Clinical trials: Disc Herniations
Herniated Disc, Low Back Pain
Efficacy of PLDD Versus ESI in the Treatment of Lumbar Radicular Pain
The most common cause of lumbar radicular pain is intervertebral disc herniation with or without pressure on the nerve root, which leads to inflammation and pain.
- Trial name
- NCT05601791
- Testing
- Epidural Steroid Injection, Percutaneous Laser Disc Decompression
- Where
- Croatia
- Volunteers
- 116 people
- Sponsor
- Osijek University Hospital
Lumbar Herniated Disc
Assesment of Epidural Platelet-Rich Plasma (PRP) Injection During Uniportal Endoscopic Lumbar Disc Herniation Excision on Residual Neuropathies
The aim of this study is to assess neuropathic pain in the lower limb at 6 months post-operation in patients who have undergone surgery for a lumbar disc herniation using single-port endoscopic discectomy combined with an…
- Trial name
- HERDISPLA (NCT07770750)
- Testing
- Uniportal endoscopic lumbar disc herniation removal
- Where
- France
- Volunteers
- 50 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Intervertebral Disc Displacement, Low Back Pain
Exercise Therapy After Caudal Epidural Steroid Injection
Brief Summary Lumbar radicular pain arising from intervertebral disc herniation is commonly managed with a caudal epidural steroid injection (CESI), a minimally invasive procedure that delivers anti-inflammatory medication to the…
- Conditions
- Intervertebral Disc Displacement, Low Back Pain, Radiculopathy
- Trial name
- CAPER (NCT06956664)
- Testing
- Conventional Physiotherapy, Aerobic Exercise Programme, Core-Stabilization Exercise Programme
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Çankırı Karatekin University
Lumbar Spine Disc Herniation, Lumbar Radiculopathy
Surgery Versus Standardized Non-operative Care for the Treatment of Lumbar Disc Herniations: A Canadian Trial
The objective of this study is to determine if surgery is superior to non-operative care for sciatica caused by a lumbar disc herniation.
- Trial name
- NCT01335646
- Testing
- Lumbar Microdiscectomy, Physiotherapy, Epidural injections, Education, Pain Medications, Anti-inflammatories
- Where
- Canada
- Volunteers
- 128 people
- Sponsor
- The London Spine Centre
Opioid Consumption, Postoperative, ESPB
Evaluation of the Postoperative Efficacy of Bilateral Lumbar Erector Spinae Plane Block (ESPB) in Patients Undergoing Lumbar Disc Herniation Repair Surgery
This prospective observational study aims to evaluate the efficacy of bilateral lumbar erector spinae plane (ESP) block in providing effective postoperative analgesia and its potential impact on early mobilization and length of…
- Conditions
- Opioid Consumption, Postoperative, ESPB, Postoperative Pain, Plane Blocks
- Trial name
- NCT07403734
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Lumbar Disc Herniation
Lumbar Epidural Analgesia Versus Local Anesthesia With Dexmedetomidine Infusion in Endoscopic Lumbar Discectomy
To compare between local anesthesia combined with intravenous Dexmedetomidine and epidural analgesia as regard the effectiveness and patient satisfaction during percutaneous transforaminal endoscopic discectomy.
- Trial name
- NCT05850455
- Testing
- Dexmedetomidine Hydrochloride 'Precedex' combined with, Lumbar epidural analgesia with Bupivacaine 0.25% 'Sunnypivacaine', General anesthesia
- Where
- Egypt
- Volunteers
- 78 people
- Sponsor
- Ain Shams University
Lumbar Disc Herniation
VR Therapy Effects in Lumbar Disc Herniation
This study aims to evaluate the effects of incorporating virtual reality (VR) therapy into routine physical therapy (RPT) on balance, pain, kinesiophobia, quality of life, and depression in individuals diagnosed with lumbar disc…
- Trial name
- NCT07309627
- Testing
- Conventional Physiotherapy, VR
- Where
- Turkey (Türkiye)
- Volunteers
- 93 people
- Sponsor
- Uskudar University
Sciatica, Intervertebral Disc Disorder
Alternative and Integrative Therapy for Lumbar Disk Herniation
The investigators report management of lumbar disc herniation with severe sciatic pain using an integrative complementary and alternative medicine approach with a 5 year follow-up.
- Trial name
- NCT01989403
- Testing
- herbal medicine, acupuncture, bee-venom acupuncture, and Chuna manipulation
- Where
- South Korea
- Volunteers
- 128 people
- Sponsor
- Jaseng Hospital of Korean Medicine
Intervertebral Disc Degeneration, Intervertebral Disc Displacement
Proprio Spine Measurement Tool
This study will prospectively collect data to evaluate the effectiveness of a novel intraoperative spinal measurement system to assist the surgeon with intraoperatively achieving pre-planned alignment-related parameters to the…
- Conditions
- Intervertebral Disc Degeneration, Intervertebral Disc Displacement, Spinal Curvatures, Spinal Osteochondrosis
- Trial name
- NCT07023393
- Testing
- Intraoperative spinal measurement system
- Where
- United States
- Sponsor
- Duke University
Lumbar Disc Disease, Lumbal Disc Herniation
Development of a Fascial Training Based Mobile Application and Investigation of Its Effectiveness in Patients With Disc Herniation
This study will compare three different groups for lumbar disc herniation. The first group will do fascia exercises via a mobile application, the second group will do fascia exercises via a home leaflet, and the third group will…
- Trial name
- Fascia-M (NCT07060235)
- Testing
- fascial exercise home brochure, Fascial exercise based mobile application, lumbal stabilizasyon home brochure
- Where
- Turkey (Türkiye)
- Volunteers
- 1 people
- Sponsor
- Baskent University
Lumbar Degenerative Disease, Lumbar Spondylolisthesis
Perioperative Nutrition Management in Patients Undergoing Open Posterior Lumbar Surgery
Patients undergoing open posterior lumbar fusion surgery often experience postoperative gastrointestinal problems, such as bloating, constipation, and delayed passage of gas and stool, and may be at nutritional risk.
