Clinical trials: Disc Herniations
Spinal Stenosis Lumbar, Lumbar Disc Herniation
Cortical Bone Trajectory Screws vs. Traditional Pedicle Screws Fixation
Transforaminal lumbar interbody fusion (TLIF) had been favorable for effectively decrease pain and disability in specific spinal disorders; however, there has been concern regarding pedicle screw placement during TLIF surgery.
- Conditions
- Spinal Stenosis Lumbar, Lumbar Disc Herniation, Intervertebral Disc Degeneration
- Trial name
- NCT03105167
- Testing
- cortical bone trajectory screws, pedicle screws
- Where
- China
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Lumbar Disc Herniation
Comparison Between Insertion of Bilateral Straight Cages Versus Unilateral Banana Cage in Lumbar Fusion Surgery
To compare the clinical outcomes of bilateral straight cages and unilateral banana cage insertion in lumbar interbody fusion surgery, assess radiological outcomes, including intervertebral disc height, lumbar lordosis angle, and…
- Trial name
- NCT07312747
- Testing
- cages in lumbar fusion surgery
- Volunteers
- 30 people
- Sponsor
- Assiut University
Refractory Lumbar Disc Prolapse
Caudal Epidural Steroid Injection Ultrasound Guided in LDP
Patients with LDP with unilateral radiculopathy diagnosed by routine clinical examination and MRI, in whom conservative treatment (medical treatment and physiotherapy) failed for more than 6 weeks and refuse surgery or were unfit…
- Trial name
- NCT03933150
- Testing
- ultrasound guided caudal epidural injection
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Mansoura University
Lumbar Disc Herniation
Paraspinal Muscle Remodeling
Lumbar disc herniation is the most common diagnosed degenerative pathology in the lumbar spine with a prevalence of 2 to 3% in the adult population.
- Trial name
- NCT03753711
- Testing
- Multifidus muscle biopsy during minimally invasive back surgery
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Hasselt University
Sciatica Due to Intervertebral Disc Disorder, Intervertebral Disc Displacement
Observational Study on Effectiveness and Safety of Integrative Korean Medicine Treatment for Inpatients With Sciatica Due to Lumbar Intervertebral Disc Herniation
Observational study on the effectiveness and safety of integrative Korean medicine treatment for inpatients with sciatica due to lumbar intervertebral disc herniation
- Conditions
- Sciatica Due to Intervertebral Disc Disorder, Intervertebral Disc Displacement, Sciatica, Sciatic Radiculopathy
- Trial name
- NCT03750591
- Testing
- Herbal medicine, Chuna manual therapy, Bee venom pharmacopuncture
- Where
- 4 sites in South Korea
- Volunteers
- 1,000 people
- Sponsor
- Jaseng Medical Foundation
Lumbar Disc Herniation, Chronic Low Back Pain
High-Intensity Laser Therapy Versus Transforaminal Epidural Steroid Injection in Chronic Lumbar Disc Herniation-Related Low Back and Radicular Pain
This prospective, randomized, single-blinded, controlled clinical trial aims to compare the effectiveness of high-intensity laser therapy and fluoroscopy-guided transforaminal epidural steroid injection in patients with chronic…
- Conditions
- Lumbar Disc Herniation, Chronic Low Back Pain, Radicular Pain, Lumbar Radiculopathy
- Trial name
- NCT07688915
- Testing
- High-Intensity Laser Therapy, Transforaminal Epidural Steroid Injections
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Ankara City Hospital Bilkent
Lumbar Spine Stenosis, Lumbar Disc Herniation
Dynamic Compliance-Guided Ventilation in Lumbar Surgery
Postoperative pulmonary complications are a frequent cause of morbidity following lumbar stabilization surgery. Conventional ventilation strategies may not adequately reflect intraoperative changes in respiratory mechanics…
- Conditions
- Lumbar Spine Stenosis, Lumbar Disc Herniation, Ventilator-Induced Lung Injury, Postoperative Complications
- Trial name
- NCT07349719
- Testing
- Dynamic Compliance Guided Ventilation, Standard Ventilation
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Ankara City Hospital Bilkent
Herniation of Lumbar Vertebral Disc
The Effect of Pressure Controlled Ventilation on the Pulmonary Mechanics in Prone Position Using the Wilson Frame: A Comparison With Volume Controlled Ventilation
Prone position in spinal surgery can increase airway pressure and decrease dynamic lung compliance by a frame used for postural stabilization.
- Trial name
- NCT01272700
- Testing
- volume control, pressure control
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Yonsei University
Lumbar Radiculopathy
Safety and Efficacy of SX600 Administered by Lumbosacral Transforaminal Epidural Injection for Radicular Pain
This is a Phase I/II, double-blind, parallel-group, randomized, placebo-controlled multi-centre trial in 180 patients randomized 1:1:1 to receive the IMP (Dexamethasone acetate microspheres for extended-release injectable…
- Trial name
- SALIENT (NCT03952377)
- Testing
- SX600
- Where
- 10 sites in Australia
- Volunteers
- 56 people
- Sponsor
- SpineThera Australia PTY LTD
Lumbar Herniated Disc
US-MR Image Fusion-guided Percutaneous Transforaminal Endoscopic Discectomy for the Treatment of Lumbar Disc Herniation
The purpose of this study is to evaluate the feasibility and efficacy of US-MR image fusion-guided percutaneous transforaminal endoscopic discectomy for the treatment of lumbar disc herniation
- Trial name
- NCT03403244
- Testing
- US-MR image fusion-guided PTED, fluoroscopy-guided PTED
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Lumbar Vertebra Hernia
Clinical Trial to Assess Safety of SI-6603 in Patients With Lumbar Disc Herniation
The purpose of this study is to evaluate the safety of SI-6603 in lumbar disc herniation patients.
