Clinical trials: Diminished Ovarian Reserve (DOR), open to volunteers
Diminished Ovarian Reserve (DOR)
Multi-Site Cortical Puncture for DOR
A multicenter, prospective, randomized controlled clinical trial. The target population consists of patients undergoing IVF/ICSI artificial reproduction who plan to undergo ovarian stimulation and embryo retrieval (DOR) within 4…
- Trial name
- MSCPD (NCT07568639)
- Testing
- multiple ovarian cortex punctures, routine oocyte retrieval procedure
- Where
- 7 sites in China
- Volunteers
- 214 people
- Sponsor
- First Affiliated Hospital of Guangxi Medical University
Diminished Ovarian Reserve (DOR)
Testing Herbal Pretreatment For IVF Success In Women With Low Ovarian Reserve
The goal of this clinical trial is to learn if a traditional Chinese herbal pretreatment can improve pregnancy outcomes in infertile women with diminished ovarian reserve (DOR) who are undergoing in vitro fertilization (IVF) or…
- Trial name
- PRIME (NCT07347340)
- Testing
- Bushen Tongzhi Formula
- Where
- China
- Volunteers
- 348 people
- Sponsor
- Peking Union Medical College Hospital
Diminished Ovarian Reserve (DOR), Thin Endometrium
A Randomized Controlled Study on the Effect of MRJPs on Improving Ovarian Function and Endometrial Receptivity
This study will assess the effects of the rose tablet candies produced by MRJPs on the subjects, evaluate the role of MRJPs in the ovarian function and endometrial receptivity of women, reveal the potential application value of…
- Trial name
- NCT07246733
- Testing
- Oral MRJPs Candy
- Where
- China
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Diminished Ovarian Reserve
The Effeciency of NMN in Improving IVF/ICSI-ET Pregnancy Outcomes in Patients With DOR
The purpose of the study is to understand the effect of nicotinamide mononucleotide (NMN) on patients with diminished ovarian reserve and the outcomes of IVF/ICSI-ET.
- Trial name
- NCT06426355
- Testing
- NMN
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking University Third Hospital
Perimenopause, Perimenopause-Related Depression
Intra Ovarian Muse Cell Injection for Perimenopause Symptom Relief and Ovarian Function Restoration (MUSE-OVARY)
This observational study examines the safety and effects of injecting Muse cells (a type of naturally occurring stem like cells found in adult tissues such as fat or bone marrow) directly into the ovaries of women aged 28 to 70…
- Conditions
- Perimenopause, Perimenopause-Related Depression, Premature Ovarian Insufficiency, Premature Ovarian Failure (POF)
- Trial name
- MUSE-OVARY (NCT07511660)
- Where
- Mexico
- Volunteers
- 12 people
- Sponsor
- Healing Hope International
Diminished Ovarian Reserve (DOR)
Clinical Study on ShouTai Pills for Improving Reduced Ovarian Reserve
Grounded in the 'disease-syndrome combination' paradigm, this study endeavors to address the pivotal scientific issues pertaining to the clinical precision of Traditional Chinese Medicine (TCM) in managing Diminished Ovarian…
- Trial name
- NCT07737847
- Testing
- Shoutai Pill
- Where
- China
- Volunteers
- 136 people
- Sponsor
- Peking Union Medical College Hospital
Infertility, Obesity
Use of Pulsatile Intravenous FSH to Mitigate Reprometabolic Syndrome
Hypothesis: The investigators hypothesize that pulsatile FSH intravenous administration to women with obesity will correct the Reprometabolic Syndrome (RMS) luteal deficiency phenotype.
- Conditions
- Infertility, Obesity, Diminished Ovarian Reserve (DOR), Diminished Ovarian Reserve
- Trial name
- NCT06414096
- Testing
- Follicle Stimulating Hormone
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Diminished Ovarian Reserve (DOR), Primary Ovarian Insufficiency (Poi)
Safety and Efficacy of Autologous Adipose-Derived Regenerative Cells (ADRCs) Injection for Improving Diminished Ovarian Reserve
Diminished Ovarian Reserve (DOR) poses significant challenges to fertility and hormonal health, with limited effective treatments.
