Clinical trials: Directly Observed Therapy
Tuberculosis
Electronic Pillbox-enabled SAT Versus DOT for TB Medication Adherence and Treatment Outcomes
To address the multifaceted challenges associated with tuberculosis (TB) in-person directly observed therapy (DOT), the World Health Organization recently recommended countries maximize the use of digital adherence technologies.
- Trial name
- SELFTB (NCT04216420)
- Testing
- MERM-observed self-administered therapy
- Where
- Ethiopia
- Volunteers
- 114 people
- Sponsor
- Addis Ababa University
Depression, Hemodialysis-Induced Symptom
Identifying and Treating Depression in Hemodialysis Patients
Depression is present in about 20-30% of hemodialysis patients and is associated with morbidity and mortality. However, depression is inadequately diagnosed and treated among dialysis patients.
- Trial name
- NCT03390933
- Testing
- Fluoxetine
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- MetroHealth Medical Center
Hepatitis C
Pilot Trial of Directly Observed Anti HCV Therapy & Contingency Management in a Population on Opiate Substitute Therapy
DOT-C is a cluster randomised trial of a pharmacist-led, directly observed anti HCV therapy pathway versus the conventional care pathway within community pharmacies.
- Trial name
- DOT-C (NCT03483818)
- Testing
- Assessment & Treatment of HCV infection with oral antivirals
- Where
- United Kingdom
- Volunteers
- 152 people
- Sponsor
- NHS Tayside
Asthma in Children
vDOT for Newly Diagnosed Pediatric Asthma
The goal of this research study is to compare the impact of video directly observed therapy on inhaler technique accuracy with participants receiving video directly observed therapy vs.
- Trial name
- NCT05120323
- Testing
- vDOT Intervention Group
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Arkansas Children's Hospital Research Institute
HIV Infections
Helping HIV Infected Patients in South Africa Adhere to Drug Regimens
Three or more anti-HIV drugs are taken in combination as part of a treatment regimen. These drug regimens must be closely followed in order to be successful.
- Trial name
- NCT00076804
- Testing
- Directly Observed Therapy
- Where
- South Africa
- Volunteers
- 274 people
- Sponsor
- Johns Hopkins University
HIV Infections, Tuberculosis
Effectiveness of Directly Observed Therapy in Combined HIV and Tuberculosis Treatment in Resource-limited Settings
Tuberculosis (TB), a bacterial infection common in HIV infected people, is a major problem in developing countries. The purpose of this study is to test the effectiveness of a combined treatment strategy using directly observed…
- Trial name
- NCT00091936
- Testing
- Didanosine, Efavirenz, Lamivudine
- Where
- 2 sites in South Africa
- Volunteers
- 592 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections
Directly Observed Therapy for HIV Infected Adolescents
Adherence to a doctor-prescribed anti-HIV drug regimen is crucial in the management of HIV infection. In previous studies with tuberculosis patients, directly observed therapy (DOT), a strategy in which patients are observed…
- Trial name
- NCT00259389
- Testing
- Directly observed therapy (DOT)
- Where
- 6 sites in United States
- Volunteers
- 24 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Tuberculosis
Innovative Approach in Tuberculosis Care in Armenia
Randomized trial tests effectiveness of self-administered drug intake by empowered TB patients - supervised by a trained family member and supported by medical counseling and reminders - to improve treatment adherence and…
- Trial name
- NCT02082340
- Testing
- TB knowledge and socio-psychological counseling session, SMS text messages, phone calls
- Where
- Armenia
- Volunteers
- 392 people
- Sponsor
- Varduhi Petrosyan
HIV, HIV Infections
Evaluation of Effectiveness of Pharmaceutical Care on the Adherence of HIV-Positive Patients to Antiretroviral Therapy
INTRODUCTION: Studies prove that the pharmaceutical care (PC) increases the adherence to the antiretroviral; thus, they increase the undetectable viral load.
