Clinical trials: Disability, open to volunteers
Autism, Infant Development
Screening for Autism in 9-Month-Olds by Measuring Social Visual Engagement
The goal of this project is to measure the clinical utility of an objective and quantitative eye-tracking assay collected on a standalone, mobile investigational device to accurately screen 9-month-old infants for autism spectrum…
- Trial name
- NCT05916430
- Testing
- EarliPoint Investigational Device
- Where
- 2 sites in United States
- Volunteers
- 2,120 people, healthy volunteers welcome
- Sponsor
- Emory University
Rett Syndrome
Lamivudine as a Novel Clinical Effort for Rett Syndrome
Rett syndrome (RTT) is a rare genetic neurodevelopmental disorder caused primarily by mutations in the MECP2 gene, leading to progressive impairments in motor function, communication, and behavior following an initial period of…
- Trial name
- LANCE (NCT07640503)
- Testing
- Lamivudine
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- Maria Denise Fernandes Carvalho de Andrade
Rett Syndrome
A Phase 3 Study of Fenfluramine Hydrochloride in Rett Syndrome
The purpose of this study is to investigate the efficacy of fenfluramine hydrochloride (HCl) versus placebo in study participants with Rett syndrome (RTT).
- Trial name
- NCT07503444
- Testing
- fenfluramine hydrochloride
- Where
- 40 sites in United States, Belgium and 10 more
- Volunteers
- 200 people
- Sponsor
- UCB BIOSCIENCES, Inc.
Mild Intellectual Disability
Effects of Modified Pilates on Improving Trunk Control and Balance in Children With Mild Intellectual Disability
This randomized controlled trial will be conducted at Spectrum Clinic, Lahore, over a duration of 8 weeks to assess the impact of Modified Pilates Exercises on trunk control in children with Intellectual Disability (ID).
- Trial name
- NCT06987188
- Testing
- Modified Pilate Exercises, General Physiotherapy Plan
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Riphah International University
Bruxism
Comparison of the Effects of Different Massage Techniques in Individuals With Bruxism
The aim of this study is to compare the effects of occlusal splint therapy and different massage techniques on pain intensity and orofacial muscle tone and stiffness in individuals with possible sleep bruxism.
- Trial name
- NCT07567183
- Testing
- Connective tissue massage, Classic massage, Occlusal Splint Group
- Volunteers
- 42 people
- Sponsor
- Okan University
Text Neck Syndrome
Eyeball Exercises and Cervical Stabilization in Text Neck Syndrome
The prolonged use of electronic devices in the population nowadays contributes to the development of various musculoskeletal disorders affecting the neck.
- Trial name
- NCT07684183
- Testing
- Physiotherapy care, Cervical Stabilization and Eyeball Exercises
- Where
- Pakistan
- Volunteers
- 74 people
- Sponsor
- University of Lahore
Knee Osteoarthritis
Tempo-controlled Low-load Resistance Training in Patients With Knee Osteoarthritis.
This randomized controlled trial aims to evaluate the effects of tempo-controlled low-load resistance training compared to conventional low-load resistance training on pain, muscle performance, and functional disability in…
- Trial name
- NCT07908589
- Testing
- Tempo-controlled low-load resistance training, Conventional Physiotherapy Training
- Where
- Pakistan
- Volunteers
- 32 people
- Sponsor
- University of Management and Technology Lahore
Stroke
Compass 3: A Novel Transition Program to Reduce Disability After Stroke
This study evaluates a program designed to help individuals transition from inpatient rehabilitation to home following an ischemic or hemorrhagic stroke.
- Trial name
- COMPASS 3 (NCT07069660)
- Testing
- COMPASS, Education Program
- Where
- 2 sites in United States
- Volunteers
- 520 people
- Sponsor
- Washington University School of Medicine
Rett Syndrome
A Pilot Study of an Antioxidant Cocktail vs. Placebo in the Treatment of Children and Adolescents With Rett Syndrome
This study will examine the potential efficacy and safety of Rett-T for core motor deficits of Rett syndrome, and will explore biological markers of safety and treatment response.
- Trial name
- NCT04041713
- Testing
- Rett-T
- Where
- Canada
- Volunteers
- 35 people
- Sponsor
- Holland Bloorview Kids Rehabilitation Hospital
Down Syndrome
Effects of Pelvic Girdle Stabililty With Use of Therapeutic Taping in Down Syndrome
A Interventional study on 16 down syndrome pateints and check effects o therapeutic taping on pelvic girdle stability on 8 weeks sessions
- Trial name
- NCT06770218
- Testing
- pelvic girdle stability training and therapeutic tapping, pelvic girdle stability training only
- Where
- 2 sites in Pakistan
- Volunteers
- 16 people
- Sponsor
- Riphah International University
Disability
A Digitally-Enabled System for Precision Assessment and Intervention of Disability Risk in Older Adults
1. Identify the primary risk factors for disability in older adults through multi-dimensional risk factor screening. 2. Develop a risk stratification model for disability in older adults by integrating outcome indicators and…
- Trial name
- NCT07508813
- Testing
- Risk Assessment of Disability and Precision Intervention
- Where
- China
- Volunteers
- 238 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Mild Intellectual Disability
Effect of Virtual Reality Distraction on Perceived Pain During Dental Hygiene in Children With Mild Intellectual Disability: A Randomized Controlled Trial
The objective of this study was to evaluate whether the use of a virtual reality (VR) distractor reduces perceived pain during professional oral hygiene sessions in children with mild ID.
