Clinical trials: Digestive System
Exocrine Pancreatic Insufficiency
An Open-Label Study to Evaluate the Intraduodenal Delivery of Enzymes From Administration of VIOKASE16 in Exocrine Pancreatic Insufficiency (EPI)
EPI leading to maldigestion is a frequent finding in many diseases of the pancreas, such as chronic pancreatitis (CP). Steatorrhea is the most important digestive manifestation in EPI.
- Trial name
- NCT00559052
- Testing
- VIOKASE 16
- Where
- 2 sites in United States
- Volunteers
- 22 people
- Sponsor
- Axcan Pharma
Colorectal Cancer
Incidence of Colorectal Cancer in Southwest China: Based on SCC Database
To evaluate recent trends in CRC incidence, treatment, and survival in the Southwest China.
- Trial name
- NCT06172049
- Testing
- treatment
- Where
- China
- Volunteers
- 5,838 people
- Sponsor
- West China Hospital
Colorectal Cancer, Colorectal Carcinoma
Microsatellite Instability in Colorectal Cancers
In this study, we aimed to identify the different histopathological features of tumors with microsatellite instability (MSI) compared to microsatellite stable (MSS) in patients who underwent surgery for colorectal cancer.
- Conditions
- Colorectal Cancer, Colorectal Carcinoma, Microsatellite Instability High, Microsatellite Instability Low
- Trial name
- MSI-CRC (NCT05162248)
- Testing
- Microsatellite instability analysis
- Where
- Turkey (Türkiye)
- Volunteers
- 231 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Colorectal Cancer
Protein Recommendation to Increase Muscle
This is a feasibility study to test the potential efficacy of diets of different amounts of protein and calories for patients with cancer.
- Trial name
- PRIMe (NCT02788955)
- Testing
- Dietary counselling, Dietary Protein
- Where
- 2 sites in Canada
- Volunteers
- 50 people
- Sponsor
- University of Alberta
Abdominal Pain
Sublingual Analgesia for Acute Abdominal Pain in Children
Acute abdominal pain is a frequent symptom in children admitted to the emergency department . In the past the fear of masking a surgical condition has justified withholding analgesia in patients with acute abdominal pain.
- Trial name
- NCT02465255
- Testing
- Ketorolac, Tramadol, Acetaminophen
- Where
- Italy
- Volunteers
- 210 people
- Sponsor
- IRCCS Burlo Garofolo
Nutrition Assessment, Geriatric Anesthesia
The Effect of Nutritional Status on Postoperative Mortality and Morbidity in the Geriatric Population Undergoing Gastrointestinal Surgery
The purpose of this study was to compare the sensitivity and specificity of the Geriatric Nutritional Risk Index (GNRI), Mini Nutritional Assessment Scale-Short Form (mNA-SF) and Systemic Immune-Inflammatory Index (SII) values…
- Trial name
- NCT07374055
- Testing
- Preoperative Risk Scoring, Postoperative Morbidite and Mortality Monitoring, Delirium Assessment Protocol
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Gastroesophageal Reflux Disease, Hiatal Hernia
Nissen and Gastroplasty in Gastroesophageal Reflux Disease (GERD)
Laparoscopic Nissen Fundoplication has established itself as the procedure of choice in the surgical management of the majority of patients suffering from gastroesophageal reflux disease (GERD).
- Conditions
- Gastroesophageal Reflux Disease, Hiatal Hernia, Barrett's Esophagus, Esophagitis
- Trial name
- NCT00872755
- Testing
- Nissen, Gastropexy
- Where
- Greece
- Volunteers
- 90 people
- Sponsor
- G. Hatzikosta General Hospital
Colorectal Adenomas
Antioxidant Supplement and Reduction of Metachronous Adenomas of the Large Bowel: a Double Blind Randomized Trial
The trial was aimed at evaluating the efficacy of a multiagent antioxidant compound (vitamin A, C, E, selenium and zinc) in reducing the incidence of metachronous adenomas of the large bowel after endoscopic polypectomy.
- Trial name
- NCT01437826
- Testing
- antioxidants
- Where
- Italy
- Volunteers
- 411 people
- Sponsor
- IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
Pancreatic Cancer
A Clinical Study of UFT/Leucovorin, Radiotherapy With or Without Cetuximab Following Induction Gemcitabine Plus Capecitabine in Patients With Locally Advanced Pancreatic Cancer (PERU)
The purpose is to assess the overall survival of patients receiving either UFT/LV + radiotherapy (RT) or UFT/LV + Cetuximab + RT after neo-adjuvant chemotherapy.
- Trial name
- PERU (NCT01050426)
- Testing
- UFT, Leucovorin, UFT/ Leucovorin + Cetuximab + Radiotherapy
- Where
- 8 sites in United Kingdom
- Volunteers
- 17 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Hepatocarcinoma, Hepatic Metastasis
Robotic Endomicroscopy to Better Define Resection Strategies Applied to Hepatic Surgery
This study aims at assessing the feasibility of Probe-based Confocal Laser Endomicroscopy (pCLE) during laparoscopic hepatic masses resection for intra-operative characterisation of hepatic masses and surgical margins assessment.