- Trial name
- PC-HIV (NCT00959361)
- Testing
- pharmaceutical care
- Where
- Brazil
- Volunteers
- 332 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
HIV Infections, Acquired Immunodeficiency Syndrome
Efficacy of Thrice Weekly Directly Observed Treatment, Short-course (DOTS) in HIV-associated Tuberculosis
Tuberculosis (TB) is the most common opportunistic infection among HIV infected persons living in developing countries. Directly observed treatment, short-course (DOTS) is the internationally recommended strategy for the…
- Conditions
- HIV Infections, Acquired Immunodeficiency Syndrome, Tuberculosis
- Trial name
- NCT00698334
- Testing
- INH, Rifampicin, Ethambutol and Pyrazinamide
- Where
- India
- Volunteers
- 150 people
- Sponsor
- All India Institute of Medical Sciences
Hypertension
Treatment of Hypertension: an Interventional Approach to Improve Blood Pressure Control
The purpose of the study is to access the change in mean daytime systolic blood pressure in participants with essential hypertension not adequately controlled (defined as mean systolic daytime ambulatory blood pressure ≥ 135…
- Trial name
- DRIVE (NCT02362893)
- Testing
- Direct Observed Therapy
- Where
- Norway
- Volunteers
- 20 people
- Sponsor
- Oslo University Hospital
Acquired Immunodeficiency Syndrome
Longitudinal Study of HAART, Social Networks, & Adherence
Our study is a randomized controlled trial that aims to evaluate the effectiveness of modified directly observed therapy (mDOT) to (1) increase both short and long term adherence to HAART treatment, and (2) improve clinical…
- Trial name
- NCT00272220
- Testing
- modified directly observed therapy (mDOT)
- Where
- Mozambique
- Volunteers
- 350 people
- Sponsor
- University of Washington
Tobacco Use Disorder, Opioid-use Disorder
A Trial of Directly Observed and Long-term Varenicline
This 2 x 2 factorial, randomized, double-blind, placebo-controlled trial will test two interventions: directly observed medication therapy, and long-term therapy with varenicline among smokers with opioid use disorder recruited…
- Trial name
- NCT03365362
- Testing
- Long-Term Varenicline, Short-Term Varenicline, Directly Observed Therapy
- Where
- United States
- Volunteers
- 243 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Stroke
Using Artificial Intelligence to Measure and Optimize Adherence in Patients on Anticoagulation Therapy.
AiCure uses artificial intelligence and visual recognition technology to confirm medication ingestion. The software is available as an app and downloaded onto a smart phone.
- Trial name
- NCT02599259
- Testing
- Monitored (M+)
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- AiCure
HIV Infections
Directly Observed Therapy in HIV Infected Adolescent Focus Groups
The purpose of this study is to help researchers use information from HIV infected adolescents to design a directly observed therapy (DOT) program that will help adolescents take their anti-HIV medications correctly.
- Trial name
- NCT00079729
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Hepatitis C, Chronic
Role of Pegylated Interferon in Combination With DAAs to Cure Hepatitis C As Soon As Possible - Hepatitis C [ASAP-C]
The primary objective of this pilot trial is to compare the efficacy, measured as sustained virologic response (SVR) at least 12 weeks after completion of therapy, across three study regimens/delivery modalities: Arm 1 - 4 weeks…
- Trial name
- NCT03480932
- Testing
- Sofosbuvir, Daclatasvir, Pegylated Interferon alfa-2a
- Where
- India
- Volunteers
- 150 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Sickle Cell Anaemia
Mobile-Directly Observed Therapy on Adherence to Hydroxyurea
To examine the effect of mobile-directly observed therapy (mDOT) on adherence to HU (mDOT-HuA) adults with SCA at Muhimbili National Hospital (MNH) in Tanzania.
- Trial name
- mDOT (NCT02844673)
- Testing
- Hydroxyurea, Mobile Directly Observed Therapy
- Where
- Tanzania
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Muhimbili University of Health and Allied Sciences
Chronic Hepatitis C
Therapy With Ledipasvir/Sofosbuvir in Patients With Genotype 1 HCV Infection Receiving Opiate Substitution Therapy
Patients with chronic hepatitis C that are under opiate substitution therapy are likely to have psychiatric comorbidities such as depression; hence an Interferon based therapy is contraindicated.
- Trial name
- NCT02638233
- Testing
- Sofosbuvir 400mg / Ledipasvir 90 mg (FDC)
- Where
- Austria
- Volunteers
- 40 people
- Sponsor
- Wilhelminenspital Vienna
HIV/AIDS, Substance Abuse
Directly Observed Therapy for Community-Released HIV+ Prisoners
The aim of this study is to develop effective interventions for HIV-infected prisoners who are released to the community. The intervention that we will study will be directly observed therapy (DAART/DOT) and we will compare this…
- Trial name
- Connect (NCT00786396)
- Testing
- Directly administered antiretroviral therapy
- Where
- 2 sites in United States
- Volunteers
- 151 people
- Sponsor
- Yale University
Asthma in Children, Directly Observed Therapy
Project ASTHMA - Aligning With Schools To Help Manage Asthma and Improve Outcomes
Children with asthma from communities that experience health inequities frequently do not receive guideline-based asthma care, and as a result, account for a disproportionate percentage of asthma exacerbations, emergency…
- Trial name
- NCT06539312
- Testing
- APP assessment and management of asthma
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- State University of New York at Buffalo