Clinical trials: Disability Diagnosis
Dyslexia
Evaluation of Speech Rhythm Training in Dyslexic Readers Aged 7 to 9 Years
Studies of dyslexia have shown altered oscillatory activity in the low gamma band (~25-35 Hz) in the left auditory cortex. Neural oscillations around 30 Hz constitute the basic sampling rate of speech, from which the ability to…
- Trial name
- RnDys (NCT05996497)
- Testing
- behavioral measures, Electrophysiological measures, Training 1
- Where
- France
- Volunteers
- 160 people
- Sponsor
- Institut Pasteur
Fragile X Syndrome
An Initial Study of AZD7325 in Adults With Fragile X Syndrome
This study will investigate the safety, tolerability and blood pharmacodynamics of treatment with oral administration of AZD7325 at 5 mg BID, 15 mg BID, and placebo BID, in adults with Fragile X Syndrome.
- Trial name
- NCT03140813
- Testing
- AZD7325 (High-Dose), AZD7325 (Low-Dose)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Mucopolysaccharidosis II
A Study of JR-141 in Patients With Mucopolysaccharidosis II (BR21)
A Phase II open-label, randomized, parallel group, 2 sites (Brazil), designed to evaluate the safety and efficacy of 3 doses of study drug for the treatment of the MPS II.
- Trial name
- NCT03359213
- Testing
- JR-141
- Where
- 2 sites in Brazil
- Volunteers
- 18 people
- Sponsor
- JCR Pharmaceuticals Co., Ltd.
Congenital Disorders
Pulmonary Hypertension in Trisomy 21 Patients
Evidence has shown poor outcome for adult patients with pre-operative pulmonary hypertension following closure of an atrial septal defect.
- Trial name
- NCT00478296
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Children's Healthcare of Atlanta
Intellectual Disability, Developmental Disability
Metformin for Antipsychotic-induced Weight Gain in Adults With Intellectual Disability
People with IDD (intellectual and developmental disability) have very high rates of obesity and die prematurely from cardiometabolic disease.
- Conditions
- Intellectual Disability, Developmental Disability, Obesity
- Trial name
- METIDD (NCT05744479)
- Testing
- Metformin, Lifestyle Intervention
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Centre for Addiction and Mental Health
Bell's Palsy
Effects of Photobiomodulation and Electrical Stimulation Among Bell's Palsy Patients
Despite promising evidence supporting both photobiomodulation (PBM) and electrical stimulation (ES) in Bell's palsy rehabilitation, key gaps remain in the literature.
- Trial name
- NCT07266636
- Testing
- Photobiomodulation alongwith facial exercise, Electrical Stimulation alongwith facial exercise
- Volunteers
- 34 people
- Sponsor
- Lahore University of Biological and Applied Sciences
Rett Syndrome
Metabolic Evaluation of Nutrition in Rett Syndrome
Rett syndrome (RTT) is an X-linked severe neurodevelopmental disorder. Despite their good appetite, many females with RTT meet the criteria for moderate to severe malnutrition. The pathological mechanism is barely understood.
- Trial name
- NCT00786071
- Where
- Netherlands
- Volunteers
- 13 people
- Sponsor
- Maastricht University Medical Center
Lumbar Spine Disease
Efficacy of Motor Control Exercise Program After Lumbar Spinal Decompression Surgery
The study will be conducted with volunteer patients who have undergone lumbar decompression surgery and who are followed up by the Neurosurgery outpatient clinic of Fethiye State Hospital.
- Trial name
- NCT06014632
- Testing
- Rehabilitation, Control
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people
- Sponsor
- Muğla Sıtkı Koçman University
Transcutaneous Vagal Nerve Stimulation (tVNS), Prader-Willi Syndrome
Proof of Concept Study of Vagus Nerve Stimulation
The investigator's recent pilot study of vagus nerve stimulation (VNS) from a surgically implanted medical device to control the excess eating behaviour characteristic of Prader-Willi Syndrome (PWS) found that it was safe and…
- Trial name
- NCT03689621
- Testing
- Transcutaneous vagus nerve stimulation (tVNS)
- Volunteers
- 9 people
- Sponsor
- Jessica Beresford-Webb
Rett Syndrome
Telehealth Support to Increase Physical Activity in Rett Syndrome
This study will recruit families with a daughter with Rett syndrome living in either Australia, Denmark or Israel, and thereafter deliver individually designed participation programs using telehealth strategies.
- Trial name
- ActivRett (NCT04167059)
- Testing
- Telehealth-delivered participation strategies to increase physical activity
- Where
- 2 sites in Denmark, Israel
- Volunteers
- 60 people
- Sponsor
- Telethon Kids Institute
Cerebral Palsy, Spinal Muscular Atrophy
Pediatric Powered Wheelchair Standing Devices: An Exploratory Study
For children who use a power wheelchair, a powered wheelchair standing device (PWSD) may be considered for daily use. A PWSD allows a child to electronically move between sitting and standing and can be driven in either position.