- Conditions
- Lumbar Degenerative Disease, Lumbar Spondylolisthesis, Lumbar Disc Herniation
- Trial name
- NCT07893938
- Testing
- Oral nutritional supplements (ONS), Carbohydrate loading (OCL), 'Probiotics (Bifidobacterium and Lactobacillus triple live capsules)'
- Where
- China
- Volunteers
- 90 people
- Sponsor
- First Affiliated Hospital of Kunming Medical University
Interleukines
Study of Cytokines Serum Levels in Chronic Low Back Pain
The purpose of this study is to: evaluate if there is an association between elevated levels of cytokines and chronic pain due to herniated disk disease measured cytokines levels in chronic low back pain and in healthy subjects.
- Trial name
- cytokine (NCT00991042)
- Testing
- blood collect
- Where
- Brazil
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Lumbar Disc Herniation
Effect of Duration of Symptoms on the Clinical and Functional Outcomes of Lumbar Microdiscectomy
97 patients in 3 randomized groups were treated by Microdiscectomy for lumbar disc herniation; Group A was operated at 6 weeks of symptoms, Group B at 3 months and group C at 6 months.
- Trial name
- NCT04538027
- Testing
- Lumbar Microdiscectomy at 6 weeks of symptoms, Lumbar Microdiscectomy at 3 months of symptoms, Lumbar Microdiscectomy at 6 months of symptoms
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Hawler Medical University
Anesthesia, Pain, Postoperative
Effect of Erector Spinae Plane Block on Postoperative Nausea and Vomiting
This study will investigate the hypothesis that preoperative erector spinae plane (ESP) block will reduce the incidence of postoperative nausea and vomiting (PONV) in patients undergoing elective lumbar disc herniation (LDH)…
- Conditions
- Anesthesia, Pain, Postoperative, Nausea and Vomiting, Postoperative
- Trial name
- NCT06710457
- Testing
- ESP, No ESP
- Where
- Turkey (Türkiye)
- Volunteers
- 81 people
- Sponsor
- Ankara City Hospital Bilkent
Temporomandibular Joint Dysfunction Syndrome
Temporomandibular Dysfunction in Patients With Cervical Disc Herniation
Cervical spine problems are associated with temporomandibular joint (TMJ) and related muscles.The aim of the present study was to investigate temporomandibular joint dysfunction (TMD) and pain in individuals with cervical disc…
- Trial name
- NCT06141863
- Testing
- questionnaire
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Karadeniz Technical University
Herniated Disc
Nucleoplasty for Contained Herniated Lumbar Discs
This is a prospective randomised double blind comparison trial. Fifty patients will be included, 25 in the nucleoplasty treatment group, 25 in the control group. The nucleoplasty group will undergo the nucleoplasty treatment.
- Trial name
- NCT00124774
- Testing
- Nucleoplasty
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- Rijnstate Hospital
Intervertebral Disc Degeneration, Intervertebral Disc Displacement
Protection of Autonomic Nervous System During Lower Spine Surgical Procedures: A Safety and Feasibility Study
A safety and feasibility study of free-run and stimulated corporal electromyography (EMG) to assess autonomic neural function during spinal and/or pelvic surgery in women and men.
- Conditions
- Intervertebral Disc Degeneration, Intervertebral Disc Displacement, Spinal Curvatures, Spinal Stenosis
- Trial name
- NCT02873182
- Testing
- Autonomic nervous system monitoring
- Volunteers
- 20 people
- Sponsor
- Stanley Skinner
Lumbar Disc Herniation, Multimodal Brain Function
Brain Effect Mechanism of Lever Positioning Manipulation on LDH Analgesia Based on Multimodal MRI
In order to further investigate the key brain targets and central response mechanism characteristics of analgesia, the dominant disease of LDH was taken as the object of this study, which was divided into operation group, comfort…
- Conditions
- Lumbar Disc Herniation, Multimodal Brain Function, Analgesia Mechanism, Lever Positioning Manipulation
- Trial name
- NCT05613179
- Testing
- Group1 (lever positioning manipulation)
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- The Third Affiliated hospital of Zhejiang Chinese Medical University
Cervical Disc Prolapse
Functional Outcome After Combined Posterior Laminectomy and Anterior Cervical Discectomy and Fusion for Large Cervical Disc Prolapse
Cervical disc herniation (CDH) is the result of the displacement of the nucleus pulposus of the intervertebral disc, which may result in impingement of the traversing nerves as they exit the neural foramen or directly compressing…
- Trial name
- NCT06847503
- Volunteers
- 25 people
- Sponsor
- Assiut University
Lumbar Spinal Stenosis, Lumbar Disc Herniation
Efficacy and Safety of Ionized Atelocollagen Adhesion Barrier (Collabarrier®) in Spine Surgery
This multicenter, randomized, subject- and evaluator-blinded, active-controlled, non-inferiority clinical trial was conducted to evaluate the efficacy and safety of Collabarrier®, a collagen-based adhesion barrier, compared to…
- Conditions
- Lumbar Spinal Stenosis, Lumbar Disc Herniation, Epidural Fibrosis, Postoperative Adhesion
- Trial name
- NCT07153822
- Testing
- Collagen-based adhesion barrier, Sodium hyaluronate(HA) and Sodium Carboxymethylcellulose(CMC)-based adhesion barrier
- Where
- 6 sites in South Korea
- Volunteers
- 69 people
- Sponsor
- DALIM TISSEN Co., Ltd.