Clinical trials: Disability, Evaluation
Down Syndrome, Fetal Aneuploidy
Clinical Evaluation of the SEQureDx T21 Test In High Risk Pregnancies
Whole blood samples will be collected from high-risk pregnant women to validate the clinical performance of the SEQureDx Trisomy 21 Test.
- Trial name
- NCT01555346
- Where
- 29 sites in United States, Canada
- Volunteers
- 3,062 people
- Sponsor
- Sequenom, Inc.
Cubital Tunnel Syndrome
Comparative Efficacy of Soft Tissue Mobilization and Ulnar Nerve-Specific Strengthening Exercises in Patients With Cubital Tunnel Syndrome
Cubital tunnel syndrome occurs when the ulnar nerve is compressed or irritated near the elbow. It can cause elbow or forearm pain, numbness or tingling in the ring and little fingers, hand weakness, and difficulty performing…
- Trial name
- NCT07797023
- Testing
- Soft Tissue Mobilization, Ulnar Nerve-Specific Strengthening and Nerve-Gliding Exercises
- Where
- Pakistan
- Volunteers
- 56 people
- Sponsor
- Hamna Sarfraz
Low Back Pain, Obesity
WATERinMOTION Aquatic Exercise Program Compared to Land-Based Rehabilitation on Low-Back Pain Relief and Quality of Life
This randomized controlled trial compares the efficacy of an 8-week WATERinMOTION aquatic exercise program versus land-based rehabilitation for reducing low-back pain (LBP) and improving quality of life in sedentary…
- Conditions
- Low Back Pain, Obesity, Sedentary Behavior
- Trial name
- WATERinMOTION (NCT06946342)
- Testing
- "Aquatic Exercise Group", Land-Based Rehabilitation Group"
- Where
- Iran
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Sistan and Baluchestan
Systemic Sclerosis (SSc), Digital Ulcer
Hand Disability In Systemic Sclerosis - Digital Ulcers
The aim of this study was to examine the Turkish validity and reliability of the Hand Disability in Systemic Sclerosis - Digital Ulcers Questionnaire (HDISS-DU) in individuals with Systemic Sclerosis.
- Trial name
- NCT06658470
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Pamukkale University
Neurodevelopmental Disorders, Intellectual Disability
Multi-Omics Genetic Investigation Strategies to Enhance the Diagnostic Workflow for Rare Diseases
LEOPARD is a multicenter study aimed at improving the genetic diagnosis of patients with neurodevelopmental disorders (NDDs) of unknown etiology, particularly those with moderate-to-severe intellectual disability.
- Conditions
- Neurodevelopmental Disorders, Intellectual Disability, Autism Spectrum Disorder, Genetic Diseases, Inborn
- Trial name
- LEOPARD (NCT07884227)
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Istituto Giannina Gaslini
Episodic Migraine, Chronic Migraine
CGRP Inhibition, Autonomic Function, and Migraine
The purpose of this clinical study is to better understand the function of the autonomic nervous system in patients with migraine. We aim to understand whether the autonomic functions change depending on the migraine status (i.e.
- Trial name
- CGRP-1 (NCT04628429)
- Testing
- Erenumab, Galcanezumab, Fremanezumab
- Where
- Austria
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Epilepsy, Insomnia
Trial of Melatonin to Improve Sleep in Children With Epilepsy and Neurodevelopmental Disabilities
The purpose of the study is to evaluate the safety and efficacy of oral melatonin in improving sleep continuity in children with epilepsy and neurodevelopmental delay who have chronic insomnia by comparing Fast Release Melatonin…
- Conditions
- Epilepsy, Insomnia, Developmental Disability
- Trial name
- NCT01161108
- Testing
- Fast Release Melatonin (FR MLT), Timed Release Melatonin (TR MLT)
- Where
- Canada
- Volunteers
- 13 people
- Sponsor
- The Hospital for Sick Children
Down Syndrome (Trisomy 21)
Qualitative Effects of AEF0217 in Down Syndrome People
Following the AEF0217-102 trial (NCT05748405), which investigated the effects of AEF0217 versus placebo, participants with Down syndrome and their caregivers who took part in the trial are invited to share their perceptions of…
- Trial name
- NCT07413224
- Where
- Spain
- Volunteers
- 28 people
- Sponsor
- Aelis Farma
Parkinson Disease, Huntington Disease
A PET Brain Imaging Study of mGluR5 in Subjects With Neuropsychiatric Conditions
Measurement of metabotropic glutamate receptor type 5 (mGluR5) binding capacity in the brain, may be a valuable tool in the early detection, understanding, or evaluation of Parkinson disease (PD), Huntington disease (HD), Fragile…
- Conditions
- Parkinson Disease, Huntington Disease, Autistic Spectrum Disorders, Fragile X Syndrome
- Trial name
- FPEB (NCT00870974)
- Testing
- [18F]FPEB
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Institute for Neurodegenerative Disorders
Knee Osteoarthritis
Comparison of Hip Strengthening Exercises and Core Stability Exercises in Patients With Knee Osteoarthritis
Knee Osteoarthritis is a chronic degenerative joint disease with complex etiology that results in loss of normal joint function due to damage to the articular cartilage.
- Trial name
- NCT06120920
- Testing
- Assigned Interventions, Conventional Physical Therapy and Routine Knee Exercises with Hip Strengthening Exercises.