- Conditions
- Diminished Ovarian Reserve (DOR), Primary Ovarian Insufficiency (Poi), Ovarian Failure, Premature
- Trial name
- ARISE-01 (NCT07117682)
- Testing
- Autologous Adipose-Derived Regenerative Cells (ADRCs) Intraovarian Injection
- Volunteers
- 25 people
- Sponsor
- Cytori Therapeutics
Diminished Ovarian Reserve (DOR), Infertility
Clinical Evaluation of Integrated Chinese-Western Medicine for Infertility With DOR Patients in Women Achieving Natural Pregnancy
This study aims to evaluate the superiority of an integrated traditional Chinese and Western medicine regimen ("Xiehe DOR Bushen Tongzhi Formula" + ovulation induction therapy with ovulation monitoring and timed intercourse)…
- Trial name
- NCT07296614
- Testing
- Western Medicine, Traditional Chinese Medicine
- Where
- China
- Volunteers
- 320 people
- Sponsor
- Peking Union Medical College Hospital
Diminished Ovarian Reserve, IVF Outcomes
The Effect of VitC on IVF Outcome of DOR Patients
In the context of the accelerating aging population and the continuous decline in birth rates nationwide, delaying reproductive aging in women and protecting the fertility of women of childbearing age have become urgent issues…
- Trial name
- DORIVF-VC (NCT06794047)
- Testing
- Vitamin C
- Where
- 6 sites in China
- Volunteers
- 1,100 people
- Sponsor
- Peking University Third Hospital
Diminished Ovarian Reserve (DOR)
Clinical and Metabolomics Studies on the Improvement of Ovarian Reserve by Acupoint Photodynamic Therapy and Traditional Chinese Medicine Treatment
Diminished Ovarian Reserve (DOR) refers to a reduction in the number of recruitable follicles in the ovaries and/or a decline in oocyte quality. Current research on its etiology and treatment remains unsatisfactory.
- Trial name
- NCT07376824
- Testing
- Traditional Chinese Medicine, Photodynamic therapy (PDT)
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Diminished Ovarian Reserve, IVF
Study of G-CSF for DOR in Patients Undergoing IVF
Diminished ovarian reserve (DOR) is defined by reduced follicle counts in women, associated with decreased fertility and lower success rates with In Vitro Fertilization (IVF).
- Conditions
- Diminished Ovarian Reserve, IVF, G-CSF, Granulocyte Colony Stimulating Factor
- Trial name
- NCT07871825
- Testing
- Neupogen 300 μg subcutaneous injection, Subcutaneous injections of a saline solution
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Center for Human Reproduction
Diminished Ovarian Reserve
Ovarian PRP for Diminished Ovarian Reserve
This prospective double-blinded randomized placebo control study aims to determine if In Vitro Fertilization (IVF) outcomes are improved by ovarian platelet-rich plasma injections (oPRP) for women diagnosed with diminished…
- Trial name
- oPRP (NCT05790655)
- Testing
- oPRP
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Generation Next Fertility
Diminished Ovarian Reserve (DOR)
The Clinical Trial of Electro-thumbtack Needle on Live Birth Rate in Patients With Ovarian Reserve Dysfunction (DOR)
This study will include 246 patients with ovarian reserve dysfunction (DOR), who will be randomly divided into a treatment group and a control group, with 123 patients in each group.
- Trial name
- NCT07142187
- Testing
- electro-thumbtack needle
- Volunteers
- 368 people
- Sponsor
- Huazhong University of Science and Technology
Diminished Ovarian Reserve (DOR)
Guishen Yijing Granules for Diminished Ovarian Reserve With Kidney Deficiency Syndrome: A Randomized Controlled Trial
This study is a multicenter, stratified block-randomized, double-blind, double-dummy clinical trial designed to evaluate the efficacy and safety of Guishen Yijing Granules in patients with diminished ovarian reserve (DOR) and…
- Trial name
- NCT07841548
- Testing
- Guishen Yijing Granules, Coenzyme Q10 (drug)
- Volunteers
- 120 people
- Sponsor
- Shi Yun
Diminished Ovarian Reserve, Female Infertility
Hippo-Related Competing Endogenous RNA (ceRNA) Network Dysregulation and In Vitro Fertilization (IVF) Outcomes in Women With Diminished Ovarian Reserve
Diminished Ovarian Reserve (DOR) is an important cause of female infertility and is associated with poor ovarian response and lower pregnancy rates during In Vitro Fertilization (IVF).
- Conditions
- Diminished Ovarian Reserve, Female Infertility, In Vitro Fertilization
- Trial name
- DOR-HIPPO-IVF (NCT07658846)
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Assiut University
Diminished Ovarian Reserve (DOR)
Yulinzhu for Women With Diminished Ovarian Reserve
This is a randomized waiting-list controlled crossover trial carried out to investigate the efficacy of traditional Chinese medicine (TCM) for DOR and its potential beneficial effects on fertility.
- Trial name
- DOR (NCT07550998)
- Testing
- Yulinzhu (a Chinese Medicinal Formulae)
- Where
- 2 sites in Hong Kong
- Volunteers
- 60 people
- Sponsor
- The University of Hong Kong
Diminished Ovarian Reserve (DOR), Infertility (IVF Patients)
RCT Study on the Effect of ETN on Live Birth Rate in DOR Patients Undergoing IVF-ET
The goal of this clinical trial is to examine the effect of ETN on live birth rate in patients with diminished ovarian reserve (DOR) undergoing in vitro fertilizitaion-embryo transfer (IVF-ET).
- Trial name
- ETN-LBR-DOR (NCT07769684)
- Testing
- electro-thumbtack needle (ETN) / thumbtack needle (TN)
- Where
- 4 sites in China
- Volunteers
- 406 people
- Sponsor
- Huazhong University of Science and Technology