Clinical trials: Disc Degeneration
Lumbar Disc Herniation, Lumbar Spinal Stenosis
Nurse-Led Early Standing Exercise After Lumbar Fusion in Older Adults
This single-center, randomized controlled trial aimed to evaluate the effects of a nurse-led early standing active exercise program on postoperative functional recovery in older adults undergoing short-segment lumbar fusion.
- Conditions
- Lumbar Disc Herniation, Lumbar Spinal Stenosis, Lumbar Spondylolisthesis, Degenerative Lumbar Scoliosis
- Trial name
- NCT07870993
- Testing
- Nurse-Led Early Standing Active Exercise Program, Routine Postoperative Rehabilitation
- Where
- China
- Volunteers
- 108 people
- Sponsor
- Xuanwu Hospital, Beijing
Intervertebral Disc Degeneration, Spinal Fusion
Minimally Invasive Surgery Techniques for One-level Degenerative Lumbar Deformities Correction
This study will be conducted at Research Institute of Traumatology and Orthopedics (NRITO) n.a. Ya.L.Tsivyan, Novosibirsk, Russia.
- Trial name
- NCT03908203
- Testing
- Minimally invasive one-level lumbar deformity correction
- Where
- Russia
- Sponsor
- Novosibirsk Research Institute of Traumatology and Orthopaedics n.a. Ya.L. Tsivyan
Degenerative Disc Disease
Clinical Evaluation of Fortilink® TETRAfuse® Interbody Fusion Device in Subjects With Degenerative Disc Disease
This is a prospective, multi-center, non-randomized post-market evaluation designed to collect and evaluate data on the safety and performance of the Fortilink IBF System with TETRAfuse 3D Technology.
- Trial name
- FORTE (NCT03761563)
- Testing
- Fortilink IBF System with TETRAfuse Technology
- Where
- 14 sites in United States
- Volunteers
- 15 people
- Sponsor
- Xtant Medical
Degenerative Disc Disease, Disc Degeneration
Clinical Trial Evaluating the Safety and Efficacy of Nucleus Pulposus Allograft in Participants With Degenerative Disc Disease
VIA Disc NP is a non-surgical intervention intended to supplement nucleus pulposus tissue in degenerated intervertebral discs. This is a randomized, sham-controlled, multi-center, double-blind clinical trial with an open label…
- Conditions
- Degenerative Disc Disease, Disc Degeneration, Lumbar Discogenic Pain
- Trial name
- RESTORE (NCT06778447)
- Testing
- VIA Disc NP
- Where
- 19 sites in United States
- Volunteers
- 325 people
- Sponsor
- VIVEX Biologics, Inc.
Chronic Pain in Degenerative Disc Diseases
The Efficacy of Erector Spinae Plane Block for the Relief of Chronic Pain in Cases of Degenerative Disc Diseases.
Erector Spinae Plane Block is an effective pain therapy technique to relieve chronic low back pain in cases of degenerative disc disorders.
- Trial name
- NCT07256132
- Testing
- erector spinae plane block
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Alexandria University
Degenerative Disc Disease
Evaluation of Safety and Effectiveness of Primary Hybrid Construct of Mobi-C and ACDF in the Treatment of Two-level Symptomatic Degenerative Disc Disease in the Cervical Spine.
The study is a prospective, multi-center cohort study of patients with two-level DDD implanted with CDA adjacent to ACDF (hybrid construct).
- Trial name
- NCT06485206
- Testing
- One level Mobi-C and one level fusion
- Where
- 2 sites in United States
- Volunteers
- 97 people
- Sponsor
- Highridge Medical
Degenerative Disc Disease, Trauma (Including Fractures)
BIO4 Clinical Case Study: Cervical Spine
The goal of this study is to investigate the efficacy of BIO4 bone matrix in patients undergoing 1 or 2-level Anterior Cervical Discectomy and Fusion (ACDF) spine surgery.
