Clinical trials: Disc Herniations
Cervical Disc Prolapse
Effect of Superficial Cervical Plexus Block on the Postoperative Quality of Recovery
Pain and discomfort after anterior cervical spine surgery is difficult to quantify and quoted as moderate in severity, often needing oral opioid analgesics.
- Trial name
- QoR (NCT01662219)
- Testing
- Superficial cervical plexus block for experimental group
- Where
- Canada
- Volunteers
- 46 people
- Sponsor
- University Health Network, Toronto
Sciatica, Low Back Pain
Artificial Intelligence (AI)-Based Prediction of Treatment Response in Sciatica Patients Receiving Transforaminal Epidural Steroid Injection
This prospective observational study aims to develop artificial intelligence (AI)-based predictive models to estimate treatment response in patients with sciatica undergoing transforaminal epidural steroid injection (TFESI).
- Conditions
- Sciatica, Low Back Pain, Lumbar Spinal Stenosis, Radiculopathy
- Trial name
- NCT07080307
- Where
- Turkey (Türkiye)
- Volunteers
- 1,500 people
- Sponsor
- Marmara University
Cervical Disc Herniation, Vibration Therapy
The Effect of Vibration Therapy on Pain, Functionality and Proprioception in İndividuals With Cervical Disc Herniation
This study aimed to examine the effects of vibration applied at different frequencies with a percussion massage gun on joint range of motion, pain, functionality and kinesiophobia in individuals with cervical disc herniation.All…
- Conditions
- Cervical Disc Herniation, Vibration Therapy, Pain, Functionality
- Trial name
- NCT06139263
- Testing
- a percussion massage gun (Compex Fix 2.0), conventional treatment program
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Medipol University
To Evaluate the Effectiveness if Microscope in Discectomy
Short Clinical Outcome of Microscope Assisted Discectomy: Results of 90 Cases in Iraq
A total of (90) patients involved in this study a randomized sampling use. The adult patient between (17) and (50) years of age complaining of lower back pain; and or radiculopathy and neurological symptoms, whom failed to…
- Trial name
- NCT04109781
- Testing
- Microscope assisted discectomy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Hawler Medical University
Scarring, Spinal Stenosis
dHACM in Lumbar Decompression and Microdiscectomy Surgery
Prospective evaluation of the safety and efficacy of dHACM on clinical outcomes in lumbar laminectomy and microdiscectomy patients as assessed by Oswestry Disability Index.
- Conditions
- Scarring, Spinal Stenosis, Herniated Disc
- Trial name
- NCT02300909
- Testing
- Lumbar Decompression Surgery, Microdiscectomy Surgery, Dehydrated Human Amnion/Chorion Membrane (dHACM)
- Where
- United States
- Volunteers
- 143 people
- Sponsor
- MiMedx Group, Inc.
Herniated Disc, Sciatica Due to Intervertebral Disc Disorder
Effects of Neural Mobilization Combined With Manual Therapy on Infrared Thermography, Inflammatory Markers and Clinical Outcomes in Patients With Lumbar Disc Herniation: A Randomized Controlled Clinical Trial
The objective of this randomized controlled clinical trial is to evaluate whether manual therapy combined with neural mobilization can improve pain, functional impairment, quality of life, inflammatory markers, and infrared…
- Trial name
- NCT07752199
- Testing
- Neural Mobilization, Manual Therapy
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Longhua Hospital
Lumbar Disk Herniation
Percutaneous Transforaminal Endoscopic Discectomy vs. Open Microdiscectomy for Lumbar Disc Herniation (PTED-study)
Rationale: Lumbosacral radicular syndrome (LSRS) is caused by a herniated lumbar nucleus pulposus (HNP) and the estimated annual incidence in The Netherlands ranges between 60,000 to 75,000 people.
- Trial name
- NCT02602093
- Testing
- Transforaminal Endoscopic Discectomy, Open Microdiscectomy
- Where
- Netherlands
- Volunteers
- 682 people
- Sponsor
- Amsterdam UMC, location VUmc
Low Back Pain, Radiculopathy Lumbar
Efficacy of Transforaminal Epidural Steroid and Its Combination With Ozone in Lumbar Radiculopathy
This retrospective study aimed to assess the clinical effectiveness and safety of transforaminal epidural injections of steroid and ozone mixture versus steroid alone in low back and radicular leg pain related to disk herniation.
- Conditions
- Low Back Pain, Radiculopathy Lumbar, Hernia, Disk Herniated Lumbar
- Trial name
- NCT06503835
- Testing
- Fluoroscopy Guided Transforaminal Epidural Ozone Injection, Fluoroscopy Guided Transforaminal Epidural Steroid Injection
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Ibn Sina Hospital
Lumbar Disc Herniation, Lumbar Degenerative Disease
Multivariate Analysis and Machine Learning Model Risk Prediction of Recurrent Pain After PLIF Surgery for Degenerative Lumbar Spine Disease At Long-term Follow-up
The study was a clinical retrospective study designed to investigate risk factors for long-term recurrent pain after PLIF in patients with lumbar degenerative disease and to improve patient outcomes
- Conditions
- Lumbar Disc Herniation, Lumbar Degenerative Disease, Sarcopenia
- Trial name
- NCT06622356
- Testing
- MRI with Eovist
- Where
- China
- Volunteers
- 452 people, healthy volunteers welcome
- Sponsor
- Hao Liu
Low Back Pain, Physical Therapy
Evaluation of the Effectiveness of Physical Therapy for Low Back Pain According to Magnetic Resonance Imaging Findings
Low back pain is a common musculoskeletal disorder associated with substantial disability and reduced quality of life. Although magnetic resonance imaging (MRI) is frequently used to identify structural spinal abnormalities, the…
- Conditions
- Low Back Pain, Physical Therapy, Lumbar Degenerative Disc Disease, Lumbar Disc Herniation
- Trial name
- NCT07648927
- Testing
- Standard Physical Therapy Program
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Bahçeşehir University
Low Back Pain, Lumbar Disc Disease
Efficacy of Mechanical Traction and Spinal Decompression Treatments in Patients With Low Back Pain
Motorized traction and non-surgical spinal decompression treatments are relatively new treatments for which there is insufficient evidence in the literature.
