Clinical trials: Directly Observed Therapy
Therapy, Directly Observed
Acceptance and Commitment Therapy and Test Anxiety
The aim of this study is to evaluate the effect of acceptance and commitment therapy-based psychoeducation on test anxiety, study skills and psychological flexibility on adolescents.
- Trial name
- NCT05665933
- Testing
- ACCEPTANCE AND COMMITMENT THERAPY-BASED PSYCOEDUCATION
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Artvin Coruh University
HIV/AIDS, Substance Abuse
Directly Observed Therapy for Community-Released HIV+ Prisoners
The aim of this study is to develop effective interventions for HIV-infected prisoners who are released to the community. The intervention that we will study will be directly observed therapy (DAART/DOT) and we will compare this…
- Trial name
- Connect (NCT00786396)
- Testing
- Directly administered antiretroviral therapy
- Where
- 2 sites in United States
- Volunteers
- 151 people
- Sponsor
- Yale University
Hepatitis C Virus Infection
Pender Assisted Therapy (PATh) - Prospective Study of the Treatment of HCV
The treatment of HCV-infected IDUs presents multiple challenges, such as adherence to therapy, relapse of substance use, re-infection, and co-morbid psychiatric disease.
- Trial name
- NCT00247884
- Where
- 2 sites in Canada
- Volunteers
- 50 people
- Sponsor
- University of British Columbia
HIV Infections
Helping HIV Infected Patients in South Africa Adhere to Drug Regimens
Three or more anti-HIV drugs are taken in combination as part of a treatment regimen. These drug regimens must be closely followed in order to be successful.
- Trial name
- NCT00076804
- Testing
- Directly Observed Therapy
- Where
- South Africa
- Volunteers
- 274 people
- Sponsor
- Johns Hopkins University
Tuberculosis
Effect of Community Mobile Outreach Approach Compared to Facility Based Directly Observed Treatment Short Course on Treatment Outcome Among Tuberculosis Patients in Jeddah: A Randomized Controlled Trial
To compare the effectiveness of the community mobile outreach approach in improving treatment outcomes (success rate) among tuberculosis patients with those being treated with facility based directly observed treatment short…
- Trial name
- NCT03787914
- Testing
- Mobile Outreach Approach
- Where
- Saudi Arabia
- Volunteers
- 200 people
- Sponsor
- Ministry of Health, Saudi Arabia
Pulmonary Tuberculosis
Directly Observed Therapy Short Course-Plus Versus DOTS for Retreatment of Relapsed Pulmonary Tuberculosis in Guangzhou
This is a prospective, randomized, parallel, controlled study comparing the efficacy and outcomes in the retreatment of pulmonary Tuberculosis (TB) in Guangzhou in a group using pretreatment susceptibility tests in selection of…
- Trial name
- NCT01618422
- Testing
- Directly Observed Therapy (DOTS) plus, Directly Observed Therapy (DOTS)
- Where
- China
- Volunteers
- 225 people
- Sponsor
- Chinese University of Hong Kong
Asthma in Children, Directly Observed Therapy
Project ASTHMA - Aligning With Schools To Help Manage Asthma and Improve Outcomes
Children with asthma from communities that experience health inequities frequently do not receive guideline-based asthma care, and as a result, account for a disproportionate percentage of asthma exacerbations, emergency…
- Trial name
- NCT06539312
- Testing
- APP assessment and management of asthma
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- State University of New York at Buffalo
Sickle Cell Disease
Applying Directly Observed Therapy to Hydroxyurea to Realize Effectiveness
This study is for caregivers of young children with sickle cell disease and adolescents with sickle cell disease who are currently prescribed hydroxyurea and are receiving care at one of the study sites.
- Trial name
- ADHERE (NCT06264700)
- Testing
- Video Directly Observed Therapy (VDOT), Health Reminder Tip Alerts
- Where
- 3 sites in United States
- Volunteers
- 60 people
- Sponsor
- Nationwide Children's Hospital
Hepatitis C, Chronic
Role of Pegylated Interferon in Combination With DAAs to Cure Hepatitis C As Soon As Possible - Hepatitis C [ASAP-C]
The primary objective of this pilot trial is to compare the efficacy, measured as sustained virologic response (SVR) at least 12 weeks after completion of therapy, across three study regimens/delivery modalities: Arm 1 - 4 weeks…
- Trial name
- NCT03480932
- Testing
- Sofosbuvir, Daclatasvir, Pegylated Interferon alfa-2a
- Where
- India
- Volunteers
- 150 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Asthma in Children
vDOT for Newly Diagnosed Pediatric Asthma
The goal of this research study is to compare the impact of video directly observed therapy on inhaler technique accuracy with participants receiving video directly observed therapy vs.
