Clinical trials: Digestive System Neoplasms, open to volunteers
Arrhythmias, Cardiac, Breast Cancer
LEARN: Learning Environment for Artificial Intelligence in Radiotherapy New Technology
This study will develop a whole-of-body markerless tracking method for measuring the motion of the tumour and surrounding organs during radiation therapy to enable real-time image guidance.
- Conditions
- Arrhythmias, Cardiac, Breast Cancer, Prostatic Cancer, Brain Cancer
- Trial name
- LEARN (NCT05184790)
- Where
- 4 sites in Australia
- Volunteers
- 300 people
- Sponsor
- University of Sydney
Colon Neoplasms
AI-Assisted Microbiome Analysis for Evaluating the Efficacy of MPRO3 and Gut Environmental Changes in Colon Cancer Surgery Patients
The goal of this clinical trial is to evaluate the effects of MPRO3(probiotics mixture) supplementation on surgical outcomes and gut health in patients undergoing surgery for colon cancer.The main question is whether MPRO3…
- Trial name
- AI-MPRO3 (NCT07792980)
- Testing
- MPRO3
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- hy Co., LTD.
Hepatocellular Carcinoma (HCC), Liver Diseases
The Treatment of Liver Injury After Liver Resection With Polyene Phosphatidylcholine
A multicenter, open-label, randomized, controlled study. It is proposed to evaluate the treatment plan of receiving 930mg polyene phosphatidylcholine injection one day before the operation, twice a day, and 930mg polyene…
- Trial name
- NCT07150624
- Testing
- Experimental Group, control group
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Anhui Provincial Hospital
Gastric Cancer, Prehabilitation
Home-based Whole Course Multimodal Prehabilitation Based on 5G + Artificial Intelligence Mobile Health
The whole course management of gastric caner patients receiving neoadjuvant therapy frequently hinders by challenges such as inaccurate exercise plans, inadequate nutritional supplementary, limited access to timely psychological…
- Trial name
- mHealth prehab (NCT07764523)
- Testing
- mHealth prehabilitation group, ERAS group
- Where
- China
- Volunteers
- 328 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Refractory Metastatic Colorectal Cancer
Ivarmacitinib Combined With Camrelizumab and Fruquintinib for Patients With Metastatic Colorectal Cancer After Failure of Second-line or Later Treatment
For patients with metastatic colorectal cancer (mCRC) who have failed two or more lines of standard therapy, treatment options are extremely limited, and the prognosis remains poor, with objective response rates (ORRs) generally…
- Trial name
- NCT07896096
- Testing
- Ivarmacitinib Sulfate Tablets, Camrelizumab, Fruquintinib
- Where
- China
- Volunteers
- 33 people
- Sponsor
- Renmin Hospital of Wuhan University
Rectal Cancer, Adenocarcinoma
SCRT-NALIRIXELOX+Sintilimab as TNT for High-Risk LARC
This is a single-center, exploratory clinical study for patients with newly diagnosed, high-risk, locally advanced rectal cancer.
- Trial name
- NCT07474103
- Testing
- SCRT, Liposomal Irinotecan, Oxaliplatin
- Where
- China
- Volunteers
- 49 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Metastatic Colorectal Carcinoma (mCRC)
Second-line Doublet Chemotherapy (FOLFOX or FOLFIRI) Plus Fruquintinib Versus Doublet Chemotherapy (FOLFOX or FOLFIRI) Plus Bevacizumab in Metastatic Colorectal Cancer
The standard second-line treatment for metastatic colorectal cancer (mCRC) involves chemotherapy (FOLFOX or FOLFIRI) combined with an antiangiogenic agent, such as bevacizumab or aflibercept.
- Trial name
- NCT07150403
- Testing
- Oxaliplatin intravenous, 5 FU bolus, Folinic acid
- Where
- 45 sites in France
- Volunteers
- 74 people
- Sponsor
- Federation Francophone de Cancerologie Digestive
Rectal Neoplasms, Rectal Neoplasms Malignant
The SMART Trial: Modified Single-Stapled Anastomosis in Laparoscopic or Robotic Low Anterior Resection for Rectal Cancer
The goal of this clinical trial is to learn whether a modified single-stapled anastomosis (MST) can reduce anastomotic leakage compared with the conventional double-stapled technique (DST) in adult patients undergoing…
- Conditions
- Rectal Neoplasms, Rectal Neoplasms Malignant, Rectal Cancer, Rectal Cancer Surgery
- Trial name
- MST (NCT07376980)
- Testing
- Modified single-stapled anastomosis technique
- Where
- 6 sites in South Korea
- Volunteers
- 450 people
- Sponsor
- Korea University Anam Hospital
Choledochal Cyst
Host-Microbe Interactions in Biliary Dilatation
This study is an observational cohort study aimed at continuously enrolling patients with biliary dilatation and healthy controls.
