Clinical trials: Disability, Evaluation
Congenital Heart Disease, ICF
Investigation of Adults With Congenital Heart Disease in the Scope of the ICF
Congenital heart disease (CHD) is one of the common birth defects with a prevalence of approximately 1 in 1000 live births worldwide.
- Conditions
- Congenital Heart Disease, ICF, Quality of Life
- Trial name
- NCT05774158
- Testing
- Physiotherapy assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Obstructive Sleep Apnea, Down Syndrome
Medications for Obstructive Sleep Apnea In Children With Down Syndrome
This is a randomized, double blind, cross-over study of the combination of atomoxetine and oxybutynin (ato-oxy) in children with DS and OSA documented by polysomnography (PSG).
- Trial name
- MOSAIC (NCT04115878)
- Testing
- Atomoxetine and oxybutynin (ato-oxy)
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Arizona
Aneuploidy, Down Syndrome
Clinical Evaluation of the SEQureDx Trisomy Test in Low Risk Pregnancies
Pregnant women with low risk indicators for fetal chromosomal aneuploidy will be enrolled. Study blood will be collected in the first or second trimester at a scheduled prenatal screening visit, processed to plasma, and stored…
- Conditions
- Aneuploidy, Down Syndrome, Noninvasive Prenatal Screening
- Trial name
- NCT01597063
- Testing
- SEQureDx Trisomy Test
- Where
- 27 sites in United States
- Volunteers
- 3,333 people
- Sponsor
- Sequenom, Inc.
Preterm Birth, Developmental Dyslexia
Reading-FREE Markers for Early Detection of Developmental Dyslexia
This study aims to identify early signs of developmental dyslexia (DD) and other reading difficulties in children born preterm, using behavioral, cognitive, and brain imaging data collected before reading problems typically…
- Trial name
- FREE-DD (NCT07072104)
- Testing
- Multidomain Neuropsychological and Reading-Free Screening Tool (RSFT) Assessment Battery - Grade 2, MRI - Grade 2, Multidomain Neuropsychological and Reading-Free Screening Tool (RSFT) Assessment Battery - Grade 3
- Where
- Italy
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Università Vita-Salute San Raffaele
Down Syndrome, Chromosome Disorders
Collaboration for Down Syndrome Progress (CDP)
The Collaboration for Down Syndrome Progress (CDP) is a long-term study that follows people with Down syndrome of all ages. The goal is to better understand their health, development, and everyday experiences over time.
- Conditions
- Down Syndrome, Chromosome Disorders, Intellectual and Developmental Disabilities
- Trial name
- CDP (NCT07625579)
- Where
- 16 sites in United States
- Volunteers
- 1,400 people
- Sponsor
- RTI International
Dementia
Dementia and Disability Simulation for College Nursing Students' Senior Activity Facilitation Skills
This study aims to evaluate the effectiveness of a dementia and disability simulation (DDS) program on dementia knowledge, attitude, empathy, and activity design skills for seniors among college nursing students.
- Trial name
- NCT06040294
- Testing
- DDS program, dementia course with no DDS
- Where
- Taiwan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Tzu Chi University
Down Syndrome
Assessment of Skills and Behaviors in Children With Down Syndrome
Parents of children with Down Syndrome can help in describing children's abilities and behavior. Most of the studies evaluating parents of children with Down Syndrome and other intellectual disabilities have focused on parental…
- Trial name
- NCT04754178
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Universidad de Granada
Lipedema, Venous Insufficiency
Assessment of Venous Insufficiency and Clinical Features in Lipedema
Lipedema is a chronic adipose tissue disorder characterized by disproportionate fat accumulation, pain, tenderness, edema, and functional impairment.
- Conditions
- Lipedema, Venous Insufficiency, Venous Disease, Disability Physical
- Trial name
- NCT07603076
- Testing
- Venous Doppler Ultrasonography, Numeric Rating Scale, Lower Extremity Functional Scale
- Where
- Turkey (Türkiye)
- Volunteers
- 82 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Preterm Birth, Development Delay
Evaluation of Digital Follow up of Preterm Infants
The aim is to study how a digital follow up tool can identify the preterm born children and their families who need further support or clinical interventions
- Conditions
- Preterm Birth, Development Delay, Sensory Disorder, Growth Disorders
- Trial name
- ePIPARI (NCT05238168)
- Testing
- ePIPARI digital follow up tool
- Where
- Finland
- Volunteers
- 70 people
- Sponsor
- Turku University Hospital
Primary Progressive Multiple Sclerosis, Primary Progressive MS
A Phase 2a Study of SUN-627 in Participants With Non-Active Secondary Progressive and Primary Progressive Multiple Sclerosis (SPMS/PPMS)
The goal of this Phase 2 clinical trial is to investigate the safety and tolerability of SUN-627 in men and women aged 18-70 years old with a diagnosis of non-active SPMS/PPMS.
