Clinical trials: Digestive System
Hepatitis B, Chronic
Safely Discontinue Antiviral Treatment in Patients With Chronic Hepatitis B
Multicenter, Prospective Open-label Single Arm Trial Chronic hepatitis B male and female adults on antiviral treatment for hepatitis B, without cirrhosis who are currently HBV DNA (-) and HBeAg (-) To evaluate the safety and…
- Trial name
- ADAPT (NCT04782375)
- Testing
- Stop group
- Where
- 4 sites in South Korea
- Volunteers
- 140 people
- Sponsor
- Asan Medical Center
Necrotizing Enterocolitis, Digestive System Abnormalities
Brain Manganese Deposition in High Risk Neonates
Excessive exposure to manganese (Mn) results in Mn deposition in the brain causing adverse neurological effects. Sick infants requiring parenteral nutrition (PN) may be at increased risk of Mn neurotoxicity because neonatal PN…
- Conditions
- Necrotizing Enterocolitis, Digestive System Abnormalities, Cholestasis
- Trial name
- NCT00392977
- Testing
- remove Mn from PN if evidence of increased brain Mn on MRI
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Vanderbilt University
Obesity, PreDiabetes
Network Meta-analysis of Intermittent Fasting and Cardiometabolic Risk
Intermittent fasting is a method of restricting calories over a defined period of time and includes regimens such as whole-day fasting, alternate-day fasting, and time-restricted feeding.
- Conditions
- Obesity, PreDiabetes, Diabetes, Hypertension
- Trial name
- NCT05309057
- Testing
- Intermittent Fasting
- Where
- 2 sites in Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Cystic Fibrosis
Ivacaftor in French Patients With Cystic Fibrosis and a G551D Mutation
The purpose of this study is to determine whether the treatment with Ivacaftor remains effective and safe in the patients with cystic fibrosis (and at least one G551D CFTR mutation) in the real life setting, after the drug has…
- Trial name
- IVACAFTOR1 (NCT02194881)
- Testing
- CF patients with a G551D mutation and treated with Ivacaftor
- Where
- France
- Volunteers
- 57 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Gastric Cancer
Trial of Preoperative Therapy for Gastric and Esophagogastric Junction Adenocarcinoma
Gastric cancer remains a significant global public health problem. Although in developed countries its incidence has dramatically decreased, on a worldwide scale it is still a leading cause of cancer-related deaths.
- Trial name
- TOPGEAR (NCT01924819)
- Testing
- Epirubicin + cisplatin + 5-fluorouracil OR epirubicin + cisplatin + capecitabine OR epirubicin + oxaliplatin + capecitabine OR 5-Fluorouracil + leucovorin + oxaliplatin + docetaxel, Preoperative chemoradiotherapy, Gastric resection
- Where
- 59 sites in Australia, Belgium and 8 more
- Volunteers
- 574 people
- Sponsor
- Australasian Gastro-Intestinal Trials Group
Anal Cancer
Study of Pembrolizumab, Carboplatin, Paclitaxel, and Radiation for the Treatment of Early-Stage Anal Cancer
A single arm phase II study of pembrolizumab, carboplatin, paclitaxel, and radiation for the treatment of early-stage anal cancer. There are 2 treatments phases and then surveillance.
- Trial name
- NCT06493019
- Testing
- Pembrolizumab, Paclitaxel, Carboplatin
- Where
- 5 sites in United States
- Volunteers
- 23 people
- Sponsor
- Dustin Deming
Fatty Liver
Weight Management in Nonalcoholic Steatohepatitis
Nonalcoholic steatohepatitis (NASH) is one of the most common chronic liver diseases. The cause of NASH is not completely understood and currently there is no effective treatment for this disease.
- Trial name
- NCT00266019
- Testing
- Weight Management (diet, exercise, and behavior modification)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Peritoneal Metastases, Gastric Cancer
HIPEC Combined With SOX and Sintilimab in the Treatment of Advanced Gastric Cancer With Peritoneal Metastasis
The prognosis of patients with peritoneal metastasis from gastric cancer is extremely poor. Although chemotherapy combined with immunotherapy has achieved promising efficacy in the first-line treatment of advanced gastric cancer…
- Trial name
- NCT06213519
- Testing
- S-1, Oxaliplatin sintilimab HIPEC
- Volunteers
- 69 people
- Sponsor
- Sichuan University
Colon Carcinoma, Colonic Polyps
Measuring the Spectrum of Tissues During Endoscopy
Lesions, polyps and other abnormalities in the gastrointestinal (GI) tract have a different composition compared to the normal mucose. The investigators plan to gather spectroscopic information from these features.
- Conditions
- Colon Carcinoma, Colonic Polyps, Intestinal Polyps
- Trial name
- NCT00996619
- Testing
- An optical fiber, inside the work channel of an endoscope, is added to the endoscopic examination
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Anal Cancer, High-grade Squamous Intraepithelial Lesion
Treatment in Preventing Anal Cancer in Patients With HIV and Anal High-Grade Lesions
The randomized phase of the trial compared topical or ablative treatment with active monitoring in preventing anal cancer in patients with human immunodeficiency virus (HIV) and high-grade squamous intraepithelial lesions (HSIL).