- Trial name
- NCT07152496
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Colorectal Cancer Metastatic
BAL/BOT/agenT-797 in pMMR CRC With Liver Metastases
The goal of this clinical trial is to learn whether the combination of balstilimab, botensilimab, and agenT-797 is safe and effective in treating adults with previously treated metastatic colorectal cancer that is microsatellite…
- Trial name
- NCT07550088
- Testing
- Balstilimab (BAL), Botensilimab (BOT), agenT-797
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Darren Sigal, MD
Colorectal Cancer (Diagnosis), Adenoma
S-Adenosylmethionine (SAMe) for Chemoprevention of Colorectal Adenomas
This study will enroll a total of 18 patients who have undergone curative surgery for stage I or II colorectal cancer and are planned for post-surgical surveillance without any need for chemotherapy at Cedars-Sinai Medical…
- Trial name
- NCT07582003
- Testing
- S-Adenosylmethionine (SAMe)
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Jun Gong, MD
Solid Tumor Malignancies, Metastatic Cancer
PROGRESS: Precision Oncology Using Genomic Reflexive Evaluations for Study Selection and Survival
This is a hybrid decentralized, single-arm, interventional study designed to evaluate the impact of precision medicine navigation and reflexive expert review of next-generation sequencing (NGS) for patients with stage IV solid…
- Conditions
- Solid Tumor Malignancies, Metastatic Cancer, Breast Cancer, Colorectal Cancer
- Trial name
- PROGRESS (NCT06896162)
- Testing
- Expert Review, Blood or tissue samples collection., The Precision Oncology Navigation
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Safety
Efficacy and Safety of AK104 Combined With Chemotherapy and Cetuximab or Bevacizumab
Evaluate the objective response rate (ORR) of AK104 combined with chemotherapy and cetuximab or bevacizumab in second-line treatment of MSS type advanced colorectal cancer
- Trial name
- NCT07253896
- Testing
- AK104 and cetuximab or bevacizumab and FOLFIRI
- Where
- 2 sites in China
- Volunteers
- 40 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Upper GI Cancer
Immunonutrition for Surgical Prehabilitation of Patients With Upper GI Cancer
Perioperative immunonutrition has been proposed as a strategy to modulate the inflammatory response and improve outcomes after upper GI surgery.
- Trial name
- IMNUTPREH-UGIC (NCT07884214)
- Testing
- Oral nutritional supplements with immunonutrition (enriched with arginine, nucleotides, vitamin D and omega-3-fatty acid), Standart of care
- Where
- Spain
- Volunteers
- 110 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Liver Cancer, Adult, Metastases to Liver
15 vs 45 Minute Pringle Maneuver in Liver Cancer Resection: Randomized Noninferiority Trial
The goal of this clinical trial is to evaluate the safety of two durations of the Pringle maneuver in adults undergoing elective liver resection for malignant tumors.
- Conditions
- Liver Cancer, Adult, Metastases to Liver, Liver Malignant Tumors
- Trial name
- NCT07237204
- Testing
- Pringle manouver
- Where
- Poland
- Volunteers
- 600 people
- Sponsor
- Medical University of Warsaw
Rectal Cancer
Hypofractionated Palliative Radiotherapy in Patients With Advanced Non-operable Rectal Cancer
Many patients with rectal cancer were not candidates for surgical resection because advanced age, comorbidities, or multiple synchronous metastases.
- Trial name
- NCT03853733
- Testing
- rectal cancer radiotherapy
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Consorci Sanitari de Terrassa
Atrial Fibrillation, Esophageal Carcinoma
Amiodarone for the Prevention of Atrial Fibrillation After Minimally Invasive Esophagectomy in Patients With Esophageal Cancer
This phase II trial studies how well amiodarone works in the prevention of atrial fibrillation (AF) after a minimally invasive esophagectomy (MIE) in patients with esophageal cancer.
- Trial name
- NCT06067438
- Testing
- Amiodarone Hydrochloride, Saline
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- OHSU Knight Cancer Institute
Liver Neoplasms
Contrast Enhanced Ultrasound to Evaluate Response to Chemoembolization in Patients With Liver Tumors
This phase II trial evaluates the diagnostic performance of contrast-enhanced ultrasound (CEUS) for assessing treatment response in patients undergoing transarterial chemoembolization (TACE) for liver tumors.
- Trial name
- NCT06261814
- Testing
- Sulfur Hexafluoride Lipid Microspheres, Contrast-Enhanced Ultrasound, Transarterial Chemoembolization
- Where
- United States
- Volunteers
- 266 people
- Sponsor
- john eisenbrey
Esophagus Cancer
Proton Therapy for Esophageal Cancer
The goal of this phase II study is to investigate the feasibility, toxicity and efficacy of a regimen incorporating a proven systemic regimen, carboplatin /paclitaxel, with conformal proton modality, followed by definitive…
- Trial name
- NCT01684904
- Testing
- Proton radiation
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Loma Linda University
Colorectal Cancer
Mailed FIT-Based Outreach Interventions
Colorectal cancer (CRC) is the second most common cancer and the second leading cause of cancer-related mortality in Singapore. Although annual fecal immunochemical testing (FIT) and periodic colonoscopy are recommended for…
- Trial name
- NCT07852793
- Testing
- SMS Reminders, SMS reminders + mailed reminder, SMS reminders + mailed reminder + patient navigation
- Where
- 5 sites in Singapore
- Volunteers
- 40,000 people, healthy volunteers welcome
- Sponsor
- National Cancer Centre, Singapore
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