- Conditions
- Primary Progressive Multiple Sclerosis, Primary Progressive MS, Primary Progressive Multiple Sclerosis (PPMS), Secondary Progressive MS (SPMS)
- Trial name
- NCT07840326
- Testing
- SUN-627
- Where
- 7 sites in United States
- Volunteers
- 20 people
- Sponsor
- Sundance Biosciences, Inc.
Fragile X Syndrome
Biomarker and DNA Collection in Subjects Participating in Protocol 22003
The subjects that meet the inclusion and exclusion criteria and consent to participate in protocol 22003 will be offered participation in 22003A which will evaluate secreted protein before and after treatment with STX209 and…
- Trial name
- NCT00892580
- Testing
- STX209
- Where
- 8 sites in United States
- Volunteers
- 32 people
- Sponsor
- Seaside Therapeutics, Inc.
Prader-Willi Syndrome
Open-Label Extension Study of DCCR in PWS Followed by Double-Blind, Placebo-Controlled, Randomized Withdrawal Period
This is a multi-center, multi-period study with an open-label period followed by a double-blind, placebo-controlled, randomized withdrawal period evaluating the safety and efficacy of DCCR treatment.
- Trial name
- NCT03714373
- Testing
- DCCR
- Where
- 28 sites in United States, United Kingdom
- Volunteers
- 115 people
- Sponsor
- Soleno Therapeutics, Inc.
Migraine, Migraine Disease
Evaluation of the Migraceutics® Phase-Specific Dietary Supplement Regimen on Quality of Life, Work Productivity, and Biomarkers in Adult Migraineurs: The Migraceutics® START Study
The purpose of this study is to evaluate the impact of the Migraceutics® phase-specific dietary supplement regimen on quality of life, work productivity, and biomarkers in adult migraineurs.
- Conditions
- Migraine, Migraine Disease, Migraine Disorder, Migraine Headache
- Trial name
- NCT07634146
- Testing
- Foundational dietary supplement, Luteal phase dietary supplement add-on, Migraine phase dietary supplement add-on
- Where
- United States
- Volunteers
- 920 people
- Sponsor
- Miracle Wellness LLC
Down Syndrome
Oral Language in Children With Down Syndrome
The objective of this research is to verify the language of children with Down syndrome concerning lexical, syntactic and semantic aspects using MLU.
- Trial name
- NCT00952354
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Fetal Alcohol Spectrum Disorders, Behavior Problem
Psychoeducation of Parents to Children With FASD
By longitudinal, prospective research in children and adolescents with Fetal Alcohol Spectrum Disorders (FASD) and their parents to explore the beneficial effects of participating in a standardized intervention program in order…
- Conditions
- Fetal Alcohol Spectrum Disorders, Behavior Problem, Adaptive Behavior, Learning Disorders
- Trial name
- NorFASDPEdu (NCT05686473)
- Testing
- Program of psychoeducation of parents and professionals
- Where
- Norway
- Volunteers
- 75 people
- Sponsor
- Sorlandet Hospital HF
Prader Willi Syndrome
Comparative Study Between Prader-Willi Patients Who Take Oxytocin Versus Placebo
The role of oxytocin (OT) is already known in the regulation of satiety but some clinical studies demonstrated that OT participates also in the regulation of social behavior by its implication on a better comprehension of emotion…
- Trial name
- NCT01038570
- Testing
- Syntocinon®/- Spray, Physiological serum (Sodium chloride)
- Where
- France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Toulouse
Adults Without Disabilities
Normative Values and Reference Equations of a New Incremental Step Test for the Assessment of Exercise Capacity for Portuguese Adults
According to the official guidelines, a range of settings for cardiorespiratory rehabilitation, including the community- and home-based models, are considered to answer to the inadequate number of rehabilitation services…
- Trial name
- NCT04801979
- Testing
- Incremental Step Test
- Where
- Portugal
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Polytechnic Institute of Porto
Complex Sensorimotor Disabilities
Evaluation of Different Visual Keyboard Organizations on People With Complex Sensorimotor Disabilities
comparison of different visual keyboard configurations
- Trial name
- SK4All (NCT06876480)
- Testing
- Keyboard
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Down Syndrome, Turner Syndrome
Hematological Profile in Children With Numerical Chromosomal Disorders
This cross-sectional study aims to evaluate the hematological profile and determine the frequency and pattern of hematological abnormalities in children with numerical chromosomal disorders attending the Pediatric Department of…
- Conditions
- Down Syndrome, Turner Syndrome, Klinefelter Syndrome, Trisomy 18
- Trial name
- NCT07807540
- Volunteers
- 158 people
- Sponsor
- Assiut University
Shoulder Pain
Central and Peripheral Sensitization, and Pain Contributing Factors in Shoulder Pain Patients and Healthy People
Compared to healthy subjects, central and peripheral sensitization will be investigated in patients with non-specific shoulder pain, since no data is available at the moment.
- Trial name
- NCT05360589
- Where
- Italy
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- University of Turin, Italy