Clinical trials: Digestive System Cancer
Colorectal Cancer, Metastatic Cancer
SCH 66336 Before Surgery in Treating Patients With Colorectal Cancer That Has Metastasized to the Liver
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Randomized phase I trial to compare the effectiveness of different doses of SCH 66336 before surgery…
- Trial name
- NCT00005030
- Testing
- SCH 66336, conventional surgery
- Sponsor
- M.D. Anderson Cancer Center
Colorectal Cancer, Stage II and III
Simultaneaous Detection of Quantitative Somatic Alterations Using the Qantitative Multiplex Pcr of Short Fluorescent Fragments Method (QMPSF) in Stage II-III Colon Cancer: a Prospective Study
Lymph node involvement remains the main criteria for postoperative chemotherapy in patients with colon cancer (CC) without distant metastasis.
- Trial name
- Code Barre (NCT02110329)
- Testing
- evaluation of the recurrence rate according to molecular analysis
- Where
- 3 sites in France
- Volunteers
- 401 people
- Sponsor
- University Hospital, Rouen
Gastric Cancer, Hepatocellular Carcinoma
Exploratory Clinical Study of Apatinib and SHR-1210 in Treating Advanced Hepatocellular Carcinoma or Gastric Cancer
The purpose of this study is to observe and preliminary explore the efficacy and safety of combination of Apatinib and SHR-1210 regimen in treating advanced hepatocellular carcinoma or gastric cancer.
- Trial name
- NCT02942329
- Testing
- apatinib, SHR-1210
- Where
- China
- Volunteers
- 60 people
- Sponsor
- The Affiliated Hospital of the Chinese Academy of Military Medical Sciences
Esophageal Cancer, Sentinel Lymph Node
The Value of Indocyanine Green-guided Near-infrared Fluorescence Technology in Tracing Sentinel Lymph Nodes During Esophagectomy
Sentinel lymph nodes, as the primary site of tumor metastasis, play a pivotal role in assessing patient prognosis and planning subsequent treatment strategies.
- Conditions
- Esophageal Cancer, Sentinel Lymph Node, Lymphadenectomy, Indocyanine Green
- Trial name
- NCT07303231
- Testing
- Minimally invasive surgery for esophageal cancer using near-infrared indocyanine green fluorescence to visualize the sentinel lymph node
- Where
- China
- Volunteers
- 144 people
- Sponsor
- Fujian Medical University Union Hospital
Gastric Cancer, Pancreatic Cancer
Chemoradiation-Induced Nausea and Emesis: Quality of Life
The primary objectives of this study are: 1. To assess the preferences of cancer patients scheduled to receive chemoradiation and caregiver controls for side-effects of chemoradiation. 1.
- Conditions
- Gastric Cancer, Pancreatic Cancer, Cervical Cancer, Vulvar Cancer
- Trial name
- NCT00394602
- Testing
- Interview, Questionnaire
- Where
- United States
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Exercise, Total Neoadjuvant Treatment
Study of Daily Step Count and Treatment Response in Rectal Cancer (STEP-R)
This study aims to examine the impact of daily physical activity, specifically step count, on treatment outcomes and side effects in patients with locally advanced rectal cancer receiving total neoadjuvant therapy (chemotherapy…
- Conditions
- Exercise, Total Neoadjuvant Treatment, Rectal Tumors, Smart Watch
- Trial name
- STEP-R (NCT06668402)
- Testing
- Utilizing a smartwatch to gather data on individuals receiving treatment for rectal neoplasm.
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 160 people
- Sponsor
- Gazi University
Squamous Cell Carcinoma of the Anal Canal
An Early Access Program Guideline to Provide Access to Retifanlimab (INCMGA00012) Together With Carboplatin and Paclitaxel for Squamous Carcinoma of the Anal Canal (SCAC)
To provide retifanlimab, on a reactive basis, to adult patients with squamous carcinoma of the anal canal in combination with carboplatin and paclitaxel and who are considered ineligible for other therapeutic options including…
- Trial name
- NCT06910137
- Testing
- retifanlimab
- Sponsor
- Incyte Corporation
Hepatocellular Carcinoma (HCC)
Expanded Activated Lymphocytes (EAL) as Adjuvant Therapy in Patients With HCC at High Risk of Recurrence After Radical Resection
This is a multi-center, randomized, open-label pivotal phase II study to evaluate the efficacy and safety of EAL as adjuvant therapy in preventing recurrence in patients with primary HCC at high recurrence risk after radical…
- Trial name
- NCT05213637
- Testing
- Expanded Activated Lymphocytes (EAL), transarterial chemoembolization (TACE)
- Where
- China
- Volunteers
- 430 people
- Sponsor
- Chinese PLA General Hospital
Pancreatic Cancer, Neoplasm
Family and Personal History of Malignancy in Intraductal Papillary Mucinous Neoplasm (IPMN)
This is a retrospective observational study to determine the proportion of patients with a family history of pancreatic cancer and other malignancies among patients who have intraductal papillary mucinous neoplasm (IPMN).
- Trial name
- NCT01104077
- Where
- United States
- Volunteers
- 277 people
- Sponsor
- Columbia University
Colon Cancer, Breast Cancer
Genomic Services Research Program
Background: Genes are the instructions a person s body uses to function. Genome sequencing reads through all of a person s genes. Everyone has many gene variants, and most do not cause disease.