- Trial name
- NCT01282606
- Testing
- SI-6603
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Seikagaku Corporation
Lumbar Disc Herniation, Sacroiliac Joint Dysfunction
The Prevalence Of Sacroiliac Joint Dysfunction In Patients With Lumbar Disc Hernia
In this study evaluated the prevalence of sacroiliac joint dysfunction in patients with lumbar disc hernia and examined the variations in clinical parameters cause by this combination.
- Trial name
- NCT03965507
- Testing
- Evaluation of the prevalence of sacroiliac joint dysfunction in lumbar disc herniation
- Volunteers
- 234 people
- Sponsor
- European University of Lefke
Lumbar Disc Herniation
Barricaid EU Post Market Study for Primary Lumbar Disc Herniation
The purpose of this multi-center post marketing surveillance study is to monitor the safety and performance of the Barricaid® ARD when used to surgically reconstruct the anulus of the L1 - S1 spinal disc.
- Trial name
- NCT01534065
- Testing
- Barricaid
- Volunteers
- 45 people
- Sponsor
- Intrinsic Therapeutics
Intervertebral Disc Displacement
Physiotherapy Following Disc Surgery: Long Term Follow-up of a RCT
Hitherto no comprehensive long-term follow-up data of 10 years and more have been obtained from survivors of disc surgery that would have considered the type of postoperative care.
- Trial name
- NCT01922063
- Testing
- Physiotherapy Intervention
- Where
- Austria
- Volunteers
- 120 people
- Sponsor
- Medical University of Vienna
Investigation the Role of BDNF and S100B Serum Level as a Predictive of Outcome of Pulsed Radiofrequency in Treatment Lumbar Disc Prolapse Patients
The Potential Role of SI00B and Brain Derived Neurotrophic Factor in Predicting Outcome From Using Pulsed Radiofrequency in Treatment of Patients With Lumbar Disc Prolapsed
Chronic lumbar radicular (CLR) pain is a term used to describe neuropathic pain symptoms in the distribution of a particular lumbar nerve root due to disc protrusion, spinal stenosis, facet hypertrophy, or fibrosis after previous…
- Trial name
- NCT05193461
- Testing
- Pulsed mood radiofrequency on dorsal root ganglion
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Beni-Suef University
Lumbar Disc Herniation
Impact of Transforaminal Epidural Steroid Injection in Lumbar Disc Prolpse on Micro RNA-155 Serum Level
Chronic pain could be considered a brain disease as it can affect multiple aspects of brain function, chemistry, neural networks and structure. Pain is associated with impaired cognitive function (1).
- Trial name
- NCT05626283
- Testing
- transforaminal epidural injection., micro RNA-155 serum level
- Where
- Egypt
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
Lumbar Spinal Stenosis, Lumbar Disc Herniation
Research on Key Technology Development and Clinical Application of Small Interactive Spinal Endoscopic Surgery Robot
The aim of the study was to investigate the correlation between the extent of decompression and patient follow-up metrics at 1 year postoperatively by analysing data from a real-world, multicentre cohort of patients, and to…
- Trial name
- NCT06480214
- Testing
- endoscopic spine surgery
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Beijing Jishuitan Hospital
Lumbar Spinal Stenisis or Lumbar Herniated Intervertebral Disc
The Analgesic Effect of Nefopam on the Fentanyl Based PCA (Patient-controlled Analgesia) After Lumbar Spinal Surgery
Posterior lumbar spinal surgical pain leads to a severe degree of pain, and, hence, various means of pain management are required.
- Trial name
- NCT01808014
- Testing
- nefopam
- Where
- South Korea
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Osteoporosis, Lumbar Disc Herniation
Baduanjin With Resistance Training Program
The purpose of this study is to improve symptoms of Lumbar Disc Herniation (LDH) and Osteoporosis (OP) by implementing an evidence-based Baduanjin exercise to reduce pain and increase muscle strength and quality of life in…
- Trial name
- NCT06853132
- Testing
- Baduanjin with Resistance Training Program
- Where
- China
- Volunteers
- 136 people
- Sponsor
- Yale University
Lumbar Intervertebral Disc Herniation
A Randomized Trial of Annular Repair With Discectomy Versus Discectomy Alone for Lumbar Disc Herniation
The goal of this study is to explore the indications and application scope of spinal endoscopy combined with annulus fibrosus repair technology, with a focus on verifying the effectiveness of annulus fibrosus suture technology…
- Trial name
- NCT07250581
- Testing
- Repair of the annulus fibrosus
- Where
- China
- Volunteers
- 300 people
- Sponsor
- The Affiliated Hospital of Qingdao University