Clinical trials: Disability
Parkinson's Disease
Psychiatric and Cognitive Manifestations of Parkinson's Disease
Parkinson's Disease (PD) is often thought of as affecting movement only. In fact, most patients also experience psychiatric and cognitive symptoms, sometimes from the disease itself, and sometimes as a side-effect of PD…
- Trial name
- NCT00360633
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Text Neck Syndrome, Telerehabilitation
Effects of Exercise Training Delivered Through Telerehabilitation on Text Neck Syndrome
To compare the effectiveness of telerehabilitation exercise program with that of supervised in-person physiotherapy in improving neck muscle endurance, pain intensity, and functional disability in university students with text…
- Conditions
- Text Neck Syndrome, Telerehabilitation, Exercise
- Trial name
- TEXT NECK (NCT07200752)
- Testing
- Telerehabilitation-Based Neck Exercise Training, Supervised physiotherapy exercise training
- Where
- Turkey (Türkiye)
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Karabuk University
Fragile X Syndrome
Probiotic Intervention for Microbiome Modifications and Clinical Improvements in Fragile X Syndrome
The primary objective of this clinical trial is to evaluate efficacy of probiotic mixture which contains Lactobacillus casei, Lactobacillus salivarius and Bifidobacterium breve, in children with Fragile X aged 3-18 years.
- Trial name
- NCT06279858
- Testing
- Probiotics
- Where
- Serbia
- Volunteers
- 15 people
- Sponsor
- Specila hospital for cerebral palsy and developmental neurology
Frozen Shoulder
Effects of Deltoid Strengthening Exercises in Patients With Adhesive Capsulitis
Adhesive capsulitis, also known as frozen shoulder, is a musculoskeletal condition that causes significant shoulder pain and restricted joint mobility.
- Trial name
- NCT07644884
- Testing
- Exercises, Standard Physical therapy
- Volunteers
- 48 people
- Sponsor
- Riphah International University
Wheelchair Users, Athletic Performance
Vibration Therapy in Wheelchair Basketball Players
No study was found that investigated the effect of vibration therapy (VT) on recovery from exercise in WCB players. Therefore, the aim of the study was to investigate the effects of wearable local vibration device on muscle…
- Conditions
- Wheelchair Users, Athletic Performance, Disability, Disabled Persons
- Trial name
- NCT06403384
- Testing
- Vibration
- Where
- Turkey (Türkiye)
- Volunteers
- 13 people
- Sponsor
- Karabuk University
Knee Osteoarthritis
Exercise and Physical Fitness for Persons With Knee Osteoarthritis
The purpose of this project is to establish evidence to support specific, targeted exercise and rehabilitation recommendations for people over 50 with osteoarthritis of the knee.
- Trial name
- NCT00265447
- Testing
- Strength training, Aerobic conditioning, Delayed exercise
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Rett Syndrome
A Study to Evaluate Ketamine for the Treatment of Rett Syndrome
This 2 cohort, sequential, ascending dose study will assess the safety, tolerability and efficacy of oral ketamine dosed in a single 5-day BID regimen in addition to placebo, in a 4-week cross-over design in patients with Rett…
- Trial name
- NCT03633058
- Testing
- Ketamine
- Where
- 7 sites in United States
- Volunteers
- 23 people
- Sponsor
- Rett Syndrome Research Trust
Heart Failure
Reducing Sedentary Time in Patients With Heart Failure
To determine the change in sedentary time and number of steps/day for older patients with heart failure at risk for mobility disability who receive a program to decrease sedentary behavior versus a standard program to increase…
- Trial name
- Rest-HF (NCT02911493)
- Testing
- Reducing Sedentary Behavior, Physical Activity Group
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Colorado, Denver
Mucopolysaccharidosis Type II, Metabolic Diseases
A Study of the Tolerance, Safety, and Pharmacokinetics of GNR-055 in Healthy Volunteers
It is a phase I open-label single-dose, dose-escalation cohort study to evaluate of the tolerance, safety, and pharmacokinetics of GNR-055 in healthy volunteers
- Trial name
- NCT06475404
- Testing
- verenafusp alfa 6 mg/kg, verenafusp alfa 9 mg/kg, verenafusp alfa 12 mg/kg
- Where
- Russia
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- AO GENERIUM
Down Syndrome, Edwards Syndrome
Whole Blood Specimen Collection From Pregnant Subjects
To obtain whole blood specimens from pregnant subjects to be used for research and development and clinical validation studies of prenatal assays.
- Conditions
- Down Syndrome, Edwards Syndrome, Patau Syndrome, Klinefelter Syndrome
- Trial name
- NCT02430584
- Testing
- Observational - no intervention
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Progenity, Inc.
Cervical Spondylosis
Upper Trapezius Stretching in Patients With Cervical Spondylosis
This study aims to investigate the effectiveness of upper trapezius stretching exercises on pain intensity, neck range of motion, and disability in patients with cervical spondylosis.
