adenocarcinoma
Pancreatic Cancer Models Developed From EUS Guided Biopsy Tissue
Pancreatic cancer is a very aggressive cancer. Over the past 40 years there has not been much progress made in reducing deaths from this cancer.
- Conditions
- Pancreatic Cancer, Pancreatic Adenocarcinoma, Pancreatic Cyst
- Trial name
- NCT03140592
- Testing
- Biopsy
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Stony Brook University
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