- Conditions
- Anal Cancer, High-grade Squamous Intraepithelial Lesion, HIV Infection, Human Papilloma Virus Infection
- Trial name
- ANCHOR (NCT02135419)
- Testing
- imiquimod, fluorouracil, infrared photocoagulation therapy
- Where
- 25 sites in United States, Puerto Rico
- Volunteers
- 4,446 people
- Sponsor
- AIDS Malignancy Consortium
Libido, Intimacy
A Clinical Study to Evaluate the Efficacy of Four Supplements on Improving Readiness for Intimacy
This study is to evaluate the efficacy of four supplements designed to help participants get ready for sexual intimacy through improving digestion, weight management, sexual drive and stamina, and physical endurance during…
- Conditions
- Libido, Intimacy, Gastrointestinal Issues
- Trial name
- NCT05862519
- Testing
- Reset, Stay Ready Fiber, Libido
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- 906 CMVI Holdings
Colon Disease, Educational Problems
Patient Education and Text Message Reminders in Colonoscopy
This study will be conducted to examine the effects of detailed education and text message reminders given to patients undergoing colonoscopy on bowel cleansing, vital signs and anxiety.
- Trial name
- NCT06073782
- Testing
- Education Group, Text Message Group
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- Amasya University
Inflammatory Bowel Disease, Crohn's Disease
FOCUS: The Future of Fecal Calprotectin Utility Study for the Diagnosis and Management of Inflammatory Bowel Disease (IBD)
Hypothesis: Fecal Calprotectin will be useful in guiding the diagnosis and management of patients with Inflammatory Bowel Disease.
- Conditions
- Inflammatory Bowel Disease, Crohn's Disease, Ulcerative Colitis
- Trial name
- FOCUS (NCT01676324)
- Where
- Canada
- Volunteers
- 289 people
- Sponsor
- University of British Columbia
Oral Microbiota, Pancreatitis
The Characteristics of Oral Microbiota in Chronic Pancreatitis and Autoimmune Pancreatitis
There are more than 700 different bacteria colonized in human oral cavity, which are collectively referred to as oral microbiota.
- Conditions
- Oral Microbiota, Pancreatitis, Pancreatic Cancer
- Trial name
- NCT07015580
- Testing
- 16S rRNA sequencing
- Where
- China
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Hepatocellular Carcinoma
Anti-cancer Potentiality of Saffron Against Hepatocellular Carcinoma
Saffron has recently gained considerable interest for its capacity to interfere with cancer at initiation and promotion stages as well as for cancer treatment.
- Trial name
- NCT06464380
- Testing
- Saffranal
- Where
- 2 sites in Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Cystic Fibrosis
Infant Study of Inhaled Saline in Cystic Fibrosis
The purpose of this study is to assess whether 7% hypertonic saline (HS) is an effective and safe therapy in infants and young children with CF.
- Trial name
- ISIS (NCT00709280)
- Testing
- 7% Hypertonic Saline (HS), 0.9% Isotonic Saline (IS)
- Where
- 30 sites in United States, Canada
- Volunteers
- 321 people
- Sponsor
- CF Therapeutics Development Network Coordinating Center
Venous Thromboses, Venous Thromboembolism
The Risk of Venous Thromboembolism in Systemic Inflammatory Disorders: a United Kingdom (UK) Matched Cohort Study
Blood clots occurring in the legs and in the lungs are relatively common; they occur in around 3 in a 1000 people per year. They can cause disability and are also potentially life threatening.
- Conditions
- Venous Thromboses, Venous Thromboembolism, Deep Vein Thrombosis, Pulmonary Embolism
- Trial name
- NCT03835780
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 266,890 people, healthy volunteers welcome
- Sponsor
- Momentum Data
Hepatocellular Carcinoma
Nivolumab Combined With BMS-986253 in HCC Patients
A phase II clinical trial is utilized to examine whether BMS-986253 (25 subjects) or Cabiralizumab (25 subjects) when combined with Nivolumab offers improved radiographic objective response rates (ORR) over Nivolumab monotherapy…
- Trial name
- NCT04050462
- Testing
- Nivolumab 240 mg IV every 2 weeks + Cabiralizumab 4 mg/kg IV every 2 weeks, Nivolumab 240 mg IV every 2 weeks + BMS-986253 1200 mg IV every 2 weeks, Nivolumab 240 mg IV every 2 weeks
- Where
- 2 sites in United States
- Volunteers
- 13 people
- Sponsor
- NYU Langone Health
Acute Cholecystitis
CBD Wall-Thickness Adjusted ICG Microdosing for Fluorescence Cholangiography in Moderate-to-Severe Acute Cholecystitis: A Single-Center Prospective Study
This is a single-center prospective study designed to develop and validate an individualized, low-dose indocyanine green (ICG) protocol for near-infrared fluorescence cholangiography during emergency laparoscopic cholecystectomy…
- Trial name
- NCT07551388
- Testing
- Indocyanine Green (ICG) Fluorescence Cholangiography
- Where
- China
- Volunteers
- 21 people
- Sponsor
- Peking Union Medical College Hospital
Pancreatic Cancer
Second-line Irinotecan Liposome Combination Regimen for Irinotecan-treated Pancreatic Cancer
This study is a prospective, single-arm, two-cohort phase II clinical study. It is expected to enroll 48 patients with advanced or metastatic pancreatic cancer who have failed prior treatment with irinotecan-containing regimens…
- Trial name
- NCT06700603
- Testing
- Irinotecan liposome (Nal-IRI) in combination with 5-FU/sodium levofolinate
- Volunteers
- 48 people
- Sponsor
- Rui-hua Xu, MD, PhD
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