Clinical trials: Disabilities, Intellectual, open to volunteers
Autism Spectrum Disorder, Intellectual Disability
Feasibility and Usability of a Virtual Reality System
Intellectual disability (ID) and autism spectrum disorder (ASD) are often co-occurring neurodevelopmental disorders that require composite intervention.
- Trial name
- NCT06291532
- Testing
- Rehabilitation with VRRS, Conventional cognitive training
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Down Syndrome (DS), Keratoconus
Compassionate Use Study of Epi-ON Corneal Collagen Crosslinking Performed Using UVA Exposure on Eyes With Ectatic Corneal Diseases for Subjects With Down Syndrome
The goal of this clinical trial is to study the effects of an experimental (not Food and Drug Administration (FDA)-approved) treatment called corneal crosslinking (CXL) for conditions in which the cornea becomes progressively…
- Conditions
- Down Syndrome (DS), Keratoconus, Pellucid Marginal Degeneration, Forme Fruste Keratoconus (FFK)
- Trial name
- NCT07135167
- Testing
- Epi-ON corneal cross-linking (CXL)
- Where
- 12 sites in United States
- Volunteers
- 225 people
- Sponsor
- Woolfson Eye Institute
Down Syndrome
Modulation of the Immune System in Down Syndrome for Improved Outcomes and Neurodevelopment - 1
This protocol describes a phase 2, double-blind, randomized, placebo-controlled clinical trial for Janus kinase (JAK) inhibition in Down syndrome (DS).
- Trial name
- MISSION-1 (NCT07598643)
- Testing
- Tofacitinib Oral Solution
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- University of Colorado, Denver
Inherited Disease, Rare Diseases
Longitudinal Study of Ultra-rare Inherited Metabolic and Degenerative Neurological Diseases.
General aim of the study is the improvement of the clinical knowledge of ultra-rare inherited metabolic and degenerative neurological diseases (prevalence less than 5:100,000) in adulthood through the systematic longitudinal…
- Conditions
- Inherited Disease, Rare Diseases, Metabolic Disease, Undiagnosed Disease
- Trial name
- NCT04880356
- Testing
- collection of data
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Health Knowledge, Intellectual Developmental Disorder
Easy-to-Read Content Effectiveness Evaluation
Individuals with intellectual disabilities face challenges in accessing medical services and health education due to communication barriers and limited support tools.
- Conditions
- Health Knowledge, Intellectual Developmental Disorder, Visual Impairment
- Trial name
- NCT07036575
- Testing
- Standard Visual Health Education, Easy-Read Instructor-Guided Education, Easy-Read Audio-Based Self-Learning
- Where
- Taiwan
- Volunteers
- 250 people
- Sponsor
- National Taiwan University Hospital
Down Syndrome
Harness-based Mobility Intervention for Infants With Down Syndrome
The emergence of crawling and walking is significantly delayed in infants with Down syndrome (DS), but the development of independent mobility provides infants with new opportunities for exploring the environment and interacting…
- Trial name
- NCT06219863
- Testing
- Body weight supported harness
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Boston University Charles River Campus
Obstructive Sleep Apnea
Optimizing the Management of OSA in Children With Down Syndrome
The objective of this retrospective descriptive study is to assess current practices for the screening and surgical treatment of OSA in children with Down syndrome at the Strasbourg University Hospital and to disseminate a…
- Trial name
- SAOS-21 (NCT07334444)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Strasbourg, France
Down Syndrome, Hemiparesis
Kinematic Analysis of Manual Dexterity
The following study aims to standardize the instrumented BBT for the objective evaluation of upper limb joint kinematics using MoCap on a population of healthy subjects between 4 and 18 years of age.
- Conditions
- Down Syndrome, Hemiparesis, Healthy Subjects
- Trial name
- SUPERFUN (NCT07875127)
- Testing
- Inertial Measurement Unit and Box and Block test
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele Roma
Down Syndrome, Down Syndrome, Partial Trisomy 21
Cholinergic Integrity in Down Syndrome in Association With Aging, Alzheimer's Disease Pathology, and Cognition
Progressive age-related cognitive deficits occurring in both AD and DS have been connected to the degeneration of several neuronal populations, but mechanisms are not fully elucidated.
- Conditions
- Down Syndrome, Down Syndrome, Partial Trisomy 21, Alzheimer Disease
- Trial name
- NCT05231798
- Testing
- [18F]-FEOBV Radiotracer
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Menkes Disease
NORTHERA (DROXIDOPA) for Dysautonomia in Pediatric Survivors of Menkes Disease
This clinical trial will evaluate the safety, tolerability, dosing, and efficacy of Northera (Droxidopa) in children with Menkes disease aged 7 to 17 years who survived the major neurodegenerative and neurocognitive effects of…
- Trial name
- NCT07398508
- Testing
- Droxidopa Oral Product
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Stephen G. Kaler
Cancer Awareness and Prevention Education, Breast Cancer Awareness
A Single-Arm Interventional Trial of Pepper- Robot Delivered Cancer Education for Adults With Intellectual Disability
Individuals with Intellectual disability face numerous barriers to cancer education, awareness and screening, including communication challenges, anxiety, and a lack of accessible educational resources.
- Conditions
- Cancer Awareness and Prevention Education, Breast Cancer Awareness, Intellectual Disabilities (F70-F79)
- Trial name
- Pep-SMARTID (NCT07477938)
- Testing
- Robot delivered Education
- Where
- Ireland
- Volunteers
- 25 people
- Sponsor
- National University of Ireland, Galway, Ireland
Cerebral Palsy
Effects of Associated Impairments on Activity and Participation in Children With Cerebral Palsy
This study will investigate the effects of associated impairments on the activity levels and social participation of school-aged children with Cerebral Palsy (aged 6-12) and their impact on their families' quality of life and…
- Trial name
- NCT06944171
- Where
- Turkey (Türkiye)
- Volunteers
- 107 people
- Sponsor
- Hacettepe University
X-linked Adrenoleukodystrophy
Validation of a Prognostic Biomarker Using Brain Diffusion MRI in X-linked Adrenoleukodystrophy
CALD is an inflammatory demyelinating disease that causes severe motor and cognitive deficit leading to rapid death. Hematopoietic stem cell transplantation (HSCT) can halt neuroinflammation in CALD through the replacement of…
- Trial name
- CALDIFF (NCT05911919)
- Testing
- brainQuant module of brainTale-care platform
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Down Syndrome (DS)
Suspension Therapy Effects on Mobility and Balance in Down Syndrome
Down syndrome (DS) is one of the most common congenital disorders. Individuals with Down syndrome present with several impairments such as hypotonia, ligament laxity, decreased muscle strength, insufficient muscular…
- Trial name
- STOMP (NCT06748248)
- Testing
- suspension Therapy, Routine Treatment
- Where
- 2 sites in Pakistan
- Volunteers
- 26 people
- Sponsor
- Riphah International University
Intellectual Disability
Effects of Exercise Snacks on Physical Health and Cognitive Function in Individuals With Intellectual Disabilities
Intellectual disability (ID) is a neurodevelopmental disorder accompanied by sedentary lifestyles, which worsens cognitive function and physical health.
- Trial name
- NCT07759232
- Testing
- High-Intensity Interval Training, Exercise Snacks
- Where
- China
- Volunteers
- 24 people
- Sponsor
- University of Macau