- Conditions
- Degenerative Disc Disease, Trauma (Including Fractures), Spondylolisthesis
- Trial name
- NCT03077204
- Testing
- 1 or 2-Level ACDF utilizing BIO4 with Bio AVS Cervical Allograft (with graft window)., Aviator Anterior Cervical Plating System
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Seton Healthcare Family
Degenerative Lumbar Disc Disease
Advanced XLIF Monitoring Multicenter Study
The objective of this study is to evaluate the utility of localized stimulation of the lumbosacral nerve roots during XLIF through correlation of observed changes in the response latency, amplitude, waveform morphology, and/or…
- Trial name
- NCT02272140
- Where
- 12 sites in United States
- Volunteers
- 324 people
- Sponsor
- NuVasive
Disc Degeneration
Low-grade Infections of the Intervertebral Discs
The purpose of this prospective, observational study was to evaluate frequency and characteristics of low-grade infections of the intervertebral discs in an unselected real-life patient population undergoing surgery for…
- Trial name
- NCT04712487
- Testing
- Microbiological culture, viral PCR, histopathological analysis
- Where
- Austria
- Volunteers
- 392 people
- Sponsor
- Kepler University Hospital
Adjacent Segment Disease, Cervical Myelopathy
Adjacent Segment Disease After Anterior Cervical Decompression Surgery
Radiculopathy and/or myelopathy due to cervical degenerative disc disease are increasingly common pathologies in our ageing population. Both can be treated non-surgically or surgically.
- Conditions
- Adjacent Segment Disease, Cervical Myelopathy, Cervical Radiculopathy, Degenerative Disc Disease
- Trial name
- ASDafterACDF (NCT04320043)
- Testing
- Anterior cervical decompression
- Where
- Netherlands
- Volunteers
- 673 people
- Sponsor
- Zuyderland Medisch Centrum
Lumbar Degenerative Disc Disease
CARES Lumbar Artificial Disc Registry
The purpose of the registry is to assess outcomes following treatment with lumbar total disc replacement (TDR) in patients outside the clinical trial setting.
- Trial name
- NCT02139527
- Testing
- Total Disc Replacement
- Volunteers
- 120 people
- Sponsor
- DePuy Spine
Cervical Spondylosis, Cervical Radiculopathy
Evaluation of DTRAX Graft in Patients With Cervical Degenerative Disc Disease
DTRAX Graft is used to relieve nerve pressure in the neck in order to provide relief for Cervical Degenerative Disc Disease. This study is being conducted to determine the effectiveness of the graft, and to find out whether or…
- Conditions
- Cervical Spondylosis, Cervical Radiculopathy, Cervical Degenerative Disc Disease
- Trial name
- NCT01616719
- Testing
- DTRAX Graft
- Where
- 2 sites in United States
- Sponsor
- Providence Medical Technology, Inc.
Degenerative Disc Disease
Adipose Cells for Degenerative Disc Disease
The intent of this clinical study is to answer the questions: 1) Is the proposed treatment safe and 2) Is treatment effective in improving the disease pathology of patients with diagnosed degenerative disc disease.
- Trial name
- NCT02097862
- Testing
- Adipose Stem Cells
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Bioheart, Inc.
Cervical Disc Herniation, Cervical Degenerative Disc Disease
Effect of Topical Corticosteroids on Dysphagia in Anterior Cervical Discectomy and Fusion
The purpose of this study is to determine what effect intraoperative topical steroids have on reducing swallowing difficulty following Anterior Cervical Discectomy and Fusion surgery.
