Clinical trials: Diminished Pleasure
Healthy Participants, Anxiety Disorders (With High Anxiety Symptoms)
tVNS and Approach-Avoidance Behavior in Anhedonia and Anxiety
This study investigates if anhedonia and anxiety symptoms are associated with alterations in reinforcement learning, effort trade-offs for wins vs. punishments, and foraging behavior under threat.
- Conditions
- Healthy Participants, Anxiety Disorders (With High Anxiety Symptoms), Depressive Disorders (With High Anhedonia Symptoms), Comorbid Depression and Anxiety Disorder (With High Anhedonia and High Anxiety Symptoms)
- Trial name
- NCT07476469
- Testing
- tVNS
- Where
- Germany
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Dr. Nils B. Kroemer
Anhedonia
TMS Alteration of the Reward Positivity
The aim of this proposal is to demonstrate that stimulation of different brain regions differently affects the electroencephalographic feature known as the Reward Positivity (RewP).
- Trial name
- NCT05443256
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Anhedonia, Obesity
Evaluating Motivation and Reward Mechanisms and Brain Substrates in Adults With Obesity
Anhedonia and abnormalities in reward behavior are core features of overweight/obesity (OW), a highly prevalent condition within MDD populations, and is independently associated with reward disturbances.
- Trial name
- NCT03939676
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- Brain and Cognition Discovery Foundation
Major Depressive Disorder
Neutralizing Interleukin (IL)-6
The proposed study aims to establish the feasibility and safety of subcutaneous tocilizumab, a monoclonal antibody (mAb) against interleukin (IL)-6 receptor, in adults with Major Depressive Disorder (MDD) and evidence of…
- Trial name
- NCT07493317
- Testing
- Tocilizumab
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Anhedonia, Inflammation
Aging and Reward System Response to Inflammation and Anxiety Study
The purpose of this study is to use an experimental inflammatory challenge to examine whether older adults with symptoms of anxiety experience loss of pleasure or loss of motivation when they are exposed to inflammation.
- Conditions
- Anhedonia, Inflammation, Anxiety, Aging
- Trial name
- ARIA (NCT05363527)
- Testing
- Endotoxin
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Anhedonia
REward Processing And Citalopram Study
The goal of this experimental medicine study is to examine the effect of increasing serotonin on reward processing in healthy volunteers. The main questions it aims to answer are: 1.
- Trial name
- REPAC (NCT06017037)
- Testing
- Citalopram 20mg
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Depressive Disorder, Major, Anhedonia
A Study of Aticaprant as Adjunctive Therapy in Adult Participants With Major Depressive Disorder (MDD) With Moderate-to-severe Anhedonia and Inadequate Response to Current Antidepressant Therapy
The purpose of this study is to evaluate the efficacy of aticaprant compared with placebo as adjunctive therapy to an antidepressant in improving depressive symptoms in adult participants with major depressive disorder (MDD) with…
- Trial name
- VENTURA-1 (NCT05455684)
- Testing
- Aticaprant
- Where
- 120 sites in United States, Argentina and 11 more
- Volunteers
- 513 people
- Sponsor
- Janssen Research & Development, LLC
Cocaine-Related Disorders, Anhedonia
Targeting Anhedonia in Cocaine Use Disorder
The purpose of this study is to examine anhedonia as a potential moderator of treatment outcomes for Cocaine Use Disorder (CUD).
- Trial name
- NCT02773212
- Testing
- d-amphetamine, Contingency management
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- University of Illinois Chicago
Coronary Heart Disease, Depression
Cardiac Markers in Depressed Patients With Coronary Heart Disease - R01HL147862
Depression doubles the risk of death in patients with coronary heart disease (CHD), but so far, there is insufficient evidence that we can reduce the risk of death by treating depression.
- Trial name
- TREND-3 (NCT04682769)
- Testing
- Other
- Where
- United States
- Volunteers
- 175 people
- Sponsor
- Washington University School of Medicine
Anhedonia, Depression
Feasibility Randomized Controlled Trial Using a 'Leapfrog' Design
This study is a small-scale randomized controlled trial (RCT) using a 'Leapfrog' design (Blackwell, Woud, Margraf, \& Schönbrodt, 2019) with the aim of investigating feasibility of this design in the context of an RCT of an…
- Trial name
- NCT04791137
- Testing
- Imagery cognitive bias modification
- Where
- Germany
- Volunteers
- 188 people
- Sponsor
- Ruhr University of Bochum
Anhedonia in Healthy Volunteers, Older Adults (50-90 Years)
A Study of Psychedelics in Healthy Older Adults With Low Well-being
This study is being conducted to understand changes in brain activity following administration of two different drugs (Psilocybin and Dextromethorphan) in older adults with low well-being.
