Clinical trials: Discomfort
Pain Due to Certain Specified Procedures
Novel Cervical Retraction Device
This study will test a suction-based method of engaging the cervix. Bioceptive has developed a device that more gently and atraumatically attaches to the cervix with no bleeding.
- Trial name
- NCT02283463
- Testing
- Intrauterine device (IUD) insertion, Endometrial biopsy
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Bioceptive
Menstrual Discomfort
Efficacy of CL22205 to Improve Menstrual Discomfort and Quality of Life
The purpose of this study is to evaluate the efficacy of CL22205 to improve menstrual discomfort and quality of life in oligomenorrheic female subjects.
- Trial name
- NCT06760988
- Testing
- CL22205
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Eetho Brands, Inc
Abdominal Pain
Study to Evaluate Bioactive Peptides' Effect on Digestive Discomfort Symptoms of the Elderly
This trial will investigate the potential of a bioactive peptide to reduce symptoms of digestive discomfort in a generally healthy elderly population.
- Trial name
- Inflammaging (NCT04450979)
- Testing
- Bioactive hydrolysate
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Nuritas Ltd
Dysmenorrhea
The Impact of Oral Probiotics on Improving the Quality of Life in Patients With Dysmenorrhea.
Menstrual pain is mainly divided into primary dysmenorrhea and secondary dysmenorrhea, the former is caused by menstrual uterine muscle movement; the latter is caused by certain diseases, such as Endometriosis, Uterine fibroids…
- Trial name
- NCT07530081
- Testing
- High dose Probiotic, Low dose probiotic
- Where
- Taiwan
- Volunteers
- 150 people
- Sponsor
- Glac Biotech Co., Ltd
Dry Eye Syndrome
Sodium Hyaluronate Ophthalmic Solution, 0.18% for Treatment of Dry Eye Syndrome
The purpose of this study was to determine if Sodium Hyaluronate, 0.18% is effective in treating the signs and symptoms of dry eye disease.
- Trial name
- NCT01382225
- Testing
- Sodium Hyaluronate Ophthalmic Solution, 0.18%, Vehicle
- Volunteers
- 1,936 people
- Sponsor
- Alcon Research
Gut Health
A Study to Assess the Effect of the Natural Orange Extract in Individuals With Gastrointestinal Discomfort
A Randomized, Double-Blind, Two-Arm, Placebo-Controlled Clinical Study to assess the Effect of the Natural Orange Extract in Individuals with Gastrointestinal Discomfort
- Trial name
- NCT06658717
- Testing
- Investigational product (IP): Natural orange extract
- Where
- 3 sites in India
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Vedic Lifesciences Pvt. Ltd.
Plaque, Dental
Efficacy of a Eugenol-based Product to Improve the Quality of Toothbrushing and Relieving Gum Discomfort Areas
The objective of this study is to evaluate the efficacy of a eugenol-based product in improving the quality of toothbrushing and relieving areas of gingival discomfort.
- Trial name
- NCT06366568
- Testing
- fluoride toothpaste containing 1450 ppm of MFP in a PCC base and eugenol gum product, fluoride toothpaste containing 1450 ppm of MFP in a PCC base
- Where
- Germany
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Quality of Life (QOL), CIPN - Chemotherapy-Induced Peripheral Neuropathy
Study for the Evaluation of the Degree of Skin Satisfaction of a Cosmetic Cream for Sensitive Skin in Oncological Patients Affected by a Palmoplantar Polyneuropathy Secondary to Chemotherapy.
It is proposed a controlled research study aimed to evaluating and comparing the degree of skin satisfaction and comfort with cosmetic creams PB-011 and PB-012 in cancer patients who can develop a palmar and plantar peripheral…
- Trial name
- NCT06733545
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- PROSPERA BIOTECH S.L.
Blepharitis
Safety and Efficacy of KPI-121 in Subjects With Inflammatory Meibomian Gland Disease
The primary purpose of this study is to determine the efficacy and safety of KPI-121 ophthalmic suspension compared to vehicle (placebo) in subjects with signs and symptoms of inflammatory meibomian gland disease.
- Trial name
- Maui (NCT02218489)
- Testing
- KPI-121, Vehicle
- Where
- 8 sites in United States
- Volunteers
- 206 people
- Sponsor
- Kala Pharmaceuticals, Inc.
Respiratory Conditions Due to Unspecified External Agent
Anti-pollution Effects of AP Green Tea Extracts
The objective of this clinical trial is to evaluate the anti-pollution effects of AP green tea extracts in subjects with discomforts related to the respiratory system by prolonged exposure to particulate matter in air pollution
- Trial name
- NCT04340375
- Testing
- AP green tea extracts
- Where
- South Korea
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Amorepacific Corporation
Knee Discomfort, Joint Pain
Turmeric Efficacy for Mobility and Joint Function
The objective of the study is to test the capacity of a 12-weeks Turmipure GOLD® supplementation to reduce joint discomfort.
- Trial name
- T-MOTION (NCT04506411)
- Testing
- Turmipure GOLD®, Turmeric rhizome PE 95% curcuminoids
- Where
- 8 sites in Croatia, Slovenia
- Volunteers
- 177 people, healthy volunteers welcome
- Sponsor
- Givaudan France Naturals
Low Intensity Knee Gonalgia
Effect of Yogurts Supplemented With Mobilee on Joint Function in Healthy Individuals With Joint Discomfort
The purpose of this study is to determine whether the daily eating of a yogurt supplemented with Mobile is effective in improving joint function and quality of life of individuals with low intensity gonalgia.
