Clinical trials: Disability, Evaluation
Prader-Willi Syndrome
Octreotide Therapy in Children and Young Adults With Prader-Willi Syndrome (PWS)
The purpose of this study is to investigate over a 6 month period the effect of octreotide therapy on food intake, sense of hunger, body weight, body composition, efficiency of burning calories, biomarkers of weight regulation…
- Trial name
- NCT00399893
- Testing
- Octreotide
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Duke University
Smith-Lemli-Opitz Syndrome
Simvastatin Therapy in Smith-Lemli-Opitz Syndrome
This study will evaluate the safety and effectiveness of simvastatin in treating children with Smith-Lemli-Opitz syndrome (SLOS).
- Trial name
- NCT00064792
- Testing
- Simvastatin Susp., OraPlus
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Forbes Porter, M.D.
AMN, AMN Gene Mutation
A Study to Evaluate Administration of SBT101 Gene Therapy in Adult Patients With Adrenomyeloneuropathy (AMN)
This is a Phase 1/2 randomized, blinded, dose-escalation study to evaluate the safety and efficacy of intrathecal (IT) administration of SBT101, a recombinant adeno-associated virus serotype 9 (AAV9) containing a functional copy…
- Conditions
- AMN, AMN Gene Mutation, X-ALD
- Trial name
- PROPEL (NCT05394064)
- Testing
- SBT101 Treatment
- Where
- 2 sites in United States, Netherlands
- Volunteers
- 9 people
- Sponsor
- SwanBio Therapeutics, Inc.
Multiple Sclerosis, Healthy Adults
Gait Adaptability in Persons With MS Having Mild Disability
Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease of the central nervous system that frequently leads to walking impairment, balance deficits, fatigue, cognitive difficulties, and an increased risk…
- Trial name
- NCT07580820
- Where
- Belgium
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Hasselt University
Multiple Sclerosis
Evaluate Safety and Efficacy of Apitox Add-on Therapy for Improving Disability and Quality of Life in MS Patients
Determine the effects of Apitox add-on therapy on the progression of disability in all forms of multiple sclerosis (MS) utilizing the Expanded Disability Status Scale (EDSS) and the MS Functional Composite (MSFC) measure. b.
- Trial name
- NCT03710655
- Testing
- Apitox - pure honeybee toxin
- Volunteers
- 468 people
- Sponsor
- Apimeds, Inc.
Primary Progressive Multiple Sclerosis, Primary Progressive MS
A Phase 2a Study of SUN-627 in Participants With Non-Active Secondary Progressive and Primary Progressive Multiple Sclerosis (SPMS/PPMS)
The goal of this Phase 2 clinical trial is to investigate the safety and tolerability of SUN-627 in men and women aged 18-70 years old with a diagnosis of non-active SPMS/PPMS.
- Conditions
- Primary Progressive Multiple Sclerosis, Primary Progressive MS, Primary Progressive Multiple Sclerosis (PPMS), Secondary Progressive MS (SPMS)
- Trial name
- NCT07840326
- Testing
- SUN-627
- Where
- 7 sites in United States
- Volunteers
- 20 people
- Sponsor
- Sundance Biosciences, Inc.
Down Syndrome
An Online Health Tool About Down Syndrome: Down Syndrome Clinic to You
The investigators conducted a national two-arm, randomized controlled trial of caregivers of individuals with DS to assess the efficacy of DSC2U in assuring adherence to evidence-based guidelines.
- Trial name
- DSC2U (NCT04227197)
- Testing
- Down Syndrome Clinic to You (DSC2U)
- Where
- United States
- Volunteers
- 281 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Health Services for the Aged, Frailty
e-GAB: Electronic Geriatric Assessment Bundle: Development of an Arabic Self-administered Android CGA Application
The aim of this study is to design and assess the accuracy of administering the electronic Geriatric Assessment Bundle (e-GAB) compared to geriatrician performed comprehensive geriatric assessment (CGA) in a group of Egyptian…
- Conditions
- Health Services for the Aged, Frailty, Cognitive Impairment, Depression
- Trial name
- NCT04211285
- Testing
- e-GAB, standard physician performed CGA
- Where
- Egypt
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Down Syndrome, Alzheimer's Dementia
Relationship Between Down Syndrome (DS) and Alzheimer's Disease (AD)
In order to treat individuals with Down syndrome (DS) better and more efficiently and to gain more insights on its relation to Alzheimer's disease (AD), a comprehensive understanding is needed for its progression in the early or…
- Trial name
- NCT02759887
- Testing
- biospecimen collection, cognitive assessments, caregiver questionnaire
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- St. Joseph's Hospital and Medical Center, Phoenix
Psychological Disability, Cognitive Impairment
Psychological Evaluation After SCS Implantation
Spinal cord stimulation (SCS) is a therapeutic option for patients with chronic low back pain (CLBP) syndrome, when pharmacological, psychological, physical and occupational therapies or surgery fail to reduce symptoms.
