Clinical trials: Digestive Neoplasms
Gastric Cancer, Organoids
A Clinical Study Aims to Assess the Consistency of Clinical Efficacy in Gastric Cancer Treatment and Drug Susceptibility Outcomes Using a Novel Drug Susceptibility Testing Method
The study is a real-world observational clinical study. Patients diagnosed as gastric cancer through histopathology were screened and enrolled.
- Trial name
- NCT06100003
- Where
- China
- Volunteers
- 104 people
- Sponsor
- Funan Liu
Gastric Cancer, Hepatic Carcinoma
Laryngopharyngeal Injury After Endotracheal Intubation Under General Anesthesia
This study retrospectively analyzed patients who underwent tracheal intubation under general anesthesia at the First Affiliated Hospital of Zhejiang University School of Medicine between October 1, 2015, and September 30, 2025…
- Conditions
- Gastric Cancer, Hepatic Carcinoma, Pulmonary Carcinoma, Pancreatic Carcinoma
- Trial name
- NCT07359586
- Where
- 2 sites in China
- Volunteers
- 1,200 people
- Sponsor
- Zhejiang University
Pancreatic Neoplasms
Gemcitabine, Oxaliplatin and Radiotherapy in Treating Patients With Completely Resected Pancreatic Cancer
A non-randomized phase II study to determine the efficacy and safety of the combination of Gemcitabine and Oxaliplatin followed by Gemcitabine and radiotherapy in patients with surgically resected pancreatic cancer.
- Trial name
- NCT00191568
- Testing
- Gemcitabine, Oxaliplatin, Radiotherapy
- Where
- 6 sites in France
- Volunteers
- 45 people
- Sponsor
- Eli Lilly and Company
Carcinoma, Hepatocellular
Evaluating the Role of ChatGPT in Educating Patients With Early-stage Hepatocellular Carcinoma
Liver cancer is a leading cause of cancer-related deaths in Taiwan, with its onset linked to factors like chronic liver conditions, cirrhosis, and genetic predispositions.
- Trial name
- NCT06384950
- Testing
- ChatGPT, patient education with traditional methods.
- Where
- Taiwan
- Volunteers
- 450 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Gastric Cancer
Microbiota in Gastric Cancer by Gastric Mucosal Brushing
Many studies have shown a significant change of diversity and composition in gut microbiota across the gastric carcinogenesis process, particularly in patients with gastric cancer.
- Trial name
- NCT06325891
- Testing
- Gastric mucosal brushing, Gastric mucosal biopsy
- Where
- 2 sites in Thailand
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- King Chulalongkorn Memorial Hospital
Hepatocellular Carcinoma, Colorectal Cancer
Prospective Clinical Validation of Next Generation Sequencing (NGS) and Patient-Derived Tumor Organoids (PDO) Guided Therapy in Patients With Advanced/ Inoperable Solid Tumors
Precision oncology aims to improve clinical outcome of patients by offering personalized treatment through identifying druggable genomic aberrations within their tumors.
- Trial name
- PDO (NCT06077591)
- Testing
- Patient-Derived Tumor Organoids
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- Chinese University of Hong Kong
Advanced or Metastatic Biliary Tract Cancer
Study of Varlitinib Plus Capecitabine in Patients With Advanced or Metastatic Biliary Tract Cancer
The purpose of the study is to assess the efficacy of varlitinib in combination with capecitabine as measured by objective response rate (ORR) assessed by independent central review (ICR), based on RECIST v1.1 criteria.
- Trial name
- NCT03129074
- Testing
- Varlitinib, Capecitabine
- Sponsor
- ASLAN Pharmaceuticals
Carcinomas of the Esophagogastric Junction
Esophagogastrectomy Versus Extended Gastrectomy in AEG II
Comparison of the oncological outcome of patients who underwent esophagogastrectomy versus extended gastrectomy due to carcinomas of the esophagogastric junction (Siewert type II)
- Trial name
- AEG-II-EG (NCT02302118)
- Testing
- Esophagogastrectomy
- Where
- Germany
- Volunteers
- 128 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Gastric Adenocarcinoma, Adenocarcinoma of the Gastroesophageal Junction
A Study of Ramucirumab Plus Pembrolizumab in Participants With Gastric or GEJ Adenocarcinoma, NSCLC, Transitional Cell Carcinoma of the Urothelium, or Biliary Tract Cancer
The main purpose of this study is to evaluate the safety and preliminary efficacy of the combination of the study drug known as ramucirumab plus pembrolizumab in participants with locally advanced and unresectable or metastatic…
- Conditions
- Gastric Adenocarcinoma, Adenocarcinoma of the Gastroesophageal Junction, Non-small Cell Lung Cancer, Carcinoma, Transitional Cell
- Trial name
- NCT02443324
- Testing
- Ramucirumab, Pembrolizumab
- Where
- 22 sites in United States, France and 4 more
- Volunteers
- 175 people
- Sponsor
- Eli Lilly and Company
Locally Advanced Pancreatic Cancer, Borderline Pancreatic Inoperable Cancer
Folfirinox or Gemcitabine-Nab Paclitaxel Followed by Stereotactic Body Radiotherapy for Locally Advanced Pancreatic Cancer
This study will implement a new treatment regimen for patients with advanced and inoperable pancreatic cancer using chemotherapy combinations of Folfirinox or gemcitabine-nab paclitaxel (abraxane) followed by a short course of…
- Conditions
- Locally Advanced Pancreatic Cancer, Borderline Pancreatic Inoperable Cancer, Pancreatic Cancer
- Trial name
- NCT03600623
- Testing
- Folfirinox, Gemcitabine nab-Paclitaxel
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Alabama at Birmingham
Hepatocellular Carcinoma
68Ga-PSMA-Dual-Contrast PET/MRI or PET/CT for Early Detection of Liver Cancer
This phase II trial studies how well 68Ga-PSMA PET/MRI or PET/CT works in early detection of liver cancer. 68Gallium-PSMA is a radioactive tracer designed to circulate through the body and attach itself to the prostate- specific…
- Trial name
- NCT04762888
- Testing
- Computed Tomography, Gallium Ga 68 Gozetotide, Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Mayo Clinic
Hepatocellular Carcinoma, Liver Cancer
TACE as an Adjuvant Therapy After Radiofrequency Ablation (RFA) for Hepatocellular Carcinoma
The purpose of this study is to prospectively evaluate whether transcatheter arterial chemoembolization (TACE) will improve the outcome of radiofrequency ablation for hepatocellular carcinoma (HCC) or not.
