Clinical trials: Digestive System
Postoperative Dumping Syndrome
Study to Assess Safety and Efficacy of sc Pasireotide in Patients With Dumping Syndrome
Dumping Syndrome consists of (1) a too rapid gastric emptying, (2) an inappropriate release of GI hormones (as a reaction to the hyperosmolar contents in the duodenum) and (3) an hyperinsulinemic response to a too rapid…
- Trial name
- CSOM230BBE01T (NCT01895296)
- Testing
- Pasireotide
- Where
- Belgium
- Volunteers
- 9 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Nonalcoholic Fatty Liver Disease (NAFLD), Type 2 Diabetes (T2DM)
Lanifibranor in Patients With Type 2 Diabetes & Nonalcoholic Fatty Liver Disease
The primary aim is to establish the safety, efficacy and mechanism of action of lanifibranor in patients with type 2 diabetes (T2DM) and nonalcoholic fatty liver disease (NAFLD).
- Trial name
- NCT03459079
- Testing
- Lanifibranor
- Where
- United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- University of Florida
Barrett Esophagus, Barrett Adenocarcinoma
Neoplastic Barrett Esophagus: Endoscopic Piecemeal vs. En Bloc Resection
The study will compare EMR versus ESD technique (both combined with subsequent ablative therapy) of mucosal resection in Barrett's esophagus with regard to efficacy and risk in a long term setting.
- Conditions
- Barrett Esophagus, Barrett Adenocarcinoma, Esophagus Neoplasm
- Trial name
- BEEPER (NCT03427346)
- Testing
- Endoscopic mucosal resection, Endoscopic submucosal dissection
- Where
- 2 sites in United States, Germany
- Volunteers
- 407 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Gastrointestinal Dysfunction, Cardiac Surgery Intensive Care Treatment
Prognosis and Diagnosis of Acute Gastrointestinal Dysfunction in Cardiac Surgery Patients
The purpose of this prospective observational clinical cohort study is to develop a scientifically based approach to the prediction and early diagnosis of intestinal dysfunction in cardiac surgery patients.
- Conditions
- Gastrointestinal Dysfunction, Cardiac Surgery Intensive Care Treatment, Cardiac Surgery, Cardiac Surgery in Adult Patient
- Trial name
- PREDICT-GICS (NCT07422246)
- Testing
- additional blood testing for specific and non-specific markers of intestinal dysfunction, ultrasound examination of abdominal organs and measurement of intra-abdominal pressure
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- Petrovsky National Research Centre of Surgery
Drug Interaction Potential
Effect of Pexidartinib on the Way the Body Processes CYP3A4 and CYP2C9 Substrates (Pharmacokinetics)
This study has two parts. Part 1 will evaluate how pexidartinib affects the way the body processes CYP3A4 and CYP2C9 substrates using midazolam and tolbutamide, respectively, as probe agents.
- Trial name
- NCT03291288
- Testing
- Tolbutamide, Midazolam, Pexidartinib
- Where
- 11 sites in United States, Netherlands and 2 more
- Volunteers
- 32 people
- Sponsor
- Daiichi Sankyo
Pancreatic Cancer
XB2001 in Combination With ONIVYDE + 5-FU/LV (+Folinic Acid) in Advanced Pancreatic Cancer
This trial will include 2 portions (phase 1 and phase 2). The first portion will be a Phase I, open label, dose escalation study to establish the maximum tolerated dose (MTD) of XB2001 as measured by Dose-Limiting Toxicity (DLT)…
- Trial name
- 1-BETTER (NCT04825288)
- Testing
- Phase I: XB2001 250 mg, Phase I: XB2001 500 mg, Phase I: XB2001 1000 mg
- Where
- 30 sites in United States
- Volunteers
- 76 people
- Sponsor
- XBiotech, Inc.
Colorectal Cancer
A Phase II Study of AMT-676 Combination Therapies in Advanced Colorectal Cancer
This study is an open, multi-center, phase II study, aiming to evaluate the safety, tolerability and efficacy of AMT-676 combined with 5-fluorouracil, leucovorin, bevacizumab (or cetuximab) in participants with advanced…
- Trial name
- NCT07474727
- Testing
- AMT-676, 5-FU, Leucovorin
- Where
- 19 sites in China
- Volunteers
- 180 people
- Sponsor
- Multitude Therapeutics Inc.
Non-alcoholic Fatty Liver Disease
Runihol in Nonalcoholic Fatty Liver Disease and Metabolic Syndrome
The study is designed to assess the safety and efficacy of different doses and dosing regimens of Runihol, tablets, enteric coated, produced by "NTFF" POLYSAN" (Russia), in prevention of liver disease progression in patients with…
- Trial name
- NCT02930161
- Testing
- Runihol
- Where
- 3 sites in Russia
- Volunteers
- 35 people
- Sponsor
- POLYSAN Scientific & Technological Pharmaceutical Company
Cystic Fibrosis
Biomarkers of Injury and Destruction in the Cystic Fibrosis Lung
Cystic fibrosis (CF) is the most common autosomal recessive genetic disease in Caucasians. It results in lung disease that affects quality of life and causes early death.
