Clinical trials: Disc Herniations
Radiculopathy of Lumbosacral Spine Due to Disc Disorder
Short-term Effectiveness of Gabapentin Versus Placebo in Acute Lumbosacral Radiculalgia by Herniation Disc (GRADE)
The study consists in evaluating the analgesic efficacy of Gabapentin versus Placebo in the short term (72h) acute lumbosacral radiculalgia due to disc herniation.
- Trial name
- GRADE (NCT04865042)
- Testing
- Gabapentin 300mg
- Where
- 5 sites in France
- Volunteers
- 144 people
- Sponsor
- Lille Catholic University
Lumbar Spine Surgery, Lumbar Disc Herniation
The Effect of Mobilization Protocol Assisted With Simulated Clinical Immersion Videos on Patients Undergoing Lumbar Spine Surgery
This study focused on examining the effect of mobilization protocol assisted with simulated clinical immersion videos on postoperative pain, fear of movement, mobility level and satisfaction in patients undergoing lumbar spine…
- Trial name
- NCT05462210
- Testing
- Mobilization Protocol Assisted with Simulated Clinical Immersion Videos
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Low Back Pain, Neck Pain
The Effect of Integrated CAM Treatment in Hospitalized Patients
This study investigates the effect of hospital-based intensive non-surgical treatment in musculoskeletal patients admitted to an integrated hospital that offers both complementary and alternative medicine (CAM) and conventional…
- Conditions
- Low Back Pain, Neck Pain, Knee Pain, Shoulder Pain
- Trial name
- NCT02257723
- Testing
- Herbal medicine, Acupuncture, Pharmacopuncture
- Where
- South Korea
- Volunteers
- 100,000 people
- Sponsor
- Jaseng Hospital of Korean Medicine
Cervical Disc Prolapse
Dynamic Cervical Implant vs. Anterior Cervical Discectomy and Fusion
Comparison between Dynamic Cervical Implant as a recently introduced technique in our department and the conventional Anterior Cervical Discectomy and Fusion in management of single-level cervical disc prolapse.
- Trial name
- NCT05101967
- Testing
- Dynamic Cervical Implant, Anterior Cervical Discectomt and Fusion
- Volunteers
- 40 people
- Sponsor
- Assiut University
Lumbar Disc Herniation, Low Back Pain
Effectiveness of WBV-Supported Core Training on Lumbar Disc Herniation
"This randomized controlled trial investigated the effects of conventional physiotherapy, core stabilization exercises, and WBV-supported core stabilization exercises on pain intensity, functional disability, quality of life, and…
- Trial name
- WBV-LDH (NCT06957951)
- Testing
- Conventional Physiotherapy, Core Stabilization Exercises, WBV-Supported Core Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Gazi University
Lumbar Disc Prolapse With Radiculopathy
Pragmatic Randomized Controlled Trial of Non-pharmacological Treatment for Lumbar Disc Herniation : A Pilot Study
This is a 2-arm parallel pragmatic randomized controlled trial that will compare non-pharmacological treatment with pharmacological therapy for lumbar disc herniation.
- Trial name
- NCT04833270
- Testing
- KM non-pharmacological treatment group, Pharmacological treatment group
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Jaseng Hospital of Korean Medicine
Low Back Pain, Lumbosacral Radiculopathy
A Prospective Study to Compare Bupivacaine and Exparel Versus Bupivacaine or Exparel Alone for Postoperative Pain Relief
The purpose of this study is to collect information about how patients feel when doctors manage their pain after lumbar spine surgery using a combination of EXPAREL® and bupivacaine injected into the lumbar spine at the end of…
- Conditions
- Low Back Pain, Lumbosacral Radiculopathy, Lumbar Disc Degeneration, Lumbar Disc Herniation
- Trial name
- NCT03514277
- Testing
- Exparel, Bupivacaine
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Virtua Health, Inc.
Low Back Pain
Erector Spina Plan Block in Patients With Lumbar Disc Herniation
Erector Spina Plan Block (ESPB) is a technique used in surgical interventions, acute and chronic pain. The aim of this study was to investigate the effect of ESPB and core stabilization exercises on functionality in patients with…
- Trial name
- NCT06469905
- Testing
- Erector Spina Plan Block, Stabilization exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Firat University
Lumbar Spine Disc Herniation, Spinal Stenosis
Pre-surgery Physiotherapy for Patients With Specific Low Back Pain
The aim is to study if pre-surgery physiotherapy improves function, pain and health in patients with specific low back pain scheduled for surgery. Patients are followed over a two year period.
- Conditions
- Lumbar Spine Disc Herniation, Spinal Stenosis, Spondylolisthesis, Grade 4
- Trial name
- PREPARE (NCT02454400)
- Testing
- Pre-surgery physiotherapy, Waiting-list
- Where
- Sweden
- Volunteers
- 197 people
- Sponsor
- Linkoeping University
Lumbar Disc Herniation
A Trial of Percutaneous Lumbar Discectomy Combined With Ozone for Treatment of LDH
Lumbar disc herniation (LDH) is a common pathological process leading to spinal surgery. Open discectomy used to be a widespread procedure for surgical treatment for symptomatic LDH.
