Clinical trials: Digestive System
Hepatitis C
Response Guided Treatment With Direct Acting Anti-Viral Medications for Chronic HCV Infection
To evaluate the efficacy and safety of direct acting anti-viral agents (DAA) therapy in chronically infected Hepatitis C Virus (HCV) patients using an individualized response guided therapy (RGT) model.
- Trial name
- NCT03603327
- Testing
- Direct acting anti-viral agents
- Where
- 2 sites in Israel
- Volunteers
- 30 people
- Sponsor
- Soroka University Medical Center
Ulcerative Colitis
Gastrointestinal Transit Times and Motility in Severe Ulcerative Colitis Obtained by Motilis-3D-transit
The purpose of this study is to describe gastrointestinal (GI) motility in patients suffering from severe Ulcerative Colitis (UC) and to compare these results with similar results from a study on healthy subjects.
- Trial name
- NCT01752361
- Testing
- Motilis-3D transit
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- University of Aarhus
Gastrointestinal Tumors, Solid Tumor
A Study of GNC-077 in Patients With Locally Advanced or Metastatic Gastrointestinal Tumors and Other Solid Tumors
This study is an open-label, multicenter, dose-escalation and cohort expansion phase I clinical study to evaluate the safety, tolerability, pharmacokinetics characteristics or preliminary efficacy and antitumor activity in…
- Trial name
- NCT06755242
- Testing
- GNC-077
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Sichuan Baili Pharmaceutical Co., Ltd.
Liver Metastases, Colorectal Cancer
Comparison of Triphasic CT, PET and MR Tumour With Pathological Findings in Colorectal Cancer Liver Metastases
The purpose of this study is to correlate the MRI CT and PET appearances of colorectal liver metastases to pathologic appearance ot better understand the accuracy of imaging to determine tumor size.
- Trial name
- NCT00242086
- Testing
- CT, PET and MRI
- Where
- Canada
- Volunteers
- 7 people
- Sponsor
- University Health Network, Toronto
Liver Cirrhosis
Changes in Lab and Ultrasonography After Endoscopic Varisceal Treatment
laboratory and ultrasongraphicc changes after endoscopical varices treatment
- Trial name
- NCT03269786
- Testing
- Liver function tests (ALT,AST,ALBUMIN,BILIRUBIN,INR,PC,CBC), biannual ultrasonography
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Acute Liver Failure, Sepsis
Transcriptional Analysis of Mechanisms in Liver Failure and Sepsis
Context Acute liver failure (ALF) is a life-threatening condition that occurs on the background of a healthy liver. The most common cause of acute liver failure in the UK is paracetamol overdose.
- Trial name
- MAP-ALF (NCT07131969)
- Testing
- blood draw
- Where
- 7 sites in United Kingdom
- Volunteers
- 100 people
- Sponsor
- University of Cambridge
Pancreatitis, Acute Necrotizing
Videoendoscopic Drainage of Infected Pancreatic Collections
The VARD (Videoendoscopic Assisted Retroperitoneal Drainage) approach as treatment for necrotizing pancreatitis proposes an alternative to standard complicated open abdomen treatment methods.
- Trial name
- NCT00061269
- Testing
- Videoscopic-Assisted Retroperitoneal Debridement (VARD)
- Where
- 6 sites in United States, Canada
- Volunteers
- 40 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Advanced Gastrointestinal Stromal Tumor (GIST)
BGJ398 in Combination With Imatinib Mesylate in Patients With Untreated Advanced Gastrointestinal Stromal Tumor (GIST)
The goal of a phase Ib clinical trial is to find the doses of drugs that are safe. Although BGJ398 has been given to patients safely on its own, it has never been given together with imatinib mesylate.
- Trial name
- NCT02257541
- Testing
- BGJ398, Imatinib Mesylate
- Where
- 7 sites in United States
- Volunteers
- 16 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Pancreatic Fistula
Comparison of Feasibility Between Internal and External Pancreatic Drainage in Pancreaticoduodenectomy
Pancreatic fistula is one of the most serious complication after pancreatoduodenectomy. To reduce pancreatic fistula, many authors recommend pancreatic stent in pancreatojejunostomy.
- Trial name
- NCT01023594
- Testing
- Pancreatic stent
- Where
- 8 sites in South Korea
- Volunteers
- 328 people
- Sponsor
- Seoul National University Hospital
Colorectal Cancer
Studying a Quality of Life Questionnaire in Patients With Colorectal Cancer
RATIONALE: Collecting information about the quality of life of patients with colorectal cancer may help doctors learn more about the disease.