- Trial name
- NCT01303432
- Testing
- Yogurt supplemented with Mobilee, Yogurt
- Where
- Spain
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Bioiberica
Blepharitis, Blepharoconjunctivitis
Performance and Safety of IRIDIUM GARZE in Blepharitis or Blepharconjunctivitis Adjuvant Treatment
The study will evaluate the clinical improvement in ocular symptoms using IRIDIUM GARZE as adjuvant treatment in patients suffering of blepharitis or blepharoconjunctivitis as primary objective.
- Trial name
- NCT07431385
- Testing
- IRIDIUM GARZE
- Where
- 5 sites in Italy
- Volunteers
- 80 people
- Sponsor
- Fidia Farmaceutici s.p.a.
Dry Eye Syndromes
Investigation of Preservative-Free Ophthalmic Solution in Ocular Dryness
This is a multicenter, prospective, observational, open-label, non-interventional study evaluating the clinical performance and the safety of 4 daily instillations of the ophthalmic solution in the treatment of eye discomfort, in…
- Trial name
- NCT05778942
- Testing
- Eyestil SYNFO
- Where
- 4 sites in Spain
- Volunteers
- 35 people
- Sponsor
- SIFI SpA
Knee Discomfort, Pain Physical Activity
Polyherbal Capsule Formulation for Joint Health
This is a multicenter, randomized, double-blind, placebo-controlled, study in subjects with exercise-related knee pain/discomfort to determine the efficacy of a polyherbal capsule compared to placebo capsule in improving exercise…
- Trial name
- NCT02157701
- Testing
- Polyherbal capsule
- Where
- 5 sites in United States
- Volunteers
- 108 people
- Sponsor
- NewChapter, Inc.
Dry Eye Syndromes, Keratoconjunctivitis Sicca
Safety and Efficacy of KPI-121 Compared to Placebo in Subjects With Dry Eye Disease
The primary purpose of this study is to determine the efficacy and safety of KPI-121 0.25% ophthalmic suspension compared to vehicle (placebo) in subjects who have a documented clinical diagnosis of dry eye disease.
- Trial name
- STRIDE 2 (NCT02819284)
- Testing
- KPI-121 0.25% Ophthalmic Suspension, Vehicle of KPI-121 0.25% Ophthalmic Suspension
- Where
- 62 sites in United States
- Volunteers
- 909 people
- Sponsor
- Kala Pharmaceuticals, Inc.
Dry Eye, Graft-versus-host-disease
Topical Fibrinogen-Depleted Human Platelet Lysate in Patients With Dry Eye Secondary to Graft vs. Host Disease
The purpose of this Phase 1/2 study is to compare the safety and tolerability of four times a day (QID) dosing of a non-preserved topical ocular drop formulation of 10 vol/vol % and 30 vol/vol % of FD hPL to vehicle control eye…
- Conditions
- Dry Eye, Graft-versus-host-disease, Ocular Discomfort
- Trial name
- NCT03414645
- Testing
- CAM-101 10%, Vehicle Control, CAM-101 30%
- Where
- 6 sites in United States
- Volunteers
- 64 people
- Sponsor
- Cambium Bio Limited
Dry Eye, Dry Eye Syndromes
Tangible Hydra-PEG: A Promising Solution for Scleral Lens Wearers With Dry Eye
Tangible Hydra-PEG is a novel coating technology designed to improve lens wettability, deposit resistance, and tear film breakup time.
- Trial name
- NCT03417505
- Testing
- Scleral lenses treated with Tangible Hydra-PEG, Untreated scleral lenses
- Where
- 3 sites in United States
- Volunteers
- 21 people
- Sponsor
- Tangible Science
Hypersensitive, Reactive and Intolerant Skin
IN-USE TOLERANCE STUDY UNDER DERMATOLOGICAL AND OPHTHALMOLOGICAL CONTROLS AND EFFICACY ASSESSMENT (Face Balm)
The aim of this study is to assess the dermatological and ophthalmological tolerance of the investigational product Baume visage / Face balm RV4942A - RY1985 after 21 days of twice daily use on the study areas, under normal…
- Conditions
- Hypersensitive, Reactive and Intolerant Skin, Redness-prone Skin, Stinger Subjects
- Trial name
- NCT05171556
- Testing
- Cosmetic product
- Where
- China
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Pierre Fabre Dermo Cosmetique
Joint Pain
Clinical Study to Evaluate the Effect of Different Doses of UC-II® Supplementation on the Range of Motion & Joint Discomfort in Healthy Subjects
A Randomized, Double-Blind, Placebo-controlled, Parallel Design Clinical Study to Evaluate the Effect of Different Doses of UC-II® Supplementation on the Range of Motion \& Joint Discomfort in Healthy Subjects
- Trial name
- NCT05212259
- Testing
- Collagen type II (40 mg/day), Collagen type II (80mg/day), Collagen type II (120 mg/day)
- Where
- 10 sites in India
- Volunteers
- 375 people, healthy volunteers welcome
- Sponsor
- Vedic Lifesciences Pvt. Ltd.