Clinical trials: Disability, Evaluation
Health Knowledge, Intellectual Developmental Disorder
Easy-to-Read Content Effectiveness Evaluation
Individuals with intellectual disabilities face challenges in accessing medical services and health education due to communication barriers and limited support tools.
- Conditions
- Health Knowledge, Intellectual Developmental Disorder, Visual Impairment
- Trial name
- NCT07036575
- Testing
- Standard Visual Health Education, Easy-Read Instructor-Guided Education, Easy-Read Audio-Based Self-Learning
- Where
- Taiwan
- Volunteers
- 250 people
- Sponsor
- National Taiwan University Hospital
Cerebral Palsy, Down Syndrome
Investigation of Parents' Anxiety Level and Health Related Quality of Life in Different Types of Physical Disabilities
Disability brings many psychosocial problems in society. The effects of the health of a disabled child on the psychological health and quality of life of the family are inevitable.
- Conditions
- Cerebral Palsy, Down Syndrome, Spina Bifida, Muscular Dystrophy
- Trial name
- NCT04035967
- Testing
- Questionnaire
- Where
- Turkey (Türkiye)
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Sanko University
Rheumatoid Arthritis
Evaluation of a Connected Interface to Improve the Quality of Life and the Disability of Patient With Rheumatic Diseases
Musculoskeletal pathologies constitute a major public health problem. Rheumatologists, whether they practice in private or hospital settings, play a major role in the management of responsible for these ailments.
- Trial name
- RHUMATO-APP (NCT05417477)
- Testing
- use of an e-health application
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Montpellier
Prader-Willi Syndrome
A Study of CSTI-500 in Patients With Prader-Willi Syndrome
This is a proof-of-concept, open-label, dose-escalation study to evaluate the safety, tolerability, pharmacokinetics, and efficacy of CSTI-500 in participants with genetically confirmed Prader-Willi Syndrome (PWS) who are 13 to…
- Trial name
- NCT07348601
- Testing
- CSTI-500
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- ConSynance Therapeutics
Fragile X Syndrome
Safety and Efficacy of AFQ056 in Adult Patients With Fragile X Syndrome
This Phase IIb study is designed to assess whether 3 doses of AFQ056 are safe and effective in treating the behavioral symptoms of Fragile X Syndrome.
- Trial name
- NCT01253629
- Testing
- AFQ056
- Where
- 31 sites in United States, Australia and 8 more
- Volunteers
- 175 people
- Sponsor
- Novartis Pharmaceuticals
Alzheimer Disease, Down Syndrome
Hero: A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics (PK) and Pharmacodynamics (PD) of ION269 in Participants With Down Syndrome (DS) at Risk for Alzheimer's Disease (AD)
The primary purpose of this study is to evaluate the safety and tolerability of ION269 in adults with Down syndrome with evidence of brain amyloid positivity.
- Trial name
- NCT06673069
- Testing
- ION269
- Where
- 6 sites in United States, Spain
- Volunteers
- 1 people
- Sponsor
- Ionis Pharmaceuticals, Inc.
Rett Syndrome
Auditory EEG and Behavioral Assessments in Individuals With Rett Syndrome
This observational research study is designed to learn more about how the brain processes sound in individuals with Rett syndrome.
- Trial name
- NCT07569445
- Testing
- Electroencephalogram (EEG) Recording
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Down Syndrome (Trisomy 21), Fragile X Syndrome (FXS)
The Neurocognitive Bases of Trust in Intellectual Disability
This project studies the neurocognitive basis of trust adjustment in intellectual disability (ID), a source of significant vulnerability for these patients, focusing on two target populations chosen for their specific social…
- Trial name
- BNConfDI (NCT07434037)
- Testing
- Confidence adjustment assessment, clinical assessment, Cognitive assessment
- Where
- France
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Autism Spectrum Disorder, Teacher Training
Implementation of a Teacher Classroom Program to Support Preschool Children With Autism or Developmental Problems
The Incredible Years® "Helping Preschool Children with Autism" (IY-HPCA) program is designed for teachers of children aged 2 to 5 years who have students with autism in their classrooms.
- Conditions
- Autism Spectrum Disorder, Teacher Training, Teacher Skills in Addressing Child Mental Health Problem, Developmental Disorders
- Trial name
- NCT06790199
- Testing
- Incredible Years® "Helping Preschool Children with Autism" program (IY-HPCA)
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Fundació Sant Joan de Déu
Rett Syndrome
A Phase 1/2/3 Study of TSHA-102 Gene Therapy in Females With Rett Syndrome (REVEAL Pivotal Study)
The primary objectives of this study are to evaluate the safety of a single intrathecal (IT) dose of TSHA-102 in females with typical Rett syndrome, to select the TSHA-102 dose with the best benefit/risk profile based on the…
- Trial name
- NCT05606614
- Testing
- TSHA-102
- Where
- 9 sites in United States, Canada
- Volunteers
- 17 people
- Sponsor
- Taysha Gene Therapies, Inc.
