Clinical trials: Disabilities, Intellectual
Intellectual Disability, Neurodevelopmental Disorder (Diagnosis)
Integration of New Generation Multi-omics Analyses for the Diagnosis of Genetic Neurodevelomental Disorders
Neurodevelopmental disorders (NDDs), including intellectual disability (ID), represent the most common indication for genetic testing.
- Conditions
- Intellectual Disability, Neurodevelopmental Disorder (Diagnosis), srGS, lrGS
- Trial name
- NEXTOMIX (NCT07755098)
- Testing
- Re-analysis of available srGS data, Re-analysis of available srGS data, followed by complementary analyses (lrGS sequencing, mRNA, and GMOs), srGS sequencing
- Where
- France
- Volunteers
- 132 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Mild Intellectual Disability, Borderline Intellectual Functioning
Improving the Cognitive Accessibility of Self-reports for People With ID
In the proposed study, the investigators aim to investigate whether the existing ABAS-3 self-report questionnaire is suitable to be completed meaningfully by individuals who are perceived as having mild intellectual disability…
- Trial name
- NCT05857592
- Testing
- Adaptive functioning self-report questionnaire, Adaptive functioning self-report questionnaire - adapted
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Koraal
Phelan-McDermid Syndrome, Autism Spectrum Disorder
Mapping the Genotype, Phenotype, and Natural History of Phelan-McDermid Syndrome
The purpose of this study is to comprehensively characterize PMS using standardized medical, cognitive, and behavioral measures and to track the natural history of the syndrome using repeated longitudinal assessments.
- Conditions
- Phelan-McDermid Syndrome, Autism Spectrum Disorder, Intellectual Disability
- Trial name
- NCT02461420
- Where
- 5 sites in United States
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Tuberous Sclerosis, Autism Disorder
Autism Spectrum Disorder (ASD) and Intellectual Disability (ID) Determinants in Tuberous Sclerosis Complex (TSC)
The purpose of this study is to characterize the developmental phenotype of ASD and ID and to identify biomarkers using advanced MRI methodology and electrophysiological biomarkers of synaptic function and connectivity predictive…
- Conditions
- Tuberous Sclerosis, Autism Disorder, Intellectual Disability
- Trial name
- NCT02461459
- Where
- 6 sites in United States
- Volunteers
- 205 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Down Syndrome (Trisomy 21), Fragile X Syndrome (FXS)
The Neurocognitive Bases of Trust in Intellectual Disability
This project studies the neurocognitive basis of trust adjustment in intellectual disability (ID), a source of significant vulnerability for these patients, focusing on two target populations chosen for their specific social…
- Trial name
- BNConfDI (NCT07434037)
- Testing
- Confidence adjustment assessment, clinical assessment, Cognitive assessment
- Where
- France
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Intellectual Disability
Evaluation of the Effect of Digital-based Games on the Visual and Cognitive Performance of Young Children With Intellectual Disabilities
This randomized controlled trial aims to evaluate the effect of digital intelligence games on visual and cognitive performance in young individuals with intellectual disabilities.
- Trial name
- NCT07476092
- Testing
- MentalUP Digital Intelligence Game
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Koç University
Intellectual Disability
Handgrip Strength, Trunk Muscle Endurance, and Functional Mobility in Adolescents With Mild Intellectual Disability
This comparative, cross-sectional observational study examined handgrip strength, trunk muscle endurance, and functional mobility in adolescents aged 12-18 years with mild intellectual disability and compared their performance…
- Trial name
- NCT06934850
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Inonu University
Psychological Resilience, Family Functioning
Does Group Therapy Improve Resilience and Family Functioning Among Mothers of Children With Intellectual Disabilities?
Abstract This study examined the effectiveness of a seven-week structured group therapy intervention designed to enhance the psychological resilience and family functioning of mothers of children with intellectual disabilities.
- Trial name
- NCT07738289
- Testing
- Structured Group Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Sinop University
Developmental Delay Disorder, Intellectual Disability
Clinical Trial of the Dual Vector Base Editor for the Treatment of the CHD3-R1025W Mutation
To evaluate the safety, tolerability and preliminary efficacy study of a single intrathecal injection of the dual vector AAV-CHD3-R1025W base editor for the treatment of developmental disorders caused by the R1025W mutation in…
- Conditions
- Developmental Delay Disorder, Intellectual Disability, Rare Diseases
- Trial name
- NCT06860672
- Testing
- Dual vector DNA base editor
- Where
- China
- Volunteers
- 1 people
- Sponsor
- Yongguo Yu
Intellectual Disabilities, Developmental Disability
Health Engagement & Access Through Learning, Training, and Health-coaching With People With Intellectual and/or Developmental Disabilities
The purpose of this study is to see if a combination of an educational curriculum and health coaching embedded within Special Olympics improves health outcomes and healthcare access compared to regular Special Olympics sport and…
- Trial name
- HEALTH 4 ME (NCT07475117)
- Testing
- Comprehensive Community Health, Regular Special Olympics programming
- Where
- United States
- Volunteers
- 1,040 people
- Sponsor
- University of Wisconsin, Madison
Intellectual Disability, Mild to Moderate
Body Awareness Training for Motor Skills and Activity Performance in Children With Intellectual Disabilities
We tested whether adding a simple, structured Body Awareness Training (BAT) program to conventional physiotherapy improves motor skills, everyday activity performance, and participation (goal achievement and satisfaction) in…
- Trial name
- BAT-MAP-ID (NCT07729163)
- Testing
- Body Awareness Training and Conventional Physiotherapy, Conventional Physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 41 people
- Sponsor
- Cyprus International University
16P11.2 Deletion Syndrome, 16p11.2 Duplications
Online Study of People Who Have Genetic Changes and Features of Autism: Simons Searchlight
Simons Searchlight is an observational, online, international research program for families with rare genetic variants that cause neurodevelopmental disorders and may be associated with autism.