- Trial name
- NCT02595957
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Body Image Disorder
Prevention of Body Image Disorder by Nurse Intervention on the Patient and Family Prior to Breast and Colon Surgery
This is a non-blinded, randomized, controlled clinical trial consisting of 64 participants, which aims to assess the effectiveness of a nursing intervention for family members and patients prior to surgery to prevent body image…
- Trial name
- NCT03726801
- Testing
- HEALTH EDUCATION
- Where
- Spain
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Universidad Complutense de Madrid
Hepatocellular Carcinoma
Effectiveness of Trans-Arterial Chemo Embolization for Hepatocellular Carcinoma on Follow-Up CT Triphasic Liver
"HCC is a major challenge due to greater recurrence rates and variable treatment responses. TACE is widely used, but its success relies on accurate follow-up imaging.
- Trial name
- NCT07048665
- Testing
- CT Imagesa in HCCT
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Superior University
Ovarian Neoplasms, Prostatic Neoplasms
A Study of DM002 in Patients With Advanced Solid Tumors
The goal of study： The study has two parts: Part 1 Dose Escalation and Part 2 Dose Expansion. In Part 1, a few participants will receive the lowest dose of study drug.
- Conditions
- Ovarian Neoplasms, Prostatic Neoplasms, Endometrial Neoplasms, Colorectal Neoplasms
- Trial name
- NCT06751329
- Testing
- DM002
- Where
- 7 sites in United States, Australia
- Volunteers
- 280 people
- Sponsor
- Xadcera Biopharmaceutical (Suzhou) Co., Ltd.
Pancreatic Cancer
A Multi-center Study on the Efficacy and Safety of AI-assisted Navigation System for Biliopancreatic EUS
Pancreatic cancer is one of the most lethal cancers. Survival rates vary largely depending on the stage at which it is diagnosed. EUS is considered one of the most sensitive modalities for pancreatic cancer detection.
- Trial name
- NCT04892329
- Testing
- Artificial intelligence assistant system
- Where
- 2 sites in China
- Volunteers
- 285 people, healthy volunteers welcome
- Sponsor
- Renmin Hospital of Wuhan University
Gastric Cancer
As a Second-line Treatment for Metastatic Gastric Adenocarcinoma Patients, the Safety and Effective of Vactosertib Administration in Combination With Paclitaxel+Ramucirumab is Evaluated, and a Phase 2a Clinical Trial to Biomarkers
This clinical trial is to evaluate the efficacy and safety of subjects with metastatic gastric adenocarcinoma or adenocarcinoma of the gastroesophageal junction.
- Trial name
- NCT04656002
- Testing
- Vactosertib
- Volunteers
- 43 people
- Sponsor
- Samsung Medical Center
Gastric Cancer
RCT With Adjuvant Mistletoe Treatment in Gastric Cancer Patients
Evaluation of safety and efficacy of a standardized mistletoe extract (abnobaVISCUM® Quercus, aVQ) in patients with gastric cancer receiving oral chemotherapy.
- Trial name
- NCT01401075
- Testing
- mistletoe extract, doxifluridine
- Where
- South Korea
- Volunteers
- 32 people
- Sponsor
- Abnoba Gmbh
Liver Tumor
Exploration of Noninvasive Differential Diagnosis of Benign and Malignant Liver Tumors
To explore an effective noninvasive method for differential diagnosis of liver tumors.
- Trial name
- NCT06524557
- Testing
- with chronic liver disease
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Xijing Hospital
Gastric Cancer
The Advantages and Disadvantages Between Uncut Roux-en-Y Reconstruction and Billroth II Reconstruction After Laparoscopy-assisted Distal Gastrectomy for Gastric
The Advantages and Disadvantages Between Uncut Roux-en-Y Reconstruction and Billroth II Reconstruction After Laparoscopy-assisted Distal Gastrectomy for Gastric.
- Trial name
- NCT02694081
- Testing
- Uncut Roux-en-Y Reconstruction, Billroth II Reconstruction
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Jilin University
Gastric Cancer
Evaluation of a Computer-aided Diagnosis System (CADx) in the Early Detection of Gastric Cancer in France. Cancer in France.
Upper gastrointestinal (GI) cancers are one of the most common cancers worldwide. Except for cardia cancers, the incidence of gastric cancer has decreased consistently since 1980, but remains at a high level.
- Trial name
- EGC-France (NCT05928819)
- Testing
- Evaluation of the proportion of gastric neoplastic lesions detected by a computer-aided diagnosis system (CADx) compared with experienced endoscopists.
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Hospices Civils de Lyon
Benign Neoplasm of Stomach, Malignant Neoplasm of Stomach
Surgicel® Fibrillar for Delayed Bleeding After ESD
The aim of this study is to assess the effect of Surgicel® Fibrillar as adjuvant treatment to H2RA on preventing ulcer bleeding after ESD for gastric epithelial tumors
- Trial name
- NCT01758965
- Testing
- PPI, H2RA and surgicel
- Where
- South Korea
- Volunteers
- 146 people
- Sponsor
- Soonchunhyang University Hospital
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