Clinical trials: Digestive System Cancer
HCC - Hepatocellular Carcinoma
Comparison of Gd-EOB-DTPA-enhanced MRI and Contrast-enhanced Ultrasound for Measuring Tumor Size of Solitary Hepatocellular Carcinoma ≤ 5cm:A Retrospective Study
Knowing the tumor size before operation is of great significance to the choice of treatment methods of surgeons and the prognosis of patients.
- Trial name
- NCT06437457
- Testing
- ceus
- Where
- China
- Volunteers
- 194 people
- Sponsor
- Anhui Medical University
Gastrointestinal Neoplasms
A Study of Velzatinib in Participants With Metastatic and/or Unresectable GIST After Imatinib, Sunitinib, Regorafenib, and Pimitespib
The goal of this study is to evaluate the study drug velzatinib (GSK6042981 / IDRX-42) to see whether velzatinib can shrink or control tumors and is safe and tolerated in Japan participants with gastrointestinal tumors (GIST) who…
- Trial name
- NCT07689201
- Testing
- Velzatinib
- Where
- 3 sites in Japan
- Volunteers
- 24 people
- Sponsor
- GlaxoSmithKline
Hepatocellular Carcinoma
Study of Axitinib in Patients With Unresectable Hepatocellular Carcinoma
The purpose of this study is to evaluate the potential role of Axitinib (AG-013736) in the treatment of unresectable/metastatic hepatocellular carcinoma (HCC)
- Trial name
- AXITINIB (NCT01334112)
- Testing
- Axitinib (AG-013736)
- Where
- 2 sites in Canada
- Volunteers
- 30 people
- Sponsor
- University Health Network, Toronto
Colorectal Cancer
Colon Capsule Versus Virtual Colonoscopy for Colorectal Cancer Screening
France is among the countries with a high incidence of colorectal cancer. The prognosis associated with colorectal cancer is related to the development stage of the disease at diagnosis.
- Trial name
- COCAGI (NCT02558881)
- Testing
- Virtual colonoscopy, Colon capsule
- Where
- France
- Volunteers
- 664 people
- Sponsor
- Hospices Civils de Lyon
Recurrent Hepatocellular Carcinoma
Comparison of Treatment of Recurrent HCC With Repeat Hepatectomy,and TACE With AFP Conversion
The purpose of this study is to compare the treatment of recurrent hepatocellular carcinoma with repeat hepatectomy,and transcatheter arterial chemoembolization (TACE) with AFP conversion.
- Trial name
- HCCTACEAFP (NCT02728219)
- Testing
- TACE, Hepatectomy
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Eastern Hepatobiliary Surgery Hospital
Colon Cancer
Use of Text Messaging Reminders to Increase FIT Completion Among Patients at the NYU FHCs
The research team will compare the efficacy of targeted text message reminders against currently used phone call reminders at increasing patient completion of fecal immunochemical test (FIT) for colon cancer screening.
- Trial name
- NCT06632054
- Testing
- Text Message Reminders
- Where
- United States
- Volunteers
- 1,283 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Hepatocellular Carcinoma, Radiotherapy
Randomized Study of Adjuvant Radiotherapy After Curative Resection of HCC With Narrow Margin (RAISE)
RAISE is a multicenter randomized controlled trial to assess the efficacy of adjuvant radiotherapy for controlling postsurgical recurrence in HCC patients with narrow margin (≤ 1 cm) after curative resection.
- Conditions
- Hepatocellular Carcinoma, Radiotherapy, Hepatectomy
- Trial name
- RAISE (NCT03732105)
- Testing
- Surgery-radiotherapy
- Where
- China
- Volunteers
- 148 people
- Sponsor
- Sun Yat-sen University
Adult Hepatocellular Carcinoma, Advanced Adult Hepatocellular Carcinoma
Cixutumumab and Sorafenib Tosylate in Treating Patients With Advanced Liver Cancer
This phase I trial is studying the side effects and best dose of cixutumumab when given together with sorafenib tosylate in treating patients with advanced liver cancer.
- Conditions
- Adult Hepatocellular Carcinoma, Advanced Adult Hepatocellular Carcinoma, Localized Non-Resectable Adult Liver Carcinoma, Recurrent Adult Liver Carcinoma
- Trial name
- NCT01008566
- Testing
- Cixutumumab, Laboratory Biomarker Analysis, Sorafenib Tosylate
- Where
- 6 sites in United States
- Volunteers
- 21 people
- Sponsor
- National Cancer Institute (NCI)
Pancreatic Cancer
Preoperative Rehabilitation During Neoadjuvant Therapy for Pancreatic Cancer
The goal of this research study is to learn if it is possible to start a home-based exercise and nutrition program for patients with pancreatic cancer or who may have pancreatic cancer before surgery (pre-operative…
- Trial name
- NCT02295956
- Testing
- Questionnaires, Exercise, Nutrition Counseling
- Where
- 2 sites in United States
- Volunteers
- 75 people
- Sponsor
- M.D. Anderson Cancer Center
Hepatic Carcinoma
Percutaneous Irreversible Electroporation to Treat Liver Cancer Close to the Gallbladder
The purpose of this study is to investigate the safety and efficacy of irreversible electroporation for unresectable Hepatic carcinoma close to the gallbladder, also Progress Free Survival (PFS) will be recorded.