- Trial name
- NCT07473479
- Testing
- Professional oral hygiene session, No distractor
- Where
- Italy
- Volunteers
- 102 people
- Sponsor
- Oasi Research Institute-IRCCS
STROKE, Rehabilitation Outcome
Prospective Evaluation of Atrial Fibrillation-Related Stroke Patients in Rehabilitation Program (PEARL), an Observational Cohort Study
The goal of this observational study is to determine if rehabilitation program intensity impacts functional recovery and specific needs in adult ischemic stroke patients who require inpatient rehabilitation.
- Conditions
- STROKE, Rehabilitation Outcome, Brain Disease, Cardiovascular Disease Acute
- Trial name
- PEARL (NCT07253974)
- Testing
- Rehabilitation program based on Physiotherapy, occupational therapy and swallow and language therapy
- Where
- Spain
- Volunteers
- 213 people
- Sponsor
- Parc de Salut Mar
Persons With Visual Disabilities, Breast Neoplasms
Breast and Cervical Cancer Awareness Training in Visually Impaired Women
This quasi-experimental study aims to determine whether a breast and cervical cancer awareness training program can increase participation in cancer screening among women with visual impairments.
- Conditions
- Persons With Visual Disabilities, Breast Neoplasms, Uterine Cervical Neoplasms, Awareness
- Trial name
- GORSEM (NCT07541859)
- Testing
- Cancer Screening Awareness Education for Visually Impaired Women
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Marmara University
Low Back Pain
Lumbar and Gluteal Motor Control in Chronic Low Back Pain
The present study aims to evaluate the effectiveness of an 8-week combined lumbar motor control and gluteal muscle strengthening program in individuals with chronic non-specific low back pain
- Trial name
- NCT07452172
- Testing
- Lumbar motor control exercises, Gluteal strengthening exercises
- Where
- Spain
- Volunteers
- 54 people
- Sponsor
- University of Castilla-La Mancha
Low Back Pian
Strain Counter Strain and Muscle Energy Technique in Non-specific Low Back Pain
Low back pain (LBP) is a condition characterized by fatigue, discomfort in the lumbosacral area, and a most common cause of disability .
- Trial name
- NCT07854028
- Testing
- Group A, Group B
- Where
- Pakistan
- Volunteers
- 62 people
- Sponsor
- Riphah International University
Chronic Pain
The Effect of Chronic Pain and Its Treatment on Quality of Life and Physical Activity
Chronic pain is pain whose duration usually exceeds a period of three months and standard treatment is ineffective. This pain brings many changes in physical and psychological functioning to the individual and can even lead to a…
- Trial name
- NCT05922007
- Testing
- Validation of the Questionnaire, Prospective quantitative study - questionnaire survey
- Where
- Czechia
- Volunteers
- 150 people
- Sponsor
- University Hospital Ostrava
Prader-Willi Syndrome
A Study of Pitolisant in Patients With Prader-Willi Syndrome
This is a Phase 3, randomized, double-blind, placebo-controlled, multicenter, global clinical study to assess the efficacy and safety of pitolisant in patients living with Prader-Willi syndrome.
- Trial name
- NCT06366464
- Testing
- Pitolisant tablet
- Where
- 57 sites in United States, Australia and 11 more
- Volunteers
- 134 people
- Sponsor
- Harmony Biosciences Management, Inc.
Adhesive Capsulitis
Bowen Technique Versus Dynamic Soft Tissue Mobilization on Pain, Range of Motion and Functional Disability in Patients With Adhesive Capsulitis
A randomized controlled trial included 72 patients diagnosed with adhesive capsulitis will conduct in University of Lahore Teaching Hospital. The study will complete within 9 months after the approval of synopsis.
- Trial name
- NCT07047846
- Testing
- Dynamic soft tissue mobilization, Bowen Technique and 3 moves
- Where
- Pakistan
- Volunteers
- 72 people
- Sponsor
- University of Lahore
Fragile X Syndrome (FXS), Creatine Transporter Deficiency
Optical Imaging in X-linked Disorders.
Fragile X syndrome (FXS, OMIM #300624) and Creatine Transporter Deficiency (CTD, #300352) are the two most common causes of X-linked intellectual disability.
- Trial name
- IMAGINER (NCT06868979)
- Testing
- Clinical assessment, Parental questionnaires, Cognitive assessment
- Where
- France
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon