Clinical trials: Digital Ulcers
Crohn's Disease, Ulcerative Colitis
Digital Mind Body Intervention Among Black and Hispanic Patients Living With Inflammatory Bowel Disease
The bidirectional effects between psychological distress and inflammatory bowel disease (IBD) activity mean that not only does increased IBD activity trigger psychological distress, but psychological distress triggers increased…
- Conditions
- Crohn's Disease, Ulcerative Colitis, Inflammatory Bowel Diseases
- Trial name
- DMBI (NCT06510296)
- Testing
- Digital Mind Body Intervention mobile application
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Systemic Sclerosis
Effect of Ozone Therapy for the Treatment of Digital Ulcer in Patients With SSc
Functionality in patients with SSc? Systemic Sclerosis (SSc) is a chronic connective tissue disease characterized by microvascular involvement, immunological dysfunction, extracellular matrix deposition in the skin and internal…
- Trial name
- NCT04826419
- Testing
- ozone therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people
- Sponsor
- Pamukkale University
Digital Ulcers
Macitentan for the Treatment of Digital Ulcers in Systemic Sclerosis Patients
The DUAL-2 study is designed as a multicenter, double-blind two-period study with an initial fixed 16-week Period 1, followed by a Period 2 of variable duration.
- Trial name
- DUAL-2 (NCT01474122)
- Testing
- Macitentan 3 mg, Macitentan 10 mg
- Volunteers
- 265 people
- Sponsor
- Actelion
Scleroderma, Scleroderma, Systemic
Effectiveness of Telerehabilitation on Scleroderma
The effects of exercises performed by telerehabilitation on individuals with hand-affected scleroderma on range of motion, grip strength, function, sensation, daily life activities and general health will be compared with the…
- Conditions
- Scleroderma, Scleroderma, Systemic, Scleroderma Associated Digital Ulcer, Hand Rheumatism
- Trial name
- NCT04563481
- Testing
- Hand Therapy via Telerehabilitation, Hand Therapy by Physiotherapist
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Istanbul University
Diabetic Foot Ulcers (DFUs)
Evaluation of the Clinical Efficacy and Feasibility of Digital Foot Care Intervention Strategies With Different Intensities in the Prevention of Diabetic Foot Ulcers.
For people with diabetes who are at risk of foot ulcers, this study compares three digital foot care strategies (with different levels of intensity) to see which one is more effective at preventing ulcers and easier to use.
- Trial name
- NCT07185048
- Testing
- Conventional Foot Care Control Group, Digital Foot Care (Low-Intensity), Digital Foot Care (Moderate-Intensity)
- Volunteers
- 1,512 people
- Sponsor
- First Affiliated Hospital of Wenzhou Medical University
Leg Ulcers, Leg Ulcers Venous
Vacuum Compression Therapy and Tissue Oxygenation in Chronic Leg Ulcers
Chronic lower limb ulcers, particularly those of venous etiology, are difficult-to-heal wounds that severely affect patients' quality of life. Adequate tissue oxygenation is essential for wound healing.
- Trial name
- NCT07901517
- Testing
- Vacuum Compression Therapy (VCT), Standard Wound Care
- Where
- Czechia
- Volunteers
- 20 people
- Sponsor
- BTL Industries Ltd.
Pressure Sore
Evaluation of the Impact of a Digital Tool MEDIASCREEN of Preventive Information for Patients on the Knowledge of the Risk of Pressure Sores Acquired During a Hospitalization
The study focuses on the impact of a digital MEDIASCREEN tool on the knowledge, technical know-how and behavioural skills in terms of pressure sores of patients.
- Trial name
- EDUCESCARRES (NCT05547295)
- Testing
- Numeric prevention, Paper prevention
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Pôle Saint Hélier
Systemic Sclerosis, Digital Ulcer
Autologous Adipose Tissue in the Treatment of Systemic Sclerosis Digital Ulcers
A randomized controlled trial will be performed to confirm preliminary uncontrolled data indicating that regional adipose tissue grafting is effective in inducing digital ulcer healing in patients with systemic sclerosis.
- Trial name
- ADUL-SSc (NCT03406988)
- Testing
- Autologous fat grafting
- Where
- Italy
- Volunteers
- 46 people
- Sponsor
- ASST Gaetano Pini-CTO
Raynaud Disease, Systemic Sclerosis
Treatment of Digital Ulcers in Korean Patients With Systemic Sclerosis: a Prospective Cohort Study
This study evaluates the efficacy and safety of routine medical treatments of digital ulcers in patients with systemic sclerosis in a prospective cohort study.
- Conditions
- Raynaud Disease, Systemic Sclerosis, Digital Ulcer
- Trial name
- NCT02642146
- Testing
- Calcium Channel Blockers, Phosphodiesterase Inhibitors, Endothelin receptor blocker
- Where
- South Korea
- Volunteers
- 71 people
- Sponsor
- Seoul National University Hospital
Scleroderma, Systemic, Digital Ulcer
Study of Diosmin for the Treatment of Digital Ulcers in Systemic Sclerosis
This study is performed to consider the safety and healing ability of diosmin in patients with systemic sclerosis (scleroderma) and open sores on their fingers (digital ulcers).
- Trial name
- NCT06256575
- Testing
- Diosmin
- Where
- 5 sites in Canada
- Volunteers
- 45 people
- Sponsor
- Primus Pharmaceuticals
Type2diabetes, Rheumatoid Arthritis
Understanding Ayurveda Disease Conditions and Treatment Responses
The goal of this observational study is to assess Prakriti \& Vikriti in patients visiting OPD of IIISM department, SRM hospital.
- Conditions
- Type2diabetes, Rheumatoid Arthritis, Osteo Arthritis Knee, Skin Diseases
- Trial name
- NCT06167226
- Testing
- Personalized Ayurveda treatment protocol
- Where
- India
- Volunteers
- 497 people
- Sponsor
- Ayurai Private Limited
Systemic Sclerosis Patients With Digital Ulcers
Effect and Safety of Local Injection of Botulinum Toxin Type B Against Digital Ulcer in Systemic Sclerosis
Efficacy and safety of local infusion of botulinum toxin type B in patients with systemic sclerosis (SSc) with digital ulcer is evaluated by a randomized, double-blind study.
- Trial name
- NCT03007004
- Testing
- Botulinum toxin type B (2500 units / vial), Physiological saline
- Where
- Japan
- Volunteers
- 10 people
- Sponsor
- Gunma University
Digital Ulcers, Systemic Sclerosis
Efficacy and Safety of Oral Bosentan on Healing/Prevention of Digital (Finger) Ulcers in Patients With Scleroderma
In an earlier clinical trial, RAPIDS-1, conducted in scleroderma patients with or without digital ulcers at baseline, bosentan significantly reduced the number of new digital ulcers versus placebo.
- Trial name
- RAPIDS-2 (NCT00077584)
- Testing
- Bosentan 62.5 mg, Bosentan 125 mg
- Volunteers
- 188 people
- Sponsor
- Actelion
Post-Acute COVID-19 Syndrome, ME/CFS
Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research
The unhide® Project is a non-interventional, longitudinal research study designed to establish a secure data repository of demographic, health, and lifestyle information from individuals with brain inflammation and related…
- Conditions
- Post-Acute COVID-19 Syndrome, ME/CFS, Rheumatic Arthritis, Juvenile Rheumatoid Arthritis (JRA)
- Trial name
- NCT04806620
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Brain Inflammation Collaborative
Scleroderma, Digital Ulcer
Effectiveness of Bosentan Therapy in Patients With Systemic scleRosis and Progressive Digital ulcEr Disease.
Digital Ulcers (DEs), are painful open sores on the fingers and toes and are due to limited perfusion of blood vessels in patients with Scleroderma.
- Conditions
- Scleroderma, Digital Ulcer, Autoimmune Diseases, Diffuse Cutaneous Systemic Sclerosis
- Trial name
- CURE (NCT05168215)
- Where
- Greece
- Volunteers
- 300 people
- Sponsor
- Elpen Pharmaceutical Co. Inc.
Systemic Sclerosis
Effect of Different Iloprost Doses on Symptoms in Systemic Sclerosis
This study compared the efficacy of different dosages of long-term iloprost treatment on Raynaud's phenomenon, ulcer healing, skin thickening, and progression of internal organ sclerosis in systemic sclerosis (SSc). Methods.
- Trial name
- ILODOSE (NCT00622687)
- Testing
- iloprost, iloprost low dose, iloprost therapy up to 2 ng/kg x min
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Charite University, Berlin, Germany
Ulcer, Scleroderma
Ozone Therapy in the Treatment of Digital Ulcers in Patients With Systemic Sclerosis
Digital ulcers (DUs) in scleroderma result from recurrent Raynaud's phenomenon (RP) and microtrauma with high impact on quality of life, management of DUs is a great challenge for clinicians.
- Trial name
- NCT02733978
- Testing
- the ozone generator device (Human Pro medic, German)
- Volunteers
- 50 people
- Sponsor
- Assiut University
Scleroderma, Scleroderma Associated Digital Ulcer
Co-designing Digital Ulcers Opportunities With Patients and Clinicians
Scleroderma (SSc) is a rare crippling chronic disease associated with damage of the blood vessels and hardening of connective tissue.
- Conditions
- Scleroderma, Scleroderma Associated Digital Ulcer, Digital Ulcer
- Trial name
- CoDUo (NCT05785403)
- Testing
- No intervention
- Volunteers
- 25 people
- Sponsor
- King's College London
Diabetic Foot, Diabetic Foot Ulcer
Digital Foot Check by Using the D-Foot, a New Software
Patients with diabetes should be thoroughly examined before they are provided with insoles and shoes. In the study the feet are examined with the help of a new software, the D-Foot. D-Foot includes questions and surveys.
- Conditions
- Diabetic Foot, Diabetic Foot Ulcer, Diabetic Foot Ulcer Neuropathic, Neuropathy;Peripheral
- Trial name
- D-Foot2019 (NCT04054804)
- Testing
- D-Foot
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Sahlgrenska University Hospital
Systemic Sclerosis, Digital Ulcers
Digital Ulceration
The CAP study is a multicenter, observational, clinical study in patients with systemic sclerosis. The study aims at determining the usefulness of nailfold videocapillaroscopy and patient-specific disease-related factors in…
- Trial name
- CAP (NCT01377090)
- Where
- 50 sites in Austria, Belgium and 13 more
- Volunteers
- 630 people
- Sponsor
- Actelion