- Conditions
- Hepatocarcinoma, Hepatic Metastasis, Hepatic Tumor
- Trial name
- PERSEE (NCT03718078)
- Testing
- Confocal Laser Endomicroscopy
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Mauna Kea Technologies
Crohn's Disease
Observational Study Evaluating the Effectiveness of Drug Concentration to Predict the Recapture of Response in Crohn's Disease Patients With Loss of Response ( PRADA )
This is a multi-center study that explores the relationship between recapture of response with escalation to weekly adalimumab and trough adalimumab concentration before escalation in patients experiencing lack of response (LOR).
- Trial name
- PRADA (NCT02896985)
- Where
- 24 sites in Canada
- Volunteers
- 98 people
- Sponsor
- AbbVie
Brain and Central Nervous System Tumors, Childhood Germ Cell Tumor
Development of Strategies to Increase Enrollment in Clinical Trials for Children With Cancer
RATIONALE: Taking part in a clinical trial may help children with cancer receive more effective treatment. PURPOSE: Determine why patients who are eligible for protocols made available through the Pediatric Oncology Group do not…
- Conditions
- Brain and Central Nervous System Tumors, Childhood Germ Cell Tumor, Extragonadal Germ Cell Tumor, Leukemia
- Trial name
- NCT00002485
- Testing
- psychosocial assessment and care
- Where
- 31 sites in United States, Canada and 2 more
- Volunteers
- 359 people
- Sponsor
- Children's Oncology Group
Drug-Induced Liver Injury
A Real World Study of Polyene Phosphatidylcholine Injection for the Prevention and Treatment of DILI in Patients With Malignant Hematological Diseases
This is a retrospective, multicenter real-world observational study. Its main goal is to find out if Polyene Phosphatidylcholine Injection works to treat drug-induced liver injury (DILI) in adults with hematologic malignancies…
- Trial name
- PPC-HM-DILI (NCT07476885)
- Testing
- polyene phosphatidylcholine
- Volunteers
- 1,000 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Colorectal Cancer Metastatic
Evaluation of CTCs Combined With Tumor Marker Detection of Efficacy of Chemotherapy in mCRC
Evaluation of individual peripheral blood circulating tumor cells combined with tumor marker detection of efficacy of chemotherapy in patients with advanced colorectal cancer: A observational clinical trial
- Trial name
- NCT02948985
- Testing
- treated with FOLFIRI±cetuximab
- Volunteers
- 100 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Cystic Fibrosis
Video Game Exercise Effectiveness of a Domiciliary Pulmonary Rehabilitation Program in Cystic Fibrosis Patients
The aim of this study is to evaluate the efficacy of a long-term domiciliary exercise program using the Wii video game platform as a training modality in Cystic Fibrosis (CF) patients.
- Trial name
- NCT02552043
- Testing
- Nintendo Wii exercise program
- Where
- Spain
- Volunteers
- 41 people
- Sponsor
- Universidad Autonoma de Madrid
Cancer, Digestive System, Cancer, Rectum
PREHAB - Improving Condition Before Surgery
The pilot research project is focused on the feasibility of a prehabilitation program for two groups of diagnoses (esophageal and stomach cancer, rectal cancer).
- Trial name
- NCT05646043
- Testing
- Physical training, Muscle strength training
- Where
- Czechia
- Volunteers
- 40 people
- Sponsor
- University Hospital Ostrava
Gastrointestinal Cancer Metastatic
MAESTRO Study: Metabolic Imaging to Improve Patient-Specific Therapy Outcomes
Patients suffering metastasized gastrointestinal cancer often receive ineffective treatments for prolonged periods of time as therapy non-response, which is hard to detect, cannot be determined earlier than nine weeks following…
- Trial name
- MAESTRO (NCT04534543)
- Testing
- MRI/Spectroscopy
- Where
- 2 sites in Netherlands
- Volunteers
- 70 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Breast Cancer, Colon Cancer
Partnership for Healthy Seniors
The Centers for Medicare and Medicaid Services (CMS) has awarded cooperative agreements to 6 sites from across the country (Salt Lake City, UT, Molokai, HI, Houston, TX, Newark, NJ, Detroit, MI, and Baltimore City) to participate…
- Conditions
- Breast Cancer, Colon Cancer, Rectum Cancer, Cervix Cancer
- Trial name
- NCT00379743
- Testing
- Health coordinator (or patient navigator), Educational materials only
- Where
- United States
- Volunteers
- 2,593 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Advanced Parkinson's Disease
Effect of Rotigotine on Motor Symptoms in Patients With Advanced Parkinson's Disease (PD) With Motor Fluctuations and Symptoms of Gastrointestinal Dysfunction
The primary purpose is to demonstrate superiority of Rotigotine over Placebo on motor symptoms when used in subjects with symptoms of Gastrointestinal Dysfunction. Hypothesis: Rotigotine will decrease OFF time compared to Placebo.
- Trial name
- ROADMAP (NCT01536015)
- Testing
- Rotigotine
- Where
- 26 sites in United States
- Volunteers
- 25 people
- Sponsor
- UCB Pharma
Cystic Fibrosis
Comparison of Inhaled Mannitol and rhDNase in Children With Cystic Fibrosis
The purpose of this study is to determine the medium term efficacy and safety profile of inhaled mannitol, on its own and also as an additional therapy to rhDNase (pulmozyme).
- Trial name
- NCT00117208
- Testing
- mannitol, mannitol + pulmozyme, Dornase alpha
- Where
- 2 sites in United Kingdom
- Volunteers
- 20 people
- Sponsor
- Syntara
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