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- University of Lahore
Joint Diseases
Evaluation of Computerized Template Entry for Compensation and Pension (C&P) Examinations
The purpose of this study is to compare C\&P examination reports performed using a Compensation and Pension Examination Program (CPEP) computerized, templated documentation tool to a customary examination performed and then…
- Trial name
- NCT00988546
- Testing
- Computer based template for exam documentation, Dictation for exam documentation
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Down Syndrome, Edwards Syndrome
Expanded Noninvasive Genomic Medical Assessment: The Enigma Study
In January 2007, the American Congress of Obstetricians and Gynecologists (ACOG) revised its guidelines that now recommend physicians are ethically obligated to fully inform all pregnant women that screening for fetal chromosomal…
- Conditions
- Down Syndrome, Edwards Syndrome, Patau Syndrome, Klinefelter Syndrome
- Trial name
- NCT02787486
- Testing
- Blood sampling for Laboratory Developed Test (LDT) analysis
- Where
- 8 sites in United States
- Volunteers
- 760 people
- Sponsor
- Progenity, Inc.
Psychiatric Disorder, Somatic Symptom
National Investigation in College and High School Among Adolescents on Health and Substances at the FSEF
For the clinical component: Describe the young people hospitalised in residential care at the FSEF, in particular through vulnerability factors and their psychosocial repercussions (school level, repetition, intensity of…
- Conditions
- Psychiatric Disorder, Somatic Symptom, Traumatic Injury
- Trial name
- EnCLASS-FSEF (NCT05225441)
- Where
- France
- Volunteers
- 598 people
- Sponsor
- Fondation Santé des Étudiants de France
Central Sensitisation, Chronic Musculoskeletal Disease
The Frequency of Central Sensitization in Patients With Chronic Musculoskeletal Pain
Central sensitization is as increased response to normal or sub-threshold stimuli of central nervous system and its close relationship with in many musculoskeletal diseases with chronic pain has been demonstrated in several…
- Conditions
- Central Sensitisation, Chronic Musculoskeletal Disease, Chronic Pain
- Trial name
- NCT04765280
- Testing
- Central sensitization inventory, Short form-36, Istanbul Low Back Pain Disability Index
- Where
- Turkey (Türkiye)
- Volunteers
- 500 people
- Sponsor
- Marmara University
Non Specific Neck Pain
Effects of Tele-rehabilitation Versus Supervised Rehabilitation Among Computer Users With Non-specific Neck Pain
The current study is a single-blinded, two-arm parallel-group randomized controlled trial involving 62 participants with non-specific neck pain among computer users.
- Trial name
- NCT07556705
- Testing
- Neck and upper back strengthening exercises by Tele-rehabilitation Intervention, Neck and upper back strengthening by Supervised Rehabilitation Intervention
- Volunteers
- 62 people
- Sponsor
- Lahore University of Biological and Applied Sciences
Caregiver Burden
Evaluation of the Effectiveness of the World Health Organization QualityRights Training in Italy
The research aims to promote human rights of people with psychosocial disabilities. The design will be a randomized controlled trial (RCT) with two groups.
- Trial name
- NCT06484205
- Testing
- WHO QualityRights e-training, Emotional intelligence e-training
- Where
- Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Cagliari
Disability
Ohio RETAIN Impact Evaluation
The Retaining Employment and Talent after Injury/Illness Network (RETAIN) demonstration is a collaborative effort between the U.S.
- Trial name
- NCT05219045
- Testing
- Ohio RETAIN
- Where
- United States
- Volunteers
- 4,525 people
- Sponsor
- Mathematica Policy Research, Inc.
Fragile X Syndrome (FXS), Neurotypical Adults
Neural Biomarkers in Fragile X Syndrome
The purpose of this non-interventional test /re-test study is to assess neural biomarkers in adult subjects with Fragile X syndrome compared to those measured in a population of typically developing adults
- Trial name
- EXP-CTH120 (NCT06957054)
- Testing
- Any
- Where
- 2 sites in Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Connecta Therapeutics, S.L.
Neck Pain, Exercise Therapy
Comparative Effects of Cervical Stabilization and Isometric Neck Exercises in Eyeglass Wearers With Non-specific Chronic Neck Pain
The goal of this randomized controlled trial is to compare the effects of cervical stabilization exercises and isometric neck exercises on pain, disability, quality of life, and kinesiophobia in eyeglasses wearers with…
- Conditions
- Neck Pain, Exercise Therapy, Isometric Exercise, Eyeglasses
- Trial name
- NCT07321054
- Testing
- Cervical Stabilization Exercises, Isometric Neck Exercises
- Where
- Pakistan
- Volunteers
- 62 people
- Sponsor
- Ibadat International University, Islamabad
Down Syndrome
Efficacy Assessment of Systematic Treatment With Folinic Acid and Thyroid Hormone on Psychomotor Development of Down Syndrome Young Children
Evaluation of the following in very young children with Down syndrome: the efficacy of systematic treatment with L-thyroxine at controlled doses (clinically and by ultrasensitive thyreostimulating hormone (TSH) assay), the…
- Trial name
- ACTHYF (NCT01576705)
- Testing
- thyroid hormone and folinic acid
- Where
- France
- Volunteers
- 175 people
- Sponsor
- Institut Jerome Lejeune