Clinical trials: Digestive System
Gastric Cancer
Prophylactic Preoperative HIPEC in Advanced Gastric Cancer at High Risk of Peritoneal Recurrence
The study was designed to evaluate the efficacy of perioperative FLOT chemotherapy in combination with perioperative hyperthermic intraperitoneal chemotherapy (HIPEC) in patients with advanced gastric cancer at high risk of…
- Trial name
- CHIMERA (NCT04597294)
- Testing
- FLOT + HIPEC + Surgery, FLOT + Surgery
- Where
- Poland
- Volunteers
- 600 people
- Sponsor
- Jagiellonian University
Chemotherapy-induced Nausea and Vomiting
A Randomized Controlled Trial of SP-01 (Granisetron Transdermal Delivery System) in Chemotherapy-induced Nausea and Vomiting
The purpose of this study is to assess the efficacy and safety of SP-01 in chemotherapy-induced nausea and vomiting (CINV) associated with the administration of moderately or highly emetogenic (ME or HE) multi-day…
- Trial name
- NCT01937156
- Testing
- SP-01 (Granisetron Transdermal Delivery System), Granisetron Hydrochloride Tablet
- Where
- China
- Volunteers
- 313 people
- Sponsor
- Solasia Pharma K.K.
Stomach Neoplasm, Gastric (Stomach) Cancer
A Phase Ib/II Trial of Neoadjuvant Zolbetuximab Plus Docetaxel, Oxaliplatin and S-1 Chemotherapy in Patients With Locally Advanced Gastric Cancer
Claudin 18.2 is a promising therapeutic target overexpressed on the surface of gastric cancer cells. The addition of zolbetuximab, the monoclonal antibody targeting Claudin 18.2 to chemotherapy in two recent Phase 3 studies…
- Trial name
- NEO-CLAUD (NCT06732856)
- Testing
- zolbetuximab, Oxaliplatin, Docetaxel
- Where
- 2 sites in South Korea
- Volunteers
- 57 people
- Sponsor
- Asan Medical Center
Pancreatic Cancer
SBRT Plus Pembrolizumab and Trametinib for Pancreatic Cancer
Hypothesis: Survival benefits could be found in SBRT Plus Pembrolizumab and Trametinib compared with SBRT plus gemcitabine.
- Trial name
- NCT02704156
- Testing
- Cyberknife plus Pembrolizumab and Trametinib, Cyberknife plus Gemcitabine
- Where
- China
- Volunteers
- 170 people
- Sponsor
- Changhai Hospital
Hypoxemia
Recovery Hypoxemia After Sedated Upper Gastrointestinal Endoscopy
Sedation during upper gastrointestinal endoscopy may lead to respiratory events not only during the procedure but also in the early recovery period.
- Trial name
- NCT07445256
- Testing
- Sedated Upper Gastrointestinal Endoscopy
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Istinye University
Gastroenteritis
Evaluation of Immunochromatographic Tests for Campylobacter Detection in Stools
For a long time, culture was the only way to detect Campylobacter. It appears that rapid immunochromatographic tests (ICT) have detected more positive cases compared to culture, ELISA and molecular tests.
- Trial name
- CAMPYTEST (NCT02274922)
- Where
- France
- Volunteers
- 308 people
- Sponsor
- University Hospital, Bordeaux
Hepatitis C Virus Infection, Response to Therapy of
Study to Assess Safety,Tolerability,Pharmacokinetics & Antiviral Activity of JTK-853 in Hepatitis C Virus Genotype 1 Infected Subjects
The purpose of this study was to determine the safety, tolerability, pharmacokinetics and anti-viral activity of JTK-853 in hepatitis C virus genotype 1 infected subjects based on reduction in viral load (HCV RNA level) from…
- Trial name
- NCT01473056
- Testing
- JTK-853, Dose 2 JTK-853, Dose 3 JTK-853
- Where
- Puerto Rico
- Volunteers
- 29 people
- Sponsor
- Shionogi Inc.
Liver Cirrhoses, Variceal Hemorrhage
HVPG-Guided Therapy vs Carvedilol Plus Endotherapy for the Prevention of Esophageal Variceal Rebleeding in Cirrhotic Patients
Variceal bleeding is a major complication of cirrhosis, associated with a hospital mortality rate of 10%-20%. Surviving patients are at high risk for recurrent hemorrhage.
- Conditions
- Liver Cirrhoses, Variceal Hemorrhage, Esophageal Varices
- Trial name
- NCT04254822
- Testing
- Transjugular intrahepatic portosystemic shunt, Carvedilol, Endoscopic variceal ligation
- Where
- China
- Volunteers
- 220 people
- Sponsor
- Air Force Military Medical University, China
Gastrointestinal Diseases, Cardiovascular Diseases
Determining the Potential of Wholegrain Wheat and Rye to Improve Gut HealTh
A dietary intervention study designed as a randomized, controlled, parallel intervention of 6-weeks duration. A total of 75 participants will be included in the study and randomly allocated to one of three interventions (refined…
- Conditions
- Gastrointestinal Diseases, Cardiovascular Diseases, Obesity
- Trial name
- RIGHT (NCT02358122)
- Testing
- Wholegrain rye, Wholegrain wheat, Refined wheat
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Regional Cerebral Blood Flow, Fecal Incontinence
Cerebral Responses During Bilateral/Unilateral Sacral Nerve Stimulation for Idiopathic Faecal Incontinence
The purpose of this study is to determine whether Sacral Nerve Stimulation (SNS) for idiopathic faecal incontinence affect cortical and deep brain activity in an acute and chronically stimulation model.
