Clinical trials: Disease, Acute
Spinal Cord Injuries
Spinal Cord Stimulation for Autonomic Recovery in Inpatient Rehabilitation After Acute SCI
This study is a randomized, single-blind, two-arm sham-controlled clinical trial to evaluate the safety and efficacy of transcutaneous spinal cord stimulation (tSCS) over the lower thoracic and upper lumbar spinal cord segments…
- Trial name
- NCT06540859
- Testing
- Transcutaneous Spinal Cord Stimulation
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of Washington
Ascending Aorta Abnormality, Ascending Aortic Dissection
Strategy for Aortic Surgery Hemostasis
SASH Trial is a multicenter, prospective, open and randomized 1:1 study. The aim of this study is to evaluate the efficacy of TDM-621(Three-D Matrix- 621) (PuraStat®) on hemostasis of ascending aortic surgery.
- Conditions
- Ascending Aorta Abnormality, Ascending Aortic Dissection, Ascending Aorta Aneurysm
- Trial name
- SASH (NCT03917862)
- Testing
- TDM-621
- Where
- Brazil
- Volunteers
- 200 people
- Sponsor
- University of Sao Paulo General Hospital
Stroke, Acute Ischemic, Strokes Thrombotic
Cerebroprotective Effect of Melatonin in Stroke
Stroke is a leading cause of mortality and disability in Mexico and worldwide. Although current treatment strategies focus on removing oclussion, they do not interrupt the signaling cascade of neuronal damage.
- Trial name
- NCT05857046
- Testing
- Melatonin 10 MG
- Where
- Mexico
- Volunteers
- 100 people
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Acute Respiratory Distress Syndrome
Open Lung Ventilation in ARDS: The PHARLAP Trial
Some people develop the condition called acute respiratory distress syndrome (ARDS). This is a condition where the lungs have become injured from one of a number of various causes, and do not work as they normally do to provide…
- Trial name
- PHARLAP (NCT01667146)
- Testing
- PHARLAP mechanical ventilation strategy, Control group mechanical ventilation strategy
- Where
- 27 sites in Australia, Ireland and 3 more
- Volunteers
- 115 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
HIV Infections
Immune Response to a Therapeutic HIV Vaccine Followed by Treatment Interruption in Patients With Acute or Recent HIV Infection
The purpose of this study is to determine whether the HIV vaccine MRKAd5 HIV-1 gag/pol/nef followed by treatment interruption can increase immune system function in adults with acute or recent HIV infection who have started…
- Trial name
- NCT00183261
- Testing
- MRKAd5 HIV-1 gag/pol/nef
- Where
- 23 sites in United States, American Samoa and 1 more
- Volunteers
- 25 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Acute Myocardial Infarction, Acute Coronary Syndrome
MERITnI - Mindray-hs-cTnI Assay: Analytical and Clinical Evaluation for the Diagnosis and RIsk AssessmenT of Myocardial InfarctIon.
The Mindray High Sensitivity Troponin-I Measurement System is an in vitro diagnostic test for the quantitative determination of high sensitivity cardiac troponin I (hs-cTnI) in human serum or plasma.
- Trial name
- MERITnI (NCT05853042)
- Testing
- high-sensitivity cardiac troponin testing
- Where
- United States
- Volunteers
- 1,559 people
- Sponsor
- Fred Apple
Acute Pain, Respiration
Clonidine-Remifentanil. Effect of the Combination on Acute Pain and Respiration in Healthy Volunteers
The hypothesis is that systemic remifentanil and Clonidine act in a synergistic manner to relief acute main in an experimental human pain model.
- Conditions
- Acute Pain, Respiration, Sedation
- Trial name
- Remiclon (NCT00730054)
- Testing
- Remifentanil+clonidine
- Where
- Norway
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Acute Kidney Injury
Acute Post-cardiac Surgery Renal Failure: Prevention Through Individualized Intensive Hemodynamic Management
BACKGROUND: The incidence of acute kidney injury (AKI) in patients undergoing cardiac surgery can reach 35% and between 2 and 5% require kidney replacement therapy during the AKI episode.
- Trial name
- PrevHemAKI (NCT04005105)
- Testing
- Intensive management
- Where
- Spain
- Volunteers
- 98 people
- Sponsor
- Hospital Clinic of Barcelona
Brain Injuries, Traumatic
Wellness and Quality of Life Perceptions of People With Traumatic Brain Injury
Telerehabilitation is a service delivery method that has grown substantially in recent years. It has both advantages and disadvantages in comparison to clinic-based services.
- Trial name
- NCT04794894
- Testing
- outpatient rehabilitation
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Quality Living, Inc.
Acute Kidney Injury, Cancer Colorectal
Propofol and Sevoflurane Anesthesia in Colorectal Cancer Surgery: Incidence of Acute Kidney Injury
The goal of this observational study is to compare anesthetic modalities (intravenous propofol anesthesia with sevoflurane gas anesthesia) in patients who underwent colorectal cancer resection surgery regarding the outcome of…
- Trial name
- PROSACC (NCT05585866)
- Testing
- Anesthesia Agent
- Where
- Sweden
- Volunteers
- 4,000 people
- Sponsor
- Uppsala University
AML, Multiple Myeloma
Phase 1 Study of 6MW5311 in Adults With Relapsed or Refractory Blood Cancers
To assess safety and tolerability at increasing dose levels of 6MW5311 in successive cohorts of participants with MM, AML and CMML in order to estimate the maximum tolerated dose (MTD) and select the recommended Phase 2 dose…
- Conditions
- AML, Multiple Myeloma, CMML
- Trial name
- NCT07914556
- Testing
- 6MW5311
- Where
- China
- Volunteers
- 122 people
- Sponsor
- Mabwell (Shanghai) Bioscience Co., Ltd.
