Clinical trials: Digestive System Cancer
Gastrointestinal Cancer, Prehabilitation
Prehabilitation to Improve Cancer Surgery Outcomes
This is a randomized control trial aiming to investigate the use of a prehabilitation regimen for patients undergoing major GI cancer surgery and its effects on measurements of HRQOL, LOS, and post-operative complications.
- Conditions
- Gastrointestinal Cancer, Prehabilitation, Surgery, Physical Activity
- Trial name
- PICaSO (NCT03502317)
- Testing
- Physical Prehabilitation, Psychological Prehabilitation
- Where
- 2 sites in Canada
- Volunteers
- 128 people
- Sponsor
- Mount Sinai Hospital, Canada
Gastrectomy, Laparoscopy
A Clinical Study for Comparison of the Effects Between Gasless Laparoscopy and Conventional Laparoscopy for Distal Gastric Cancer
The aim of this trial is to confirm the non-inferiority of Gasless laparoscopy-assisted distal D2 radical gastrectomy to the conventional laparoscopy-assisted distal D2 radical gastrectomy for the treatment of advanced gastric…
- Trial name
- NCT05495217
- Testing
- Conventional Laparoscopy, Gasless Laparoscopy
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Xue Yingwei
Liver Cancer
Interventional X-ray and Scintigraphy Imaging of 99mTc-MAA During the Radioembolisation Pretreatment Procedure
To establish the safety and feasibility of interventional x-ray and scintigraphy imaging during the pre-treatment procedure of hepatic radioembolization
- Trial name
- IXSI (NCT06013774)
- Testing
- IXSI
- Where
- Netherlands
- Volunteers
- 12 people
- Sponsor
- UMC Utrecht
Cancer Gi
Eye Gaze Technology for Endoscopic Inspection of the Gastrointestinal Tract
Robotic controlled endoscopy of GI tract.
- Trial name
- NCT06581718
- Testing
- Eye Gaze Control
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Imperial College London
Hepatitis B Virus, Hepatocellular Carcinoma
TACE and Adefovir Compared With Transarterial Chemoembolization (TACE) Alone for Hepatitis B Virus (HBV)-Related Unresectable Hepatocellular Carcinoma (HCC)
Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies in China, and approximately 90% of the patients with HCC are also infected with hepatitis B virus (HBV).
- Trial name
- TACE (NCT00960518)
- Testing
- adefovir, TACE
- Where
- 2 sites in China
- Volunteers
- 216 people
- Sponsor
- Tongji University
Locally Advanced Esophageal Squamous Cell Carcinoma
Sintilimab Injection Combined With Concurrent CCRT in Locally Advanced Esophageal Squamous Cell Carcinoma
This study evaluated the effectiveness and safety of sintilimab combined with cCRT in patients with locally advanced ESCC.
- Trial name
- NCT04602013
- Testing
- Sintilimab, Chemotherapy, Radiation Therapy
- Where
- China
- Volunteers
- 53 people
- Sponsor
- Sichuan Cancer Hospital and Research Institute
Stomach Cancer, Esophageal Cancer
A Study of Ramucirumab in Participants With Gastric, Esophageal, and Gastroesophageal Cancer
The purpose of this study is to determine whether ramucirumab when used in conjunction with chemotherapy treatment can help participants with stomach, esophagus, and gastroesophageal cancer.
- Trial name
- NCT01246960
- Testing
- Ramucirumab, Oxaliplatin, Leucovorin
- Where
- 58 sites in United States
- Volunteers
- 168 people
- Sponsor
- Eli Lilly and Company
Colorectal Cancer
SHR-3821 in Advanced Colorectal Cancer: an Exploratory Study
To evaluate the safety and efficacy of SHR-3821 combined with fruquintinib in the advanced colorectal cancer after failure of standard therapy
- Trial name
- NCT07515820
- Testing
- SHR-3821 and fruquintinib
- Volunteers
- 12 people
- Sponsor
- Meng Qiu
Carcinoma, Hepatocellular
A Dose-escalation Study of Lipotecan® Plus Radiotherapy in Locally Advanced Hepatocellular Carcinoma
Radiotherapy (R/T) for locally advanced hepatocellular carcinoma (HCC) is often used in patient who is not suitable for transarterial chemoembolization (TACE) and other local therapy, especially in those with portal vein tumor…
- Trial name
- NCT01425996
- Testing
- Lipotecan® (TLC388)
- Where
- 2 sites in Taiwan
- Volunteers
- 3 people
- Sponsor
- Taiwan Liposome Company
Rectal Cancer
Selective sPlenic flExure Mobilization for Low colorEctal Anastomosis After D3 lYmph Node Dissection (Speedy Trial)
In the Low Anterior Resection of rectum for cancer, the section level of IMA and the need of SFM is still debated. The aim of this study is to explore the different impacts of high and low ligation with peeling off vascular…
- Trial name
- SpeeDy (NCT03895255)
- Testing
- Paraaortic lymph node dissection, IMA high ligation, TME, routine splenic flexure mobilization, Paraaortic lymph node dissection, IMA low ligation, TME, selective splenic flexure mobilization
- Where
- Russia
- Volunteers
- 142 people
- Sponsor
- Russian Society of Colorectal Surgeons
Pancreatic Cancer, Metastatic Pancreatic Cancer
Retrospective Analysis of 2nd-line Nab-Paclitaxel + Gemcitabine After 1st-line FOLFIRINOX in Pancreatic Cancer
In this study, clinical data of patients who received 2nd-line Nab-paclitaxel plus Gemcitabine (nab-P+GEM) after progression on 1st-line FOLFIRINOX will be reviewed retrospectively.