- Conditions
- 16P11.2 Deletion Syndrome, 16p11.2 Duplications, 1Q21.1 Deletion, 1Q21.1 Microduplication Syndrome (Disorder)
- Trial name
- NCT01238250
- Where
- 2 sites in United States
- Volunteers
- 100,000 people
- Sponsor
- Simons Searchlight
Developmental Dysphasia, Epileptic Encephalopathy, Childhood-Onset
CNKSR2 Natural History Study
This prospective natural history study is being conducted to define the electroclinical, neurodevelopmental, and behavioral characteristics of CNKSR2 epilepsy aphasia syndrome (EAS) and intellectual disability (ID) in children…
- Conditions
- Developmental Dysphasia, Epileptic Encephalopathy, Childhood-Onset, X-Linked Intellectual Disability
- Trial name
- CNKSR2 (NCT06500260)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, San Francisco
Fragile X Syndrome (FXS), Fragile X Syndrome
Safety, Tolerability, and Preliminary Effectiveness of CTH120 in Fragile X Syndrome
The purpose of this Phase IIa study is to evaluate the safety, tolerability, and effectiveness of CTH120 in adult males with Fragile X syndrome.
- Trial name
- FXS-CTH120-01 (NCT07654114)
- Testing
- CTH120
- Where
- 2 sites in Spain
- Volunteers
- 30 people
- Sponsor
- Connecta Therapeutics, S.L.
Developmental Disability, Intellectual Disability
Online Learning Module to Advance Research Related to People With Disabilities
This study will measure the effects of a brief one-time eLearning intervention on researcher Knowledge, Attitudes, and Perceptions (KAP) of including people with disabilities (PWDs) in biomedical \& behavioral research.
- Conditions
- Developmental Disability, Intellectual Disability, Disability
- Trial name
- D2/R3 (NCT07220837)
- Testing
- eLearning module, Control
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Being 18 Years of Age or Older, Having a Child Registered in a Special Education School
Awareness Of Home Accident Preventıon Among Parents Of Disabled Children And Evaluation Of The Basic First Aid Training Provided
This study was conducted to assess the awareness of parents of children with disabilities regarding the prevention of home accidents and the effectiveness of the basic first aid training provided.
- Conditions
- Being 18 Years of Age or Older, Having a Child Registered in a Special Education School, Providing Care for a Child With an Intellectual Disability, Providing Care for a Visually Impaired Child
- Trial name
- NCT07698860
- Testing
- Prevention of Household Accidents and Basic First Aid Training for Accidents
- Where
- Turkey (Türkiye)
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Kayseri University
Rett Syndrome
A Phase 1/2/3 Study of TSHA-102 Gene Therapy in Females With Rett Syndrome (REVEAL Pivotal Study)
The primary objectives of this study are to evaluate the safety of a single intrathecal (IT) dose of TSHA-102 in females with typical Rett syndrome, to select the TSHA-102 dose with the best benefit/risk profile based on the…
- Trial name
- NCT05606614
- Testing
- TSHA-102
- Where
- 9 sites in United States, Canada
- Volunteers
- 17 people
- Sponsor
- Taysha Gene Therapies, Inc.
Mild Intellectual Disability
Comparison of Sensory-Adapted and Regular Dental Environments in Patients With Mild Intellectual Disability and Moderate Dental Anxiety
This study compared a sensory-adapted dental environment (SADE) with a regular dental environment (RDE) in 6-7-year-old children with mild intellectual disability and moderate dental anxiety.
- Trial name
- SADE vs RDE (NCT07413016)
- Testing
- SADE, RDE
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Oasi Research Institute-IRCCS
Tardive Dyskinesia, Intellectual Disability
Deutetrabenazine Treatment for Tardive Dyskinesia in Intellectual/Developmental Disabilities
The primary goal of this study is to investigate the efficacy of deutetrabenazine treatment of TD in this previously untreated patient population.
- Conditions
- Tardive Dyskinesia, Intellectual Disability, Developmental Disabilities
- Trial name
- TD-AIDD (NCT06997198)
- Testing
- Deutetrabenazine Oral Capsule
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University Hospitals Cleveland Medical Center
Brain Injury, Chronic, Intellectual Disability, Mild to Moderate
The (Cost)Effectiveness of a Social Robot for Persons With Problems in Daily Structure and Planning in Disability Care
The goal of this multiple baseline single case study is to study the (cost)effectiveness of a social robot in reducing professional caregiver support and promoting independence for individuals in long-term disability care…
- Conditions
- Brain Injury, Chronic, Intellectual Disability, Mild to Moderate, Autism Spectrum Disorder, Down Syndrome
- Trial name
- NCT06592404
- Testing
- Robot Tessa
- Where
- 4 sites in Netherlands
- Volunteers
- 32 people
- Sponsor
- Academy Het Dorp