- Conditions
- Low Back Pain, Lumbar Disc Disease, Lumbar Disc Herniation, Lumbar Radiculopathy
- Trial name
- NCT05617924
- Testing
- Physical Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 160 people
- Sponsor
- Afyonkarahisar Health Sciences University
Degenerative Disc Disease
PEEK and Allograft Spacers Evaluation in Spinal Fusion Surgeries
Purpose The primary purpose of this study is to prospectively compare clinical and radiographic clinical outcomes in patients undergoing cervical or lumbar interbody fusions and randomized to receive either polyetheretherketone…
- Trial name
- PEEK (NCT01406405)
- Testing
- Posterior/Transforaminal Lumbar Interbody Fusion (P/TLIF), Anterior Cervical Discectomy and Fusion (ACDF)
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Justin Parker Neurological Institute
Cervical Lordosis Rehabilitation
Does Improvement Towards a Normal Cervical Sagittal Configuration Aid in the Management of Lumbosacral Radiculopathy
A randomized controlled study with six months follow-up will be conducted to investigate the effects of sagittal head posture correction on 3D spinal posture parameters, back and leg pain, disability, and S1 nerve root function…
- Trial name
- NCT05553002
- Testing
- Deneroll cervical extension traction, Traditional treatment
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Cairo University
Pain, Myofacial, Pain, Neck
Does Dry Needling Affect Treatment Outcomes of Interlaminar Epidural Steroid Injection in Cervical Disc Herniation?
Chronic neck pain is among the most frequently seen chronic painful conditions. As an important cause of disability, chronic neck pain is a musculoskeletal disorder that negatively affects quality of life.
- Conditions
- Pain, Myofacial, Pain, Neck, Pain, Chronic
- Trial name
- NCT04914637
- Testing
- Cervical interlaminar epidural steroid injection, Dry needling
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Marmara University
Analgesia
Regional Blocks for Lumbar Disc Surgery Analgesia
Objective The goal of this prospective randomized controlled experiment was comparing the analgesic efficacy, opioid needs, and adverse effect profiles of Paravertebral Block (PVB), Thoracolumbar Interfascial Plane Block (TLIP)…
- Trial name
- NCT06933641
- Testing
- Regional Analgesia
- Where
- Turkey (Türkiye)
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Erzincan University
Postoperative Recovery, Lumbar Disc Herniation
Lower Back Muscle Size and Recovery After Lumbar Disc Herniation Surgery
Recovery after surgery for a herniated disc in the lower back differs from person to person. The size of the muscles around the lower spine may be related to recovery, but this relationship is not well understood.
- Trial name
- NCT07768241
- Testing
- Preoperative Psoas and Multifidus Muscle Measurements
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Lumbar Disc Herniation
Percutaneous Discectomy to Treat Symptomatic Lumbar Disc Herniation : Evaluation of Clinical Efficiency, Patient Reported Outcomes and Economical Impact by Assessing Time Before Return to Work and Duration of Hospitalization Stay
This study aims to evaluate the clinical (pain) and functional (patient reported outcomes) efficacy of percutaneous discectomies under CT guidance to treat lumbar disc herniations resistant to conservative treatment and nerve…
- Trial name
- NCT05772143
- Testing
- Percutaneous discectomies under CT
- Where
- France
- Volunteers
- 87 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Lumbar Disc Herniation
A Prospective, Randomized, Multicenter Study to Demonstrate the Superiority of the Barricaid to Discectomy for Primary Lumbar Disc Herniation
A randomized study to demonstrate the superiority of the Barricaid® when used in conjunction with limited discectomy, compared to limited discectomy alone, with regard to preventing reherniation and the recurrence of pain or…
- Trial name
- NCT01283438
- Testing
- Barricaid, Standard of Care
- Where
- 21 sites in Austria, Belgium and 4 more
- Volunteers
- 554 people
- Sponsor
- Intrinsic Therapeutics
Cervical Disc Herniation, Chronic Pain
Action Observation and Motor Imagery Training in Cervical Disc Herniation
Cervical disc herniation is a common degenerative spinal disorder associated with chronic neck pain, impaired cervical function, reduced motor control, and decreased quality of life.
- Conditions
- Cervical Disc Herniation, Chronic Pain, Kinesiophobia, Cervical Pain
- Trial name
- NCT07781982
- Testing
- Conventional Physiotherapy, Action Observation and Motor Imagery Training
- Volunteers
- 36 people
- Sponsor
- İrem Çetinkaya
Spinal Stenosis Lumbar, Disc Herniation, Lumbar
More Realistic Spine Patients: Assessing the Effect of Dialogue Support Tool.
This multicenter randomized controlled trial will evaluate whether an additional preoperative study visit using the Dialogue Support (DS) tool improves patient information, expectations, and outcomes among adults scheduled for…
- Conditions
- Spinal Stenosis Lumbar, Disc Herniation, Lumbar, Degenrative Disc Disease
- Trial name
- MORESP (NCT07788872)
- Testing
- Dialogue Support Study Visit
- Where
- 2 sites in Norway
- Volunteers
- 440 people
- Sponsor
- University Hospital, Akershus