- Trial name
- NCT02332551
- Testing
- NanoKnife
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Fuda Cancer Hospital, Guangzhou
Colorectal Cancer Metastatic
Irinotecan Liposomes Combined with Cetuximab + Vermofenib in First-line Failure of Advanced Colorectal Cancer
Efficacy and safety of irinotecan liposomes combined with cetuximab + vermofenib in first-line failure of advanced RAS wild /BRAF mutated colorectal cancer, Exploratory analysis of biomarkers (including but not limited to ctDNA…
- Trial name
- VICPROIRI (NCT06763029)
- Testing
- Irinotecan liposomes combined with cetuximab + vermofenib
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Fudan University
Advanced Solid Tumor, Non Small Cell Lung Cancer
A Study of CLSP 5282 in HLA-A*03:01 Positive Adult Patients With Solid Tumors (SENTINEL-101)
Phase 1, open-label, multicenter study to evaluate the safety, tolerability, PK, PD, and preliminary clinical activity of CLSP 5282 when administered to HLA A*03:01-positive adult patients with advanced solid tumors that harbor…
- Conditions
- Advanced Solid Tumor, Non Small Cell Lung Cancer, Pancreatic Carcinoma, Colorectal Cancer
- Trial name
- NCT07650357
- Testing
- CLSP-5282
- Where
- 4 sites in United States
- Volunteers
- 140 people
- Sponsor
- Clasp Therapeutics, Inc.
Gastric Cancer Adenocarcinoma Metastatic, Ovarian Cancer
Utidelone Capsule Monotherapy for Patients with Advanced Solid Tumors
This trial is an open, multicenter, phase II clinical trial to evaluate the efficacy and safety of Utidelone capsules in patients with advanced solid tumors.
- Conditions
- Gastric Cancer Adenocarcinoma Metastatic, Ovarian Cancer, Bile Duct Cancer
- Trial name
- NCT06730581
- Testing
- Utidelone Capsule 60mg/m2/d, Utidelone capsule 75mg/m2, Utidelone Capsule
- Volunteers
- 100 people
- Sponsor
- Beijing Biostar Pharmaceuticals Co., Ltd.
Gastrointestinal Stromal Tumors
Study of Dose Escalation Versus no Dose Escalation of Imatinib in Metastatic Gastrointestinal Stromal Tumors (GIST) Patients
The purpose of this study is to determine if escalating the dose of imatinib to keep the drug blood level at ≥ 1100 ng/ml leads to better outcomes for patients.
- Trial name
- NCT01031628
- Testing
- Imatinib mesylate
- Where
- 13 sites in United States
- Volunteers
- 5 people
- Sponsor
- Sarcoma Alliance for Research through Collaboration
Colorectal Carcinoma
Comparative Study of Cetuximab and Radiation Vs Surgery Before or After Radiation in Patients With Colorectal Carcinoma
RATIONALE: Monoclonal antibodies, such as Cetuximab, can target tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells.This is an anti-cancer drug which has already been approved…
- Trial name
- NCT00725400
- Testing
- Cetuximab and Radiation Therapy, Surgery and Radiation Therapy
- Where
- United States
- Volunteers
- 450 people
- Sponsor
- American Scitech International
Gastrointestinal Stromal Tumors, Resected Gastrointestinal Stromal Tumors
Efficiency of Imatinib Treatment Maintenance or Interruption After 3 Years of Adjuvant Treatment in Patients With Gastrointestinal Stromal Tumours (GIST)
This is a 2 arms study concerning patients with primary GIST who followed an Imatinib adjuvant treatment for 3 years after surgery and who have a high risk of recurrence.
- Conditions
- Gastrointestinal Stromal Tumors, Resected Gastrointestinal Stromal Tumors, Non-metastatic, High Risk of Recurrence
- Trial name
- ImadGist (NCT02260505)
- Testing
- Imatinib maintenance
- Where
- 17 sites in France
- Volunteers
- 136 people
- Sponsor
- Centre Leon Berard
Peritoneal Carcinomatosis, Gastric Cancer
Intraoperative ICG Fluorescence Imaging for Peritoneal Carcinomatosis Detection
Background. Peritoneal carcinomatosis is a frequent and deadly localization of gastric cancer. Available imaging techniques have a low accuracy in detecting small peritoneal nodules, and direct laparoscopic visualization may fail…
- Trial name
- NCT04352894
- Testing
- Fluorescence guided peritoneal exploration
- Volunteers
- 120 people
- Sponsor
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Gallstone, Gastric Cancer
The Incidence of Gallstones After Gastrectomy
To provide preventive and therapeutic strategies for participants with gallstones after gastric cancer by comparing the risk of postoperative gallbladder stone formation with two different resection ranges using the Roux-en-Y…
- Trial name
- NCT05965466
- Testing
- Distal gastrectomy and radical resection, Total gastrectomy and radical resection
- Where
- 2 sites in China
- Volunteers
- 531 people
- Sponsor
- Hepatopancreatobiliary Surgery Institute of Gansu Province
Colorectal Cancer, Colorectal Carcinoma
Combining Risk Factors and Faecal Immunochemical Testing in Colorectal Cancer Screening: a Randomized Controlled Trial
Colorectal Carcinoma (CRC) is the third most frequent diagnosed cancer worldwide, with 1.4 million new cases every year. In an attempt to reduce this number many countries have implemented a nationwide screening programme…
- Conditions
- Colorectal Cancer, Colorectal Carcinoma, Colorectal Neoplasms, Colorectal Adenoma
- Trial name
- NCT04490551
- Testing
- Risk-based logistic regression model, FIT
- Where
- Netherlands
- Volunteers
- 6,753 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Metastatic Colorectal Cancer
Dabrafenib + Trametinib + PDR001 In Colorectal Cancer
This research study is studying a combination of drugs as a possible treatment for metastatic colorectal cancer characterized by BRAF V600E mutation.
- Trial name
- NCT03668431
- Testing
- Dabrafenib, Trametinib, PDR001
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- Massachusetts General Hospital
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