Clinical trials: Disc Herniations
Lumbar Disc Degeneration, Lumbar Disc Herniation
Human Umbilical Cord Mesenchymal Stem Cells For the Treatment of Lumbar Disc Degeneration Disease
This study aims to investigate the safety and efficiency of Human Umbilical Cord Mesenchymal Stem Cells (hUCMSC) for treating lumbar disc degeneration diseases.
- Trial name
- NCT04414592
- Testing
- human umbilical cord mesenchymal stem cells
- Where
- 2 sites in China
- Volunteers
- 20 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Pain, Chronic
Comparison of Unilateral and Bilateral Transforaminal Epidural Steroid Injection
Lumbar radicular pain affects the person's quality of life. The most common cause of lumbar radicular pain is disc herniation. In radicular pain due to lumbar disc herniation, epidural steroid injections are frequently applied to…
- Trial name
- NCT06240793
- Testing
- unilateral transforaminal epidural steroid block, bilateral transforaminal epidural steroid block
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people
- Sponsor
- Ankara University
Cervical Disc Herniation, Cervical Radicular Pain
Does the Presence of Cervical Facet Tropism Affect the Response to Interlaminar Epidural Steroid Injections?
Facet joints are synovial joints located on the dorsolateral side of the vertebral column. Normally, both facet joints are symmetrical.
- Conditions
- Cervical Disc Herniation, Cervical Radicular Pain, Facet Tropism
- Trial name
- NCT05638074
- Testing
- Interlaminar Epidural Steroid Injection
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Janbubi Jandaulyet
Lumbar Disc Herniation, Spinal Disk Injury
Decompression With ELDOA on Lumbar Disc Protrusion Patient
Decompression therapy is a result-oriented approach but it expensive and minimum availability in Pakistan. In physical therapy, we use different exercises to solve multiple spine problems.
- Conditions
- Lumbar Disc Herniation, Spinal Disk Injury, Protrusion
- Trial name
- NCT04760210
- Testing
- Control Group, Decompression Group, ELDOA
- Where
- Pakistan
- Volunteers
- 180 people
- Sponsor
- Aqua Medical Services (Pvt) Ltd
Cervical Radiculopathy, Cervical Disc Herniation
Clinical Outcomes of Magnesium Sulfate in Cervical Interlaminar Epidural Steroid Injection
This single-center observational comparative cohort study evaluates clinical outcomes following two cervical interlaminar epidural steroid injection protocols used in routine care for chronic cervical radicular pain due to…
- Trial name
- NCT07788820
- Testing
- Magnesium Sulfate, Normal Saline
- Where
- Turkey (Türkiye)
- Volunteers
- 123 people
- Sponsor
- Marmara University
Low Back Pain
AlloGen-LI Treatment of Spinal Stenosis
In this pilot study, investigators will test the efficacy of AlloGen-LI, an allograft derived from amniotic fluid, injected into the epidural space at the level of spinal stenosis as an anti-inflammatory treatment to relieve back…
- Trial name
- NCT02932020
- Testing
- AlloGen-LI, depomedrol, MRI
- Where
- United States
- Sponsor
- University of Southern California
Cervical Disc Herniation, Cervical Foraminal Stenosis
Endoscopic Posterior Cervical Foraminotomy Versus Anterior Cervical Discectomy and Fusion for Cervical Radiculopathy
Cervical radiculopathy caused by cervical disc herniation or foraminal stenosis is a common condition that may result in upper limb pain, sensory disturbances, and motor deficits.
- Conditions
- Cervical Disc Herniation, Cervical Foraminal Stenosis, Cervical Radiculopathy
- Trial name
- ENDOFOR (NCT07894159)
- Testing
- Uniportal Endoscopic Posterior Cervical Foraminotomy, Anterior Cervical Discectomy and Fusion
- Where
- France
- Volunteers
- 46 people
- Sponsor
- Central Hospital, Nancy, France
Lumbar Disc Herniation
Microendoscopic Discectomy Vs Transforaminal Endoscopic Lumbar Discectomy Vs Open Discectomy
In our study, a multicenter randomized controlled，single blind trial will be performed to evaluate the effectiveness and safety of these three procedures for the treatment of symptomatic lumbar disc herniation.
- Trial name
- NCT02358291
- Testing
- open discectomy, microendoscopic discectomy, transforaminal endoscopic lumbar discectomy
- Volunteers
- 240 people
- Sponsor
- Southeast University, China
Herniated Disk, Temporomandibular Disorders
Randomized Clinical Trial of Treatment for Temporomandibular Joint (TMJ) Disc Displacement
The effectiveness of physical therapy for treatment of anterior disc displacement without reduction of temporomandibular disorders has not been well defined.
- Trial name
- NCT00936338
- Testing
- splint and joint mobilization self exercise
- Where
- Japan
- Volunteers
- 44 people
- Sponsor
- Tokyo Medical and Dental University
RADICULAR PAIN
Efficacy of Intravenous Dexamethasone for Acute Disc Herniation-Induced Sciatica
Acute low back pain is one of the most common reasons for all physician visits(1). Phospholipase A2 (PLA2), a potent inflammatory mediator, has demonstrated to be released by discs following injury(4).
- Trial name
- NCT00516009
- Testing
- DEXAMETHASONE
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Ziv Hospital
Cervical Disc Herniation
Functional Outcome After Surgery for Cervical Disc Prolapse
Cervical disc herniation (CDH) is the result of the displacement of the nucleus pulposus of the intervertebral disc, which may result in impingement of the traversing nerves as they exit the neural foramen or directly compressing…
- Trial name
- NCT06857643
- Volunteers
- 30 people
- Sponsor
- Assiut University
Lumbar Herniated Disc
Percutaneous HydroDiscectomy Compared to TESI for Radiculopathy
To compare the outcomes of percutaneous lumbar Hydrodiscectomy (HydroD) with the SpineJet Hydrodiscectomy System to transforaminal epidural steroid injections (TESI) in patients with lumbar radiculopathy due to contained disc…
- Trial name
- NCT02414698
- Testing
- Percutaneous Hydrodiscectomy, TESI
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Montefiore Medical Center
Lumbar Disc Herniation, Radiculopathy Lumbar
The Effect of Subcutaneous Fat Tissue Thickness on Lumbar Transforaminal Epidural Steroid Injection Treatment Success
Nerve compression due to lumbar disc herniation and related radicular pain is a very common condition when the lifetime prevalence is considered.
- Conditions
- Lumbar Disc Herniation, Radiculopathy Lumbar, Obesity
- Trial name
- NCT05556538
- Testing
- Transforaminal Epidural Steroid Injection
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Marmara University
Lumbar Disc Herniation
Imaging Characteristics of Chronic Lumbar Disc Herniation From the Perspective of Core Muscles and Subcutaneous Fat Tissue Thickness
Fat infiltration and atrophy of lumbar muscles are related to spinal degenerative conditions, which can be seen reliably on MRI scans of lumbar disc herniation (LDH) patients.
- Trial name
- ICCLDHPCMSFT (NCT05649592)
- Testing
- Magnetic Resonance Hydrolipid Separation Imaging
- Where
- China
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Zhan Yunfan
Low Level Laser Therapy
Combined Effect of Low Level Laser Therapy and Neural Mobilization on Lumber Disc Prolapse
This study attempts to answer the following research question: what is the combined effect of low level laser therapy and neural mobilization on lumber disc prolapse in decreasing pain, improving functional disability, improving…
- Trial name
- LLLT-NM-LDP (NCT07138300)
- Testing
- Low Level Laser Therapy by (Eme Physio, Lasermed 2200), GaAs laser, 1 cm2 beam area,7,000 Hz, 17 mW, 1 J/cm2, Pesaro, Italy), neural mobilization
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Pain, Back
The Effect of Magnesium Deficiency on Transforaminal Epidural Steroid Injection Success: An Observational Study
Transforaminal epidural steroid injection (TFESE) is an interventional method frequently used in the treatment of radicular pain due to disc herniation.
- Trial name
- NCT06551792
- Testing
- Effect of Serum Magnesium Level on the Success of Transforaminal Epidural Steroid Injection
- Where
- Turkey (Türkiye)
- Volunteers
- 118 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Pain Measurement
Pain Monitoring of Herniated Disc Surgery Patients With Oura Ring
The objective of this research study is to show whether data given by Oura ring could be used to objectively measure patients pain and well-being before and after disc surgery.
- Trial name
- NCT05129007
- Testing
- Oura ring
- Where
- Finland
- Volunteers
- 30 people
- Sponsor
- Tampere University Hospital
Intervertebral Disc Displacement, Sciatica
The Effectiveness of Doin (Conduction Exercise) of the Pelvic Joint for HLD With Radiating Leg Pain
A prospective pilot study will be conducted to investigate the effectiveness and safety in herniated lumbar disc (HLD) patients receiving integrative Korean medicine treatment including Doin (conduction exercise) at a Korean…
- Conditions
- Intervertebral Disc Displacement, Sciatica, Sciatic Radiculopathy
- Trial name
- NCT03571503
- Testing
- Doin (conduction exercise), Herbal medicine, Chuna manual therapy
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Jaseng Medical Foundation
Low Back Pain, Sciatica
Non-surgical Spinal Decompression in Patients With Chronic Low Back Pain
The goal of this quasi-experimental trial was to evaluate the effects of non-surgical spinal decompression on disability and pain in patients with chronic low back pain and sciatica throughout a two-month follow-up, and to…
- Conditions
- Low Back Pain, Sciatica, Lumbar Disc Herniation
- Trial name
- NCT06275750
- Testing
- Spinal decompression with BTL-6000 spinal decompression system (BTL Industries Ltd.)
- Where
- Mexico
- Volunteers
- 39 people
- Sponsor
- Hospital Civil de Guadalajara
Lumbar Disc Herniation, Lumbar Spinal Stenosis
Application of 3D Printing Guide Plate in Spinal Minimally Invasive and Interventional Surgeries
Application of 3D printing guide plate in spinal minimally invasive and interventional surgeries
- Conditions
- Lumbar Disc Herniation, Lumbar Spinal Stenosis, Radiculopathy, Lumbosacral Facet Joint Syndrome
- Trial name
- NCT05487690
- Testing
- 3D printing guide plate, Conventional guidance
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Peking University Third Hospital