- Conditions
- Cervical Disc Herniation, Cervical Degenerative Disc Disease, Cervical Spondylotic Myelopathy, Dysphagia
- Trial name
- NCT02539394
- Testing
- Methylprednisolone Acetate, Hemostatic Matrix Kit
- Volunteers
- 128 people
- Sponsor
- Hospital for Special Surgery, New York
Cervical Disc Degenerative Disorder
Evaluating The Safety and Effectiveness of The NeoDisc™ Versus ACDF in Subjects With Single-Level Cervical Disc Disease
The purpose of the study is to evaluate the safety and effectiveness of the NeoDisc compared to anterior cervical discectomy and fusion (ACDF) for the treatment of single-level cervical disc disease, by demonstrating non-inferior…
- Trial name
- NeoDisc™ (NCT00478088)
- Testing
- NeoDisc, Instrumented Anterior Cervical Discectomy and Fusion (ACDF)
- Where
- 22 sites in United States
- Volunteers
- 488 people, healthy volunteers welcome
- Sponsor
- NuVasive
Degenerative Disc Disease, Spinal Stenosis
Single-Armed Use of ViviGen Cellular Bone Matrix in Patients Undergoing Posterolateral Lumbar Surgery
This is a prospective, single-arm post market study of patients to assess fusion in one or multiple continuous levels of the lumbosacral spine (L1-S1) using ViviGen Cellular Bone Matrix.
- Conditions
- Degenerative Disc Disease, Spinal Stenosis, Spondylosis, Spondylolisthesis
- Trial name
- NCT04007094
- Testing
- ViviGen Cellular Bone Matrix
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Ohio State University
Lumbar Degenerative Disc Disease, Cervical Degenerative Disc Disease
Evaluation of the Prosthetic Disc Replacement
Until now, arthrodesis (intervertebral fusion) is the formal treatment for the lumbar and cervical degenerative disc disease : arthrodesis has been the standard surgical treatment for the patients when nonsurgical management has…
- Conditions
- Lumbar Degenerative Disc Disease, Cervical Degenerative Disc Disease, Kyphosis
- Trial name
- EVA (NCT00640029)
- Testing
- Arthrodesis, Arthroplasty (PRODISC-C® , PRODISC-L®, Mobi-C®, Mobidisc®, PrestigeLP®, A-Mav®, O-Mav®, DISCOCERV®)
- Where
- 2 sites in France
- Volunteers
- 301 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Degenerative Disc Disease
Retrospective Multicenter Clinical Evaluation of Complications for Single or Multilevel VEO® Lateral Access and Interbody Fusion System and eXtreme Lateral Interbody Fusion (XLIF®) Subjects
The purpose of this retrospective clinical evaluation is to compare VEO® single or multilevel results to XLIF® single or multilevel results relative to the safety endpoints.
- Trial name
- NCT01878149
- Where
- 4 sites in United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Baxano Surgical, Inc.
Intervertebral Disc Degeneration, Stenosis, Spinal
Intraoperative Monitoring for the Lateral Lumbar Interbody Fusion Procedure
This study is designed to evaluate the clinical utility of a known intraoperative neuromonitoring modality (SSEP) using saphenous nerve as the site of stimulation to identify changes to the lumbar nerves which may be at risk…
- Conditions
- Intervertebral Disc Degeneration, Stenosis, Spinal, Spondylolisthesis, Spinal Deformity
- Trial name
- NCT05648474
- Testing
- Somatosensory evoked potential [SSEP] intraoperative monitoring
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Alphatec Spine, Inc.
Degenerative Disc Disease, Grade 1 Spondylolisthesis
Retrospective Study With Patients Treated With STALIF® C or M and Ti or FLX Implants for 1 and 2 Levels
This is a Retrospective, Observational Multi-Center study, utilizing patients diagnosed with up to a Grade1 spondylolisthesis or retrolisthesis or symptomatic degenerative disc disease and treated with STALIF® C, or M, Ti and/or…
- Conditions
- Degenerative Disc Disease, Grade 1 Spondylolisthesis, Retrolisthesis, Symptomatic Cervical Disc Disease
- Trial name
- Stalif (NCT05610397)
- Testing
- STALIF®
- Volunteers
- 200 people
- Sponsor
- Centinel Spine