Clinical trials: Disability, Intellectual
Cerebral Palsy, Autism
Rehabilitation of Children With Multiple Disabilities
The objective of the study is to compare the usual care and treatment of children and youth (0-19 years) with multiple developmental delays and disabilities and their families in Simcoe York with a co-ordinated, navigated…
- Conditions
- Cerebral Palsy, Autism, Down's Syndrome, Brain Injury
- Trial name
- NCT01379443
- Testing
- CTN model of care for children and their families
- Where
- Canada
- Volunteers
- 445 people
- Sponsor
- Children's Treatment Network
Intellectual Disability, Developmental Disability
Clinical Trial of Nabilone for Aggression in Adults With Intellectual and Developmental Disabilities
Innovative treatments are urgently needed for severe behavioural problems (SBPs) in adults with intellectual and developmental disabilities (IDD).
- Conditions
- Intellectual Disability, Developmental Disability, Aggression, Behavior Problem
- Trial name
- N-AND (NCT05273320)
- Testing
- Nabilone
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Hsiang-Yuan Lin
Alzheimer's Disease in Down Syndrome
Down Syndrome Clinical Trials - Study of Alzheimer's Disease in Down Syndrome
The primary objective is to characterize trajectories of change on the primary outcome measures in this study population through longitudinal collection of measures of cognition, function, behavior, and health status.
- Trial name
- LIFE-DSR (NCT04149197)
- Where
- 14 sites in United States
- Volunteers
- 252 people
- Sponsor
- LuMind IDSC Foundation
Fragile X Syndrome
An Initial Study of AZD7325 in Adults With Fragile X Syndrome
This study will investigate the safety, tolerability and blood pharmacodynamics of treatment with oral administration of AZD7325 at 5 mg BID, 15 mg BID, and placebo BID, in adults with Fragile X Syndrome.
- Trial name
- NCT03140813
- Testing
- AZD7325 (High-Dose), AZD7325 (Low-Dose)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Rett Syndrome
Pilot Study of the Effects of the Desipramine on the Neurovegetative Parameters of the Child With Rett Syndrome
Rett syndrome is a neurodevelopmental disorder characterized by cognitive impairment, communication dysfunction, stereotypic movement disorder, and growth failure.
- Trial name
- NCT00990691
- Testing
- Administration of a high dose of desipramine, Administration of a low dose of desipramine
- Where
- France
- Volunteers
- 36 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Autism Spectrum Disorder, Intellectual Disability
Effectiveness of Music Therapy in Social Skill Intervention for Children With ASD/ID
Autism spectrum disorder (ASD) is a developmental impairment characterized by persistent deficits in social communication and interactions.
- Trial name
- NCT04557488
- Testing
- Music therapy, Behavioral-based social skill training
- Where
- Hong Kong
- Volunteers
- 77 people
- Sponsor
- Education University of Hong Kong
Fragile X Syndrome, Fragile X Syndrome (FXS)
Clinical Study of Cannabidiol in Children, Adolescents, and Young Adults With Fragile X Syndrome
This is a randomized, double-blind, placebo-controlled, multiple-center study, to assess the efficacy and safety of cannabidiol administered as ZYN002 for the treatment of children, adolescent, and young adult patients with…
- Trial name
- RECONNECT (NCT04977986)
- Testing
- ZYN002
- Where
- 27 sites in United States, Australia and 3 more
- Volunteers
- 257 people
- Sponsor
- Harmony Biosciences Management, Inc.
Rett Syndrome
Single-Dose AAV-MECP2 Safety/Tolerability and Efficacy in Rett Syndrome
Rett syndrome (RTT) is a serious neurodevelopmental disorder that has a significant impact on patients and their families. Patients suffer from severe social dysfunction and poor quality of life, and there is currently no…
- Trial name
- NCT06856759
- Testing
- Intrathecal injection of AAV-MECP2 for the treatment of Rett syndrome
- Where
- China
- Volunteers
- 8 people
- Sponsor
- Guangzhou Women and Children's Medical Center
Down Syndrome, Aneuploidy
Noninvasive Screening for Affected Pregnancies: Assay Development & Optimization in Affected Pregnancies
To collect samples for the purpose of developing and optimizing an in vitro noninvasive prenatal diagnostic (NIPD) test. The NIPD test employs circulating cell free (ccff) DNA extracted from whole blood samples collected from…
- Trial name
- CHARMM-AP (NCT01052688)
- Testing
- Maternal blood draw of 30 to 50ml
- Where
- 10 sites in United States
- Volunteers
- 150 people
- Sponsor
- Sequenom, Inc.