- Trial name
- NCT01805713
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Minnesota
Cirrhosis, Liver
Platelet Indices Could Predict Spontaneous Bacterial Peritonitis in Cirrhotic Ascitic Patients
Spontaneous bacterial peritonitis (SBP) is an ascitic fluid infection in cirrhotic patients
- Trial name
- NCT03172013
- Testing
- Platelet indices
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tanta University
Stomach Neoplasms
Study Of Sunitinib In Combination With Cisplatin/Capecitabine Or Oxaliplatin/Capecitabine In Patients With Advanced Gastric Cancer
The purpose of the study is to determine the safe and tolerable doses of sunitinib given together with either cisplatin and capecitabine or oxaliplatin and capecitabine in patients who have advanced gastric cancer who have not…
- Trial name
- NCT00555620
- Testing
- capecitabine, oxaliplatin, sunitinib malate
- Where
- 3 sites in South Korea
- Volunteers
- 76 people
- Sponsor
- Pfizer
Radiotherapy Induced Mucositis, Head and Neck Cancer
A Randomized Placebo-Controlled Trial of Manuka Honey for Oral Mucositis Due to Radiation Therapy for Cancer
The primary hypothesis of this study is that regular topical oral application of Manuka Honey will reduce the severity and duration of oral mucositis in patients who are undergoing mucotoxic radiation therapy for cancer treatment.
- Trial name
- NCT00615420
- Testing
- manuka honey
- Where
- 2 sites in Canada
- Volunteers
- 106 people
- Sponsor
- British Columbia Cancer Agency
Colorectal Neoplasms
Study to Determine Safety, Pharmacokinetics, Pharmacodynamics of BAY73-4506 in Combination With mFOLFOX6 or FOLFIRI
This multi-center, open-label, non-randomized, non-placebo-controlled, Phase I study will define the safety profile and tumor response profile of the multi-kinase inhibitor BAY73-4506 as oral treatment in combination with the…
- Trial name
- NCT00934882
- Testing
- Regorafenib (BAY73-4506)
- Where
- 7 sites in Germany
- Volunteers
- 45 people
- Sponsor
- Bayer
Cystic Fibrosis
The Effect of Inhaled N-Acetylcysteine Compared to Normal Saline on Sputum Rheology and Lung Function
Inhalation treatment with mucolytics is one of the cornerstones of CF treatment for respiratory problems. The efficacy of inhalation treatment with recombinant DNAse and hypertonic saline is well established.
- Trial name
- NCT00996424
- Testing
- Acetylcysteine, normal saline
- Where
- Belgium
- Volunteers
- 19 people
- Sponsor
- University Hospital, Ghent
Colorectal Neoplasms
Understanding Sugar-Sweetened Beverages (SSB) and Colorectal Cancer (CRC)
This study will recruit and consent approximately 120 subjects in the baseline study until the follow-up study recruitment goals of 20 subjects is met.
- Trial name
- SSB and CRC (NCT06669923)
- Testing
- iSIPsmarter Program, Patient Education
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Gynecologic Cancer, Colorectal Cancer
Long-Term Follow-up Study of Subjects Treated With Autologous T Cells Using the Sleeping Beauty System to Express TCRs
Long-Term Follow-Up Study for Subjects Enrolled in the Phase I/II Study of Autologous T Cells Engineered using the Sleeping Beauty System to Express T cell Receptors (TCRs) Reactive Against Cancer-specific Mutations in Subjects…
- Conditions
- Gynecologic Cancer, Colorectal Cancer, Pancreatic Cancer, Non-small Cell Lung Cancer
- Trial name
- NCT05292859
- Testing
- Neoantigen specific TCR-T cell drug product
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Alaunos Therapeutics
Locally Advanced Rectal Cancer, Electrochemotherapy
Endoscopic Assisted Electrochemotherapy in Addition to Neoadjuvant Treatment of Locally Advanced Rectal Cancer
The purpose of this study is to evaluate the efficacy and safety of neoadjuvant electrochemotherapy on locally advanced rectal cancer (UICC II-III) in an intended curative clinical setting, using an endoscopic electroporation…
- Conditions
- Locally Advanced Rectal Cancer, Electrochemotherapy, Neoadjuvant Therapy, Down Staging
- Trial name
- nECT (NCT03040180)
- Testing
- Electrochemotherapy with bleomycin, EndoVE
- Where
- 2 sites in Denmark
- Volunteers
- 40 people
- Sponsor
- Zealand University Hospital
Nonalcoholic Fatty Liver Disease
Therapeutic Effects of Compound Zhenzhu Tiaozhi Capsules in NAFLD
This is a randomised clinical trial which aims to evaluate the efficacy of Compound Zhenzhu Tiaozhi capsules in the treatment of NAFLD and analyze the relationship between improvement in NAFLD parameters and changes in intestinal…
- Trial name
- NCT03375580
- Testing
- TLC, metformin, Compound Zhenzhu Tiaozhi capsule
- Where
- China
- Volunteers
- 196 people
- Sponsor
- The First Affiliated Hospital of Guangdong Pharmaceutical University
Inflammatory Bowel Diseases, Crohn Disease
The PRognostic Effect of Environmental Factors in Crohn's and Colitis
The PREdiCCt Study: This is a major study that is now being launched. This is the first study of its kind and is specifically directed toward understanding how environmental factors and the gut microorganisms influence IBD flare…
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis
- Trial name
- PREdiCCt (NCT03282903)
- Where
- 41 sites in United Kingdom
- Volunteers
- 2,629 people
- Sponsor
- University of Edinburgh
Chronic Pancreatitis
Fatigue, Psychological Comorbidity and Quality of Life Among Patients With Chronic Pancreatitis in China.
This study will investigate the status of fatigue, psychological comorbidity and quality of life among patients with chronic pancreatitis in China and analyze their influencing factors.
- Trial name
- NCT05489003
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Changhai Hospital
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