Neck Pain, Neck Pain Musculoskeletal
Neck Musculoskeletal Symptoms Among Turkish Endodontists
This observational study aims to evaluate the prevalence, severity, and characteristics of neck musculoskeletal symptoms among Turkish endodontists.
- Conditions
- Neck Pain, Neck Pain Musculoskeletal, Musculoskeletal Assessment, Musculoskeletal Disorder of the Neck
- Trial name
- ENDO-NECK (NCT07516782)
- Testing
- No intervention (observational study)
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Atlas University
Bariatric Surgery, Central Sensitization
The Effect of Bariatric Surgery to Central Sensitization
Nowadays obesity is emerging as a very common health problem. It has been shown in various studies that obesity may be an important risk factor for the onset and progression of knee osteoarthritis (OA).
- Trial name
- NCT03460691
- Testing
- Bariatric surgery
- Volunteers
- 50 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Disabilities Multiple
Investigation of the Relationship Between Pulmonary Function and Muscle Strength in Athletes With Disability
To investigate the relationship between respiratory function and core muscles strength in athletes with disabilities and compare with healthy athletes.
- Trial name
- NCT03769480
- Testing
- Muscle strength evaluation and Respiratory function Tests
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Ankara Yildirim Beyazıt University
Down Syndrome
Turkish Adaptation of Segmental Assessment of Trunk Control Scale
In infants with Down syndrome at risk in terms of neurosensory motor development retardation, the level of trunk control can determine the level of trunk control towards motor development in infants with down syndrome.
- Trial name
- NCT04657276
- Where
- Turkey (Türkiye)
- Volunteers
- 27 people
- Sponsor
- Hacettepe University
Adrenoleukodystrophy
A Clinical Study to Evaluate the Efficacy and Safety of MIN-102 (IMP) in Male AMN Patients
This is a Phase II/III, randomized, double-blind, placebo-controlled, multicenter, two parallel-group study in male patients with the adrenomyeloneuropathy (AMN) phenotype of X-linked adrenoleukodystrophy (X-ALD) to assess the…
- Trial name
- Advance (NCT03231878)
- Testing
- Leriglitazone
- Where
- 10 sites in United States, France and 6 more
- Volunteers
- 116 people
- Sponsor
- Minoryx Therapeutics, S.L.
Developmental Delay, Behavioural Problem
Early Detection and Intervention in Developmental Delay / Behavioral Problems in Preschool Children - PLUSS
The PLUSS (Mental health, learning, development, collaboration around preschool children) is a collaborative project involving guardians, Jönköping County´s health care, preschools and social services.
- Conditions
- Developmental Delay, Behavioural Problem, Neurodevelopmental Delay
- Trial name
- PLUSS (NCT04815889)
- Testing
- PRIMUS parent training Group
- Where
- Sweden
- Volunteers
- 600 people
- Sponsor
- Region Jönköping County
Alzheimer Disease and Related Dementias, Cognition
Home-Based Brain Stimulation for Motoric Cognitive Risk Syndrome
The objective of this study is to determine the effects of a 6-month, home-based personalized transcranial direct current stimulation (tDCS) intervention targeting the left dorsolateral prefrontal cortex on cognitive function…
- Conditions
- Alzheimer Disease and Related Dementias, Cognition, Mobility Disability
- Trial name
- TDCS4MCR (NCT06821568)
- Testing
- Personalized Transcranial Direct Current Stimulation (tDCS)
- Where
- 2 sites in United States, Israel
- Volunteers
- 128 people
- Sponsor
- Hebrew SeniorLife
Fragile X Syndrome (FXS), Fragile X Syndrome
Safety, Tolerability, and Preliminary Effectiveness of CTH120 in Fragile X Syndrome
The purpose of this Phase IIa study is to evaluate the safety, tolerability, and effectiveness of CTH120 in adult males with Fragile X syndrome.
- Trial name
- FXS-CTH120-01 (NCT07654114)
- Testing
- CTH120
- Where
- 2 sites in Spain
- Volunteers
- 30 people
- Sponsor
- Connecta Therapeutics, S.L.
Prader-Willi Syndrome
A Study of Pitolisant in Participants With Prader-Willi Syndrome
The purpose of this study is to assess safety of pitolisant in eligible participants with Prader-Willi syndrome (PWS) who completed the End of Treatment (EOT) visit in a parent study (HBS-101-CL-002 [Open Label Extension (OLE)]…
- Trial name
- NCT07219485
- Testing
- Pitolisant
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Harmony Biosciences Management, Inc.
Multiple Sclerosis
OFSEP Very High Definition Cohort
Multiple sclerosis (MS) is the most common acquired neurological disease leading to disability in young adults. MS often leads to the development of a physical and/or cognitive impairment that disables patients in their daily…
- Trial name
- VHD cohort (NCT05622643)
- Testing
- MRI
- Where
- 5 sites in France
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- EDMUS Foundation