Clinical trials: Disability, Evaluation
Chronic Low Back Pain (CLBP)
Voice-Derived Acoustic Features and Pain Intensity in Chronic Low Back Pain
This observational study investigated whether characteristics of a person's voice are associated with pain intensity in adults with chronic low back pain and whether voice recordings can help predict individual pain levels.
- Trial name
- NCT07078019
- Testing
- Voice Recording Procedure
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people
- Sponsor
- nurmuhammet tas
Intellectual Disability
Development and Application-Smart Football for Movement Evaluation and Training in the Special Education Population
Children with disabilities are frequently ignored by the general population, hence the development of movement evaluation and training devices for use in special education settings are relatively overlooked.
- Trial name
- NCT02486081
- Testing
- smart soccer ball
- Where
- 2 sites in Taiwan
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Hearing Loss
Thai-version Five Minute Hearing Test
This study is aimed to test the sensitivity and specificity of Thai-version Five Minutes Hearing test against the audiometry to screen hearing problem in community.
- Trial name
- Thai_FMHT (NCT01408992)
- Testing
- Audiometry, Thai-Five Minute Hearing Test
- Where
- Thailand
- Volunteers
- 558 people, healthy volunteers welcome
- Sponsor
- Khon Kaen University
Down Syndrome
Evaluation of Patients With Down Syndrome Compliance to Dental Therapy
Since subjects with Down Syndrome (DS) have different and variable levels of intellectual deficit, in approaching the patient with DS and before evaluating the different therapeutic strategies and carrying out a dental and…
- Trial name
- NCT05755464
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Rett Syndrome
Auditory EEG and Behavioral Assessments in Individuals With Rett Syndrome
This observational research study is designed to learn more about how the brain processes sound in individuals with Rett syndrome.
- Trial name
- NCT07569445
- Testing
- Electroencephalogram (EEG) Recording
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Glut1 Deficiency Syndrome, De Vivo Disease
Early Diagnosis of the GLUT1 Deficiency Syndrome With a Blood Based Test
The study aims at validating the diagnostic performances of the METAglut1, a blood in vitro diagnostic test, for the simple and early diagnosis of the Glut1 deficiency syndrome (Glut1DS, or De Vivo disease).
- Conditions
- Glut1 Deficiency Syndrome, De Vivo Disease, Seizures, Movement Disorders
- Trial name
- METAglut1 (NCT03722212)
- Testing
- METAglut1
- Where
- 28 sites in France
- Volunteers
- 636 people
- Sponsor
- METAFORA biosystems
Prader Willi Syndrome
Evaluation of Tolerance, Suckling and Food Intake After Repeated Nasals Administrations of Oxytocin in PWS Infants
The Prader-Willi syndrome (PWS) includes severe neonatal hypotonia with impaired suckling leading to failure to thrive in the most severe cases, subsequently followed by an early onset of morbid obesity with hyperphagia and…
- Trial name
- OTBB2 (NCT02205034)
- Testing
- oxytocin
- Where
- France
- Volunteers
- 18 people
- Sponsor
- University Hospital, Toulouse
Alzheimer Disease, Down Syndrome
Hero: A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics (PK) and Pharmacodynamics (PD) of ION269 in Participants With Down Syndrome (DS) at Risk for Alzheimer's Disease (AD)
The primary purpose of this study is to evaluate the safety and tolerability of ION269 in adults with Down syndrome with evidence of brain amyloid positivity.
- Trial name
- NCT06673069
- Testing
- ION269
- Where
- 6 sites in United States, Spain
- Volunteers
- 1 people
- Sponsor
- Ionis Pharmaceuticals, Inc.
Down Syndrome
Trial to Evaluate Safety and Efficacy of GM-CSF /Sargramostim in Down Syndrome
This trial protocol is designed to evaluate primarily whether the use of sargramostim (recombinant human GM-CSF), administered five days per week for four consecutive weeks (20 treatment days), will be well tolerated by and safe…
- Trial name
- NCT05482334
- Testing
- Sargramostim for Injection
- Where
- United States
- Sponsor
- University of Colorado, Denver
Patients With Intellectual Disabilities Without an Obvious Clinical Diagnosis, Patients With Normal Array CGH and Previous Negative Genetic Investigations (WES-solo or WES-trio)
Contribution of High Throughput RNA Sequencing Combined With Sequencing of Whole Genomes in the Diagnosis of Intellectual Disability
Intellectual disability (ID) is a clinically and genetically heterogeneous condition that often results in a diagnostic odyssey.
- Trial name
- DI-WA (NCT03857997)
- Testing
- Patient blood sampling, Parents blood sampling
- Where
- France
- Volunteers
- 62 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Physical Activity, Social Responsibility
Imitation-based Dog Assisted Intervention, for Children With Developmental Disabilities.
This R21 application will provide a multidisciplinary One Health approach to DAID physical activity intervention for adolescents with developmental disabilities and their family dog.