- Trial name
- NCT05120323
- Testing
- vDOT Intervention Group
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Arkansas Children's Hospital Research Institute
Hypertension
Prevalence of Resistant Hypertension With DOT
High blood pressure is a risk factor for bad clinical events, such as heart failure, stroke, kidney failure and death. This risk is much higher in those with 'resistant' hypertension, in whom the blood pressure remains high…
- Trial name
- DOT (NCT02513524)
- Testing
- Direct Observed Therapy test
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Ottawa Hospital Research Institute
HIV, HIV Infections
Evaluation of Effectiveness of Pharmaceutical Care on the Adherence of HIV-Positive Patients to Antiretroviral Therapy
INTRODUCTION: Studies prove that the pharmaceutical care (PC) increases the adherence to the antiretroviral; thus, they increase the undetectable viral load.
- Trial name
- PC-HIV (NCT00959361)
- Testing
- pharmaceutical care
- Where
- Brazil
- Volunteers
- 332 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Hypertension
Treatment of Hypertension: an Interventional Approach to Improve Blood Pressure Control
The purpose of the study is to access the change in mean daytime systolic blood pressure in participants with essential hypertension not adequately controlled (defined as mean systolic daytime ambulatory blood pressure ≥ 135…
- Trial name
- DRIVE (NCT02362893)
- Testing
- Direct Observed Therapy
- Where
- Norway
- Volunteers
- 20 people
- Sponsor
- Oslo University Hospital
Latent Tuberculosis
Video Based Directly Observed Therapy for Latent TB
Center for Disease Control (CDC) data reveal that after years of sustained decrease, the incidence of active tuberculosis (TB) disease in the US has plateaued.
- Trial name
- NCT03783728
- Testing
- Rifapentine 600 mg orally, Isoniazid 900 mg orally, Pyridoxine 50 mg orally
- Where
- United States
- Sponsor
- St. Louis University
Tuberculosis, Drug-resistant Tuberculosis
An Evaluation of Traditional Directly Observed Therapy (DOT) and Electronic DOT for TB Treatment
This study is a U.S.-based, 1 site (with 4 clinical settings), randomized controlled trial (with funding from the Centers for Disease Control and Prevention's (CDC) Antibiotic Resistance Solutions Initiative) that will be…
- Conditions
- Tuberculosis, Drug-resistant Tuberculosis, Adherence, Medication, Adherence, Patient
- Trial name
- NCT03266003
- Testing
- Electronic DOT, In-person DOT
- Where
- 4 sites in United States
- Volunteers
- 216 people
- Sponsor
- Centers for Disease Control and Prevention
Acquired Immunodeficiency Syndrome
Longitudinal Study of HAART, Social Networks, & Adherence
Our study is a randomized controlled trial that aims to evaluate the effectiveness of modified directly observed therapy (mDOT) to (1) increase both short and long term adherence to HAART treatment, and (2) improve clinical…
- Trial name
- NCT00272220
- Testing
- modified directly observed therapy (mDOT)
- Where
- Mozambique
- Volunteers
- 350 people
- Sponsor
- University of Washington
Hepatitis C
Pilot Trial of Directly Observed Anti HCV Therapy & Contingency Management in a Population on Opiate Substitute Therapy
DOT-C is a cluster randomised trial of a pharmacist-led, directly observed anti HCV therapy pathway versus the conventional care pathway within community pharmacies.
- Trial name
- DOT-C (NCT03483818)
- Testing
- Assessment & Treatment of HCV infection with oral antivirals
- Where
- United Kingdom
- Volunteers
- 152 people
- Sponsor
- NHS Tayside
Tuberculosis, Latent Tuberculosis Infection
VDOT for Monitoring Adherence to LTBI Treatment
The three-month short-course treatment with isoniazid [H] and rifapentine [P] (3HP) recently recommended by the Centers for Disease Control and Prevention could dramatically increase the number of persons starting and completing…
- Trial name
- VMALT (NCT02641106)
- Testing
- Video Directly Observed Therapy, In-Person DOT
- Where
- United States
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Hepatitis C, Medication Adherence
Smartphone Based aDOT Treatment With Fixed-Dose Elbasvir and Grazoprevir in PWIDs
People who Inject Drugs (PWIDs) constitute 60% of the approximately 5 million people in the United States infected with hepatitis C virus (HCV).
- Trial name
- NCT03127358
- Testing
- AiCure, AiCure with gamification
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Albert Einstein College of Medicine
HIV Infections, Acquired Immunodeficiency Syndrome
Efficacy of Thrice Weekly Directly Observed Treatment, Short-course (DOTS) in HIV-associated Tuberculosis
Tuberculosis (TB) is the most common opportunistic infection among HIV infected persons living in developing countries. Directly observed treatment, short-course (DOTS) is the internationally recommended strategy for the…
- Conditions
- HIV Infections, Acquired Immunodeficiency Syndrome, Tuberculosis
- Trial name
- NCT00698334
- Testing
- INH, Rifampicin, Ethambutol and Pyrazinamide
- Where
- India
- Volunteers
- 150 people
- Sponsor
- All India Institute of Medical Sciences