Adult Acute Basophilic Leukemia, Adult Acute Eosinophilic Leukemia
Idarubicin, Cytarabine, and Tipifarnib in Treating Patients With Newly Diagnosed Myelodysplastic Syndromes or Acute Myeloid Leukemia
This phase I/II trial is studying the side effects and best dose of tipifarnib when given with idarubicin and cytarabine and to see how well it works in treating patients with newly diagnosed myelodysplastic syndromes or acute…
- Conditions
- Adult Acute Basophilic Leukemia, Adult Acute Eosinophilic Leukemia, Adult Acute Megakaryoblastic Leukemia (M7), Adult Acute Minimally Differentiated Myeloid Leukemia (M0)
- Trial name
- NCT00096122
- Testing
- cytarabine, idarubicin, tipifarnib
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- National Cancer Institute (NCI)
Acute Respiratory Infections
Echinacea and Acute Respiratory Illness
The primary objective of this study is to evaluate the effectiveness of ingesting an alkylamide-rich echinacea root product (Quick Defense, Gaia Herbs) for 2 days immediately following each onset of acute respiratory illness…
- Trial name
- NCT02003651
- Testing
- Quick Defense
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Appalachian State University
B-Cell Acute Lymphoblastic Leukemia, Adult
Sequential CD19 and CD22 CAR-T Therapy for Newly Diagnosed Ph+ B-ALL
Clinical Trial for the Efficacy and Safety of Sequential CD19 and CD22 CAR-T Therapy for Adult Patients With Newly Diagnosed Ph Chromosome Positive B-cell Acute Lymphoblastic Leukemia
- Trial name
- NCT04788472
- Testing
- CAR-T cells targeting CD19 and CD22
- Where
- China
- Volunteers
- 28 people
- Sponsor
- Zhejiang University
Allogeneic Hematopoietic Stem Cell Transplantation Recipient, Acute Myeloid Leukemia (AML)
VABu Conditioning in Elderly AML HSCT
This is an open-label, multi-center, single-arm clinical study evaluating the efficacy and safety of the VABu conditioning regimen in elderly patients (≥60 years) with acute myeloid leukemia (AML) undergoing allogeneic…
- Trial name
- NCT07583888
- Testing
- VaBU
- Where
- China
- Volunteers
- 20 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Acute Ischemic Stroke
Susceptibility Weighted Imaging for Detection of Thrombus in Acute Ischemic Stroke.
It is a retrospective cross-sectional study, where consecutive stroke patients with vessel occlusion on magnetic resonance angiography (MRA) will be included for the study for one year.
- Trial name
- NCT05738070
- Testing
- Magnetic resonance imaging
- Where
- Nepal
- Volunteers
- 105 people
- Sponsor
- Upendra Devokta Memorial National Institute of Neurology and Allied Scicences
Stroke, Dehydration
BUN/Cr-based Hydration Therapy to Improve Outcomes for Dehydrated Patients With Acute Ischemic Stroke.
The investigators' preliminary findings suggest that providing patients with acute ischemic stroke hydration therapy on the basis of their presenting BUN/Cr ratio may help reduce the occurrence of stroke-in-evolution(SIE) and…
- Trial name
- HYDO (NCT02099383)
- Testing
- normal saline
- Where
- Taiwan
- Volunteers
- 244 people
- Sponsor
- Chang Gung Memorial Hospital
Stroke, Acute Ischemic
Early Endovascular Treatment in Isolated Internal Carotid Artery Occlusion
The primary hypothesis being tested in this trial is that acute ischemic stroke with isolated internal carotid artery occlusion will have improved clinical outcomes when given early endovascular treatment compared with that of…
- Trial name
- EVT-iICAO (NCT07016854)
- Testing
- Endovascular treatment, The best medical treatment
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Sir Run Run Shaw Hospital
Leukemia
Aminopterin in Treating Patients With Refractory Leukemia
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of aminopterin in treating patients who have refractory…
- Trial name
- NCT00003305
- Testing
- aminopterin, leucovorin calcium
- Where
- 14 sites in United States
- Volunteers
- 75 people
- Sponsor
- Genzyme, a Sanofi Company
Acute Respiratory Distress Syndrome
Clinical Study to Assess the Safety and Preliminary Efficacy of HCR040 in Acute Respiratory Distress Syndrome
The main objective of the study is to assess the feasibility, safety, and tolerability of the administration of HCR040, a drug whose active substance is HC016, allogeneic adipose-derived adult mesenchymal stem cells expanded and…
- Trial name
- NCT04289194
- Testing
- HCR040 (Phase 1), HCR040 (Phase 2)
- Where
- 2 sites in Spain
- Volunteers
- 26 people
- Sponsor
- Histocell, S.L.
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