- Trial name
- NCT05920564
- Testing
- Upper fibers of trapezius stretching, Standard care
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Ahram Canadian University
Headache
Arabic Version Of Henry Ford Hospital Headache Disability Inventory Questionnaire : Validity, And Reliability
ARABIC VERSION OF HENRY FORD HOSPITAL HEADACHE DISABILITY INVENTORY QUESTIONNAIRE: CROSS-CULTURAL ADAPTATION, VALIDITY, AND RELIABILITY
- Trial name
- NCT06125821
- Testing
- questionnaire
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Cairo University
Ischemic-Hypoxic Encephalopathy
Long Term Prognostic of Neonatal Hypoxic Ischemic Encephalopathy With Hypothermia Treatment
The primary objective is to evaluate neonatal characteristics, and biological and clinical investigations as predictive factors of death, or of severe and moderate neurodevelopmental disability at 3 years, in a large…
- Trial name
- LyTONEPAL (NCT02676063)
- Where
- 22 sites in France
- Volunteers
- 800 people
- Sponsor
- University Hospital, Grenoble
Down Syndrome, Recurrent B Acute Lymphoblastic Leukemia
A Study to Compare Blinatumomab Alone to Blinatumomab With Nivolumab in Patients Diagnosed With First Relapse B-Cell Acute Lymphoblastic Leukemia (B-ALL)
This phase II trial studies the effect of nivolumab in combination with blinatumomab compared to blinatumomab alone in treating patients with B-cell acute lymphoblastic leukemia (B-ALL) that has come back (relapsed).
- Trial name
- NCT04546399
- Testing
- 3-Dimensional Conformal Radiation Therapy, Asparaginase Erwinia chrysanthemi, Biospecimen Collection
- Where
- 227 sites in United States, Australia and 2 more
- Volunteers
- 461 people
- Sponsor
- National Cancer Institute (NCI)
Down Syndrome, Alzheimer's Dementia
Relationship Between Down Syndrome (DS) and Alzheimer's Disease (AD)
In order to treat individuals with Down syndrome (DS) better and more efficiently and to gain more insights on its relation to Alzheimer's disease (AD), a comprehensive understanding is needed for its progression in the early or…
- Trial name
- NCT02759887
- Testing
- biospecimen collection, cognitive assessments, caregiver questionnaire
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- St. Joseph's Hospital and Medical Center, Phoenix
Hematologic Malignancies, Inborn Errors of Metabolism Disorders
Expanded Access to T-cell Depleted Haplo-Identical Stem Cells for Patients Receiving Haplo-Identical and Unrelated Cord Blood Transplants
The objective of this study is to make T-cell depleted stem cells from a family member who is a half match (haplo-identical) available on an expanded access basis to patients receiving one or two unrelated cord blood transplants…
- Conditions
- Hematologic Malignancies, Inborn Errors of Metabolism Disorders, Immune Deficiencies
- Trial name
- NCT01881334
- Testing
- CliniMACS CD34 Reagent System
- Where
- United States
- Sponsor
- Joanne Kurtzberg, MD
Intellectual Disability, Autism
Sensors for Communication for Persons Who Cannot Communicate Unequivocally
Some persons with intellectual disability or comprehensive cerebral palsy cannot communicate unequivocally how they are, how they react to situations and people, whether they are in pain or experience discomfort, anger or fear.
- Conditions
- Intellectual Disability, Autism, Cerebral Palsy
- Trial name
- NCT04199299
- Testing
- Heart rate and respiration rate sensors
- Where
- Norway
- Volunteers
- 100 people
- Sponsor
- University of Oslo
Prader-Willi Syndrome
Phase 2 Trial to Evaluate Safety and Efficacy of Setmelanotide (RM-493) in Obese Participants With Prader-Willi Syndrome
The purpose of this study was to evaluate the effects of a once daily subcutaneous injectable formulation of setmelanotide in obese participants with Prader-Willi syndrome on tolerability, weight loss, and hyperphagia-related…
- Trial name
- NCT02311673
- Testing
- Setmelanotide
- Where
- 5 sites in United States
- Volunteers
- 40 people
- Sponsor
- Rhythm Pharmaceuticals, Inc.
Flexible Flatfoot
Pediatric Pes Planus: Effect of Insoles With and Without SFE
The goal of this randomised control trial is to determine the effects of insoles with and without short foot exercises on pain, disability and foot posture in children with pes planus.
- Trial name
- NCT05877482
- Testing
- Short foot exercises, Insoles
- Where
- Pakistan
- Volunteers
- 26 people
- Sponsor
- Riphah International University
Depression
BEAT-IT: Behavioural Activation and Severe Learning Disabilities
Depression is common, but no psychological interventions have been tested to see if they work for adults with severe intellectual disabilities.
- Trial name
- NCT04744259
- Testing
- Behavioural Activation
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- NHS Greater Glasgow and Clyde