Clinical trials: Disbiosis
Constipation, End Stage Renal Disease on Dialysis
Effects of Synbiotics Supplementation on the Uremic Toxin Indoxyl Sulfate Level and Constipation in End-stage Renal Disease Patients Undergoing Hemodialysis
This is a double-blind, placebo-controlled, randomized clinical trial conducted to evaluate the effects of synbiotics supplementation on the level of the uremic toxin indoxyl sulfate, symptoms of constipation, and…
- Trial name
- NCT04527640
- Testing
- Synbiotics containing Lactobacillus acidophilus & Bifidobacterium longum 5x10^9 CFU and FOS 60 mg
- Volunteers
- 60 people
- Sponsor
- Universitas Indonesia
Dysbiosis
Ex-vivo Evaluation of the Effect of 2 Probiotic Solutions (Lactibiane ATB and Lactibiane Enfant) and 5 Classes of Drugs on the Intestinal Microbiota
The objective is to test ex-vivo the effects of two probiotic solutions (Lactibiane ATB and Lactibiane Enfant) and five classes of drugs (antibiotic, proton pump inhibitor, non-steroidal anti-inflammatory, anxiolytic and…
- Trial name
- EPROMED (NCT06114303)
- Testing
- Stool sampling
- Where
- France
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Larena SAS
Endometriosis
Impact of Microbiome in Endometriosis Development
Endometriosis is a chronic disease, of which the pathophysiology is still unknown. Several theories exist, the one of menstrual blood flow has been retained until now but does not fully explain it.
- Trial name
- ENDOBIOME (NCT07576361)
- Where
- Guadeloupe
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de la Guadeloupe
Renal Failure Chronic
Probiotics and Low Protein Diet in Advanced Chronic Kidney Disease
Here the investigators will perform a double-blinded randomized placebo-controlled clinical trial to evaluate the synergic effect of low protein diet and prebiotics in reducing the microbial inflammatory uremic toxins.
- Trial name
- ProLowCKD (NCT04204005)
- Testing
- Probiotics
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Probiotical S.p.A.
Lipedema, Obesity
Microbiota and Lipedema Evaluation in Obese Patient Treated With Very Low Energy Ketogenic Vegan Therapy
Lipedema is a progressive, hereditary, multifactorial disease that occurs primarily in women, characterized by an abnormal and painful accumulation of subcutaneous fatty tissue.
- Conditions
- Lipedema, Obesity, Dysbiosis
- Trial name
- MLVLEKVT (NCT07041684)
- Testing
- Very Low Energy Ketogenic Therapy with vegan meal replacements
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- University of Roma La Sapienza
Dysbiosis, Catheter-Related Infections
Cutaneous Microbiota Evolution in ICU Patients With CVC (ICMc)
Intensive Care Unit (ICU) patients are exposed to catheter-related infections with an important morbidity. Catheter colonization is constant but infection is not. Cutaneous dysbiosis could be the missing link.
- Trial name
- ICMc (NCT06095076)
- Testing
- Skin swabbing, Data collection
- Where
- French Guiana
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier de Cayenne
Ulcerative Colitis in Remission
Impact of Bread Diet on Intestinal Dysbiosis and Irritable Bowel Syndrome Symptoms in Quiescent Ulcerative Colitis
The present study aimed to compare the in vivo prebiotic properties of bread produced by traditional breadmaking techniques with that made using a modern breadmaking method on Irritable Bowel Syndrome-like symptoms in patients…
- Trial name
- NCT05656391
- Testing
- Treatment vs control bread
- Where
- Spain
- Volunteers
- 31 people
- Sponsor
- Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta
Alcohol Use Disorder, Risk Behavior, Health
Alcohol Misuse, Gut Microbial Dysbiosis and PrEP Care Continuum: Application and Efficacy of SBIRT Intervention
This randomized control trial study among Pre-exposure prophylactic users (PrEP) aims to learn and determine the efficacy of Screening, brief intervention, and referral to treatment (SBRIT) in reducing the risk of alcohol use.
- Conditions
- Alcohol Use Disorder, Risk Behavior, Health, Dysbiosis, HIV Infections
- Trial name
- SEAL (NCT06005298)
- Testing
- Screening, Brief Intervention, Referral to Treatment (SBIRT)
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Shirish S Barve
Bariatric Surgery Candidate, Dysbiosis
The Effect of Probiotics on Systemic Inflammation and Metabolic Endotoxemia in Patients Undergoing Bariatric Surgery
This study explores the effects of probiotic administration on the outcomes of surgical treatment, and also on the state of the intestinal microbiota and the intestinal barrier.
- Trial name
- NCT05407090
- Testing
- probiotic supplementation
- Where
- Poland
- Volunteers
- 80 people
- Sponsor
- Medical University of Gdansk
Periodontal Diseases, IBD
Effects Of Periodontal Therapy In Patients With Inflammatory Bowel Disease
Periodontitis and inflammatory bowel disease have been associated by meta-epidemiologic evidence, although their mechanistic connection needs to be further explored.
- Conditions
- Periodontal Diseases, IBD, Dysbiosis, Inflammation
- Trial name
- NCT07905859
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University of Turin, Italy
Hemodialysis
NATURE 3.2_New Approach for the Reduction of REnal Uremic Toxins
The objective of the pilot study is to validate a combined approach based on the use of an innovative symbiotic and an innovative dialysis cartridge in patients on hemodialysis (HD).
- Trial name
- NATURE32 (NCT03946176)
- Testing
- Symbiotic, DVB cartridge
- Where
- Italy
- Volunteers
- 16 people
- Sponsor
- Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari
Dysbiosis, Cardiometabolic Health Indicators
Almonds, Gut Microbiome and Kids
This 8-week parallel-arm randomized controlled trial (N=70; ages 6-13) will determine the impact of daily almond butter consumption on gut microbiome composition and function, intestinal barrier integrity, and cardiometabolic…
- Trial name
- NCT07636850
- Testing
- Creamy Richards 100% Almonds! Creamy Natural Almond Butter, Cadbury Milk Chocolate Spread
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Florida State University
Periodontal Diseases, Gastritis
Evaluation of Microbial Status in Gastritis Patients in Different Periodontal Conditions
The aim of this study to evaluate the microbial profile in gastritis and healthy patients in different periodontal conditions via next generation technologies.
- Trial name
- NCT07378540
- Testing
- saliva collection
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Mental Disorder
Microbiome and the Gut-Brain Axis
This research study will examine the relationship interconnecting medical body health, mental health, and microbes of the digestive tract in persons living with serious mental illnesses,as compared to persons without such…
- Trial name
- NCT02693327
- Testing
- Biological Sample, Blood Sample
- Where
- 2 sites in United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of Florida
Intestinal Infections, Dysbacteriosis
INVESTIGATION of the EFFICACY and SAFETY of the DRUG "AS-PROBIONORM"
The subject of this clinical trial is the medicine "AS-Probionorm". Pharmacological group - Antidiarrheal drugs. Antidiarrheal microorganisms. Microorganisms that produce lactic acid.
- Trial name
- NCT06886399
- Testing
- "AS-Probionorm"
- Where
- Kazakhstan
- Volunteers
- 210 people
- Sponsor
- Industrial Microbiology LLP
Arterial Stiffness, Dysbiosis
Lifestyles, Arterial Aging and Intestinal Microbiota (MIVAS III Study)
This is an observational cross-sectional study whose objective is to analyse associations between the intestinal and salivate microbiota with lifestyles (eating patterns, physical activity, tobacco and alcohol consumption)…
- Trial name
- NCT04924907
- Where
- 2 sites in Spain
- Volunteers
- 1,015 people, healthy volunteers welcome
- Sponsor
- Instituto de Investigación Biomédica de Salamanca
Dysbiosis, Clostridium Difficile
REMBRANDT: REcovery of the MicroBiome fRom Antibiotics for Dental implanTs
Antimicrobial therapy can lead to disruption of the gut microbiome and infection with Clostridioides difficile, a disease associated with high morbidity and mortality, particularly among the elderly.
- Conditions
- Dysbiosis, Clostridium Difficile, Pet-Human Bonding, Antibiotic-Associated Colitis
- Trial name
- NCT05622721
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Pennsylvania
Cancer
Correlates of CRCI and Gut Microbiome Dysbiosis; a Pilot Study
The aim of this study is to characterize the microbiome and assess fatigue and cognition of patients with cancer undergoing standard of care treatment.
- Trial name
- NCT06098404
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Autism Spectrum Disorder
Intestinal Dysbiosis and BBB Integrity in Autism
Autism Spectrum Disorder (ASD) is characterised by an impairment of social interactions and communication, associated with repetitive behaviour and restrictive interests.
- Trial name
- LEDA (NCT04321915)
- Testing
- Analysis of intestinal microbiota in autism spectrum desorder, Analysis of neuroinflammation markers in autism spectrum desorder
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Montpellier
Healthy Volunteers
Human Milk Oligosaccharide-Based Synbiotic Supplement for Intestinal Microbiota Dysbiosis
Background: Human intestines are home to a complex gut flora, also called microbiome; this is a natural occurring community of bacteria, fungi, yeast, and viruses.
- Trial name
- NCT06615986
- Testing
- Cardiosyn
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)