Prader-Willi Syndrome, Constipation
The Intestinal Function in People With Prader-Willi Syndrome
The projects aim is to investigate the intestinal function of patients suffering from Prader-Willi Syndrome. The methods used are ultrasonographic measurement of the rectal diameter and gastrointestinal transit time
- Conditions
- Prader-Willi Syndrome, Constipation, Incontinence
- Trial name
- NCT01523288
- Where
- Denmark
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Down Syndrome
Effects of Infant Massage on Development of Down Syndrome Babies
The aim of ths study is to know the effects of infant massage in the maturation of the baby with Down syndrome. Scale Psychomotor Development Early Childhood Brunet-Lézine-Revised will be used to measure the maturational…
- Trial name
- NCT03084497
- Testing
- Infant Massage
- Where
- Spain
- Volunteers
- 32 people
- Sponsor
- University of Seville
Intellectual Disabilities (F70-F79), Down Syndrome (DS)
Using Technologies to Promote HEalthy Lifestyles in Adolescents With Intellectual Disabilities
IDHEApp will implement various educational technology tools and work with the families, teachers and caregivers to increase physical activity (PA) and improve healthy eating.
- Conditions
- Intellectual Disabilities (F70-F79), Down Syndrome (DS), Autism Disorder
- Trial name
- IDHEAPP (NCT07101523)
- Testing
- mHealth
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- University of Seville
Adrenomyeloneuropathy, Adrenoleukodystrophy
MD1003-AMN MD1003 in Adrenomyeloneuropathy
The primary objective of the trial is to demonstrate the superiority of biotin at 300 mg/day over placebo in the clinical improvement (walking tests) of patients with adrenomyeloneuropathy
- Conditions
- Adrenomyeloneuropathy, Adrenoleukodystrophy, AMN
- Trial name
- NCT02961803
- Testing
- MD1003 100 mg capsule
- Where
- 4 sites in France, Germany and 1 more
- Volunteers
- 67 people
- Sponsor
- MedDay Pharmaceuticals SA
Fragile X Syndrome
Metformin in Children and Adults With Fragile X Syndrome
Fragile X Syndrome (FXS) is caused by loss of FMR1 expression on the X chromosome that leads to increased mRNA translation, which results in hyperactivation of ERK (extracellular signal-regulated kinase) and mTORC1 (mechanistic…
- Trial name
- NCT03722290
- Testing
- Metformin
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Université de Sherbrooke
Fragile X Syndrome
Placebo-Controlled, Single-Dose Challenge Study of Gaboxadol in Adult Males With Fragile X Syndrome (FXS)
This is a single dose, placebo-controlled study. Male subjects aged 18 to 40 years (inclusive) with a diagnosis of FXS. Eligible subjects may enroll in this study comprised of two in home and two in clinic visits each 14 days…
- Trial name
- NCT06334419
- Testing
- Gaboxadol
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Craig Erickson
Abnormalities, Failure to Thrive
Evaluation of Patients With Unresolved Chromosome Abnormalities
The purpose of this research is to study a new way to test for chromosome abnormalities. Chromosomes are strands of DNA (the genetic material in the cell nucleus) that are made up of genes-the units of heredity.
- Conditions
- Abnormalities, Failure to Thrive, Mental Retardation, Microcephaly
- Trial name
- NCT00001639
- Where
- United States
- Volunteers
- 263 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Aneuploidy, Down Syndrome
Does an Educational Video for Aneuploidy Screening Improve Informed Choice Among Pregnant Women?
Informed decision-making regarding aneuploidy screening has been reported to be low. Poor knowledge and the lack of deliberation have been cited as reasons for uninformed choices, highlighting the need for adequate pre-test…
- Conditions
- Aneuploidy, Down Syndrome, Pregnancy Early
- Trial name
- EVA (NCT05492981)
- Testing
- Enhanced (intervention) education
- Where
- Singapore
- Volunteers
- 286 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Autistic Disorder, Pervasive Developmental Disorder
Advanced Grandparental Age as a Risk Factor for Autism
The Division of Medical Genetics at the University of Mississippi Medical Center is recruiting parents of children with a pervasive developmental disorder (including autism, autistic spectrum disorder, PDD-NOS, Asperger syndrome…
- Conditions
- Autistic Disorder, Pervasive Developmental Disorder, Asperger Syndrome, Childhood Disintegrative Disorder
- Trial name
- NCT00464477
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Mississippi Medical Center
Intellectual Disability, Mild to Moderate, Adolescence
Real-Time Pose Recognition Technology for Improving Tennis Learning in Individuals With Intellectual Disabilities
This study investigates the effect of real-time pose recognition technology on learning tennis skills in individuals with mild to moderate intellectual disabilities.
- Trial name
- NCT07517016
- Testing
- RPRS Tennis Training, Traditional Face-to-Face Tennis Training
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Burdur Mehmet Akif Ersoy University
MPS II, Hunter Syndrome (MPS II)
RGX-121-3102 Gene Therapy in Participants With MPS II (Hunter Syndrome)
RGX-121 is a gene therapy which is intended to deliver a functional copy of the iduronate-2-sulfatase gene (IDS) to the central nervous system.
- Trial name
- NCT07236606
- Testing
- RGX-121-3102
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- REGENXBIO Inc.