- Trial name
- NCT01095029
- Testing
- Medtronic InterStim II - 3058
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- University of Aarhus
Steatohepatitis, Nonalcoholic, Osteo Arthritis
DDI Study of ECC0509 With Metformin, Midazolam, and Caffeine
This is a Phase 1, open-label, 2-part, fixed-sequence, single-center, two-period, drug-drug interaction trial in healthy adult participants to determine if ECC0509 administration at steady state affects the pharmacokinetics (PK)…
- Trial name
- NCT07873229
- Testing
- ECC0509, Metformin, Caffeine
- Where
- Australia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Eccogene
Gut Health
Effectiveness of a Butyrate Formulation and Butyrate + Polyphenol Formulation on Gut Health, Permeability and Associated Symptoms
The purpose of this study is the assess the effectiveness and safety of a Butyrate formulation and a Butyrate + Polyphenol formulation on gut health, permeability and associated symptoms
- Trial name
- NCT06419231
- Testing
- Butyrate Formulation, Butyrate + Polyphenol Formulation
- Where
- United States
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- Supplement Formulators, Inc.
Hepatocellular Carcinoma
SBRT as Bridging Therapy for Hepatocellular Carcinoma Patients on Transplant Waitlist
This is a single center, prospective study to assess the efficacy and safety of using stereotactic body radiation therapy (SBRT) as bridging treatment for hepatocellular carcinoma (HCC) patients on transplant waitlist.
- Trial name
- NCT03950102
- Testing
- SBRT
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- The University of Hong Kong
Gastric Cancer, Precancerous Lesion
Nasal Endoscopic Screening and Risk Assessment for Early Gastric Cancer
Pepsinogens (PGs) can be used for gastric cancer (GC) screening, but the cutoff levels vary among studies, and PG levels are influenced by numerous factors.
- Conditions
- Gastric Cancer, Precancerous Lesion, Helicobacter Pylori Infection
- Trial name
- NCT04989153
- Testing
- pepsinogen
- Where
- 9 sites in China
- Volunteers
- 5,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Cancer
Oligogenic Determinism of Colorectal Cancer
The majority of the clinical situations suggestive of an increased genetic risk for colorectal cancer (CRC) are not explained by a simple monogenic model.
- Trial name
- DOCC (NCT01057953)
- Testing
- Blood drawn
- Where
- 16 sites in France
- Volunteers
- 1,550 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Colitis, Ulcerative
Safety and Tolerability Study of GSK2586184 in Patients With Moderate to Severely Active Ulcerative Colitis.
This is an open label exploratory study to investigate the safety of 400 milligram (mg ) twice a day (b.i.d.) GSK2586184 in patients with moderate to severe, active ulcerative colitis (UC).
- Trial name
- NCT02000453
- Testing
- GSK2586184 400mg
- Where
- Netherlands
- Volunteers
- 2 people
- Sponsor
- GlaxoSmithKline
Esophageal Cancer
Tissue Collection Protocol for Gastroesophageal Cancers
This proposed collection of primary tumor cells lines will benefit esophageal cancer research within the University Health Network.
- Trial name
- NCT02495337
- Testing
- Tissue Collection
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University Health Network, Toronto
Colonic Polyps, Colonic Neoplasms
The Impact of Warmed Carbon Dioxide Insufflation During Colonoscopy on Polyp Detection
Colorectal cancer is the second most common cancer in the world and the second leading cause of cancer-related mortality. Colorectal cancers arise from precursor adenomatous polyps in a well characterized adenoma to carcinoma…
- Trial name
- NCT02065037
- Testing
- room temperature air insufflation, warmed carbon dioxide insufflation
- Where
- Canada
- Volunteers
- 229 people
- Sponsor
- Queen's University
Primary Sclerosing Cholangitis, IgG4-related Sclerosing Cholangitis
Multicenter Observational Study of PSC and IgG4-SC in China
The investigators aimed to collect demographic features and clinical outcomes in patients diagnosed with PSC and IgG4-SC by utilizing participants database from multiple medical centers across Mainland China.
- Trial name
- NCT05463445
- Testing
- Only observation
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- RenJi Hospital
Liver Cancer, Dropout, Patient
A Worldwide Score for Hepatocellular Cancer and Liver Transplantation
The present study has been developed with multiple aims: 1) to refine available models for liver transplantation which would be able to cover the fate of HCC candidates from an ITT point of view; 2) to develop such an approach on…
- Conditions
- Liver Cancer, Dropout, Patient, Recurrence
- Trial name
- TRAIN-SCORE (NCT03595345)
- Testing
- Liver transplantation
- Where
- Belgium
- Volunteers
- 3,100 people
- Sponsor
- European Hepatocellular Cancer Liver Transplant Group
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