- Trial name
- NCT00564694
- Testing
- psychosocial assessment and care, quality-of-life assessment
- Where
- 5 sites in France, Germany and 1 more
- Volunteers
- 350 people
- Sponsor
- National Cancer Institute (NCI)
Droplet Transmission
Exposure Measurements and Interventions for Aerosol Produced by Gastrointestinal Endoscopy
Study objective: To clarify the risk of exposure to the exhaled aerosol droplets from patients for medical staffs during digestive endoscopy via labelling the oral mucosa with vitamin B2 solution, and evaluate the protective…
- Trial name
- NCT05321056
- Testing
- masks (surgical mask, respirator)
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Peking Union Medical College Hospital
Crohn's Disease
Fundamental Modification of the Gut Microbiota in the Treatment of Refractory Crohn's Disease
To determine the effect of a novel gut microbiota-targeted therapeutic regimen (bowel lavage and antibiotics with or without an antifungal) in the management of active Crohn's Disease (CD) that is refractory to conventional…
- Trial name
- Holiday (NCT02765256)
- Testing
- Fluconazole, Vancomycin, Neomycin
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Pennsylvania
Gastric Cancer
Palliative Radiotherapy for Symptomatic Locally Advanced Gastric Cancer: A Phase II Trial
The hypothesis of this study is that a radiotherapy dose of 36Gy in 12 fractions, which equates to a BED of 48.6Gy, increases the response rates of symptom relief compared to historical controls.
- Trial name
- NCT01341756
- Testing
- Palliative Radiotherapy
- Where
- Singapore
- Volunteers
- 63 people
- Sponsor
- National University Hospital, Singapore
Colon Cancer
Healthy Eating for Colon Cancer Prevention
The purpose of this study is to help develop diets for colon cancer prevention. This study will compare the Mediterranean diet to the Healthy People 2010 diet in 120 subjects with increased risk for colorectal cancer.
- Trial name
- NCT00475722
- Testing
- 1 Healthy Eating, 2 Mediterranean
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Chronic Hepatitis B
Safety and Antiviral Study of ACH-126, 443 (Beta-L-Fd4C) in the Treatment of Adults With Chronic Hepatitis B Infection.
The purpose of this study is to determine the safety and antiviral HBV activity of ACH-126,443 (beta-L-Fd4C) in the treatment of Subjects of Previous Achillion-Sponsored Phase 1 and 2 Studies in Chronic Hepatitis B Infection.
- Trial name
- NCT00037622
- Testing
- ACH-126, 443 (beta-L-Fd4C)
- Volunteers
- 100 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
Portal Hypertension
Acute Hemodynamic Response to Carvedilol in Children With Clinically Significant Portal Hypertension.
Clinically significant portal hypertension (CSPH) is defined as Hepatic Venous Pressure gradient (HVPG) >10 mmHg. Patients with CSPH are at risk of developing esophageal varices and clinical decompensation (variceal bleeding…
- Trial name
- NCT05767229
- Testing
- Carvedilol
- Where
- India
- Volunteers
- 40 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Gastrointestinal Cancer
Effectiveness of Low Dose Aspirin in Decreasing the Chance Getting Stomach and Intestine Cancer
In this study, researchers wanted to learn more about the effect of Aspirin taken as low dose (75 - 300 mg) in preventing stomach, colorectal and esophagus cancer.
- Trial name
- ENgAGE-HK (NCT04081831)
- Testing
- Acetylsalicylic Acid (Aspirin, BAYE4465)
- Where
- Hong Kong
- Volunteers
- 99,999 people
- Sponsor
- Bayer
Cancer Survivor, Dysphagia
Manual Therapy in Treating Fibrosis-Related Late Effect Dysphagia in Head and Neck Cancer Survivors
This trial studies how well manual therapy works in treating fibrosis-related late effect dysphagia in head and neck cancer survivors.
- Conditions
- Cancer Survivor, Dysphagia, Fibrosis, Head and Neck Carcinoma
- Trial name
- MANTLE (NCT03612531)
- Testing
- Manual Therapy
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- M.D. Anderson Cancer Center
Incontinence, Urinary, Incontinence, Fecal
Testing the Protective and Caring Effect of a Water-in-oil Formulation in Patients Suffering From Urinary and/or Fecal Incontinence and Requiring Incontinence Care Products
The aim of this study is to test the protecting and caring effect of a protective balm on patients suffering from urinary and/or fecal incontinence and need incontinence care products.
- Trial name
- NCT06924502
- Testing
- Protective Balm
- Where
- Germany
- Volunteers
- 33 people
- Sponsor
- Dr. August Wolff GmbH & Co. KG Arzneimittel
Nonalcoholic Steatohepatitis (NASH)
Study in Healthy Volunteers to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of GS-9674 (Cilofexor), and the Effect of Food on GS-9674 Pharmacokinetics and Pharmacodynamics
This study will evaluate the safety and tolerability of escalating single- and multiple-oral doses of cilofexor, and characterize the single- and multiple-dose pharmacokinetics (PK) of cilofexor.
- Trial name
- NCT02654002
- Testing
- Cilofexor
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Gilead Sciences
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.