- Trial name
- OAD1 (NCT07386730)
- Testing
- Psilocybin (drug), Dextromethorphan (DXM)
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Jennifer Mitchell
Depressive Disorder, Depressive Disorder, Major
Synaptic Imaging and Network Activity in Treatment Resistant Depression
The main aim of this research is to explore the effects that ketamine has on the functional connectivity of the brain in participants with treatment resistant depression (TRD).
- Conditions
- Depressive Disorder, Depressive Disorder, Major, Depressive Disorder, Treatment-Resistant, Bipolar Disorder
- Trial name
- SIGNATURE (NCT05870501)
- Testing
- Ketamine, Midazolam
- Where
- United Kingdom
- Volunteers
- 56 people
- Sponsor
- King's College London
Outpatients / Inpatients With Depression
Study on the Optimal Diagnosis and Treatment Strategy of Major Depressive Disorder Based on Anhedonia
This study is a multicenter clinical research and focuses on the exploring of optimal diagnosis and treatment strategies of MDD based on anhedonia.
- Trial name
- NCT05389046
- Testing
- Escitalopram, Escitalopram+Aripiprazole, Escitalopram+omega-3 PUFAs
- Where
- 3 sites in China
- Volunteers
- 252 people
- Sponsor
- Peking University
Suicide, Mental Health Disorder
Optimizing a Just-in-time Adaptive Intervention for Suicide Safety Planning in Adolescents
Despite efforts to prevent suicide, US rates are climbing, and suicide is the second leading cause of death amongst youth. Digital tools, especially personal smartphones, are promising avenues to address these issues and can be…
- Conditions
- Suicide, Mental Health Disorder, Anhedonia
- Trial name
- NCT06665620
- Testing
- ViraBrite nudges
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Ksana Health
Stable Schizophrenia
A Randomized, Double-Blind, Placebo Controlled, Two-Period Cross-Over, Proof of Activity Study to Evaluate the Effects of TAK-041 on Motivational Anhedonia as Add-On to Antipsychotics in Participants With Stable Schizophrenia
The purpose of the study is to determine whether motivation/reward deficits observed in schizophrenia are attenuated and whether cognitive impairment associated with schizophrenia is improved by add-on TAK-041 administration to…
- Trial name
- NCT03319953
- Testing
- TAK-041, Second Generation Antipsychotics (SGA)
- Where
- United Kingdom
- Volunteers
- 23 people
- Sponsor
- Neurocrine Biosciences
Healthy
Chatbot Intervention Effects on Belief Updating in Anhedonia
The main aim of the present study is to investigate the effects of a Motivational Interviewing-based artificial intelligence chatbot on belief updating in college students with elevated levels of depression and anhedonia by…
- Trial name
- NCT07663019
- Testing
- MI Chatbot Interaction, Active Control Chatbot Interaction
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Depression, Anhedonia
Family Promoting Positive Emotions Pilot Study
Anhedonia is characterized by loss of interest or pleasure. The proposed pilot study would be the first to test an innovative, neuroscience-informed intervention in mothers reporting depressive symptoms and stress to enhance…
- Conditions
- Depression, Anhedonia, Stress, Depressive Disorder
- Trial name
- NCT05223842
- Testing
- Family Promoting Positive Emotions (F-PPE), Written Information
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Vanderbilt University
Depression - Major Depressive Disorder, Depression Disorder
Link Between Reduction of Suicide Ideation by Esketamine in Add-On and Initial Levels of Psychological Pain and Anhedonia
This study is looking at how intranasal esketamine (a nasal spray) can help reduce suicidal thoughts in patients with severe depression who are experiencing suicidal thoughts.
- Conditions
- Depression - Major Depressive Disorder, Depression Disorder, Suicide
- Trial name
- IODA (NCT07199179)
- Where
- France
- Volunteers
- 456 people
- Sponsor
- University Hospital, Montpellier
Emotions, Anhedonia
Geolocation Positional System (GPS) Experience
The purpose of this study is to use smartphone technology to capture individual location emotional and cognitive data, to examine how real-world behaviors thoughts, emotions, and brain activity are related to one another.
- Conditions
- Emotions, Anhedonia, Depression
- Trial name
- NCT05991713
- Testing
- Modifying Exploration
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Miami
Depression
The Effects of taVNS on Motivation in MDD With Anhedonia
Study of non-invasive transcutaneous auricular vagus nerve stimulation (taVNS) intervention to improve the reward motivation and response inhibition of major depression disorder and its brain network mechanism.
- Trial name
- NCT06026904
- Testing
- transcutaneous auricular vagus nerve stimulation
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Anhui Medical University