Clinical trials: Disability Evaluation, open to volunteers
Primary Progressive Multiple Sclerosis, Primary Progressive MS
A Phase 2a Study of SUN-627 in Participants With Non-Active Secondary Progressive and Primary Progressive Multiple Sclerosis (SPMS/PPMS)
The goal of this Phase 2 clinical trial is to investigate the safety and tolerability of SUN-627 in men and women aged 18-70 years old with a diagnosis of non-active SPMS/PPMS.
- Conditions
- Primary Progressive Multiple Sclerosis, Primary Progressive MS, Primary Progressive Multiple Sclerosis (PPMS), Secondary Progressive MS (SPMS)
- Trial name
- NCT07840326
- Testing
- SUN-627
- Where
- 7 sites in United States
- Volunteers
- 20 people
- Sponsor
- Sundance Biosciences, Inc.
Methyl CpG Binding Protein 2 (MECP2) Duplication Syndrome
ATTUNE: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Intrathecally-Administered ION440 in Participants With Methyl CpG Binding Protein 2 (MECP2) Duplication Syndrome (MDS)
The primary purpose of this study is to evaluate the safety and tolerability of ION440.
- Trial name
- NCT06430385
- Testing
- ION440
- Where
- 12 sites in United States, Austria and 3 more
- Volunteers
- 48 people
- Sponsor
- Ionis Pharmaceuticals, Inc.
Intellectual Disability, Mild
Evaluation of CO-OP for Adolescents With Mild Intellectual Disability
Intellectual disability (ID) affects a person throughout life and includes difficulties to manage what is expected in everyday life based on age.
- Trial name
- CO-OPIF (NCT06691698)
- Testing
- The Cognitive Orientation to Daily Occupational Performance Approach
- Where
- 2 sites in Sweden
- Volunteers
- 60 people
- Sponsor
- Örebro University, Sweden
Psoriasis Vulgaris
Pre-Post Multimodal Assessment Of Severe Psoriasis Vulgaris Using Clinical, Dermoscopic And QoL Measures
The goal of this observational study is to learn about the comprehensive changes in severe plaque psoriasis (Psoriasis Vulgaris) in adult participants undergoing standard treatment.
- Trial name
- NCT07495657
- Volunteers
- 45 people
- Sponsor
- Assiut University
Tinnitus, Neural Therapy of Huneke
The Effects of Conventional Therapy on Tinnitus, Disability, and Quality of Life in Patients With Tinnitus
A randomized, single-blind, controlled trial to evaluate the effects of neural therapy on tinnitus severity, disability, and quality of life in patients with tinnitus.
- Trial name
- NCT07334002
- Testing
- Neural Therapy of Huneke, Betahistine 24 mg bid (Betaserc)
- Volunteers
- 30 people
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Myofascial Pain Syndrome
Focused Shockwave Therapy for Neck and Shoulder Myofascial Pain
Myofascial pain syndrome of the neck and shoulder is a common condition characterized by persistent muscle pain, tenderness, stiffness, and limitations in daily activities.
- Trial name
- NCT07660523
- Testing
- Second-Generation Focused Extracorporeal Shockwave Therapy, Home-Based Neck Exercise Program
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Cishan Hospital, Ministry of Health and Welfare
Neurodevelopmental Disorders, Intellectual Developmental Disorder
High Depth Exome Sequencing on DNA From a Salivary Sample by Mouth Smear.
Despite technological advances, a genetic etiology has been identified in only about 50% to 60% of patients with Neurodevelopmental disorders (NDDs), with a higher diagnostic yield in the syndromic NDD and IDD subgroups.
- Trial name
- SEPASA (NCT07492199)
- Testing
- genetic
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Pregnant Individuals, Aneuploidy
The ADVANCE (Assay Development and Validation for Pre-Natal and Obstetric Conditions) Study is the Largest U.S.-Based Prospective Study Demonstrating a Circulating Fetal Cell (CFC) Based Approach to Non-invasive Fetal Risk Assessment
The goal of the ADVANCE (Assay Development and Validation for Pre-Natal and Obstetric Conditions) study is to compare the concordance of results of a novel non-invasive circulating fetal cell (CFC) assay to the results of…
- Conditions
- Pregnant Individuals, Aneuploidy, Down Syndrome (Trisomy 21), 22q11.2 Deletion Syndrome
- Trial name
- ADVANCE (NCT07643896)
- Where
- 9 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- BillionToOne Inc.
Systemic Sclerosis (SSc), Digital Ulcer
Hand Disability In Systemic Sclerosis - Digital Ulcers
The aim of this study was to examine the Turkish validity and reliability of the Hand Disability in Systemic Sclerosis - Digital Ulcers Questionnaire (HDISS-DU) in individuals with Systemic Sclerosis.
- Trial name
- NCT06658470
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Pamukkale University
Non Specific Neck Pain
Effects of Tele-rehabilitation Versus Supervised Rehabilitation Among Computer Users With Non-specific Neck Pain
The current study is a single-blinded, two-arm parallel-group randomized controlled trial involving 62 participants with non-specific neck pain among computer users.