- Trial name
- NCT03462407
- Testing
- DAID, Dog walking
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Oregon State University
Migraine
Evaluation of the Performance of the Doraldo-Castelletti Scale in Supporting the Neurologist's Decision to Refer Migraine Patients to Physiotherapy
Migraine is the leading cause of disability worldwide among people aged 15 to 49. Although therapies targeting the CGRP pathway have improved the management of the condition, there are large groups of patients who do not respond…
- Trial name
- MIGSKA (NCT07626307)
- Testing
- Doraldo-Castelletti scale
- Where
- Italy
- Volunteers
- 439 people
- Sponsor
- Istituto Auxologico Italiano
Health Knowledge, Intellectual Developmental Disorder
Easy-to-Read Content Effectiveness Evaluation
Individuals with intellectual disabilities face challenges in accessing medical services and health education due to communication barriers and limited support tools.
- Conditions
- Health Knowledge, Intellectual Developmental Disorder, Visual Impairment
- Trial name
- NCT07036575
- Testing
- Standard Visual Health Education, Easy-Read Instructor-Guided Education, Easy-Read Audio-Based Self-Learning
- Where
- Taiwan
- Volunteers
- 250 people
- Sponsor
- National Taiwan University Hospital
Aging, Disability or Chronic Disease Leading to Disablement
Community-based Personalized Care and QOL
A pragmatic randomized trial to evaluate the impact of an integrated patient experience and outcome measurement system supported by citizens, caregivers and community through eHealth technology.
- Trial name
- NCT03263169
- Testing
- Community-based personalized care
- Where
- Canada
- Volunteers
- 1,100 people, healthy volunteers welcome
- Sponsor
- Windsor-Essex Compassionate Care Community
Rett Syndrome
Lamivudine as a Novel Clinical Effort for Rett Syndrome
Rett syndrome (RTT) is a rare genetic neurodevelopmental disorder caused primarily by mutations in the MECP2 gene, leading to progressive impairments in motor function, communication, and behavior following an initial period of…
- Trial name
- LANCE (NCT07640503)
- Testing
- Lamivudine
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- Maria Denise Fernandes Carvalho de Andrade
Down Syndrome, Chromosome Disorders
Collaboration for Down Syndrome Progress (CDP)
The Collaboration for Down Syndrome Progress (CDP) is a long-term study that follows people with Down syndrome of all ages. The goal is to better understand their health, development, and everyday experiences over time.
- Conditions
- Down Syndrome, Chromosome Disorders, Intellectual and Developmental Disabilities
- Trial name
- CDP (NCT07625579)
- Where
- 16 sites in United States
- Volunteers
- 1,400 people
- Sponsor
- RTI International
Autism Spectrum Disorder, Intellectual Disabilities
An Evaluation of Care (Education) and Treatment Reviews for People With Learning Disabilities and Autistic People
Aims In this research project, we will determine whether Care (Education) and Treatment Reviews are helpful for people with learning disabilities and autistic people and their families.
- Trial name
- CECiLiA (NCT06918483)
- Volunteers
- 695 people
- Sponsor
- Coventry and Warwickshire Partnership NHS Trust
COVID-19, Quality of Life
Cohort Study for the Assessment of Long-term Impact of COVID-19 Among Moderate and Severe COVID-19 Patients in Brazil
The present prospective cohort study aims to assess factors associated with of one-year health-related quality of life and physical, cognitive and mental health outcomes among adult survivors of hospitalization for COVID-19.
- Conditions
- COVID-19, Quality of Life, Disability Physical, Disabilities Mental
- Trial name
- NCT05165979
- Testing
- Hospitalization due to COVID-19
- Where
- 24 sites in Brazil
- Volunteers
- 650 people
- Sponsor
- Hospital Moinhos de Vento
Being 18 Years of Age or Older, Having a Child Registered in a Special Education School
Awareness Of Home Accident Preventıon Among Parents Of Disabled Children And Evaluation Of The Basic First Aid Training Provided
This study was conducted to assess the awareness of parents of children with disabilities regarding the prevention of home accidents and the effectiveness of the basic first aid training provided.
- Conditions
- Being 18 Years of Age or Older, Having a Child Registered in a Special Education School, Providing Care for a Child With an Intellectual Disability, Providing Care for a Visually Impaired Child
- Trial name
- NCT07698860
- Testing
- Prevention of Household Accidents and Basic First Aid Training for Accidents
- Where
- Turkey (Türkiye)
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Kayseri University
Autism Spectrum Disorder, Developmental Disorder
Children's Autism Metabolome Project
Development and Clinical Evaluation of the Stemina Metabolic Biomarker-Based Test to Diagnose Autism Spectrum Disorder in Early Childhood.
- Trial name
- CAMP-01 (NCT02548442)
- Where
- 8 sites in United States
- Volunteers
- 1,102 people, healthy volunteers welcome
- Sponsor
- Stemina Biomarker Discovery, Inc.