- Trial name
- TACE-RFA (NCT00556803)
- Testing
- radiofrequency ablation, TACE after RFA
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Sun Yat-sen University
Rectum Cancer
Machine Learning-based Surgical Guidance System for Robot-assisted Rectal Surgery
The aim of the study is to evaluate the technical feasibility and applicability of a surgical assistance system based on image recognition algorithms in a first-in-human pilot study.
- Trial name
- CoBot2 (NCT05652361)
- Testing
- Additional visualisation of surgical assistance during surgery
- Where
- Germany
- Volunteers
- 12 people
- Sponsor
- Technische Universität Dresden
Esophageal Squamous Cell Carcinoma
Tumor Microenvironment Changes After Neoadjuvant Chemo-Immunotherapy in Esophageal Squamous Cell Carcinoma
This prospective observational study aims to characterize dynamic changes in the tumor microenvironment of patients with esophageal squamous cell carcinoma receiving standard neoadjuvant chemotherapy combined with immunotherapy…
- Trial name
- TME-ESCC (NCT07482774)
- Testing
- Biological: Tumor Tissue and Blood Sample Collection
- Volunteers
- 12 people
- Sponsor
- Nanjing Medical University
Esophageal Cancer
Combination Chemotherapy and Interferon Alfa Followed by Surgery and/or Radiation Therapy in Treating Patients With Stage I, Stage II, or Stage III Esophageal Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Interferon alfa may interfere with the growth of cancer cells.
- Trial name
- NCT00004897
- Testing
- recombinant interferon alfa, cisplatin, fluorouracil
- Where
- United States
- Sponsor
- Northwestern University
Breast Cancer, Colorectal Cancer
A Study of Poziotinib in Patients With Epidermal Growth Factor Receptor (EGFR) or Human Epidermal Growth Factor Receptor 2 (HER2) Activating Mutations in Advanced Malignancies
This is a Phase 2, open-label, multicenter study whose principal objectives are to evaluate the efficacy and safety/tolerability of poziotinib in five cohorts of 30 previously-treated patients each.
- Conditions
- Breast Cancer, Colorectal Cancer, Solid Tumor, Glioblastome Multiforme
- Trial name
- NCT04172597
- Testing
- Poziotinib Hydrochloride, Loperamide
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Spectrum Pharmaceuticals, Inc
Malignant Neoplasm of Stomach
Radical Gastrectomy and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Locally Advanced Gastric Cancer
The efficacy of HIPEC in prevention of local recurrence, distant metastasis or peritoneal metastasis in locally advanced gastric cancer is not definite.
- Trial name
- NCT02528110
- Testing
- Hyperthermic intraperitoneal chemotherapy (HIPEC), D2 radical gastrectomy, SOX postoperative chemotherapy
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Wuhan University
Peritoneal Carcinomatosis, Pancreas Neoplasm
Combined Nabpaclitaxel Pressurized IntraPeritoneal Aerosol Chemotherapy With Systemic Nabpaclitaxel-Gemcitabine Chemotherapy for Pancreatic Cancer Peritoneal Metastases
Combined chemotherapy consisting of endovenous Nabpaclitaxel-Gemcitabine and Nabpaclitaxel-PIPAC may be a promising treatment for patients affected by pancreatic cancer PM who are in need of curative options.
- Trial name
- Nab-PIPAC (NCT05371223)
- Testing
- Combined Nabpaclitaxel Pressurized IntraPeritoneal Aerosol Chemotherapy With Systemic Nabpaclitaxel-Gemcitabine
- Where
- Italy
- Volunteers
- 38 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Biliary Tract Neoplasms
Second-line Irinotecan and Capecitabine Versus Irinotecan for Gemcitabine and Cisplatin Refractory Biliary Tract Cancer
This study is designed to investigate the effect of second-line irinotecan and capecitabine versus irinotecan alone for gemcitabine and cisplatin refractory advanced biliary tract cancer patients.
- Trial name
- NCT02558959
- Testing
- Irinotecan, Capecitabine
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Zhejiang University
Gastric Cancer
An Open Label Phase 2 Study to Evaluate the Safety and Efficacy of Lenvatinib With Pembrolizumab or Lenvatinib, Pembrolizumab and FLOT in the Neoadjuvant / Adjuvant Treatment for Patients With Gastric Cancer
This study is an open label phase 2 study to evaluate the safety and efficacy of Lenvatinib with Pembrolizumab or Lenvatinib, Pembrolizumab and FLOT in the neoadjuvant / adjuvant treatment for Patients with Gastric Cancer.
- Trial name
- NCT04745988
- Testing
- Lenvatinib 20mg, Pembrolizumab, Lenvatinib 8mg
- Where
- Japan
- Volunteers
- 43 people
- Sponsor
- National Cancer Center Hospital East
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