- Trial name
- NCT02372032
- Testing
- percutaneous lumbar discectomy, ozone therapy
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Zhongda Hospital
Lumbar Disc Herniation
Comparison of Ultrasound-Guided Classic And Lateral Approach Thoracolumbar Interfascial Plane Block
US-guided peripheral nerve blocks have been used increasingly due to the advantages of ultrasound in anesthesia practice. TLIP block is one of these nerve blocks performed under US guidance.
- Trial name
- NCT03854240
- Testing
- Classic block (Group C) and modified block (Group M) groups
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Medipol University
Lumbar Disc Herniation, Postoperative Rehabilitation
The Influence of the Timing of Postoperative Rehabilitation Intervention on the Clinical Efficacy of Unilateral Biportal Endoscopic Spine System in the Treatment of Lumbar Disc Herniation
This study focuses on the impact of the timing of postoperative rehabilitation intervention on the clinical efficacy of unilateral biportal endoscopic spine surgery in the treatment of lumbar disc herniation.
- Trial name
- NCT07161232
- Testing
- Standardized Postoperative Rehabilitation Protocol
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Li Xiang
Lumbar Radiculopathy, Lumbar Herniated Disk
Does Intraoperative Application of Steroids Affect Early Outcomes in Patients Undergoing Endoscopic Lumbar Discectomy?
Prospective randomised trial assessing whether intraoperative application of steroids leads to better clinical outcomes in patients submitted to lumbar discectomy
- Trial name
- NCT07411326
- Testing
- Intervention Group, Control group (Normal Saline) (C)
- Where
- Portugal
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Centro Hospitalar De São João, E.P.E.
Lumbar Disc Herniation, Radiculopathy
Rehabilitation Following Lumbar Disc Surgery
The proposed study will be a randomized clinical trial designed to determine the most effective physical therapy program for individuals who have undergone lumbar discectomy surgery.
- Trial name
- NCT00894972
- Testing
- Rehabilitation following lumbar disc surgery (discectomy)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Utah
Disc Herniation
Discogen for Low Back Pain
This study will be a double-blinded, two-arm, prospective, randomized controlled pilot feasibility study in 40 evaluable subjects (20 in each arm) at one study site within the United States.
- Trial name
- NCT06611397
- Testing
- Discogen Low pulsed ultrasound treatment
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Columbia University
Low Back Pain, Disk Herniated Lumbar
Effect of the Cognitive Strategy During Trunk Muscle Endurance in Patients With Lumbar Hernia Surgery
Muscle endurance will be evaluated on two exercises: Biering-Sorensen Test and Prone Plank Test. Each test will be assessed in different days following a randomized order.
- Trial name
- NCT03784144
- Testing
- Biering-Sorensen Test and Prone Plank Test
- Where
- Chile
- Volunteers
- 15 people
- Sponsor
- Hospital San José, Chile
Lumbar Spondylolisthesis, Degenerative Lumbar Scoliosis
A Study on the Clinical Use of a New Expandable OLIF Cage With Posterior Bone Grafting in Lumbar Spine Surgery
This clinical trial aims to evaluate the safety and effectiveness of a novel expandable OLIF (Oblique Lateral Interbody Fusion) cage with posterior bone grafting in patients with lumbar degenerative diseases.
- Conditions
- Lumbar Spondylolisthesis, Degenerative Lumbar Scoliosis, Lumbar Disc Herniation, Lumbar Spinal Stenosis
- Trial name
- NCT07028099
- Testing
- Expandable OLIF cage with posterior bone grafting, Conventional OLIF cage
- Volunteers
- 340 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Low Back Pain, Inflammatory Response
The Effect of Resolvins on the Resolve of Inflammatory Low Back Pain
Brief Summary: Inflammatory back pain is a chronic condition localized in the axial spine and sacroiliac joints.1 It often accompanies mechanical issues like lumbar disc herniation.
- Conditions
- Low Back Pain, Inflammatory Response, Lumbar Disc Herniation
- Trial name
- NCT06356844
- Testing
- Resolvin supplement
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Bezmialem Vakif University
Diskectomy
Randomized Study of Anular Repair With the Xclose Tissue Repair System
The purpose of this study is to evaluate the benefits of anulus fibrosus repair utilizing Xclose™ compared to a discectomy without anulus fibrosus repair.
- Trial name
- NCT00760799
- Testing
- Discectomy with anular repair
- Where
- 34 sites in United States
- Volunteers
- 750 people
- Sponsor
- Anulex Technologies, Inc.
Lumbar Disc Herniation, Preoperative Anxiety
Comparison of Virtual Reality-Based and Routine Preoperative Education on Surgical Anxiety and Salivary Cortisol
This randomized controlled pilot study aims to compare the effects of virtual reality-based preoperative education and routine preoperative education on surgical anxiety in patients undergoing lumbar disc surgery.
- Trial name
- NCT07443111
- Testing
- Virtual Reality-Based Preoperative Education, Routine Preoperative Education
- Volunteers
- 56 people
- Sponsor
- Bezmialem Vakif University