- Trial name
- NCT04133155
- Testing
- nab paclitaxel plus gemcitabine
- Where
- South Korea
- Volunteers
- 103 people
- Sponsor
- Asan Medical Center
Pancreas Cancer
A Phase 1b Study of Gemcitabine and Nab-paclitaxel in Combination With IM156 in Patients With Advanced Pancreatic Cancer.
To learn if adding a new medication, IM156, to treatment with gemcitabine and nab-paclitaxel is safe and tolerable. The ability of this combination to improve the success of this treatment for these patients will also be studied.
- Trial name
- NCT05497778
- Testing
- Gemcitabine, Nab paclitaxel, IM156
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- M.D. Anderson Cancer Center
MSI-H Colorectal Cancer, Melanoma
Efficacy of Tislelizumab and Spartalizumab Across Multiple Cancer-types in Patients with PD1-high MRNA Expressing Tumors
This is an open-label, parallel group, non-randomized, multicenter phase II study to evaluate the efficacy of spartalizumab (cohorts 1 and 2) and tislelizumab (cohort 3) in monotherapy in patients with PD1-high-expressing tumors.
- Conditions
- MSI-H Colorectal Cancer, Melanoma, Anal Carcinoma, Mesothelioma
- Trial name
- ACROPOLI (NCT04802876)
- Testing
- Spartalizumab, Tislelizumab
- Where
- Spain
- Volunteers
- 184 people
- Sponsor
- SOLTI Breast Cancer Research Group
Pancreatic Cancer
SBRT Plus vNKT for Pancreatic Cancer
Owing to that the previous study of the investigators showed that SBRT plus pembrolizumab and trametinib provided favorable outcomes compared with SBRT plus gemcitabine for pancreatic cancer, therefore, the investigators aim to…
- Trial name
- NCT05783076
- Testing
- Stereotactic body radiation therapy, adoptive cell therapy with vNKT cells
- Where
- China
- Volunteers
- 29 people
- Sponsor
- Changhai Hospital
Adenocarcinoma of the Colon, Adenocarcinoma of the Rectum
Human Intestinal Microbiome and Surgical Outcomes in Patients Undergoing Colorectal Cancer Surgery
Intro: Recent studies on colorectal cancer surgery have been focusing on the role of intestinal microbiome on surgical outcomes.
- Trial name
- Microbiota (NCT04005118)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cancer-related Fatigue
The Effects of a Food Product Containing Mushroom Extracts (AndoSanTM) in Subjects With Colorectal Cancer-related Fatigue
Effects of a food product containing mushroom extracts (AndoSanTM) in subjects with colorectal cancer-related fatigue. AndoSanTM is a specialized liquid food product that includes fermented extracts from the fungi Agaricus…
- Trial name
- NCT06599710
- Testing
- AndoSanTM
- Where
- 3 sites in Germany
- Sponsor
- Mycotech Pharma AS
Esophageal Cancer
S-1 Plus Nedaplatin With Concurrent Radiotherapy for Advanced Esophageal Cancer
Patients with advanced esophageal cancer will receive thoracic radiation therapy 60Gy over 30 fractions,and concurrent with s-1 and nedaplatin.
- Trial name
- NCT01175460
- Testing
- S-1, Nedaplatin
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Zhejiang Cancer Hospital
Colorectal Cancer
Intratumoral Influenza Vaccine for Early Colorectal Cancer
The aim of this explorative phase II clinical trial is to establish the safety and efficacy of intratumoral influenza vaccine in patients with colorectal cancer, as an additive treatment prior to intended curative surgery.
- Trial name
- NCT04591379
- Testing
- Influenza Vaccines
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- Zealand University Hospital
Colorectal Cancer
FITting Non-invasive Tests in Lynch Syndrome Surveillance
The purpose of this clinical study is to evaluate the accuracy of the fecal immunochemical test (FIT) in comparison to colonoscopy in patients with Lynch Syndrome (LS) who are undergoing colonoscopy surveillance.
- Trial name
- NCT06898996
- Testing
- Fecal immunochemical test
- Where
- 3 sites in United States
- Volunteers
- 400 people
- Sponsor
- University of Chicago
Colon Cancer, Rectal Cancer
Magnetic Resonance Study of Liver in Chemotherapy
The purpose of this study is to see whether magnetic resonance (MR) techniques can detect changes caused by chemotherapy in the livers of patients who have been treated for colorectal cancer.
- Trial name
- NCT00578838
- Testing
- Magnetic Resonance
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
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