- Conditions
- Psychological Disability, Cognitive Impairment, Quality of Life
- Trial name
- NCT05624814
- Testing
- Spinal Cord Stimulation, Standard therapies
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University Magna Graecia
Effectiveness of Toothbrush
The Study of Parental Toothbrushing Efficacy Assessment With Triple-Headed and Single-Headed Toothbrushes in Preschool Children With Developmental Disability
The Objectives 1. To evaluate the efficacy of dental plaque removal between triple-headed and single-headed toothbrushes in preschool children with developmental disabilities through parental brushing 2.
- Trial name
- NCT07373249
- Testing
- Triple-headed toothbrush
- Where
- Thailand
- Volunteers
- 24 people
- Sponsor
- Mahidol University
Hunter Syndrome
A Study of Elaprase in Children and Adults With Hunter Syndrome (Mucopolysaccharidosis II) in India
The main aim of this study is to learn more about the safety profile of Elaprase in Indian children and adults with hunter syndrome.
- Trial name
- NCT05058391
- Testing
- Elaprase
- Where
- 5 sites in India
- Volunteers
- 5 people
- Sponsor
- Takeda
Rett Syndrome
A Novel, Regulated Gene Therapy (NGN-401) Study for Females With Rett Syndrome
This study will evaluate the efficacy and safety profiles of the investigational gene therapy, NGN-401, in females with typical Rett syndrome.
- Trial name
- NCT05898620
- Testing
- NGN-401
- Where
- 16 sites in United States, Australia and 1 more
- Volunteers
- 33 people
- Sponsor
- Neurogene Inc.
Chronic Pain, Quality of Life
Evaluation of a Pilot Shard-care Program for Patients With Chronic Pain in the Champlain-LHIN
The study is evaluating an intervention consisting of a five week online mindfulness program for patients being referred to the Pain Clinic and triaged to eConsult.
- Trial name
- Shared-Care (NCT03531476)
- Testing
- Online Chronic Pain Management Program
- Where
- Canada
- Volunteers
- 240 people
- Sponsor
- Ottawa Hospital Research Institute
Mental Retardation, Autism Spectrum Disorder
A Cross-sectional Study to Evaluate Speech and Language Development in Chinese Children Aged 2-6 Years
The purpose of this study is to establish a new Chinese children's speech and language norm by obtaining the latest data of speech and language development of children aged 2 ~ 6 from different regions in China.
- Conditions
- Mental Retardation, Autism Spectrum Disorder, Attention Deficit Hyperactivity Disorder
- Trial name
- NCT05442229
- Testing
- establish a new Chinese children's speech and language norm
- Volunteers
- 5,744 people
- Sponsor
- Tongji Hospital
Disability, Intellectual
Importance of Multidimensional Assessments in Accompanying Schooling of Children With Mild to Moderate Intellectual Disability.
The EVAL'ID study aims to demonstrate the value of a multidimensional assessment in accompanying schooling of children with Intellectual Disability.
- Trial name
- EVAL'ID (NCT03088007)
- Testing
- Cognitive, adaptive, behavioral and academic assessment
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Hospices Civils de Lyon
Chronic Physical Health Conditions
MANAGE AT WORK: Addressing the Challenge of Chronic Physical Health Conditions in the Workplace
The specific aim of the study is to evaluate the health benefits of a series of group workshops designed for workers with chronic physical health conditions.
- Trial name
- NCT01978392
- Testing
- Self-management group workshops
- Where
- 4 sites in United States
- Volunteers
- 122 people
- Sponsor
- Liberty Mutual Research Institute for Safety
Down Syndrome, Regression
Therapies for Down Syndrome Regression Disorder
Individuals with Down syndrome (DS) have an increased risk of numerous co-occurring conditions, including the neuropsychiatric condition known as Down Syndrome Regression Disorder (DSRD).
- Trial name
- NCT05662228
- Testing
- Lorazepam, Intravenous immunoglobulin (IVIG), Tofacitinib
- Where
- 2 sites in United States
- Volunteers
- 66 people
- Sponsor
- University of Colorado, Denver
Cerebral Palsy, Covid19
Covid-19 Pandemic and Cerebral Palsy
Investigator aimed to analyzed the effect of Covid-19 pandemic on the physical-psychosocial and cognitive state of the children, to benefit form the health, education services and the caregiver's quality of life with telemedicine.
- Conditions
- Cerebral Palsy, Covid19, Telemedicine, Caregiver Quality of Life
- Trial name
- NCT04686565
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Diskapi Yildirim Beyazit Education and Research Hospital
Neck Pain
Eccentric Exercise in Patients With Non-Specific Neck Pain
Neck pain is one of the most frequently investigated and common musculoskeletal disorders that cause disability in the community.If neck pain is due to multifactorial etiology, it is defined as non-specific neck pain.Eccentric…
- Trial name
- NCT05826730
- Testing
- Eccentric Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people
- Sponsor
- Istinye University