- Conditions
- Cerebral Palsy, Spinal Muscular Atrophy, Spinal Cord Injuries, Spina Bifida
- Trial name
- NCT05117827
- Testing
- Power Wheelchair Standing Device
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Grand Valley State University
Multiple Sclerosis
Blood Flow Restriction And Veterans With MS
There currently is a lack of evidence to support exercise interventions in people with advanced disability due to MS (i.e., need assistance to walk or use a wheelchair).
- Trial name
- BRAVe-MS (NCT05433103)
- Testing
- Low-Load Exercise with Blood Flow Restriction, Low-Load Exercise Control Group
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- VA Office of Research and Development
COVID-19, Quality of Life
Cohort Study for the Assessment of Long-term Impact of COVID-19 Among Moderate and Severe COVID-19 Patients in Brazil
The present prospective cohort study aims to assess factors associated with of one-year health-related quality of life and physical, cognitive and mental health outcomes among adult survivors of hospitalization for COVID-19.
- Conditions
- COVID-19, Quality of Life, Disability Physical, Disabilities Mental
- Trial name
- NCT05165979
- Testing
- Hospitalization due to COVID-19
- Where
- 24 sites in Brazil
- Volunteers
- 650 people
- Sponsor
- Hospital Moinhos de Vento
Dyslexia, Special Education
Multiple Family Narrative Therapy for Chinese Families of Children With Dyslexia
The goal of this randomized controlled trial (RCT) is to develop and to implement a multiple family narrative therapy (MFNT) intervention consisting of parent-child relationships training among Chinese families of children with…
- Conditions
- Dyslexia, Special Education, Special Needs Children
- Trial name
- MFNT-CDYS (NCT05949346)
- Testing
- Multiple Family Narrative Therapy (MFNT), School services for families of children with Dyslexia
- Where
- Hong Kong
- Volunteers
- 123 people
- Sponsor
- Hong Kong Baptist University
Multiple Sclerosis, Relapsing-Remitting
Study to Investigate the Immune Response and Safety of Prophylactic Vaccines in Patients Treated for Multiple Sclerosis
The aim of this study is to determine whether prophylactic vaccines recommended are effective and safe in patients with multiple sclerosis(MS) under MS-specific therapy.
- Trial name
- NCT02275741
- Testing
- prophylactic vaccine (tetanus, diphtheria, pertussis, poliomyelitis, influenza, hepatitis A, hepatitis B, tick-borne encephalitis, meningococcal, pneumococcal)
- Where
- Germany
- Volunteers
- 226 people
- Sponsor
- Dr. med. Micha Loebermann
Chronic Pain, Opioid Use
Improving Pain Disability With the Use of Oral Cannabinoids
The investigators are conducting a pilot (i.e. a small study) in order to find out the effectiveness and safety of medical cannabis in the management of chronic pain.
- Conditions
- Chronic Pain, Opioid Use, Cannabis
- Trial name
- NCT05351905
- Testing
- CBD oil ( MPL-001), CDB+THC oil (MPL-005)
- Where
- Canada
- Volunteers
- 51 people
- Sponsor
- University Health Network, Toronto
Dyslexia, Developmental
Neural Mechanisms of Successful Intervention in Children With Dyslexia
Dyslexia, an impairment in accurate or fluent word recognition, is the most common learning disability affecting roughly ten percent of children.
- Trial name
- NCT04323488
- Testing
- Lindamood-Bell Seeing Stars
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Stanford University
Autism, Autism Spectrum Disorder High-Functioning
PRT for Adolescents With High Functioning Autism
The purpose of this study is to identify improvement in behavioral and social function and changes in the brain following Pivotal Response Treatment (PRT) for Adolescents in highly verbal adolescents with autism spectrum disorder…
- Conditions
- Autism, Autism Spectrum Disorder High-Functioning, Developmental Disability, Child Development
- Trial name
- NCT05987761
- Testing
- PRT for Adolescents
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Stanford University
Prader-Willi Syndrome
Respiratory Restriction in Prader-Willi Syndrome
The main aim of this study is therefore to evaluate the impact of Prader Willi Syndrome (PWS) on lung and thoracoabdominal volumes, respiratory muscle strength and awake ventilatory pattern, and to quantify and localize the…
- Trial name
- RESPIPWS (NCT06851351)
- Testing
- Spirometry and optoelectronic plethysmography
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Istituto Auxologico Italiano
Spinal Cord Injury
Customized Employment for Veterans With Spinal Cord Injury
The reason for conducting this study is to learn about the best ways to help Veterans with spinal cord injury (SCI) gain meaningful employment.
- Trial name
- ACCESS-Vets (NCT04832802)
- Testing
- ACCESS, IPS
- Where
- 2 sites in United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development