- Trial name
- NCT07556705
- Testing
- Neck and upper back strengthening exercises by Tele-rehabilitation Intervention, Neck and upper back strengthening by Supervised Rehabilitation Intervention
- Volunteers
- 62 people
- Sponsor
- Lahore University of Biological and Applied Sciences
FOXP1, Mental Retardation With Language Impairment and With or Without Autistic Features
FOXP1 Syndrome: The Seaver Autism Center for Research and Treatment is Characterizing FOXP1-related Neurodevelopmental Disorders Using Genetic, Medical, and Neuropsychological Measures.
FOXP1, also known as Forkhead-box Protein P1, is a transcription factor protein belonging to the FOX gene family. Disruptions in the FOXP1 gene cause a phenotype characterized by global developmental delay, speech deficits, mild…
- Conditions
- FOXP1, Mental Retardation With Language Impairment and With or Without Autistic Features, Autism Spectrum Disorder
- Trial name
- NCT03718923
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Migraine
Validity and Reliability of the Greek Pain Catastrophizing Scale
Migraine is a common neurological disorder that can significantly affect daily activities, quality of life, and emotional well-being. How individuals think and feel about pain may also influence their experience of migraine.
- Trial name
- NCT07847528
- Where
- Greece
- Volunteers
- 130 people
- Sponsor
- National and Kapodistrian University of Athens
Intellectual Disability
Evaluation of the Effect of Digital-based Games on the Visual and Cognitive Performance of Young Children With Intellectual Disabilities
This randomized controlled trial aims to evaluate the effect of digital intelligence games on visual and cognitive performance in young individuals with intellectual disabilities.
- Trial name
- NCT07476092
- Testing
- MentalUP Digital Intelligence Game
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Koç University
Multiple Sclerosis, Sarcopenia
Investigation of the Prevalence of Sarcopenia and Dynapenia According to Disease Stage in Patients With Multiple Sclerosis and Evaluation of the Relationship Between Sarcopenia Severity and Clinical and Functional Parameters
This cross-sectional observational study aims to determine the prevalence of sarcopenia and dynapenia across disability stages in patients with multiple sclerosis (MS) and investigate their associations with clinical and…
- Conditions
- Multiple Sclerosis, Sarcopenia, Dynapenia
- Trial name
- MS-Sarcopenia (NCT07842731)
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Atılım University
Developmental Delay, Behavioural Problem
Early Detection and Intervention in Developmental Delay / Behavioral Problems in Preschool Children - PLUSS
The PLUSS (Mental health, learning, development, collaboration around preschool children) is a collaborative project involving guardians, Jönköping County´s health care, preschools and social services.
- Conditions
- Developmental Delay, Behavioural Problem, Neurodevelopmental Delay
- Trial name
- PLUSS (NCT04815889)
- Testing
- PRIMUS parent training Group
- Where
- Sweden
- Volunteers
- 600 people
- Sponsor
- Region Jönköping County
Lipedema, Venous Insufficiency
Assessment of Venous Insufficiency and Clinical Features in Lipedema
Lipedema is a chronic adipose tissue disorder characterized by disproportionate fat accumulation, pain, tenderness, edema, and functional impairment.
- Conditions
- Lipedema, Venous Insufficiency, Venous Disease, Disability Physical
- Trial name
- NCT07603076
- Testing
- Venous Doppler Ultrasonography, Numeric Rating Scale, Lower Extremity Functional Scale
- Where
- Turkey (Türkiye)
- Volunteers
- 82 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Congenital Disorders of Glycosylation
Clinical and Basic Investigations Into Known and Suspected Congenital Disorders of Glycosylation
Background: Proteins, fats, and other molecules are the body s building blocks. Many of these molecules must have sugars, or chains of sugars, attached to work properly.
- Trial name
- NCT02089789
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Migraine
Validity and Reliability of the Greek WPAI:Migraine
Migraine is a common neurological disorder that can substantially impair work productivity and daily functioning through both absenteeism and presenteeism.
- Trial name
- NCT07847554
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- National and Kapodistrian University of Athens
Multiple Sclerosis
Longitudinal Assessment of Iron Rims in MS Lesions
In multiple sclerosis (MS), the presence of white matter lesions surrounded by a rim of iron is suggested to signify a more severe disease course.
- Trial name
- NCT05123443
- Testing
- Blood sample provided, 7-T MRI scan
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Nottingham University Hospitals NHS Trust
Diet Habits, Body Composition
Body Composition and Lifestyles in Athletes With Disabilities
Disability involves limitations that affect mobility and the ability to perform daily activities and achieve competitive goals. It is expected that disability has a significant impact on body composition, including reductions in…
- Conditions
- Diet Habits, Body Composition, Athlete Assessment, Sport Nutrition
- Trial name
- PADES (NCT07464899)
- Testing
- Diet, body composition, Physical activity
- Where
- Spain
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Alicante